Angiogénesis
Los inhibidores de la angiogénesis son compuestos que interfieren con la formación de nuevos vasos sanguíneos, un proceso crucial en el crecimiento y la metástasis del cáncer. Al inhibir la angiogénesis, estos compuestos pueden restringir el suministro de sangre a los tumores, ralentizando o deteniendo su crecimiento. Los inhibidores de la angiogénesis son esenciales en la investigación del cáncer y en el desarrollo terapéutico, proporcionando información sobre los mecanismos de progresión tumoral y ofreciendo posibles tratamientos para el cáncer y otras enfermedades relacionadas con la angiogénesis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la angiogénesis de alta calidad para apoyar su investigación en oncología y biología vascular.
Subcategorías de "Angiogénesis"
- BTK(151 productos)
- Bcr-Abl(107 productos)
- EGFR(592 productos)
- FAK(75 productos)
- FLT(88 productos)
- Receptor del factor de crecimiento de fibroblastos (FGFR)(172 productos)
- JAK(244 productos)
- PDGFR(126 productos)
- RAAS(88 productos)
- Src(80 productos)
- Syk(37 productos)
- Trombina(52 productos)
- VDA(2 productos)
- VEGFR(261 productos)
Mostrar 6 subcategorías más
Se han encontrado 1739 productos de "Angiogénesis"
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LB 42708
CAS:Producto controlado<p>Applications LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.<br>References Kim, C., et. al.: Mol. Pharmacol., 78, 142 (2010)<br></p>Fórmula:C30H27BrN4O2Forma y color:NeatPeso molecular:555.46Atrasentan
CAS:Producto controlado<p>Applications Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.<br>References Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);<br></p>Fórmula:C29H38N2O6Forma y color:Off-WhitePeso molecular:510.62N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS:Producto controladoFórmula:C20H16FN5O3Forma y color:Light Yellow To YellowPeso molecular:393.37Tyrphostin AG 1478
CAS:Producto controlado<p>Applications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.<br></p>Fórmula:C16H14ClN3O2Forma y color:NeatPeso molecular:315.75Dehydrodivanillin (~90%, contains up to 10% unknown inorganics)
CAS:Fórmula:C16H14O6Forma y color:NeatPeso molecular:302.2792,3-Naphthalic Anhydride
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.<br>References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)<br></p>Fórmula:C12H6O3Forma y color:NeatPeso molecular:198.17Pulsatilla Saponin D (90%)
CAS:Producto controlado<p>Applications Pulsatilla Saponin D shows antiangiogenic and antitumor activity.<br>References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);<br></p>Fórmula:C47H76O17Pureza:90%Forma y color:NeatPeso molecular:913.1Tyrphostin AG 112
CAS:Producto controlado<p>Applications Tyrphostin AG 112 is an EGFR inhibitor.<br></p>Fórmula:C13H8N4OForma y color:NeatPeso molecular:236.23Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Producto controlado<p>Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.<br>References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)<br></p>Fórmula:C24H20ClN5O2Forma y color:NeatPeso molecular:445.9SU11274
CAS:SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.Fórmula:C28H30ClN5O4SPureza:98.62% - 99.53%Forma y color:Orange PowderPeso molecular:568.09E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Forma y color:SolidPeso molecular:378.46Bucillamine
CAS:<p>Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF.</p>Fórmula:C7H13NO3S2Pureza:99.47%Forma y color:SolidPeso molecular:223.31JTV-519 free base
CAS:JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmicFórmula:C25H32N2O2SPureza:98%Forma y color:SolidPeso molecular:424.6Ebselen oxide
CAS:Ebselen oxide (EB-2) is a HER2 inhibitor with antibacterial and antifungal activity and has shown cytoprotective effects against HN2 in vitro.Fórmula:C13H9NO2SePureza:98%Forma y color:SolidPeso molecular:290.18SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Fórmula:C26H25Cl2FN4O2Pureza:98%Forma y color:SolidPeso molecular:515.41BTK-IN-23
CAS:BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.Fórmula:C27H28N6O2Forma y color:SolidPeso molecular:468.55EGFR/CDK2-IN-1
CAS:EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFórmula:C19H12BrClO2Forma y color:SolidPeso molecular:387.65Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Fórmula:C29H39N7O3SForma y color:SolidPeso molecular:565.73TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Fórmula:C23H17N5O2SPureza:98%Forma y color:SolidPeso molecular:427.48GDC-0834 S-enantiomer
CAS:GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK).Fórmula:C33H36N6O3SPureza:98%Forma y color:SolidPeso molecular:596.74Atopaxar
CAS:<p>Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Fórmula:C29H38FN3O5Pureza:97.07% - 98.07%Forma y color:SolidPeso molecular:527.63PHM16
CAS:PHM16 is an ATP competitive FAK and FGFR2 inhibitor.Fórmula:C20H22N6O4Pureza:98%Forma y color:SolidPeso molecular:410.43BI-1622
CAS:BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Fórmula:C26H24N10O2Forma y color:SolidPeso molecular:508.53ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Fórmula:C18H20FN3O2SForma y color:SolidPeso molecular:361.43EGFR-IN-57
CAS:EGFR-IN-57: potent EGFR-TK blocker, IC50 0.054 μM, oral. Halts VEGFR-2, CK2α, topo IIβ, tubulin. Causes G2/M, pre-G1 arrest, cancer cell death.Fórmula:C22H15N3O2SForma y color:SolidPeso molecular:385.44CPL304110
CAS:CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54EGFR/HER2/CDK9-IN-3
CAS:<p>EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.</p>Fórmula:C24H21N3O4S2Forma y color:SolidPeso molecular:479.57EGFR-IN-52
CAS:EGFR-IN-52, a potent EGFR inhibitor, has IC50s: 0.358 μM (wild-type), 86.02 μM (L858R-TK), 432.67 μM (T790M-TK); induces cancer cell apoptosis.Fórmula:C19H18N4O3SForma y color:SolidPeso molecular:382.44UNC-CA359
CAS:<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Fórmula:C18H14ClN3O2Forma y color:SolidPeso molecular:339.78ZK-304709 HCl
CAS:ZK-304709 is an oral multitarget tumor growth inhibitor with activity against cell-cycle progression and angiogenesis.Fórmula:C22H29ClN6O2Forma y color:SolidPeso molecular:444.96NSC 33994
CAS:NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Fórmula:C28H42N2O2Pureza:98%Forma y color:SolidPeso molecular:438.65JAK3/BTK-IN-6
CAS:JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Fórmula:C21H17BF3N5O3Forma y color:SolidPeso molecular:455.2EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Fórmula:C36H44BrN10O2PForma y color:SolidPeso molecular:759.68Rogaratinib
CAS:<p>Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).</p>Fórmula:C23H26N6O3SPureza:99.54%Forma y color:SolidPeso molecular:466.56BCR-ABL-IN-6
CAS:BCR-ABL-IN-6, an imatinib derivative, inhibits Bcr-AblWT (4.6 nM IC50) and T315I (277 nM), for chronic myeloid leukemia study.Fórmula:C27H22F3N5O2Forma y color:SolidPeso molecular:505.49VS 8
CAS:VS 8: potent oral VEGFR-2 inhibitor, anti-angiogenic, induces cancer cell apoptosis & migration, acts on CSCs.Fórmula:C26H20F3N3O3Forma y color:SolidPeso molecular:479.45EGFR/HER2-IN-2
CAS:EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Fórmula:C31H30ClFN4O3SForma y color:SolidPeso molecular:593.11EGFR-IN-25
CAS:EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Fórmula:C34H43N9O2Forma y color:SolidPeso molecular:609.76EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Fórmula:C17H14N4O4S3Forma y color:SolidPeso molecular:434.51NSC114792
CAS:NSC114792 is a selective JAK3 inhibitor.Fórmula:C26H32N4O2SPureza:98%Forma y color:SolidPeso molecular:464.62FGFR2-IN-2
CAS:<p>FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.</p>Fórmula:C23H22N4OPureza:98.09%Forma y color:SolidPeso molecular:370.45SUN13837
CAS:SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.Fórmula:C21H29N5O2Forma y color:SolidPeso molecular:383.49TYK2-IN-11
CAS:TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.Fórmula:C18H17N5O3SForma y color:SolidPeso molecular:383.42EGFR/HER2-IN-3
CAS:EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49FLT3-IN-18
CAS:FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.Fórmula:C26H36N8OForma y color:SolidPeso molecular:476.62(R)-Elsubrutinib
CAS:(R)-Elsubrutinib ((R)-ABBV-105) is a Btk inhibitor and an isomer of Elsubrutinib, suitable for inflammation research.Fórmula:C17H19N3O2Pureza:99.05%Forma y color:SolidPeso molecular:297.35JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Fórmula:C24H28Cl2N6O3Pureza:98%Forma y color:SolidPeso molecular:519.42EGFR-IN-69
CAS:EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Fórmula:C31H37Cl2N7O3SForma y color:SolidPeso molecular:658.64VEGFR2 Kinase Inhibitor II
CAS:VEGFR2 kinase inhibitor II: Reversible, cell-permeable, targets VEGFR2 (IC50=70nM), less effective on PDGFRβ (IC50=920nM). Blocks VEGF/PDGF-stimulated growth.Fórmula:C17H15BrN2OForma y color:SolidPeso molecular:343.22
