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Proteasas / Proteasoma

Proteasas / Proteasoma

Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.

Subcategorías de "Proteasas / Proteasoma"

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Se han encontrado 1076 productos de "Proteasas / Proteasoma"

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  • TAPI-1
    Targetmol
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    TAPI-1

    CAS:
    <p>TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.</p>
    Fórmula:C26H37N5O5
    Pureza:≥95%
    Forma y color:Solid
    Peso molecular:499.6

    Ref: TM-T6009

  • ADAMTS-5-IN-2
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    ADAMTS-5-IN-2

    CAS:
    <p>ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 µM, and holds potential for osteoarthritis research.</p>
    Fórmula:C17H15N3OS
    Forma y color:Solid
    Peso molecular:309.39

    Ref: TM-T72868

  • Elasnin
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    Elasnin

    CAS:
    <p>Elasnin is a reversible inhibitor of elastase for human granulocyte and pancreatic enzymes with IC50 values of 1.3 and 30 µg/ml, respectively.</p>
    Fórmula:C24H40O4
    Forma y color:Solid
    Peso molecular:392.57

    Ref: TM-T27251

  • Safironil
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    Safironil

    CAS:
    Safironil, a novel antifibrotic, competitively inhibits collagen synthesis and modulates fibrosis, impacting type I/III collagen levels.
    Fórmula:C15H23N3O4
    Pureza:99.83%
    Forma y color:Solid
    Peso molecular:309.36

    Ref: TM-T67961

  • ZM223 hydrochloride (2031177-48-5 free base)
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    ZM223 hydrochloride (2031177-48-5 free base)

    <p>ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.</p>
    Fórmula:C23H18ClF3N4O2S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:538.99

    Ref: TM-T13412L

  • Tyrosinase-IN-5
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    Tyrosinase-IN-5

    CAS:
    Tyrosinase-IN-5 (16c) inhibits tyrosinase with 0.02 μM IC50, reduces melanogenesis, and is low-toxicity.
    Fórmula:C18H13N3O6
    Forma y color:Solid
    Peso molecular:367.31

    Ref: TM-T61425

  • BRD-8899
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    BRD-8899

    CAS:
    BRD-8899 is a STK33 inhibitor, with an IC 50 of 11 nM [1].
    Fórmula:C17H22N4O3S
    Forma y color:Solid
    Peso molecular:362.45

    Ref: TM-T61361

  • Navuridine
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    Navuridine

    CAS:
    <p>Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.</p>
    Fórmula:C9H11N5O4
    Pureza:99.83%
    Forma y color:Solid
    Peso molecular:253.22

    Ref: TM-T21474

  • HCV-IN-36
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    HCV-IN-36

    CAS:
    <p>HCV-IN-36: oral HCV inhibitor, EC50 0.016 μM, CC50 8.78 μM, potent antiviral.</p>
    Fórmula:C30H36ClN5
    Forma y color:Solid
    Peso molecular:502.09

    Ref: TM-T63407

  • NNGH
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    NNGH

    CAS:
    <p>NNGH is a matrix metalloproteinase 3 (MMP-3) inhibitor with anticancer activity that counteracts the inhibitory effects of E2 and DHT on RANKL membrane-binding.</p>
    Fórmula:C13H20N2O5S
    Pureza:98.41%
    Forma y color:Solid
    Peso molecular:316.37

    Ref: TM-T21735

  • GLS1 Inhibitor-3
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    GLS1 Inhibitor-3

    CAS:
    GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.
    Fórmula:C30H32N10O2S
    Forma y color:Solid
    Peso molecular:596.71

    Ref: TM-T64211

  • Odalasvir
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    Odalasvir

    CAS:
    Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C.
    Fórmula:C60H72N8O6
    Forma y color:Solid
    Peso molecular:1001.26

    Ref: TM-T70731

  • MMP-2/9-IN-1
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    MMP-2/9-IN-1

    CAS:
    <p>MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation.</p>
    Fórmula:C14H16IN7S
    Forma y color:Solid
    Peso molecular:441.29

    Ref: TM-T62555

  • (R)-ND-336
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    (R)-ND-336

    CAS:
    <p>(R)-ND-336: potent, selective MMP-9 inhibitor (K i = 19 nM); inhibits MMP-2 (127 nM), MMP-14 (119 nM); studied for diabetic foot ulcers.</p>
    Fórmula:C16H18ClNO3S2
    Forma y color:Solid
    Peso molecular:371.89

    Ref: TM-T61491

  • L-873724
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    L-873724

    CAS:
    L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.
    Fórmula:C23H26F3N3O3S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:481.53

    Ref: TM-T16092

  • JO146
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    JO146

    CAS:
    JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂，其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM，可应用于细菌感染的抑制。
    Fórmula:C31H44N3O7P
    Forma y color:Solid
    Peso molecular:601.67

    Ref: TM-T73532

  • Pyrithione cadmium
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    Pyrithione cadmium

    CAS:
    Pyrithione cadmium suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase
    Fórmula:C10H8CdN2O2S2
    Forma y color:Solid
    Peso molecular:364.73

    Ref: TM-T70082

  • Immunoproteasome inhibitor 1
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    Immunoproteasome inhibitor 1

    CAS:
    Potent, reversible immunoproteasome inhibitor; Ki: β5c 1.18 μM, β1i 0.27 μM, β5i 1.91 μM; potential in treating cancer.
    Fórmula:C20H26N2O4
    Forma y color:Solid
    Peso molecular:358.43

    Ref: TM-T61320

  • CAA0225
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    CAA0225

    CAS:
    CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.
    Fórmula:C28H29N3O5
    Forma y color:Solid
    Peso molecular:487.55

    Ref: TM-T26938

  • MDL 27399
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    MDL 27399

    CAS:
    MDL 27399 suppresses human neutrophil cathepsin G.
    Fórmula:C26H36N4O8
    Forma y color:Solid
    Peso molecular:532.59

    Ref: TM-T25783