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Angiogénesis

Angiogénesis

Los inhibidores de la angiogénesis son compuestos que interfieren con la formación de nuevos vasos sanguíneos, un proceso crucial en el crecimiento y la metástasis del cáncer. Al inhibir la angiogénesis, estos compuestos pueden restringir el suministro de sangre a los tumores, ralentizando o deteniendo su crecimiento. Los inhibidores de la angiogénesis son esenciales en la investigación del cáncer y en el desarrollo terapéutico, proporcionando información sobre los mecanismos de progresión tumoral y ofreciendo posibles tratamientos para el cáncer y otras enfermedades relacionadas con la angiogénesis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la angiogénesis de alta calidad para apoyar su investigación en oncología y biología vascular.

Subcategorías de "Angiogénesis"

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Se han encontrado 1483 productos de "Angiogénesis"

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  • BMS-066
    Targetmol
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    BMS-066

    CAS:
    BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
    Fórmula:C19H21N7O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:379.42

    Ref: TM-T14669

  • Logo de CymitQuimica
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    VEGFR-2-IN-16

    <p>VEGFR-2-IN-16 (Compound 15b) is a potent inhibitor of VEGFR-2 (IC50: 86.36 nM) that exhibits antitumour effects.</p>
    Fórmula:C21H13Cl2N3O2
    Forma y color:Solid
    Peso molecular:410.25

    Ref: TM-T62071

  • Logo de CymitQuimica
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    FGFR4-IN-10

    <p>FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.</p>
    Fórmula:C20H19F3N6O3
    Forma y color:Solid
    Peso molecular:448.4

    Ref: TM-T62682

  • TYK2 ligand 2
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    TYK2 ligand 2

    CAS:
    <p>TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.</p>
    Fórmula:C24H20FN7O4
    Forma y color:Solid
    Peso molecular:489.458

    Ref: TM-T206678

  • (3S,4R)-Tofacitinib
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    (3S,4R)-Tofacitinib

    CAS:
    (3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
    Fórmula:C16H20N6O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:312.37

    Ref: TM-T13427

  • Logo de CymitQuimica
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    BTK-IN-15

    <p>BTK-IN-15: Oral BTK inhibitor, IC50 0.7 nM, induces cancer cell apoptosis, selective with anti-tumor effects.</p>
    Fórmula:C28H24FN5O2
    Forma y color:Solid
    Peso molecular:481.52

    Ref: TM-T63182

  • FGFR-IN-6
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    FGFR-IN-6

    CAS:
    <p>FGFR-IN-6 (Compound 5) is an FGFR inhibitor.</p>
    Fórmula:C23H22N6O3
    Forma y color:Solid
    Peso molecular:430.46

    Ref: TM-T62391

  • Logo de CymitQuimica
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    FLT3-IN-13

    <p>FLT3-IN-13 inhibits topoisomerase II/FLT3 in leukemia with IC50 of 2.26 μM, causes G2/M arrest, and promotes apoptosis.</p>
    Fórmula:C20H14N4O2
    Forma y color:Solid
    Peso molecular:342.35

    Ref: TM-T61101

  • SJ-C1044
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    SJ-C1044

    CAS:
    <p>SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.</p>
    Fórmula:C25H14F7N7O
    Forma y color:Solid
    Peso molecular:561.41

    Ref: TM-T200357

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Fórmula:C10H8N2O
    Forma y color:Solid
    Peso molecular:172.183

    Ref: TM-T204167

  • iBFAR2
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    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Fórmula:C19H15F3N2O2
    Forma y color:Solid
    Peso molecular:360.33

    Ref: TM-T204531

  • BML-265
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Fórmula:C18H15N3O2
    Forma y color:Solid
    Peso molecular:305.331

    Ref: TM-T204769

  • JAK3/BTK-IN-4
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    JAK3/BTK-IN-4

    CAS:
    <p>JAK3/BTK-IN-4, a dual inhibitor for JAK3/BTK, shows synergy in autoimmune disease treatment. (Patent WO2021147953A1, compound 003)</p>
    Fórmula:C21H25ClN8O
    Forma y color:Solid
    Peso molecular:440.93

    Ref: TM-T62553

  • BMS-986143
    Targetmol
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    BMS-986143

    CAS:
    <p>BMS-986143: oral BTK inhibitor, IC50=0.26 nM, potential for autoimmune research, also targets TEC, BLK, BMX, TXK, YES1, ITK.</p>
    Fórmula:C31H24Cl2N4O4
    Forma y color:Solid
    Peso molecular:587.45

    Ref: TM-T39129

  • Andamertinib
    Targetmol
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Fórmula:C31H36N8O3
    Forma y color:Solid
    Peso molecular:568.669

    Ref: TM-T206579

  • Logo de CymitQuimica
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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Fórmula:C26H28ClN3O4
    Forma y color:Solid
    Peso molecular:481.97

    Ref: TM-T63189

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Fórmula:C27H25ClN2O4
    Forma y color:Solid
    Peso molecular:476.951

    Ref: TM-T204772

  • CEP-11981
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    CEP-11981

    CAS:
    <p>CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.</p>
    Fórmula:C28H27N7O
    Pureza:99.58%
    Forma y color:Solid
    Peso molecular:477.56

    Ref: TM-T68539

  • EGFR-IN-160
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    EGFR-IN-160

    CAS:
    EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).
    Fórmula:C15H12N2O4
    Forma y color:Solid
    Peso molecular:284.27

    Ref: TM-T207600

  • Tyk2-IN-15
    Targetmol
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    Tyk2-IN-15

    CAS:
    <p>Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].</p>
    Fórmula:C21H25F2N7O
    Forma y color:Solid
    Peso molecular:429.47

    Ref: TM-T87584