MEK
MEK es una quinasa de doble especificidad que juega un papel central en la vía de señalización MAPK/ERK al activar ERK mediante fosforilación. La señalización de MEK es crucial para regular el crecimiento, la supervivencia y la diferenciación celular. La actividad aberrante de MEK se ha implicado en diversos cánceres y trastornos del desarrollo, lo que la convierte en un objetivo terapéutico importante. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de MEK para apoyar su investigación en oncología, señalización celular y desarrollo terapéutico.
Se han encontrado 75 productos de "MEK"
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Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Forma y color:Needles From Benzene Or Alcohol SolidPeso molecular:234.34Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Forma y color:SolidPeso molecular:288.82Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Forma y color:White Crystal PowderPeso molecular:270.798Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Forma y color:Odour SolidMEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Fórmula:C28H23F3IN3O4Forma y color:SolidPeso molecular:649.4MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Fórmula:C13H10FN3O2SForma y color:SolidPeso molecular:291.3PD 198306
CAS:<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23MEK/PI3K-IN-1
CAS:<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Fórmula:C36H37F5IN9O6Forma y color:SolidPeso molecular:913.63FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Forma y color:LiquidDebromohymenialdisine
CAS:Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.Fórmula:C11H11N5O2Forma y color:SolidPeso molecular:245.242BAY-6035
CAS:BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.Fórmula:C22H28N4O3Pureza:99.97%Forma y color:SolidPeso molecular:396.48MEK/PI3K-IN-2
CAS:<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Fórmula:C38H41F5IN9O7Forma y color:SolidPeso molecular:957.68U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFórmula:C8H10N4S2Pureza:98%Forma y color:SolidPeso molecular:226.32NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Fórmula:C22H18F2N4O5SPureza:98.62%Forma y color:SolidPeso molecular:488.46DS03090629
<p>DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.</p>Fórmula:C25H26ClN5O2Forma y color:SolidPeso molecular:463.96Midkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPureza:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCForma y color:Lyophilized PowderPeso molecular:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asForma y color:Lyophilized PowderPeso molecular:16.46 kDa (predicted) same as Tris-Bis PAGE result.Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Forma y color:Odour LiquidMidkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asForma y color:Lyophilized PowderPeso molecular:16.46 kDa (predicted) same as Tris-Bis PAGE result.
