Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Se han encontrado 177 productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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Nintedanib esylate
CAS:Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/βFórmula:C31H33N5O4·C2H6O3SPureza:99.43% - 99.98%Forma y color:SolidPeso molecular:649.76GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98Ref: TM-T6930
10mg44,00€25mg70,00€50mg96,00€100mg140,00€200mg229,00€500mg329,00€1mL*10mM (DMSO)34,00€KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Fórmula:C26H30Cl2N6O4Pureza:98.65%Forma y color:SolidPeso molecular:561.46Ref: TM-TQ0015
1mg77,00€2mg100,00€5mg166,00€10mg289,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)200,00€Alofanib
CAS:Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.Fórmula:C19H15N3O6SPureza:99.53% - 99.81%Forma y color:SolidPeso molecular:413.4R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Fórmula:C18H14ClFN4OPureza:98.422%Forma y color:SolidPeso molecular:356.78Ref: TM-TQ0317
1mg39,00€2mg52,00€5mg84,00€10mg130,00€25mg264,00€50mg423,00€100mg640,00€1mL*10mM (DMSO)93,00€TG 100801
CAS:TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Forma y color:SolidPeso molecular:580.08FGFR2-IN-3
CAS:FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].
Fórmula:C28H24FN7O2Pureza:99.63%Forma y color:SoildPeso molecular:509.53FGFR-IN-13
CAS:FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].Fórmula:C23H21N5O3Peso molecular:415.44FGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Fórmula:C23H22N4OPureza:98.09%Forma y color:SolidPeso molecular:370.45FGFR3-IN-2
CAS:FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).Fórmula:C28H39N9O4SForma y color:SolidPeso molecular:597.73ARQ 069
CAS:ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.Fórmula:C18H15N3Pureza:98%Forma y color:SolidPeso molecular:273.33MAX-40279 hemifumarate
CAS:MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.Fórmula:C48H50F2N12O6S2Forma y color:SolidPeso molecular:993.12TG 100801 Hydrochloride
CAS:TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Fórmula:C33H31Cl2N5O3Pureza:98%Forma y color:SolidPeso molecular:616.54SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Fórmula:C18H16N2O4Pureza:98%Forma y color:SolidPeso molecular:324.33TG 100572
CAS:TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2Fórmula:C26H26ClN5O2Pureza:98%Forma y color:SolidPeso molecular:475.97MAX-40279 hemiadipate
CAS:MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)Fórmula:C50H56F2N12O6S2Forma y color:SolidPeso molecular:1023.19MAX-40279
CAS:MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.Fórmula:C22H23FN6OSForma y color:SolidPeso molecular:438.52FGFR4-IN-5
CAS:FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.Fórmula:C23H23Cl2N5O5Forma y color:SolidPeso molecular:520.37CPL304110
CAS:CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54
