DUB
Los inhibidores de las deubiquitinasas (DUB) se dirigen a las enzimas que eliminan las moléculas de ubiquitina de las proteínas, regulando así la estabilidad, localización y actividad de las proteínas dentro de la célula. Las deubiquitinasas desempeñan roles esenciales en varios procesos celulares, incluidos la regulación del ciclo celular, la reparación del ADN y las respuestas inmunitarias. La desregulación de la actividad de las DUB está vinculada al cáncer, a los trastornos neurodegenerativos y a las infecciones virales. Los inhibidores de las DUB pueden modular estos procesos, ofreciendo enfoques terapéuticos potenciales para estas condiciones. En CymitQuimica, proporcionamos inhibidores de DUB para apoyar su investigación en homeostasis de proteínas, cáncer y neurobiología.
Se han encontrado 84 productos de "DUB"
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MF-094
CAS:<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Fórmula:C30H37N3O4SPureza:99.93%Forma y color:SolidPeso molecular:535.7C527
CAS:<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Fórmula:C25H28ClN3OPureza:97.71%Forma y color:SolidPeso molecular:421.96IU1-47
CAS:<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85Subquinocin
<p>Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.</p>Fórmula:C20H27N3O4SForma y color:SolidPeso molecular:405.17223USP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Fórmula:C19H20ClF3N4OSPureza:99.92%Forma y color:SolidPeso molecular:444.9OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Fórmula:C19H18N2O6S2Pureza:98.19%Forma y color:SolidPeso molecular:434.49BAY-728
<p>BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].</p>Fórmula:C24H28F3N5O2SForma y color:SolidPeso molecular:507.57MS7131
<p>MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.</p>Forma y color:Odour SolidGK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Fórmula:C21H22N6O2Forma y color:SolidPeso molecular:390.44USP7-IN-10 hydrochloride
<p>USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39</p>Fórmula:C26H30Cl2N4O3SForma y color:SolidPeso molecular:549.51USP7-IN-15
<p>USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.</p>Forma y color:Odour SolidUBD1031
<p>UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.</p>Forma y color:Odour SolidUSP8-IN-3
CAS:<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Fórmula:C18H18F3N5O2SPureza:99.79%Forma y color:SolidPeso molecular:425.43USP7-IN-16
CAS:<p>USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.</p>Fórmula:C43H45N7O6SForma y color:SolidPeso molecular:787.93GK16S
<p>GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].</p>Fórmula:C11H15N3OForma y color:SoildPeso molecular:205.12151Ubiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Forma y color:Odour SolidJAMM protein inhibitor 2
CAS:<p>JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.</p>Fórmula:C21H26N2O2Pureza:98.57%Forma y color:SolidPeso molecular:338.44OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Fórmula:C22H17Cl2FN2O4Pureza:99.92%Forma y color:SolidPeso molecular:463.29STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5
