Proteasoma
Los inhibidores del proteasoma son compuestos que inhiben el proteasoma, un gran complejo proteico responsable de degradar proteínas no deseadas o dañadas dentro de la célula. La inhibición del proteasoma conduce a la acumulación de proteínas, lo que puede inducir la detención del ciclo celular y la apoptosis, especialmente en células que se dividen rápidamente, como las células cancerosas. Los inhibidores del proteasoma son cruciales en la investigación y terapia contra el cáncer, especialmente en el tratamiento del mieloma múltiple y otras malignidades hematológicas. En CymitQuimica, ofrecemos inhibidores del proteasoma para apoyar su investigación en oncología, biología celular y desarrollo de fármacos.
Se han encontrado 95 productos de "Proteasoma"
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UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFórmula:C15H12F4N4O2Pureza:98.12%Forma y color:SolidPeso molecular:356.27Ref: TM-T13273
1mg52,00€5mg119,00€10mg187,00€25mg354,00€50mg533,00€100mg825,00€1mL*10mM (DMSO)131,00€RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Fórmula:C19H13Cl4NOPureza:98.89% - 99.38%Forma y color:SolidPeso molecular:413.12Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Fórmula:C17H27N3O7SPureza:99.2% - 99.64%Forma y color:White CrystalPeso molecular:417.48DBPR108
CAS:DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.Fórmula:C16H25FN4O2Pureza:99.68%Forma y color:SolidPeso molecular:324.39Ref: TM-T15079
1mg50,00€5mg105,00€10mg140,00€25mg226,00€50mg324,00€100mg437,00€200mg605,00€1mL*10mM (DMSO)116,00€Trelagliptin
CAS:Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Fórmula:C18H20FN5O2Pureza:98.88%Forma y color:SolidPeso molecular:357.38ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Fórmula:C17H24BF3N2O4Pureza:97.06%Forma y color:SolidPeso molecular:388.19Ref: TM-T12079
1mg115,00€2mg166,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€200mg1.825,00€1mL*10mM (DMSO)301,00€Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Forma y color:SolidPeso molecular:429.85Saxagliptin hydrate
CAS:Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Fórmula:C18H25N3O2·H2OPureza:99.52%Forma y color:SolidPeso molecular:333.43RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Fórmula:C28H23Cl5N2O2Pureza:97.7%Forma y color:SolidPeso molecular:596.76Ref: TM-T13858
1mg57,00€5mg115,00€10mg168,00€25mg245,00€50mg437,00€100mg642,00€1mL*10mM (DMSO)150,00€Sitagliptin
CAS:Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.Fórmula:C16H15F6N5OPureza:99.33% - 99.83%Forma y color:Yellow GreasePeso molecular:407.31Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Fórmula:C34H63N5O9Pureza:96.74% - 99.94%Forma y color:SolidPeso molecular:685.89Gly-Pro-pNA hydrochloride
CAS:<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Fórmula:C13H17ClN4O4Pureza:99.84%Forma y color:SolidPeso molecular:328.75Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Forma y color:SolidPeso molecular:395.38Ref: TM-T9710
1mg96,00€5mg202,00€10mg305,00€25mg550,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)224,00€DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Forma y color:Odour SolidProcizumab
Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Fórmula:C33H27N7O3Forma y color:SolidPeso molecular:569.613Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Fórmula:C144H231F3N36O46SForma y color:SolidPeso molecular:3291.65VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Fórmula:C18H32N4O5SForma y color:SolidPeso molecular:416.535LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Fórmula:C27H22FN7O6Pureza:99.89%Forma y color:SoildPeso molecular:559.51Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SForma y color:SolidPeso molecular:909.06
