LRRK2
Los inhibidores de LRRK2 son compuestos que se dirigen y inhiben la actividad de la quinasa rica en repeticiones de leucina 2 (LRRK2), una enzima involucrada en varios procesos celulares, como la autofagia, el tráfico vesicular y la inflamación. Las mutaciones en el gen LRRK2 están asociadas con un mayor riesgo de desarrollar la enfermedad de Parkinson, lo que convierte a LRRK2 en un objetivo significativo para la investigación de enfermedades neurodegenerativas. Los inhibidores de LRRK2 son cruciales para explorar su papel en la enfermedad de Parkinson y para desarrollar posibles estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de inhibidores de LRRK2 para apoyar su investigación en neurodegeneración, señalización de quinasas y desarrollo terapéutico.
Se han encontrado 33 productos de "LRRK2"
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BIX 02565
CAS:<p>BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).</p>Fórmula:C26H30N6O2Pureza:97.44% - 99.7%Forma y color:SolidPeso molecular:458.56MLi-2
CAS:<p>MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.</p>Fórmula:C21H25N5O2Pureza:98.96%Forma y color:SolidPeso molecular:379.46CZC-54252 hydrochloride
CAS:<p>CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.</p>Fórmula:C22H26Cl2N6O4SPureza:98.21%Forma y color:SolidPeso molecular:541.45JH-XII-03-02
CAS:<p>JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD</p>Fórmula:C43H51N9O10Pureza:98%Forma y color:SolidPeso molecular:853.92XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Fórmula:C50H64ClFN10O6S2Forma y color:SolidPeso molecular:1019.69LRRK2 inhibitor 1
CAS:<p>LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.</p>Fórmula:C20H23N5O4Pureza:99.94%Forma y color:SolidPeso molecular:397.43EB-42486
CAS:<p>EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.</p>Fórmula:C22H22N8OPureza:99.53%Forma y color:SolidPeso molecular:414.46Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Forma y color:Odour LiquidPF-06447475
CAS:<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Fórmula:C17H15N5OPureza:98.61% - 99.62%Forma y color:SolidPeso molecular:305.33GNE0877
CAS:<p>GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).</p>Fórmula:C14H16F3N7Pureza:98.01% - 99.97%Forma y color:SolidPeso molecular:339.32LRRK2-IN-1
CAS:<p>LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.</p>Fórmula:C31H38N8O3Pureza:98% - 98.82%Forma y color:SolidPeso molecular:570.69PFE-360
CAS:<p>PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).</p>Fórmula:C16H16N6OPureza:98.14% - 99.73%Forma y color:SolidPeso molecular:308.34GSK2578215A
CAS:<p>GSK2578215A is a potent and selective LRRK2 kinase inhibitor.</p>Fórmula:C24H18FN3O2Pureza:99.57% - 99.94%Forma y color:SolidPeso molecular:399.42GNE-7915 tosylate
CAS:<p>GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.</p>Fórmula:C26H29F4N5O6SForma y color:SolidPeso molecular:615.6PF-06454589
CAS:<p>PF-06454589 is a potent inhibitor of LRRK2.</p>Fórmula:C14H16N6OPureza:99.06%Forma y color:SolidPeso molecular:284.32HG-10-102-01
CAS:<p>HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).</p>Fórmula:C17H20ClN5O3Pureza:99.59%Forma y color:SolidPeso molecular:377.83CZC-25146 hydrochloride
CAS:<p>CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.</p>Fórmula:C22H26ClFN6O4SPureza:98.76%Forma y color:SolidPeso molecular:525JH-II-127
CAS:<p>JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).</p>Fórmula:C19H21ClN6O3Pureza:98.32%Forma y color:SolidPeso molecular:416.86IKK 16
CAS:<p>IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.</p>Fórmula:C28H29N5OSPureza:98.76% - 99.61%Forma y color:SolidPeso molecular:483.63CZC-25146
CAS:<p>CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).</p>Fórmula:C22H25FN6O4SPureza:97.68%Forma y color:SolidPeso molecular:488.54
