LRRK2
Los inhibidores de LRRK2 son compuestos que se dirigen y inhiben la actividad de la quinasa rica en repeticiones de leucina 2 (LRRK2), una enzima involucrada en varios procesos celulares, como la autofagia, el tráfico vesicular y la inflamación. Las mutaciones en el gen LRRK2 están asociadas con un mayor riesgo de desarrollar la enfermedad de Parkinson, lo que convierte a LRRK2 en un objetivo significativo para la investigación de enfermedades neurodegenerativas. Los inhibidores de LRRK2 son cruciales para explorar su papel en la enfermedad de Parkinson y para desarrollar posibles estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de inhibidores de LRRK2 para apoyar su investigación en neurodegeneración, señalización de quinasas y desarrollo terapéutico.
Se han encontrado 42 productos de "LRRK2"
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BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Fórmula:C26H30N6O2Pureza:97.44% - 99.7%Forma y color:SolidPeso molecular:458.56Ref: TM-T5428
1mg56,00€2mg79,00€5mg118,00€10mg177,00€25mgA consultar50mgA consultar1mL*10mM (DMSO)145,00€MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Fórmula:C21H25N5O2Pureza:98.96%Forma y color:SolidPeso molecular:379.46Ref: TM-T16115
1mg58,00€2mg88,00€5mg133,00€10mg188,00€25mg432,00€50mg652,00€100mg929,00€1mL*10mM (DMSO)142,00€EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Fórmula:C22H22N8OPureza:99.53%Forma y color:SolidPeso molecular:414.46Ref: TM-T39972
1mg70,00€2mg93,00€5mg156,00€10mg226,00€25mg409,00€50mg610,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)170,00€RN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Forma y color:Odour SolidJH-XII-03-02
CAS:JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFórmula:C43H51N9O10Pureza:98%Forma y color:SolidPeso molecular:853.92CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Fórmula:C22H26Cl2N6O4SPureza:98.21%Forma y color:SolidPeso molecular:541.45Ref: TM-T39202
5mg52,00€10mg75,00€25mg135,00€50mg215,00€100mg319,00€200mg449,00€1mL*10mM (DMSO)64,00€XL01126
XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.Fórmula:C50H64ClFN10O6S2Forma y color:SolidPeso molecular:1019.69LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Fórmula:C20H23N5O4Pureza:99.98%Forma y color:SolidPeso molecular:397.43Ref: TM-T11878
1mg74,00€2mg97,00€5mg160,00€10mg264,00€25mg557,00€50mg944,00€100mg1.491,00€1mL*10mM (DMSO)170,00€CC-3240
CAS:CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Fórmula:C52H64N6O7SPeso molecular:917.17RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Forma y color:Odour SolidAnti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Forma y color:Odour LiquidGNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Fórmula:C26H29F4N5O6SForma y color:SolidPeso molecular:615.6LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Fórmula:C31H38N8O3Pureza:98% - 98.82%Forma y color:SolidPeso molecular:570.69PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
Fórmula:C16H16N6OPureza:98.14% - 99.73%Forma y color:SolidPeso molecular:308.34CZC-25146 hydrochloride
CAS:CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
Fórmula:C22H26ClFN6O4SPureza:98.76%Forma y color:SolidPeso molecular:525GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Fórmula:C14H16F3N7Pureza:98.01% - 99.97%Forma y color:SolidPeso molecular:339.32Ref: TM-T6031
1mg44,00€2mg57,00€5mg113,00€10mg177,00€25mg356,00€50mg532,00€100mg760,00€500mg1.558,00€1mL*10mM (DMSO)90,00€PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Fórmula:C14H16N6OPureza:99.06%Forma y color:SolidPeso molecular:284.32Ref: TM-T7729
2mg34,00€5mg52,00€10mg75,00€25mg128,00€50mg187,00€100mg290,00€200mg419,00€1mL*10mM (DMSO)52,00€PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Fórmula:C17H15N5OPureza:98.61% - 99.62%Forma y color:SolidPeso molecular:305.33GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Fórmula:C24H18FN3O2Pureza:99.57% - 99.94%Forma y color:SolidPeso molecular:399.42HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Fórmula:C17H20ClN5O3Pureza:99.59%Forma y color:SolidPeso molecular:377.83Ref: TM-T7196
2mg35,00€5mg55,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)62,00€
