Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(36 productos)
- Cisteína proteasa(110 productos)
- DPP-4(20 productos)
- Glutaminasa(44 productos)
- Proteasa del VIH(502 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(54 productos)
- Proteasoma(95 productos)
- Serina proteasa(56 productos)
- p97(15 productos)
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Se han encontrado 1092 productos de "Proteasas / Proteasoma"
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Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Fórmula:C25H33N5O6Forma y color:SolidPeso molecular:499.566-Acetylnimbandiol
CAS:6-Acetylnimbandiol, a non-toxic agent, inhibits tyrosinase (IC50=69.85 μM), melanin, and MITF; useful in melanoma studies.Fórmula:C28H34O8Forma y color:SolidPeso molecular:498.56Ac-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Fórmula:C19H20N4O5Forma y color:SolidPeso molecular:384.39α 1(I) Collagen (614-639), human
CAS:This is a peptide inhibitor of collagen fibrillar matrix assembly.Fórmula:C134H189N37O39Pureza:98%Forma y color:SolidPeso molecular:2942.16Cyanopeptolin 954
CAS:Cyanopeptolin 954 is a chlorine-containing Microcystis aeruginosa NIVA Cya 43 chymotrypsin Inhibitor.Fórmula:C46H63ClN8O12Pureza:98%Forma y color:SolidPeso molecular:955.5BMS-767778
CAS:BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.Fórmula:C19H20Cl2N4O2Forma y color:SolidPeso molecular:407.29Histargin
CAS:Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.Fórmula:C14H25N7O4Forma y color:SolidPeso molecular:355.39(-)-Sitagliptin Carbamoyl Glucuronide
CAS:Minor phase II metabolite of DPP-4 inhibitor sitagliptin, found in rat and dog plasma.Fórmula:C23H23F6N5O9Forma y color:SolidPeso molecular:627.453Tyrosinase-IN-38
Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.Forma y color:Odour SolidRJS308
<p>RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)</p>Fórmula:C63H75N13O11SForma y color:SolidPeso molecular:1222.42Stevia Powder
Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.Forma y color:Odour SolidZetomipzomib maleate
CAS:Zetomipzomib maleate (KZR-616) selectively targets LMP7/2 in immunoproteasomes, potential for autoimmune research.Fórmula:C34H46N4O12Forma y color:SolidPeso molecular:702.758PROTAC 20S proteasome subunit β5 degrader 2
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.Forma y color:Odour SolidADAM8-IN-1
CAS:<p>ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.</p>Fórmula:C44H44Br4N6O12S2Forma y color:SolidPeso molecular:1232.6Leptosin D
CAS:Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)Fórmula:C25H24N4O3S2Forma y color:SolidPeso molecular:492.61Ecallantide TFA
Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention ofForma y color:Odour SolidTyrosinase-IN-34
Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.Fórmula:C19H14BrClN4OForma y color:SolidPeso molecular:429.76,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFórmula:C30H42N2O4SForma y color:SolidPeso molecular:526.73Ac-PAL-AMC
CAS:Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.Fórmula:C26H34N4O6Forma y color:SolidPeso molecular:498.57Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Fórmula:C31H43N9O14Forma y color:SolidPeso molecular:765.73
