Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(6 productos)
- BCL(11 productos)
- Caspasa(127 productos)
- FOXO1(3 productos)
- IAP(65 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(24 productos)
- Serina / treonina quinasa(15 productos)
- Survivin(13 productos)
- TNF(91 productos)
- c-RET(51 productos)
- p53(62 productos)
Mostrar 6 subcategorías más
Se han encontrado 5622 productos de "Apoptosis"
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RMC-9805
CAS:<p>RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.</p>Fórmula:C63H88F3N11O7Pureza:98.10% - 99.51%Forma y color:SolidPeso molecular:1168.44Z-Ala-Ala-Asp-CMK
CAS:<p>Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.</p>Fórmula:C19H24ClN3O7Pureza:99.967%Forma y color:SolidPeso molecular:441.86Spexin TFA
<p>Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.</p>Fórmula:C76H115F3N20O21SForma y color:SolidPeso molecular:1733.9Oxatomide
CAS:<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Fórmula:C27H30N4OPureza:98.82% - 99.72%Forma y color:White PowderPeso molecular:426.55Thalidomide-O-amido-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.</p>Fórmula:C21H26N4O8Forma y color:SolidPeso molecular:462.459KB03-SLF
CAS:<p>KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.</p>Fórmula:C50H63ClF3N5O12Forma y color:SolidPeso molecular:1018.51Holothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Fórmula:C54H86NaO27SForma y color:SolidPeso molecular:1222.3Taltirelin acetate
CAS:<p>Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an</p>Fórmula:C19H27N7O7Pureza:99.21%Forma y color:SolidPeso molecular:465.46Vonlerolizumab
CAS:<p>Vonlerolizumab (MOXR 0916) is a humanized IgG OX40 agonist monoclonal antibody with potential in cancer and immune disease research.</p>Pureza:SDS-PAGE:97.3%;SEC-HPLC:99.4%Forma y color:LiquidPeso molecular:145.25 kDaNecroIr1
<p>NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.</p>Fórmula:C40H29ClIrN5OForma y color:SolidPeso molecular:823.36Topoisomerase I/II inhibitor 6
<p>TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.</p>Fórmula:C31H28F2N4O6SForma y color:SolidPeso molecular:622.64Thymidine 3',5'-diphosphate tetrasodium
CAS:<p>Thymidine 3',5'-diphosphate tetrasodium inhibits staphylococcal nuclease, SND1 & tyrosyl nuclease; has anti-tumor properties & catalyzes biochemical reactions.</p>Fórmula:C10H12N2Na4O11P2Forma y color:SolidPeso molecular:490.12Nerelimomab
CAS:<p>Nerelimomab (BAYX1351), an anti-TNF-α antibody, is utilized in sepsis research [1] [2].</p>Forma y color:LiquidVerproside
CAS:<p>Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.</p>Fórmula:C22H26O13Forma y color:SolidPeso molecular:498.437Pomstafib-2
CAS:<p>Pomstafib-2, a potent and selective inhibitor of STAT5b, reduces pSTAT5b expression and effectively induces apoptosis [1] [2].</p>Fórmula:C52H66N2O20P2Forma y color:SolidPeso molecular:1101.03SC-2001
CAS:<p>SC-2001 inhibits MCL-1 and STAT3, enhances SHP-1, induces apoptosis in breast cancer, and counters STAT3-driven sorafenib resistance in liver cancer.</p>Fórmula:C18H14BrN3OPureza:98%Forma y color:SolidPeso molecular:368.23YJ1206
CAS:YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader oral, DNA damage and cell-cycle arrest,and inhibits the proliferation of prostate cancer cells.Fórmula:C49H52FN11O5Pureza:97.14%Forma y color:SolidPeso molecular:894.01N-Acetylpsychosine
CAS:<p>N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties.</p>Fórmula:C26H49NO8Forma y color:SolidPeso molecular:503.67MG-C-30
CAS:<p>MG-C-30 is an orally active CD27 agonist with an EC50 of 0.84 μM. It activates co-stimulatory signaling in NK cells and T cells, thereby enhancing the immune response. In the EG7-OVA mouse model, MG-C-30 demonstrates antitumor activity.</p>Fórmula:C24H26N4O3SForma y color:SolidPeso molecular:450.55Silicon naphthalocyanine dichloride
CAS:<p>Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.</p>Fórmula:C48H24Cl2N8SiForma y color:SolidPeso molecular:811.75Sodium propionate
CAS:Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.Fórmula:C3H5NaO2Forma y color:SoildPeso molecular:96.06PROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Fórmula:C32H29IN4O4S2Forma y color:SolidPeso molecular:724.63Phosphocreatine dipotassium
CAS:<p>Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives.</p>Fórmula:C4H8K2N3O5PPureza:98%Forma y color:SolidPeso molecular:287.29PROTAC MNK1 degrader-1
<p>ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.</p>Fórmula:C35H38N6O6SForma y color:SolidPeso molecular:670.78(E/Z)-LAQ824
CAS:<p>(E/Z)-LAQ824 is an inhibitor of histone deacetylase.</p>Fórmula:C22H25N3O3Pureza:98%Forma y color:SolidPeso molecular:379.46Antitumor photosensitizer-3
<p>Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laser</p>Fórmula:C48H34N4O4Forma y color:SolidPeso molecular:730.81Bursehernin
CAS:<p>Bursehernin is a useful organic compound for research related to life sciences and the catalog number is T124894.</p>Fórmula:C21H22O6Forma y color:SolidPeso molecular:370.401Antiproliferative agent-23
<p>Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.</p>Fórmula:C23H28Cl3N3O6PtForma y color:SolidPeso molecular:743.93MBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Fórmula:C17H35N4O14P3Pureza:98%Forma y color:SolidPeso molecular:612.4Danburstotug
CAS:<p>Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).</p>Pureza:98%Forma y color:LiquidProlgolimab
CAS:<p>Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.</p>Pureza:>95%Forma y color:LiquidP-gp inhibitor 16
<p>P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.</p>Fórmula:C35H35N5O4Peso molecular:589.2689Fuscin
CAS:<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>Fórmula:C15H16O5Forma y color:SolidPeso molecular:276.288Cu(I) chelator 1
<p>Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.</p>Fórmula:C16H27NO4S3Peso molecular:393.11022MALT1-IN-13
MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.Fórmula:C20H15BrClN3O3S2Peso molecular:522.94267HDAC6-IN-28
<p>HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.</p>Fórmula:C23H16FN3O2Peso molecular:385.12265Necrosis inhibitor 2 (hydrocholide)
<p>Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.</p>Fórmula:C24H26ClN5O5Peso molecular:499.16225PROTAC PD-L1 degrader-1
<p>PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.</p>RIP1 kinase inhibitor 9
<p>RIP1 kinase inhibitor 9 (compound SY-1) is a selective inhibitor of RIP kinase. It effectively reduces central inflammatory responses caused by seizures. RIP1 kinase inhibitor 9 also obstructs Z-VAD-FMK-induced necroptosis in HT-29 cells, with an EC50 of 7.04 nM.</p>Fórmula:C25H21N3O3Peso molecular:411.15829Canfosfamide
CAS:<p>Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.</p>Fórmula:C26H40Cl4N5O10PSForma y color:SolidPeso molecular:787.47Topoisomerase II inhibitor 17
<p>TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.</p>Fórmula:C25H22Cl3N3O5SPeso molecular:581.03458PROTAC EGFR degrader 9
CAS:<p>PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.</p>Fórmula:C45H48F3N9O6SPeso molecular:899.98Milademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Fórmula:C37H44Cl2FN5O8SForma y color:SolidPeso molecular:808.74Chloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Fórmula:C15H16O3Forma y color:SolidPeso molecular:244.29Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Fórmula:C80H113N25O27Forma y color:SolidPeso molecular:1856.932IDH1/2-IN-1
<p>IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.</p>Forma y color:Odour SolidTrilexium
CAS:<p>Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].</p>Fórmula:C24H23FO6Forma y color:SolidPeso molecular:426.43Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
<p>Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.</p>Fórmula:C27H35F3N4O11Pureza:98%Forma y color:SolidPeso molecular:648.58Thalidomide-5-propargyne-NH2 hydrochloride
CAS:<p>Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.</p>Fórmula:C16H14ClN3O4Forma y color:SolidPeso molecular:347.753Mcl1-IN-26
CAS:<p>Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.</p>Fórmula:C45H52ClN5O6SForma y color:SolidPeso molecular:826.44
