Proteasoma
Los inhibidores del proteasoma son compuestos que inhiben el proteasoma, un gran complejo proteico responsable de degradar proteínas no deseadas o dañadas dentro de la célula. La inhibición del proteasoma conduce a la acumulación de proteínas, lo que puede inducir la detención del ciclo celular y la apoptosis, especialmente en células que se dividen rápidamente, como las células cancerosas. Los inhibidores del proteasoma son cruciales en la investigación y terapia contra el cáncer, especialmente en el tratamiento del mieloma múltiple y otras malignidades hematológicas. En CymitQuimica, ofrecemos inhibidores del proteasoma para apoyar su investigación en oncología, biología celular y desarrollo de fármacos.
Se han encontrado 94 productos de "Proteasoma"
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UT-34
CAS:<p>UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild</p>Fórmula:C15H12F4N4O2Pureza:98.12%Forma y color:SolidPeso molecular:356.27RAMB4
CAS:<p>RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.</p>Fórmula:C19H13Cl4NOPureza:98.89% - 99.38%Forma y color:SolidPeso molecular:413.12Gabexate mesylate
CAS:<p>Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.</p>Fórmula:C17H27N3O7SPureza:99.2% - 99.64%Forma y color:White CrystalPeso molecular:417.48DBPR108
CAS:<p>DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.</p>Fórmula:C16H25FN4O2Pureza:99.68%Forma y color:SolidPeso molecular:324.39Trelagliptin
CAS:<p>Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.</p>Fórmula:C18H20FN5O2Pureza:98.88%Forma y color:SolidPeso molecular:357.38ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Fórmula:C17H24BF3N2O4Pureza:97.06%Forma y color:SolidPeso molecular:388.19Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Forma y color:SolidPeso molecular:429.85Saxagliptin hydrate
CAS:<p>Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).</p>Fórmula:C18H25N3O2·H2OPureza:99.52%Forma y color:SolidPeso molecular:333.43RA190
CAS:<p>RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.</p>Fórmula:C28H23Cl5N2O2Pureza:97.7%Forma y color:SolidPeso molecular:596.76Sitagliptin
CAS:<p>Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.</p>Fórmula:C16H15F6N5OPureza:99.33% - 99.83%Forma y color:Yellow GreasePeso molecular:407.31Pepstatin
CAS:<p>Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.</p>Fórmula:C34H63N5O9Pureza:96.74% - 99.94%Forma y color:SolidPeso molecular:685.89Gly-Pro-pNA hydrochloride
CAS:<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Fórmula:C13H17ClN4O4Pureza:99.84%Forma y color:SolidPeso molecular:328.75Dazcapistat
CAS:<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Fórmula:C21H18FN3O4Pureza:99.11%Forma y color:SolidPeso molecular:395.38DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Forma y color:Odour SolidProcizumab
<p>Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Fórmula:C33H27N7O3Forma y color:SolidPeso molecular:569.613Acetyl-Calpastatin(184-210)(human) TFA
<p>Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.</p>Fórmula:C144H231F3N36O46SForma y color:SolidPeso molecular:3291.65VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Fórmula:C18H32N4O5SForma y color:SolidPeso molecular:416.535LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Fórmula:C27H22FN7O6Pureza:99.89%Forma y color:SoildPeso molecular:559.51Proteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Fórmula:C48H56N6O10SForma y color:SolidPeso molecular:909.06
