HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 142 productos de "HIF / HIF Prolilhidroxilasa"
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Albendazole
CAS:<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Fórmula:C12H15N3O2SPureza:98.21% - 98.76%Forma y color:Colorless Crystals SolidPeso molecular:265.33Hydralazine hydrochloride
CAS:<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Fórmula:C8H9ClN4Pureza:99.85% - 99.86%Forma y color:Yellow Crystals White Crystalline SolidPeso molecular:196.64Amifostine
CAS:<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Fórmula:C5H15N2O3PSPureza:99.88%Forma y color:White SolidPeso molecular:214.22(-)-Hydroxycitric acid lactone
CAS:<p>(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which</p>Fórmula:C6H6O7Pureza:99.91%Forma y color:SolidPeso molecular:190.11Minocycline hydrochloride
CAS:<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Fórmula:C23H28ClN3O7Pureza:99.28% - >99.99%Forma y color:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94Vadadustat
CAS:<p>Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.</p>Fórmula:C14H11ClN2O4Pureza:99.02% - 99.80%Forma y color:SolidPeso molecular:306.7PT2399
CAS:<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Fórmula:C17H10F5NO4SPureza:98.8% - 99.45%Forma y color:SolidPeso molecular:419.32Deferoxamine Mesylate
CAS:<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Fórmula:C26H52N6O11SPureza:94.68% - 99.8%Forma y color:SolidPeso molecular:656.79Roxadustat
CAS:<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Fórmula:C19H16N2O5Pureza:99% - 99.88%Forma y color:SolidPeso molecular:352.34Oltipraz
CAS:<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Fórmula:C8H6N2S3Pureza:98.79% - 99.77%Forma y color:SolidPeso molecular:226.34Glucosamine
CAS:<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Fórmula:C6H13NO5Pureza:99.8% - 99.8%Forma y color:CoaPeso molecular:179.17HIF-2α-IN-2
CAS:<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Fórmula:C17H13F2NO4SPureza:99.24%Forma y color:SolidPeso molecular:365.35Enarodustat
CAS:<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Fórmula:C17H16N4O4Pureza:99.73% - 99.75%Forma y color:SolidPeso molecular:340.33Tilorone dihydrochloride
CAS:<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Fórmula:C25H36Cl2N2O3Pureza:98% - 99.86%Forma y color:Orange Yellow Crystal PowderPeso molecular:483.47SYP-5
CAS:<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Fórmula:C18H16O3SPureza:98.31%Forma y color:SolidPeso molecular:312.38Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.84%Forma y color:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecular:323.13Citric acid trilithium salt tetrahydrate
CAS:<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Fórmula:C6H13Li3O11Pureza:99.88%Forma y color:White Crystalline PowderPeso molecular:281.98Hydroxycitric acid tripotassium hydrate
CAS:<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Fórmula:C6H7K3O8Pureza:99.85%Forma y color:White Solid CrystallinePeso molecular:324.41EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Fórmula:C28H35NO3Pureza:98.36%Forma y color:SolidPeso molecular:433.58Glucosamine hydrochloride
CAS:<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Fórmula:C6H13NO5·HClPureza:99.77%Forma y color:White Solid CrystallinePeso molecular:215.63Molidustat
CAS:<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Fórmula:C13H14N8O2Pureza:98.79%Forma y color:SolidPeso molecular:314.3ZG-2033
CAS:<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Fórmula:C15H14N2O2SForma y color:SolidPeso molecular:286.35NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Fórmula:C24H27N7O4Forma y color:SolidPeso molecular:477.21245Adaptaquin
CAS:<p>Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].</p>Fórmula:C21H16ClN3O2Pureza:99.75%Forma y color:SolidPeso molecular:377.821,4-DPCA
CAS:<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>Fórmula:C13H8N2O3Pureza:97.77%Forma y color:SolidPeso molecular:240.21(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Fórmula:C41H46N6O6SForma y color:SolidPeso molecular:750.91Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Fórmula:C19H15N3O2SPureza:99.67%Forma y color:SolidPeso molecular:349.41ISM012-042
<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>Fórmula:C26H28N6O4Forma y color:SolidPeso molecular:488.538Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.137-Hydroxyneolamellarin A
CAS:<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Fórmula:C24H19NO5Forma y color:SolidPeso molecular:401.41Fibrostatin C
CAS:<p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>Fórmula:C18H19NO8SForma y color:SolidPeso molecular:409.41HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Fórmula:C28H35NO5Forma y color:SolidPeso molecular:465.58HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Fórmula:C26H24N2O3Pureza:99.59%Forma y color:SolidPeso molecular:412.48HIF-1α-IN-6
<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>Pureza:98%Forma y color:Odour SolidHIF-1α-IN-2 hydrochloride
<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>Fórmula:C21H20ClN3OSPureza:98%Forma y color:SolidPeso molecular:397.92VHL-IN-1
<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>Fórmula:C28H37FN4O4SPureza:98%Forma y color:SolidPeso molecular:544.68ML228
CAS:<p>ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.</p>Fórmula:C27H21N5Pureza:99.54%Forma y color:SolidPeso molecular:415.49Mersalyl
CAS:<p>Mersalyl is an organic mercurial diuretic.</p>Fórmula:C13H16HgNNaO6Forma y color:SolidPeso molecular:505.854IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Fórmula:C20H19N3O5Pureza:97.64% - 99.31%Forma y color:SolidPeso molecular:381.39HIF-1 inhibitor-4
CAS:<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Fórmula:C18H19IN2O2Pureza:99.26%Forma y color:SolidPeso molecular:422.26Izilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Fórmula:C22H28ClN3O4Pureza:99.95%Forma y color:SolidPeso molecular:433.93TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Fórmula:C111H188N42O24S2Pureza:98%Forma y color:SolidPeso molecular:2559.1Daprodustat
CAS:<p>Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.</p>Fórmula:C19H27N3O6Pureza:97% - 99.82%Forma y color:SolidPeso molecular:393.43HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Forma y color:Odour SolidAxl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Fórmula:C14H19ClO8Pureza:98%Forma y color:SolidPeso molecular:350.75HIF-1 α (556-574)
CAS:<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Fórmula:C101H150D2N20O34S2Pureza:98%Forma y color:SolidPeso molecular:2254.6HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Fórmula:C20H39B12N4O2Peso molecular:499.41897ZG-2305
<p>ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.</p>Fórmula:C17H11Cl2N3O5Forma y color:SolidPeso molecular:408.19HIV-IN-7
<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>Fórmula:C32H61N3O10P2Pureza:98%Forma y color:SolidPeso molecular:709.79KG-548
CAS:<p>KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.</p>Fórmula:C9H4F6N4Pureza:99.62%Forma y color:SolidPeso molecular:282.15HIF-IN-1
CAS:<p>HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.</p>Fórmula:C17H12N2OPureza:99.48%Forma y color:SolidPeso molecular:260.29HIF-1α-IN-2
CAS:<p>HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.</p>Fórmula:C21H19N3OSPureza:99.90% - >99.99%Forma y color:SolidPeso molecular:361.461,4-DPCA ethyl ester
CAS:<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Fórmula:C15H12N2O3Pureza:99.54%Forma y color:SolidPeso molecular:268.27UNC6934
CAS:<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Fórmula:C24H21N5O4Pureza:98.67%Forma y color:SolidPeso molecular:443.45TP0463518
CAS:<p>TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).</p>Fórmula:C20H18ClN3O6Pureza:99.52%Forma y color:SolidPeso molecular:431.83HNHA
CAS:<p>HNHA is an inhibitor of HDAC.</p>Fórmula:C17H21NO2SPureza:98.04%Forma y color:SolidPeso molecular:303.42Ethyl 3,4-dihydroxybenzoate
CAS:<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Fórmula:C9H10O4Pureza:99.88%Forma y color:White Crystal Or PowderPeso molecular:182.17Fraxinellone
CAS:<p>1.</p>Fórmula:C14H16O3Pureza:99.35% - 99.92%Forma y color:SolidPeso molecular:232.27AKBA
CAS:<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Fórmula:C32H48O5Pureza:97.85% - 99.77%Forma y color:SolidPeso molecular:512.72Izilendustat hydrochloride
CAS:<p>Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.</p>Fórmula:C22H29Cl2N3O4Forma y color:SolidPeso molecular:470.39FG-2216
CAS:<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:280.66N-Oxalylglycine
CAS:<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Fórmula:C4H5NO5Pureza:99.23%Forma y color:Colourless SolidPeso molecular:147.09IDF-11774
CAS:<p>IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).</p>Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51IOX2
CAS:<p>IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.</p>Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Fórmula:C20H21N5O2Pureza:99.8%Forma y color:SolidPeso molecular:363.41Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:White CrystalPeso molecular:277.25M1001
CAS:<p>M1001 is a HIF-2α agonist.</p>Fórmula:C17H17N3O2SPureza:98.83%Forma y color:SolidPeso molecular:327.4Deoxyshikonin
CAS:<p>1.</p>Fórmula:C16H16O4Pureza:99.36% - ≥95%Forma y color:SolidPeso molecular:272.3VH-298
CAS:<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Fórmula:C27H33N5O4SPureza:99.17% - >99.99%Forma y color:SolidPeso molecular:523.65PHD-1-IN-1
CAS:<p>PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).</p>Fórmula:C13H8N4Pureza:99.74%Forma y color:SolidPeso molecular:220.23GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Fórmula:C18H15N3O2Pureza:99.52%Forma y color:SolidPeso molecular:305.33B2
CAS:<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Fórmula:C20H17ClN4O3Pureza:99.66%Forma y color:SolidPeso molecular:396.83BAY 87-2243
CAS:<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Fórmula:C26H26F3N7O2Pureza:98% - 99.95%Forma y color:SolidPeso molecular:525.53Chlorogenic Acid
CAS:<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Fórmula:C16H18O9Pureza:98.84% - 99.67%Forma y color:SolidPeso molecular:354.31JNJ-42041935
CAS:<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65dencichine
CAS:<p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Forma y color:SolidPeso molecular:176.13Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Fórmula:C21H25ClO6Pureza:99.5% - 99.93%Forma y color:SolidPeso molecular:408.87DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14MK-8617
CAS:<p>MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).</p>Fórmula:C24H21N5O4Pureza:99.38% - >99.99%Forma y color:SolidPeso molecular:443.45KC7F2
CAS:<p>KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.</p>Fórmula:C16H16Cl4N2O4S4Pureza:98% - 99.11%Forma y color:SolidPeso molecular:570.382,4-DPD
CAS:<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Fórmula:C11H13NO4Pureza:99.74%Forma y color:Yellow Solid CrystallinePeso molecular:223.23HIF-2α-IN-4
CAS:<p>HIF-2a translation inhibitor is a compound used as a molecular building block.</p>Fórmula:C9H9N3O4S2Pureza:≥98%Forma y color:SolidPeso molecular:287.32PT-2385
CAS:<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Fórmula:C17H12F3NO4SPureza:98.91% - 99.55%Forma y color:SolidPeso molecular:383.34Oroxylin A
CAS:<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Fórmula:C16H12O5Pureza:98.72% - 99.55%Forma y color:SolidPeso molecular:284.26IOX4
CAS:<p>IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)</p>Fórmula:C15H16N6O3Pureza:99.97%Forma y color:SolidPeso molecular:328.33Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73LW6
CAS:<p>LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.</p>Fórmula:C26H29NO5Pureza:98.1% - 98.22%Forma y color:SolidPeso molecular:435.51Belzutifan
CAS:<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Fórmula:C17H12F3NO4SPureza:99.34% - 99.88%Forma y color:SolidPeso molecular:383.34Amifostine trihydrate
CAS:<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27PX-478
CAS:<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Forma y color:SolidPeso molecular:394.12Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Fórmula:C16H16N2O4Pureza:98%Forma y color:SolidPeso molecular:300.31E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Forma y color:SolidPeso molecular:378.46OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Fórmula:C24H42N6O5Forma y color:SolidPeso molecular:494.63CL67
CAS:<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Fórmula:C38H42N10O2Forma y color:SolidPeso molecular:670.81ZK-261991
CAS:<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Fórmula:C24H25N7O2Pureza:98%Forma y color:SolidPeso molecular:443.5Dimethyl-bisphenol A
CAS:<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Fórmula:C17H20O2Forma y color:SolidPeso molecular:256.34FM19G11
CAS:<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Fórmula:C23H17N3O8Pureza:99.70%Forma y color:SolidPeso molecular:463.4GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Forma y color:SolidPeso molecular:348.33HIF-1α-IN-3
CAS:<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Fórmula:C19H17N5O2Forma y color:SolidPeso molecular:347.37TM6008
CAS:<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Fórmula:C21H17N5O3Pureza:98%Forma y color:SolidPeso molecular:387.39
