HIF / HIF Prolilhidroxilasa

PT2399 is a first-in-class, orally available, small molecule inhibitor of HIF-2 that selectively disrupts the …

Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, …

Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has …

Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.

Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated …

HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).

Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.

Minocycline is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for …

Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, …

VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. …

Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also …

Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.

Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical …

Albendazole is used as a drug indicated for the treatment of a variety of worm …

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential …

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II …

Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of …

HIF1-IN-3 is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used …

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced …

THS-044 binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and …

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of …

Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a …

TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces …

Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic …

WAY-299838 is a HIF-1 inhibitor with IC50 of 560 nM. WAY-299838 reduces the HIF-1α protein …

ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 …

Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric …

Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in …

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence …

Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly …

1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation …

(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced …

Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is …

Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities

Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.

Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in …

IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in …

ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).

Extracted from synthetic product;Store the product in sealed, cool and dry condition

2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by …

M1001 is a HIF-2α agonist.

VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response …

IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)

HNHA is an inhibitor of HDAC.

PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).

AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form …

1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic …

1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. …

(25RS)-Ruscogenin is a natual product.

PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).

PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 is an …

LW6 is a novel HIF-1 inhibitor.

PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).

GN44028 is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α …

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.

HIF-2a translation inhibitor is a compound used as a molecular building block.