Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(36 productos)
- Cisteína proteasa(110 productos)
- DPP-4(20 productos)
- Glutaminasa(44 productos)
- Proteasa del VIH(502 productos)
- PAI-1(25 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(54 productos)
- Proteasoma(95 productos)
- Serina proteasa(56 productos)
- p97(15 productos)
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Se han encontrado 1092 productos de "Proteasas / Proteasoma"
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HCV-IN-41
CAS:HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.Fórmula:C48H56N6O8Forma y color:SolidPeso molecular:844.99STK33-IN-1
CAS:STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.Fórmula:C24H27N7O2Forma y color:SolidPeso molecular:445.527Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Forma y color:Odour SolidRelacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Fórmula:C27H32N4O6SForma y color:SolidPeso molecular:540.64Ichorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Forma y color:LiquidHCV-IN-7 hydrochloride
CAS:HCV-IN-7 hydrochloride: Oral, potent HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Fórmula:C40H50Cl2N8O6SPureza:98%Forma y color:SolidPeso molecular:841.85HIV-1 Rev (34-50)
CAS:HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity.Fórmula:C97H173N51O24Pureza:99.91%Forma y color:SolidPeso molecular:2437.74MMP-9/MMP-13 Inhibitor I
CAS:MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.Fórmula:C25H25N3O6SForma y color:SolidPeso molecular:495.55NS5A-IN-4
CAS:NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.Fórmula:C47H48N8O6Forma y color:SolidPeso molecular:820.93Tilpisertib fosmecarbil TFA
CAS:Tilpisertib fosmecarbil TFA, the TFA salt form of Tilpisertib, acts as an inhibitor of serine/threonine kinases. This compound also exhibits anti-inflammatory activity.Fórmula:C37H37ClF3N8O9PForma y color:SolidPeso molecular:861.16AAF-CMK (trifluoroacetate salt)
CAS:TPPII, a serine peptidase, cleaves tripeptides from oligopeptides. AAF-CMK irreversibly inhibits TPPII at 10-100 μM, sparing proteasome activity.Fórmula:C18H23ClF3N3O5Forma y color:SolidPeso molecular:453.84PSI-353661
CAS:PSI-353661 (GS-558093), inhibits HCV's NS5B polymerase; EC90: 8nM (wild-type), 11nM (S282T); active in human hepatocytes.Fórmula:C24H32FN6O8PForma y color:SolidPeso molecular:582.52Ellipyrone B
Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50Fórmula:C25H38O7Forma y color:SolidPeso molecular:450.57Elastase (high purity)
Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.Forma y color:Odour SolidNIM811
CAS:NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.Fórmula:C62H111N11O12Pureza:98%Forma y color:SolidPeso molecular:1202.635Tyrosinase-IN-36
Tyrosinase-IN-36 is a moderately potent inhibitor of tyrosine, exhibiting an inhibition percentage of 42.75% compared to kojic acid at a concentration of 100 μM and possesses antioxidant activity.Forma y color:Odour SolidFXIIa-IN-1
CAS:XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].Fórmula:C21H16N2O6Forma y color:SoildPeso molecular:392.36Sofosbuvir impurity L
<p>Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>Fórmula:C22H29FN3O10PPureza:98%Forma y color:SolidPeso molecular:545.45Bictegravir Sodium
CAS:Bictegravir Sodium is an HIV-1 integrase inhibitor with 7.5 nM IC50, offering strong, selective anti-HIV effects and minimal toxicity.Fórmula:C21H17F3N3NaO5Pureza:99.97%Forma y color:SolidPeso molecular:471.36VD2173
CAS:<p>VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.</p>Fórmula:C31H45N9O6SForma y color:SolidPeso molecular:671.81
