MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 893 productos de "MAPK"
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Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Forma y color:SolidPeso molecular:615.67APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Forma y color:SolidPeso molecular:423.89ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Forma y color:SolidPeso molecular:405.41PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Forma y color:SolidPeso molecular:413.83Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Forma y color:SolidPeso molecular:540.01(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Forma y color:SolidPeso molecular:560.594Necrosulfonamide
CAS:<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Fórmula:C18H15N5O6S2Pureza:98.85% - 99.49%Forma y color:SolidPeso molecular:461.47SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Fórmula:C19H15ClN4OPureza:98.56%Forma y color:SolidPeso molecular:350.8NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Fórmula:C29H30F3N5O2Pureza:98.32% - ≥95%Forma y color:SolidPeso molecular:537.58ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Forma y color:SolidPeso molecular:747.85Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Fórmula:C17H11BrFN3O2Pureza:99.01%Forma y color:SolidPeso molecular:388.19Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Fórmula:C24H21F2NO4Pureza:99.56% - >99.99%Forma y color:SolidPeso molecular:425.42BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Fórmula:C28H33F2N7O2SPureza:97.33% - 99.07%Forma y color:SolidPeso molecular:569.67UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Forma y color:SolidPeso molecular:640.68ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Fórmula:C19H23F2N5O2Pureza:98.51% - 99.43%Forma y color:SolidPeso molecular:391.42SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Forma y color:SolidPeso molecular:359.41Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Forma y color:SolidPeso molecular:431.2PF-4708671
CAS:<p>PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).</p>Fórmula:C19H21F3N6Pureza:99.48% - 99.67%Forma y color:SolidPeso molecular:390.41GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Fórmula:C23H21ClN2O3Pureza:99.73%Forma y color:SolidPeso molecular:408.87APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Fórmula:C23H16F8N4O3Pureza:99.39%Forma y color:SolidPeso molecular:548.39Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Fórmula:C20H28ClN7O3SPureza:99.85%Forma y color:SolidPeso molecular:482Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8Pureza:99.91%Forma y color:SolidPeso molecular:478.94GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Forma y color:SolidPeso molecular:372.42ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Forma y color:SolidPeso molecular:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.58%Forma y color:SolidPeso molecular:531.51NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Fórmula:C21H21N5O2Pureza:97.04% - 99.89%Forma y color:SolidPeso molecular:375.42VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Forma y color:SolidPeso molecular:404.32AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Fórmula:C34H30F4N6OPureza:98.73%Forma y color:SoildPeso molecular:614.64Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Fórmula:C25H24FIN6O5SForma y color:SolidPeso molecular:666.46AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Fórmula:C31H32ClF2N7O5Pureza:98.01% - 99.84%Forma y color:SoildPeso molecular:656.08ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Fórmula:C17H14F4N6O2Peso molecular:410.33FMK
CAS:<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Fórmula:C18H19FN4O2Pureza:99.71%Forma y color:SolidPeso molecular:342.37ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Fórmula:C24H19N5O2Forma y color:SolidPeso molecular:409.44Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Forma y color:SolidPeso molecular:603.756H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Forma y color:SolidPeso molecular:476.12SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Fórmula:C15H12N2OPureza:98%Forma y color:SolidPeso molecular:236.27Cephradine monohydrate
CAS:<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Fórmula:C16H21N3O5SPureza:99.91%Forma y color:SolidPeso molecular:367.42PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Forma y color:SolidPeso molecular:512.53Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Fórmula:C26H25Cl2FN8Pureza:99.85%Forma y color:SolidPeso molecular:539.43Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.35%Forma y color:SolidPeso molecular:340.41(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Fórmula:C16H14ClF2IN2O4Forma y color:SolidPeso molecular:498.65BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Forma y color:SolidPeso molecular:456.47ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.05PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Fórmula:C27H26N6O2Pureza:98.04%Forma y color:SolidPeso molecular:466.53MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Fórmula:C24H20N4O4Pureza:98%Forma y color:SolidPeso molecular:428.44PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Fórmula:C26H54NO7PPureza:98%Forma y color:SolidPeso molecular:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Forma y color:SoildPeso molecular:439.89KRAS G12D inhibitor 10
CAS:KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).Fórmula:C33H41ClN8O2Forma y color:SolidPeso molecular:617.18GGTI-286
CAS:GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.Fórmula:C23H31N3O3SForma y color:SolidPeso molecular:429.58MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Fórmula:C33H36N2O3Pureza:97.23%Forma y color:OilPeso molecular:508.65KYA1797
CAS:KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.Fórmula:C17H12N2O6S2Pureza:98%Forma y color:SolidPeso molecular:404.42RSK2-IN-2
CAS:<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Fórmula:C16H11N5OForma y color:SolidPeso molecular:289.29GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Forma y color:SolidPeso molecular:304.38B-Raf IN 8
CAS:<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Fórmula:C18H17N3O2Forma y color:SolidPeso molecular:307.35HPK1-IN-24
CAS:<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Fórmula:C19H14FN5Forma y color:SolidPeso molecular:331.35UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9JNK3 inhibitor-2
CAS:<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Fórmula:C20H14N2O2Forma y color:SolidPeso molecular:314.34Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Fórmula:C21H14ClFN6Pureza:98%Forma y color:SolidPeso molecular:404.83SX 011
CAS:SX 011 is a p38α inhibitor.Fórmula:C26H27ClFN3O3Pureza:98%Forma y color:SolidPeso molecular:483.96KRAS inhibitor-7
CAS:<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Fórmula:C26H27ClF2N6O2Pureza:98%Forma y color:SolidPeso molecular:528.98HPK1-IN-25
CAS:HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.Fórmula:C23H25N5OForma y color:SolidPeso molecular:387.48KRAS G12C inhibitor 43
CAS:<p>KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).</p>Fórmula:C33H35N7O3Forma y color:SolidPeso molecular:577.68GGTI-286 hydrochloride
CAS:GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).Fórmula:C23H32ClN3O3SForma y color:SolidPeso molecular:466.04SMAP-2
CAS:SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.Fórmula:C27H27F3N2O4SPureza:98%Forma y color:SolidPeso molecular:532.57HPK1-IN-26
CAS:HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47ZINC09659342
CAS:<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Fórmula:C23H15F3N2O4Forma y color:SolidPeso molecular:440.37NSC-658497
CAS:NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.Fórmula:C20H10N2O6S2Pureza:98%Forma y color:SolidPeso molecular:438.43SR 3576
CAS:JNK3 inhibitor, potent and selectiveFórmula:C27H27N5O5Pureza:98%Forma y color:SolidPeso molecular:501.53CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3KRAS G12C inhibitor 22
CAS:KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.Fórmula:C32H41N7O2Forma y color:SolidPeso molecular:555.71Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Fórmula:C11H10ClN3OForma y color:SolidPeso molecular:235.67SB-747651A
CAS:SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.Fórmula:C16H22N8OPureza:98%Forma y color:SolidPeso molecular:342.4EO 1428
CAS:p38α and p38β2 inhibitorFórmula:C20H16BrClN2OPureza:98%Forma y color:SolidPeso molecular:415.71p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Fórmula:C27H33N5O3Forma y color:SolidPeso molecular:475.58pan-KRAS-IN-16
CAS:3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H26N2O3Pureza:98%Forma y color:SolidPeso molecular:390.47B-Raf IN 6
CAS:B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.Fórmula:C24H21F3N6O2S2Forma y color:SolidPeso molecular:546.59(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOForma y color:SolidPeso molecular:351.01SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:512.53TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Forma y color:SolidPeso molecular:368.31B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Forma y color:SolidPeso molecular:328.33KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Fórmula:C18H17ClFN3O4SPureza:98%Forma y color:SolidPeso molecular:425.86KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Forma y color:SolidPeso molecular:600.15Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Fórmula:C21H17FKN5O5SForma y color:SolidPeso molecular:509.553,4-Dephostatin
CAS:3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.Fórmula:C7H8N2O3Forma y color:SolidPeso molecular:168.15ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Fórmula:C24H23Cl2FN4O2Forma y color:SolidPeso molecular:489.37Ras modulator-1
CAS:Ras modulator-1 is a modulator of Ras.Fórmula:C29H21N5O4SForma y color:SolidPeso molecular:535.57KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Forma y color:SolidPeso molecular:586.13MW108
CAS:MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.Fórmula:C21H19ClN4Forma y color:SolidPeso molecular:362.86(S)-CCG-1423
(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.Fórmula:C18H13ClF6N2O3Pureza:98%Forma y color:SolidPeso molecular:454.8K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.Fórmula:C21H19Cl3N2O3Forma y color:SolidPeso molecular:453.75ML 3403
CAS:p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Fórmula:C23H21FN4SForma y color:SolidPeso molecular:404.5CCG-232601
CAS:CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.Fórmula:C24H20ClF2N3O2Pureza:98%Forma y color:SolidPeso molecular:455.88Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SForma y color:SolidPeso molecular:456.89PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFórmula:C24H23N3O3SPureza:98%Forma y color:SolidPeso molecular:433.52BRAF V600E/CRAF-IN-1
CAS:BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.Fórmula:C25H17F6N3O2Forma y color:SolidPeso molecular:505.41KRAS inhibitor-6
CAS:KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Fórmula:C27H30ClF2N5O3Pureza:98%Forma y color:SolidPeso molecular:546.01
