Angiogénesis
Los inhibidores de la angiogénesis son compuestos que interfieren con la formación de nuevos vasos sanguíneos, un proceso crucial en el crecimiento y la metástasis del cáncer. Al inhibir la angiogénesis, estos compuestos pueden restringir el suministro de sangre a los tumores, ralentizando o deteniendo su crecimiento. Los inhibidores de la angiogénesis son esenciales en la investigación del cáncer y en el desarrollo terapéutico, proporcionando información sobre los mecanismos de progresión tumoral y ofreciendo posibles tratamientos para el cáncer y otras enfermedades relacionadas con la angiogénesis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la angiogénesis de alta calidad para apoyar su investigación en oncología y biología vascular.
Subcategorías de "Angiogénesis"
- BTK(166 productos)
- Bcr-Abl(117 productos)
- EGFR(549 productos)
- FAK(72 productos)
- FLT(88 productos)
- Receptor del factor de crecimiento de fibroblastos (FGFR)(176 productos)
- JAK(243 productos)
- PDGFR(127 productos)
- RAAS(86 productos)
- Src(82 productos)
- Syk(37 productos)
- Trombina(51 productos)
- VDA(2 productos)
- VEGFR(236 productos)
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Se han encontrado 2266 productos de "Angiogénesis"
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JAK-IN-1
CAS:JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Fórmula:C20H24N6O2Pureza:98%Forma y color:SolidPeso molecular:380.44ALK-IN-6
CAS:ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).Fórmula:C26H29ClD3N5O3SPureza:98%Forma y color:SolidPeso molecular:533.1SIM010603
CAS:SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Fórmula:C22H25FN4O2Forma y color:SolidPeso molecular:396.46UNC4203
CAS:UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Fórmula:C30H44N6OForma y color:SolidPeso molecular:504.71DosatiLink-1
CAS:DosatiLink-1 acts as an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Fórmula:C69H93Cl2F2N13O17SForma y color:SolidPeso molecular:1517.52VEGFR-2-IN-37
CAS:VEGFR-2-IN-37 (compound 12), a VEGFR-2 inhibitor, exhibits an inhibition rate of approximately 56.9 μM at a concentration of 200 μM.Fórmula:C18H16N2O2SPureza:98%Forma y color:SolidPeso molecular:324.4BTK inhibitor 13
CAS:BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).Fórmula:C29H26FN5O3Pureza:98%Forma y color:SolidPeso molecular:511.55EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFórmula:C54H54Cl2FN7O7S2Pureza:98%Forma y color:SolidPeso molecular:1067.08FGFR-IN-4
CAS:FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.Fórmula:C24H21N7O2Forma y color:SolidPeso molecular:439.47HPK1-IN-2 dihydrochloride
CAS:HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Fórmula:C19H22Cl2N6OSForma y color:SolidPeso molecular:453.39Tubulin/JAK2-IN-1
CAS:Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFórmula:C22H20N6O3Forma y color:SolidPeso molecular:416.43EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFórmula:C26H30N8O2Pureza:98%Forma y color:SolidPeso molecular:486.57EGFR-IN-61
CAS:EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Fórmula:C33H37ClN8O3Pureza:98%Forma y color:SolidPeso molecular:629.15BEBT-109
CAS:BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Fórmula:C27H32N8O3Pureza:97.26%Forma y color:SolidPeso molecular:516.6FC 11
CAS:FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Fórmula:C41H42F3N13O9SForma y color:SolidPeso molecular:949.91Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Fórmula:C20H16FN5O2Pureza:99.95%Forma y color:SolidPeso molecular:377.37Ref: TM-T79851
1mg132,00€5mg319,00€10mg512,00€25mg1.018,00€50mg1.468,00€100mg1.972,00€200mg2.655,00€1mL*10mM (DMSO)354,00€DosatiLink-2
CAS:DosatiLink-2 is an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Fórmula:C65H85Cl2F2N13O15SForma y color:SolidPeso molecular:1429.4215-deoxy-Δ12,14-Prostaglandin D2
CAS:15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.Fórmula:C20H30O4Forma y color:SolidPeso molecular:334.456HER2-IN-5
CAS:HER2-IN-5 is an effective inhibitor of orally active HER-2.Fórmula:C27H33N7O3Forma y color:SolidPeso molecular:503.6Nazartinib S-enantiomer
CAS:Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Fórmula:C26H31ClN6O2Pureza:98%Forma y color:SolidPeso molecular:495.02
