STAT
Las proteínas STAT son componentes críticos de la vía de señalización JAK/STAT, que transmite señales extracelulares de citoquinas y factores de crecimiento al núcleo celular, influyendo en la expresión génica. Las proteínas STAT están involucradas en la regulación de respuestas inmunitarias, crecimiento celular, diferenciación y supervivencia. La desregulación de la señalización STAT está implicada en diversas enfermedades, incluido el cáncer, trastornos autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos una amplia gama de moduladores de la vía STAT para apoyar su investigación en transducción de señales, inmunología y desarrollo terapéutico.
Se han encontrado 98 productos de "STAT"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Artesunate
CAS:<p>Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.</p>Fórmula:C19H28O8Pureza:97.67% - 99.9%Forma y color:White Crystalline PowderPeso molecular:384.42Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Fórmula:C10H12FN5O4Pureza:99.65% - 99.89%Forma y color:White SolidPeso molecular:285.23STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Fórmula:C28H29NO6Pureza:95.89% - 95.89%Forma y color:SolidPeso molecular:475.53Diosgenin
CAS:<p>Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.</p>Fórmula:C27H42O3Pureza:98.87% - 99.87%Forma y color:Flaky Or Needle CrystalPeso molecular:414.62L002
CAS:<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Fórmula:C15H15NO5SPureza:98.59%Forma y color:SolidPeso molecular:321.35Nifuroxazide
CAS:<p>Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.</p>Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Forma y color:Yellow SolidPeso molecular:275.22Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Fórmula:C15H15Cl2N3O5Pureza:99.89%Forma y color:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Peso molecular:388.20UC-514321
CAS:<p>UC-514321 directly targets STAT3/5 and represses TET1 expression.</p>Fórmula:C26H35NO5Pureza:98.50%Forma y color:SolidPeso molecular:441.56Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:414.45Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Forma y color:Pale Yellow Crystals SolidPeso molecular:327.12STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Fórmula:C22H30F3NO7Forma y color:SolidPeso molecular:477.471Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Forma y color:LiquidSTAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Forma y color:Odour SolidNeocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Fórmula:C31H42O8Pureza:98%Forma y color:SolidPeso molecular:542.66STAT3-IN-39
CAS:<p>STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.</p>Fórmula:C20H17F3N2O3SForma y color:SolidPeso molecular:422.42(R)-Lisofylline
CAS:<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Fórmula:C13H20N4O3Pureza:99.50%Forma y color:SolidPeso molecular:280.32JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour SolidSTAT3 HiBiT degrader 1
CAS:<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Fórmula:C58H63F4N10O14PSForma y color:SolidPeso molecular:1263.21Anticancer agent 259
<p>Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.</p>Fórmula:C30H26N2O2Forma y color:SolidPeso molecular:446.54CMD178
<p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>Fórmula:C46H59N9O7Pureza:98%Forma y color:SolidPeso molecular:850.03STAT3-IN-37
CAS:<p>STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.</p>Fórmula:C23H25Cl2N5O2Forma y color:SolidPeso molecular:474.38Eupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Fórmula:C20H26O6Pureza:98%Forma y color:SolidPeso molecular:362.42STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Fórmula:C25H27N5OForma y color:SolidPeso molecular:413.51STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Fórmula:C22H14N4O3Pureza:99.61%Forma y color:SolidPeso molecular:382.37STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Fórmula:C16H15NO3SForma y color:SolidPeso molecular:301.36STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Fórmula:C19H16N2O4SForma y color:SolidPeso molecular:368.41MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Fórmula:C15H12N2O2Pureza:99.74%Forma y color:SolidPeso molecular:252.27Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Fórmula:C26H24N2O11P2Pureza:97.18%Forma y color:SolidPeso molecular:602.42Balsalazide
CAS:<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Fórmula:C17H15N3O6Pureza:99.31%Forma y color:Yellow To Orange Crystalline PowderPeso molecular:357.32SC-43
CAS:<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Fórmula:C21H13ClF3N3O2Pureza:98.44%Forma y color:SolidPeso molecular:431.8SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Fórmula:C29H27F5N2O5SPureza:98% - 99.12%Forma y color:SolidPeso molecular:610.59SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Pimozide
CAS:<p>Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.</p>Fórmula:C28H29F2N3OPureza:99.63% - >99.99%Forma y color:SolidPeso molecular:461.55WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Fórmula:C17H14BrN3OPureza:98.92% - 99.73%Forma y color:SolidPeso molecular:356.22Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Fórmula:C30H42O7Pureza:96.69% - 99.8%Forma y color:SolidPeso molecular:514.65RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Fórmula:C17H20N4O2Pureza:99.30%Forma y color:SolidPeso molecular:312.37Cryptotanshinone
CAS:<p>Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.</p>Fórmula:C19H20O3Pureza:97.94% - ≥95%Forma y color:Orange Needle CrystalPeso molecular:296.36Scutellarin
CAS:<p>Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.</p>Fórmula:C21H18O12Pureza:97.12% - 99.75%Forma y color:SolidPeso molecular:462.36Brevilin A
CAS:<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Fórmula:C20H26O5Pureza:99.97% - >99.99%Forma y color:SolidPeso molecular:346.42AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Atranorin
CAS:<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Fórmula:C19H18O8Pureza:98.76% - 99.57%Forma y color:SolidPeso molecular:374.34HO-3867
CAS:<p>HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.</p>Fórmula:C28H30F2N2O2Pureza:91.18% - 99.21%Forma y color:SolidPeso molecular:464.55S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Fórmula:C16H15NO7SPureza:97.83%Forma y color:SolidPeso molecular:365.36Morusin
CAS:<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Fórmula:C25H24O6Pureza:98.68% - 99.8%Forma y color:SolidPeso molecular:420.45STAT5-IN-1
CAS:<p>STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.</p>Fórmula:C16H11N3O3Pureza:99.44% - ≥95%Forma y color:SolidPeso molecular:293.28Napabucasin
CAS:<p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>Fórmula:C14H8O4Pureza:98.43% - 99.85%Forma y color:SolidPeso molecular:240.21Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Forma y color:SolidPeso molecular:332.39Garcinone D
CAS:<p>Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).</p>Fórmula:C24H28O7Pureza:99.94%Forma y color:SolidPeso molecular:428.47Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Fórmula:C20H18O6Pureza:99.81%Forma y color:Off White PowderPeso molecular:354.35HJC0152 hydrochloride
CAS:<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Fórmula:C15H14Cl3N3O4Pureza:99.01% - 99.06%Forma y color:SolidPeso molecular:406.64Nitidine chloride
CAS:<p>1.</p>Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Forma y color:SolidPeso molecular:383.82RO8191
CAS:<p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>Fórmula:C14H5F6N5OPureza:98% - 98.85%Forma y color:SolidPeso molecular:373.21Balsalazide disodium dihydrate
CAS:<p>Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.</p>Fórmula:C17H17N3Na2O8Pureza:98.95% - 99.49%Forma y color:Yellow To Orange Crystalline PowderPeso molecular:437.31BP-1-102
CAS:<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Fórmula:C29H27F5N2O6SPureza:99.25% - 99.44%Forma y color:SolidPeso molecular:626.59ML116
CAS:<p>ML116 is a potent and selective STAT3 inhibitor.</p>Fórmula:C18H19N3SPureza:99.49%Forma y color:SolidPeso molecular:309.43Picroside I
CAS:<p>Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.</p>Fórmula:C24H28O11Pureza:99.70%Forma y color:SolidPeso molecular:492.47SH5-07
CAS:<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Fórmula:C29H28F5N3O5SPureza:95.54%Forma y color:SolidPeso molecular:625.61FLLL32
CAS:<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Fórmula:C28H32O6Pureza:97% - 97.90%Forma y color:SolidPeso molecular:464.552-(1,8-naphthyridin-2-yl)phenol
CAS:<p>2-NP is a STAT1 enhancer.</p>Fórmula:C14H10N2OPureza:99.33% - 99.82%Forma y color:SolidPeso molecular:222.24TPCA-1
CAS:<p>TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases</p>Fórmula:C12H10FN3O2SPureza:95.03% - 97.86%Forma y color:SolidPeso molecular:279.29Saikosaponin D
CAS:<p>Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.</p>Fórmula:C42H68O13Pureza:98.34% - 99.73%Forma y color:White PowderPeso molecular:780.98Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Fórmula:C15H12O5Pureza:99.42% - 99.82%Forma y color:SolidPeso molecular:272.25AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Fórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Forma y color:SolidPeso molecular:397.86BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Fórmula:C14H13N3OSPureza:99.02%Forma y color:SolidPeso molecular:271.34Astaxanthin
CAS:<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Fórmula:C40H52O4Pureza:95.1% - 99.79%Forma y color:Needles From Acetone/Light Petroleum SolidPeso molecular:596.84AS1810722
CAS:<p>AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.</p>Fórmula:C25H25F2N7OPureza:99.13%Forma y color:SolidPeso molecular:477.511-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Fórmula:C21H13ClF3N3O2Pureza:99.41%Forma y color:SolidPeso molecular:431.8Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Forma y color:SolidPeso molecular:230.3C188-9
CAS:<p>C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.</p>Fórmula:C27H21NO5SPureza:98.07% - >99.99%Forma y color:SolidPeso molecular:471.52Casticin
CAS:<p>Casticin combats vascular inflammation by blocking ROS-NF-κB and could lead in prostate cancer treatment.</p>Fórmula:C19H18O8Pureza:99.37% - ≥95%Forma y color:SolidPeso molecular:374.34Fraxinellone
CAS:<p>1.</p>Fórmula:C14H16O3Pureza:99.35% - 99.92%Forma y color:SolidPeso molecular:232.27Corylifol A
CAS:<p>1.</p>Fórmula:C25H26O4Pureza:97.19% - 99.5%Forma y color:SolidPeso molecular:390.47AG490
CAS:<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Forma y color:Yellow SolidPeso molecular:294.3Alantolactone
CAS:<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Fórmula:C15H20O2Pureza:99.02% - 99.66%Forma y color:Crystalline PowderPeso molecular:232.32Angoline
CAS:<p>Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.</p>Fórmula:C22H21NO5Pureza:99.43% - 99.96%Forma y color:SolidPeso molecular:379.41Mogrol
CAS:<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Fórmula:C30H52O4Pureza:99.85% - 99.90%Forma y color:SolidPeso molecular:476.73Colivelin
CAS:<p>Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).</p>Fórmula:C119H206N32O35Pureza:96.56%Forma y color:SolidPeso molecular:2645.1Stafia-1
CAS:<p>Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.</p>Fórmula:C24H27O10PPureza:98.08%Forma y color:SolidPeso molecular:506.44Ochromycinone
CAS:<p>Ochromycinone (STA 21) is a selective STAT3 inhibitor.</p>Fórmula:C19H14O4Pureza:99.21%Forma y color:SolidPeso molecular:306.31Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73Tetramethylcurcumin
CAS:<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Fórmula:C25H28O6Pureza:97.69% - 99.94%Forma y color:SolidPeso molecular:424.49Stattic
CAS:<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Fórmula:C8H5NO4SPureza:98.32% - 99.76%Forma y color:SolidPeso molecular:211.19Homoharringtonine
CAS:<p>Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.</p>Fórmula:C29H39NO9Pureza:98.21% - 99.78%Forma y color:Off-White CrystPeso molecular:545.62inS3-54-A26
CAS:<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Fórmula:C25H19ClN2O2Pureza:99.57%Forma y color:SolidPeso molecular:414.88STAT3-IN-B9
CAS:<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Fórmula:C20H13NO5SPureza:98.19%Forma y color:SolidPeso molecular:379.39inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Fórmula:C23H16ClNO2Pureza:99.68%Forma y color:SolidPeso molecular:373.83Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Fórmula:C28H26N2O12P2Pureza:98.48%Forma y color:SolidPeso molecular:644.46ML115
CAS:<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Fórmula:C15H15ClN2O4Pureza:99.97%Forma y color:SolidPeso molecular:322.74STAT6-IN-3
CAS:<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Fórmula:C32H35IN3O7PPureza:98%Forma y color:SolidPeso molecular:731.51STAT3-IN-20
CAS:<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Fórmula:C30H27F4N7SPureza:98%Forma y color:SolidPeso molecular:593.64Antitumor agent-73
CAS:<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Fórmula:C50H82BrO4PPureza:98%Forma y color:SolidPeso molecular:858.06STAT6-IN-2
CAS:<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Fórmula:C28H31N5O2Pureza:99.67%Forma y color:SolidPeso molecular:469.58WZ-2-033
CAS:<p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>Fórmula:C25H18F3N3O4SForma y color:SolidPeso molecular:513.49STAT3-IN-35
CAS:<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Fórmula:C21H23NO4Forma y color:SolidPeso molecular:353.41PMMB-187
CAS:<p>PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.</p>Fórmula:C27H23BrN2O6S2Forma y color:SolidPeso molecular:615.52STAT3-IN-8
CAS:<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Fórmula:C19H7F7N2O3Pureza:98%Forma y color:SolidPeso molecular:444.26STAT3-IN-36
CAS:<p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>Fórmula:C30H24F2N2O9S2Forma y color:SolidPeso molecular:658.65
