Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(50 productos)
- Cisteína proteasa(120 productos)
- DPP-4(27 productos)
- Glutaminasa(46 productos)
- Proteasa del VIH(487 productos)
- PAI-1(30 productos)
- Inhibidores de la proteasa(49 productos)
- Receptor activado por proteasa(57 productos)
- Proteasoma(91 productos)
- Serina proteasa(70 productos)
- p97(15 productos)
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Se han encontrado 921 productos para "Proteasas / Proteasoma".
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KP-457
CAS:KP-457 is a ADAM17 and a TNFα converting enzyme TACE inhibitor that blocks the production of soluble TNF (sTNF).Fórmula:C21H24N2O7S2Pureza:98.33%Forma y color:SolidPeso molecular:480.56Ref: TM-T77778
1mg96,00€5mg205,00€1mL*10mM (DMSO)219,00€10mg334,00€25mg620,00€50mg982,00€100mg1.333,00€Danoprevir
CAS:Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).Fórmula:C35H46FN5O9SPureza:98% - 99.80%Forma y color:Yellow SolidPeso molecular:731.83PSI
CAS:PSI is a proteasome inhibitor.Fórmula:C32H50N4O8Pureza:97% - 98.33%Forma y color:SolidPeso molecular:618.76Triton X-45(n=4)
CAS:Triton X-45: nonionic, low HLB surfactant, dispersible in water, high Krafft point, relevant for HCV research.Fórmula:C22H38O5Forma y color:SolidPeso molecular:382.53KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Fórmula:C21H23N3O6Forma y color:SolidPeso molecular:413.42Nelfinavir Mesylate
CAS:Fórmula:C32H45N3O4S·CH4O3SPureza:>97.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:663.89(-)-Gallocatechin Gallate
CAS:Fórmula:C22H18O11Pureza:>95.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:458.38ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Fórmula:C19H35N3O4SPureza:98%Forma y color:SolidPeso molecular:401.56S 2160
CAS:S 2160 is a synthetic chromogenic substrate for thrombin.Fórmula:C33H40N8O6Forma y color:SolidPeso molecular:644.72HCV-IN-30
CAS:HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).Fórmula:C36H44N6O4Pureza:99.6%Forma y color:White SolidPeso molecular:624.77AGG-523
CAS:AGG-523, an aggrecanase inhibitor, may slow cartilage wear after joint injury by reducing ARG-aggrecan in rats.Fórmula:C28H29FN2O4Forma y color:SolidPeso molecular:476.54NVP-DPP728 dihydrochloride
CAS:NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.Fórmula:C15H20Cl2N6OForma y color:SolidPeso molecular:371.27Carboxypeptidase G2 (CPG2) Inhibitor
CAS:Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) is a new CPG2 Inhibitor with antitumor activity.Fórmula:C13H15NO6SPureza:99.96%Forma y color:SolidPeso molecular:313.33Cathepsin Inhibitor 1
CAS:Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.Fórmula:C20H24ClN5O2Pureza:99.78%Forma y color:SolidPeso molecular:401.89Ref: TM-T6015
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg236,00€50mg371,00€100mg522,00€200mg743,00€Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Fórmula:C27H36BN3O7Pureza:99.56%Forma y color:SolidPeso molecular:525.4ER 27319 maleate
CAS:Selective inhibitor of Syk kinaseFórmula:C22H24N2O5Pureza:98.45%Forma y color:Yellow SolidPeso molecular:396.44Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Fórmula:C16H29N3O4Pureza:98%Forma y color:SolidPeso molecular:327.42Tyrosinase-IN-4
CAS:Tyrosinase-IN-4, a potent inhibitor, has uses in skin-whitening, food preservation, cosmetics, agriculture, and medicine.Fórmula:C15H9ClO3Forma y color:SolidPeso molecular:272.68YD-3
CAS:YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC(50)=28.3 microM). In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.Fórmula:C23H20N2O2Forma y color:SolidPeso molecular:356.42MyoMed 205
CAS:MyoMed-205 is an inhibitor of MuRF1 (muscle ring finger protein 1) activity. It effectively prevents early diaphragm contractile dysfunction and atrophy following 12 hours of unilateral phrenic nerve denervation. By inhibiting MuRF1, MyoMed-205 reduces muscle protein ubiquitination and subsequent proteasome degradation. It also increases the protein levels of phosphorylated Akt (ser473), an essential signaling molecule for muscle growth and maintenance. MyoMed-205 is applicable in the research and treatment of diaphragm dysfunction and atrophy (DIDD) due to early disuse, particularly in clinical situations such as diaphragm paralysis or mechanical ventilation.Fórmula:C26H25N3O5SForma y color:SolidPeso molecular:491.56
