Apoptosis
Los inhibidores de la apoptosis son compuestos que previenen o retrasan el proceso de muerte celular programada, conocido como apoptosis. Estos inhibidores son vitales para estudiar los mecanismos de supervivencia celular y se utilizan para investigar enfermedades donde la apoptosis está desregulada, como el cáncer, los trastornos neurodegenerativos y las enfermedades autoinmunes. Al modular la apoptosis, estos inhibidores pueden ayudar en el desarrollo de terapias dirigidas a controlar la muerte celular. En CymitQuimica, ofrecemos una amplia selección de inhibidores de la apoptosis de alta calidad para apoyar su investigación en biología celular, oncología y campos relacionados.
Subcategorías de "Apoptosis"
- ASK(9 productos)
- BCL(1 productos)
- Caspasa(154 productos)
- FOXO1(2 productos)
- IAP(67 productos)
- Mdm2(12 productos)
- PD-1 / PD-L1(126 productos)
- PDK(9 productos)
- PERK(23 productos)
- Serina / treonina quinasa(17 productos)
- Survivin(14 productos)
- TNF(91 productos)
- c-RET(61 productos)
- p53(63 productos)
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Se han encontrado 6170 productos de "Apoptosis"
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GP130-IN-1
CAS:GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0/G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.Fórmula:C21H10F5NO3Forma y color:SolidPeso molecular:419.30BRD4/CK2-IN-1
CAS:BRD4/CK2-IN-1 is a small-molecule inhibitor targeting BRD4 and CK2, inducing apoptosis and autophagy-related cell death.Fórmula:C29H30ClN5O5Pureza:99.02%Forma y color:SolidPeso molecular:564.03Samuraciclib hydrochloride hydrate
Samuraciclib (CT7001) is a potent oral CDK7 inhibitor (IC50: 41 nM) with anti-breast cancer properties.Fórmula:C22H35ClN6O3Forma y color:SolidPeso molecular:521.7Topoisomerase II inhibitor 20 TFA
TopoisomeraseII Inhibitor 20 TFA is a potent inhibitor of topoisomerase II with an IC50 of 0.98 µM. It can induce cell apoptosis and exhibits broad-spectrum anticancer activity.Fórmula:C24H24F5N5O4SForma y color:SolidPeso molecular:573.54DOR agonist 2
CAS:Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Fórmula:C29H26N2O3Forma y color:SolidPeso molecular:450.53PF-3837
CAS:PF-3837 is an inhibitor of the Mps1 kinase, with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, thereby reducing genomic stability and leading to cancer cell apoptosis (Apoptosis). PF-3837 is utilized in the study of breast cancer.Fórmula:C21H26N8O2Forma y color:SolidPeso molecular:422.48MB710
CAS:MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Fórmula:C16H16IN3O3SPureza:99.02%Forma y color:SolidPeso molecular:457.29hCAIX/XII-IN-1
hCAIX/XII-IN-1: potent CAIX inhibitor (KI=0.48μM), CAXII (KI=0.83μM), antiproliferative, induces apoptosis in MCF-7 cells.Fórmula:C19H11NO5S2Forma y color:SolidPeso molecular:397.42PARP/NAMPT-IN-1
CAS:PARP/NAMPT-IN-1 (Compound 13j) is a dual-target inhibitor of PARP and NAMPT, with IC50 values of 0.8 nM for PARP1 and 18 nM for NAMPT. It suppresses breast cancer cell proliferation and migration, inducing apoptosis. PARP/NAMPT-IN-1 is applicable for research on triple-negative breast cancer.Fórmula:C34H36FN7O3Forma y color:SolidPeso molecular:609.693Sabialimon P
CAS:Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.Fórmula:C31H50O4Forma y color:SolidPeso molecular:486.73CRT0066101
CAS:CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7 nM and demonstrates anticancer effects [2].Fórmula:C18H22N6OForma y color:SolidPeso molecular:338.41Sampangine
CAS:Sampangine, an alkaloid, induces apoptosis by causing cell cycle arrest at the G0/G1 phase and inhibits the biosynthesis of heme.Fórmula:C15H8N2OForma y color:SolidPeso molecular:232.24FAK-IN-4
FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].Fórmula:C20H22N4OForma y color:SolidPeso molecular:334.41PARP1-IN-12
PARP1-IN-12: potent PARP1 inhibitor, IC50 2.99 nM, triggers cell apoptosis, G2/M arrest, induces DSBs in BRCA-deficient cells.Fórmula:C43H56FN5O5Forma y color:SolidPeso molecular:741.93Antitumor agent-37
Antitumor agent-37: strong anti-growth, anti-spread, induces DNA damage, apoptosis via Bcl-2/Bax/caspase3, boosts immune response.Fórmula:C16H18Cl2N2O4PtForma y color:SolidPeso molecular:568.32EGFR/HER2-IN-6
EGFR/HER2-IN-6 is a dual inhibitor of EGFR, HER2, and DHFR with IC50s: 0.122, 0.078, and 0.585 μM, showing anticancer potential and selectivity.Fórmula:C18H21N5O3SForma y color:SolidPeso molecular:387.46SLCB050
CAS:SLCB050 is a compound with anticancer activity that inhibits the interaction between DX2 and p14/ARF. It decreases the viability of human lung cancer cells, particularly small cell lung cancer cells, in a p14/ARF-dependent manner, and induces cell apoptosis (apoptosis) and senescence.Fórmula:C21H18O6Forma y color:SolidPeso molecular:366.36HDAC-IN-34
HDAC-IN-34 inhibits HDAC1 (IC50: 0.022 μM) & HDAC6 (IC50: 0.45 μM), binds DNA causing damage, and halts HCT-116 cell growth (IC50: 1.41 μM).Fórmula:C24H26N6O3Forma y color:SolidPeso molecular:446.5L5-DA
L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.Fórmula:C32H34N6O2Forma y color:SolidPeso molecular:534.65PI3K/AKT-IN-1
CAS:PI3K/AKT-IN-1 is a dual inhibitor of PI3K and AKT with anti-cancer activity, inhibiting the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis.Fórmula:C23H23N5O4SPureza:99.84%Forma y color:SoildPeso molecular:465.53Ref: TM-T62997
1mg71,00€5mg152,00€10mg205,00€25mg356,00€50mg485,00€100mg708,00€200mg982,00€1mL*10mM (DMSO)156,00€
