Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 180 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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JK-P3
CAS:JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.Fórmula:C18H17N3O3Pureza:99.57%Forma y color:SolidPeso molecular:323.35Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Fórmula:C31H33N5O4Pureza:98% - 99.92%Forma y color:SolidPeso molecular:539.62Dovitinib
CAS:Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.
Fórmula:C21H21FN6OPureza:99.35% - 99.92%Forma y color:SolidPeso molecular:392.43PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:97.39%Forma y color:SolidPeso molecular:405.28ODM-203
CAS:ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor ImmunityFórmula:C26H21F2N5O2SPureza:99.85%Forma y color:SolidPeso molecular:505.54KHS101 hydrochloride
CAS:KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.Fórmula:C18H22ClN5SPureza:99.6%Forma y color:SolidPeso molecular:375.92Ref: TM-T5170
2mg34,00€5mg52,00€10mg80,00€25mg147,00€50mg239,00€100mg350,00€200mg497,00€1mL*10mM (DMSO)58,00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47DGY-06-116
CAS:DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.Fórmula:C32H33ClN8O2Pureza:97.65%Forma y color:SolidPeso molecular:597.11Ref: TM-T22306
2mg39,00€5mg60,00€10mg92,00€25mg173,00€50mg269,00€100mg404,00€200mg570,00€1mL*10mM (DMSO)66,00€Infigratinib
CAS:Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFórmula:C26H31Cl2N7O3Pureza:98% - 98.97%Forma y color:SolidPeso molecular:560.48Ref: TM-T1975
5mg44,00€10mg57,00€25mg84,00€50mg90,00€100mg144,00€200mg259,00€500mg437,00€1mL*10mM (DMSO)48,00€TG 100801
CAS:TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Forma y color:SolidPeso molecular:580.08FGFR2-IN-3
CAS:FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].
Fórmula:C28H24FN7O2Pureza:99.63%Forma y color:SoildPeso molecular:509.53FGFR-IN-13
CAS:FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].Fórmula:C23H21N5O3Peso molecular:415.44Aminoquinuride
CAS:Surfen, or Aminoquinuride, reduces inflammation but blocks remyelination in MS mouse models and regulates murine T cell activation.Fórmula:C21H20N6OForma y color:SolidPeso molecular:372.42FGFR4-IN-5
CAS:FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.Fórmula:C23H23Cl2N5O5Forma y color:SolidPeso molecular:520.37MAX-40279
CAS:MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.Fórmula:C22H23FN6OSForma y color:SolidPeso molecular:438.52FGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Fórmula:C23H22N4OPureza:98.09%Forma y color:SolidPeso molecular:370.45FGFR2-IN-1
CAS:FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.Fórmula:C22H19N3O2Pureza:98.71%Forma y color:SolidPeso molecular:357.41CP-547632 hydrochloride
CAS:CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.Fórmula:C20H25BrClF2N5O3SForma y color:SolidPeso molecular:568.86MAX-40279 hemiadipate
CAS:MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)Fórmula:C50H56F2N12O6S2Forma y color:SolidPeso molecular:1023.19TG 100572
CAS:TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2Fórmula:C26H26ClN5O2Pureza:98%Forma y color:SolidPeso molecular:475.97
