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<p>6-Carboxyindole is an indole that binds to the IL-17A receptor, which leads to the production of pro-inflammatory cytokines. It has been shown to be involved in autoimmune diseases and other inflammatory conditions. 6-Carboxyindole can be used as a probe for studying the biology of IL-17A, by binding to it and inhibiting its effects. The chemical structure of 6-carboxyindole is also useful for diagnostic purposes, as it can bind to antibodies and antigens for detecting infectious diseases or other biological processes. 6-Carboxyindole can be used in the treatment of heart tissue by binding with monoclonal antibodies that are specific for cardiac proteins such as myosin light chain kinase.</p>

<p>5-(Trifluoromethoxy)-1H-indole-2,3-dione is a potent anticancer agent that inhibits the growth of cancer cells by inducing apoptosis. It binds to DNA, forming hydrogen bonds with guanine and adenine residues. This binding prevents the formation of hydrogen bonds between DNA bases, which are essential for maintaining the stability of DNA. The disruption of these bonds leads to chromosomal degradation and eventually cell death. 5-(Trifluoromethoxy)-1H-indole-2,3-dione has shown antifungal activity against Cryptococcus neoformans in vitro and in vivo. This drug also has an allosteric modulator effect on HL60 cells.</p>

<p>4-Nitroimidazole has a redox potential that is well suited to the reduction of nitro groups. It is an antimicrobial agent that inhibits the growth of microorganisms by inhibiting DNA synthesis. 4-Nitroimidazole can be used for the treatment of infectious diseases such as tuberculosis, leprosy, and brucellosis. In rat liver microsomes, 4-nitroimidazole reacts with NADPH to produce a nitro group and an imidazole ring with a new configuration. The reaction mechanism is based on electron transfer from NADPH to the nitro group in 4-nitroimidazole via a series of reactions that involve cytochrome P450 enzymes. This reaction has kinetic energy and matrix effects that affect its pharmacokinetics and pharmacodynamics.</p>

<p>3-Amino-5-nitroindazole is an anticancer drug that inhibits the growth of cancer cells. It has been shown to inhibit the growth of cancer cells by blocking the synthesis and repair of DNA, leading to cell death. 3-Amino-5-nitroindazole also blocks the production of new proteins, which are needed for cell division. This drug also acts on pathways that are important for tumor development and progression, such as signaling pathways and transcription factors. This compound has been shown to be selective against human squamous cell carcinoma cells and has been studied in combination with other anticancer drugs in clinical trials.</p>

<p>6-Methoxyindole-2-carboxylic acid (6MI) is a potent inhibitor of the enzyme catechol-O-methyltransferase (COMT). This inhibition prevents the conversion of catecholamines, such as dopamine and norepinephrine, to their corresponding methylated products. COMT inhibitors are used clinically to treat Parkinson's disease and other diseases that result from excessive levels of these neurotransmitters. 6MI is also an effective inhibitor of tyrosinase activity in vitro. It has been shown to inhibit the synthesis of melanin by melanocytes and inhibits the production of eumelanin, which is responsible for black or brown skin pigments. The inhibitory potency of 6MI was found to be greater than that for kojic acid, arbutin, and hydroquinone. Optimization studies showed that 6MI was most potent at a concentration of 1 mM and had an IC50 value of 0.3 mM in</p>

<p>Thiamine monophosphate chloride dihydrate is a form of the vitamin thiamine. It has been used in control analysis to measure the activity of enzymes that require thiamine as a cofactor, such as transketolase and pyruvate kinase. Thiamine monophosphate chloride dihydrate has also been studied in biochemical properties, where it was found that this compound can be cleaved by picolinic acid to form thiazole phosphate. The matrix effect is an important factor in polymerase chain reactions and has been shown to be dependent on the presence of dinucleotide phosphate. This compound is an essential component of energy metabolism and plays a role in protein synthesis. Thiamine monophosphate chloride dihydrate also has toxicological studies, including a model system using wild-type strains of yeast. These studies have shown that this compound leads to physiological effects such as inhibition of glycolysis and lactic acid production.</p>

<p>3-Acetylindole is a dibenzopyran compound that has been shown to have anti-inflammatory properties. 3-Acetylindole inhibits the acylation reaction of arachidonic acid with coenzyme A and thereby blocks the production of prostaglandin E2. This compound also binds to the benzene ring, which may be due to its acidic nature. 3-Acetylindole has been shown to inhibit T-cell leukemia and other cancers in animal models. It has also been shown to inhibit the growth of cancer cells in culture by blocking DNA synthesis and inhibiting proliferation. The binding constants for this compound have been determined by x-ray crystal structures and protonation studies.</p>

<p>The 6-Acetyl-7-methylpyrazolo[1,5-α]pyrimidine-3-carboxylic acid is a fine chemical that belongs to the group of speciality chemicals. It is an intermediate that can be used in research or as a building block for more complex compounds. This compound has been shown to have many useful properties, including its versatility as a scaffold and its ability to react with other compounds. The 6-Acetyl-7-methylpyrazolo[1,5-α]pyrimidine-3-carboxylic acid is also considered high quality and can be used in reactions related to the production of pharmaceuticals, agrochemicals, polymers and dyes.</p>

<p>4',6-Diamidino-2-phenylindole 2HCl (DAB) is a chemical compound used as a histological stain to detect and identify different types of cancer cells. It has been shown to have cytotoxic activity against cancer cells in vitro, but not normal cells. DAB inhibits the growth of cancer cells by disrupting the mitochondrial membrane potential, leading to the release of cytochrome c and apoptosis. The use of this substance has shown that it is not toxic to maternal blood or embryonic tissues. DAB binds to nuclear DNA and polymerase chain reaction products, providing an accurate way to measure cancer cell proliferation.</p>

<p>Isopteryxin is a natural compound classified as a furanocoumarin, which is primarily derived from plants in the Apiaceae family, such as various species of Angelica. It is synthetically produced or extracted from these botanical sources using advanced chromatographic techniques. The mode of action of Isopteryxin involves interactions with cellular and molecular targets through its capability to intercalate with DNA and modulate enzyme activity. This confers notable biological activities, including antimicrobial, antifungal, and potentially anticancer effects. It may inhibit certain cell signaling pathways, thus influencing cellular processes such as apoptosis and proliferation.</p>

<p>Diuretic; cardiac stimulant; smooth muscle relaxant; bronchodilator</p>

<p>4'-Hydroxy-2,2':6',2''-terpyridine is a molecule with the molecular formula C24H22N4O8. It is an organic compound that belongs to the group of heterocycles. It has been found to be a ligand for metal ions and has been shown to interact with particles at temperatures below 20°C. 4'-Hydroxy-2,2':6',2''-terpyridine crystallizes in two polymorphs: tetragonally (alpha) at room temperature and trigonally (beta) at temperatures below 20°C. The alpha form has been observed to undergo a photophysical reaction as it absorbs light and emits light in the ultraviolet region of the spectrum.</p>

<p>6-Bromo-1H-indole-3-carboxylic acid is a natural product that is isolated from the marine sponge Smenospongia purpurea. It was first reported in 1979 and has been used for the synthesis of other compounds. 6-Bromoindole, a precursor to 6-bromo-1H-indole-3-carboxylic acid, is biosynthesized from methyl ester and NMR spectra indicate that it has a dihedral angle of 173°. This compound has been shown to have antibacterial activity against staphylococcus.</p>

<p>1,10-Phenanthroline monohydrate is a metal chelate that binds to DNA by hydrogen bonds. It has been shown to have an intramolecular hydrogen and a linear calibration curve with a coefficient of determination (r2) of 0.998. The rate constant for the reaction of 1,10-phenanthroline monohydrate with DNA is 5.00 x 10 M-1 s-1 at 25°C in water and pH 7.4 buffer. The coordination geometry for 1,10-phenanthroline monohydrate is octahedral with the axial ligands occupying the equatorial positions and the equatorial ligands occupying the axial positions. This compound has been shown to be active against HL-60 cells, which causes cancerous transformations in vitro. Fluorescence spectrometry data shows that 1,10-phenanthroline monohydrate can bind to DNA in vitro but not in vivo.</p>

<p>4-Benzyloxyindole-2-carboxylic acid ethyl ester is a cyclic compound that has been synthesized through an intramolecular carboxylate cyclization. This class of compounds are known for their ability to form propargylic analogues, which have the potential to be used as anticancer drugs. The compound was first reported in 1969 by Schardt and co-workers and was found to have activity against leukemia cells. It has been shown to undergo a series of cyclizations, which are triggered by the presence of oxygen or other electron acceptors.</p>

<p>(1S,4S)-1,7,7-Trimethyl-3-(Trifluoroacetyl)Bicyclo[2.2.1]Heptan-2-One is a white solid with a melting point of -76.8°C and a boiling point of 265°C at 10 mm Hg. It has the following functional groups: particle, luminescent, lanthanide, stabilizer, ligand, voltammetry, thermally stable and has nmr spectra that show light emission and coordination chemistry. This compound is a sulfoxide but can also be considered to be a phosphine or an amine depending on its structural features. The compound's nature is dependent on the temperature and pressure as well as the solvent it is being dissolved in.&gt;&gt;END&gt;&gt;</p>

<p>4-Methylindole-3-carboxaldehyde is a lipophilic extract that inhibits the growth of fungi. It has been shown to be effective against phytopathogenic fungi, and it has been used as an antibiotic in the treatment of bacterial infections. 4-Methylindole-3-carboxaldehyde is an analog of streptochlorin, which inhibits protein synthesis by binding to the ribosome. This leads to cell death by inhibiting the production of proteins vital for cell division. 4-Methylindole-3-carboxaldehyde also has antifungal activity against Candida albicans and Trichophyton mentagrophytes.</p>

<p>4,5-Dimethoxyindole is a chemical compound that has been shown to exhibit radical scavenging activity. It is an inhibitor of integrase, which are enzymes involved in the integration of viral DNA into host cell chromosomes. This compound has been synthesized and its optical properties have been studied. The synthesis of 4,5-dimethoxyindole derivatives has also been investigated using molecular modeling. Schrodinger software was used to predict the geometry of these synthesized derivatives. These studies suggest that 4,5-dimethoxyindole may be a potential anti-cancer agent due to its ability to inhibit cancer cell growth and induce apoptosis.</p>

<p>Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid is a pyrimidine analog and an electron transfer agent. It is a potent inhibitor of the enzyme dehydrogenase, which catalyzes the conversion of nicotinamide adenine dinucleotide (NAD) to nicotinamide adenine dinucleotide phosphate (NADP). Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid has been shown to have anti-inflammatory properties and also inhibits the production of b-raf protein. This drug has also been shown to be a potent inhibitor of mitochondrial electron transport in cancer cells. Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid binds to the metal centers in mitochondria, thereby inhibiting oxidative phosphorylation and reducing ATP synthesis. This ultimately leads to cell death by apoptosis.</p>

<p>(8S,9R,10S,11S,13S)-9-Fluoro-11-Hydroxy-10,13-Dimethyl-1,2,6,7,8,11,12,14,15,16-Decahydrocyclopenta[a]Phenanthrene-3,17-Dione is a corticosteroid that is used in the treatment of inflammatory diseases. It has been shown to have immunosuppressive and antiinflammatory effects in animals. The drug is metabolized by cytochrome P450 enzymes to produce the active form prednisolone. Prednisolone binds to glucocorticoid receptors and blocks the production of inflammatory leukotrienes. The drug also inhibits neovascularization and ophthalmic disorders.</p>

<p>Intermediate in the synthesis of nintedanib</p>

<p>3-(2-Aminoethyl)-5-methoxy-1H-indole-2-carboxylic acid is a fine chemical that is used as a building block for research chemicals, reagents, and specialty chemicals. It has the CAS No. 52648-13-2. 3-(2-Aminoethyl)-5-methoxy-1H-indole-2-carboxylic acid is also a versatile building block for synthesis of complex compounds with high quality and is a reaction component in many reactions. This compound can serve as an intermediate or scaffold in chemical synthesis.</p>

<p>Plant hormone of the auxin class; promotes root growth</p>

<p>Plant hormone; auxin; inducer of root development; used in plant rooting</p>

<p>5-Hydroxyisoquinoline is a quinoline derivative that is synthesized from aziridine. It has been shown to be a potent insulin sensitizing agent in mice with type 2 diabetes mellitus. 5-Hydroxyisoquinoline has been shown to inhibit the activity of purified enzymes preparations and show high selectivity for chloride channels, which are responsible for the transport of chloride ions across cell membranes. This inhibition leads to an influx of protons into the cell, which may lead to a change in the redox potential and changes in the molecular structure of the molecule. The reaction mechanism involves substitution at position 5 of the isoquinoline ring by hydroxy groups (OH).</p>

<p>Apterin is a naturally occurring compound, classified as a coumarin derivative, which is isolated from members of the Apiaceae family. Its source is primarily derived from plant species known for their therapeutic properties.</p>

<p>5-Methylindole-2-carboxylic acid (5MICA) is a synthetic compound that has been shown to be cytotoxic in vitro. It has been shown to inhibit the growth of multiple cancer cell lines, including hepatoma cells, and is currently being studied as a potential anticancer drug. 5MICA inhibits the synthesis of protein and RNA by binding to the ribosome. This inhibition leads to cell death by apoptosis. 5MICA also exhibits an antimicrobial effect against opportunistic fungal pathogens such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. The mechanism for this inhibition is unknown but may involve inhibition of protein synthesis or other cellular processes.</p>

<p>8-Hydroxy-7-methoxycoumarin is a fluorescent compound, which is a derivative of the coumarin family. This compound is typically sourced through synthetic organic chemistry processes involving the modification of natural coumarin compounds. Its mode of action involves the ability to absorb ultraviolet light and re-emit it as visible light, a characteristic feature of fluorescent molecules. This property makes it particularly useful in scientific research.</p>

<p>9-Methylxanthine is a purine alkaloid that is structurally related to caffeine. It is used as a bronchodilator and to treat cardiac arrhythmias. 9-Methylxanthine has been shown to have an effect on the rate of DNA replication by binding to the enzyme xanthosine phosphorylase, which converts xanthosine monophosphate (XMP) to xanthosine diphosphate (XDP). The drug's effect on other nucleobases, such as adenosine monophosphate (AMP), cannot be ruled out. 9-Methylxanthine also has a strong affinity for macrochelates, which are compounds that contain chelating agents with a large number of ethylenediaminetetraacetic acid (EDTA) groups. This property is due to the high number of nitrogen atoms in the molecule and its ability to form hydrogen bonds between water molecules</p>

<p>5-Methoxyindole-3-carboxaldehyde is a molecule that belongs to the genus of indolequinones. It has been shown to have potent inhibitory activity against prostate cancer cells, and also has anti-cancer properties. 5-Methoxyindole-3-carboxaldehyde inhibits the proliferation of cancer cells by inducing apoptosis in prostate cancer cells. 5-Methoxyindole-3-carboxaldehyde also suppresses the growth of cervical cancer cells and breast cancer cells. This molecule binds to the hydrogen bond sites on DNA, which may be one reason for its anti-cancer properties. The molecule is fluorescent and can be used as a marker for detecting cancers or other diseases in living tissue.</p>

<p>5-Nitroindole is a chemical used in wastewater treatment. It is an electron acceptor that can be used to reduce the cost of the process. 5-Nitroindole has significant cytotoxicity and polymerase chain activity in human pathogens, such as Escherichia coli, Salmonella enterica, Staphylococcus aureus, and Mycobacterium tuberculosis. The drug is stable under aerobic conditions and has shown no significant cytotoxicity to mammalian cells. 5-Nitroindole has been shown to hybridize with DNA duplexes containing guanine bases and form covalent bonds in a model system. The drug also has been shown to be present in colonies of colony-stimulating factor (CSF) cells that are found in the blood stream of healthy individuals.</p>

<p>6-Amino-9H-purine-9-propanoic acid is an acid lactam that belongs to the class of dihedral molecules. It is a colorless solid that crystallizes in plates, which have been shown to have a strong affinity for ammonium ions. 6-Amino-9H-purine-9-propanoic acid has been shown to be a substrate for the enzyme purine nucleoside phosphorylase, which catalyzes the phosphorolysis of nucleosides with the release of inorganic phosphate and ribose 5'-phosphate. The molecule can also react with electron radiation to form gamma rays, which may lead to its use as a molecular probe.</p>

<p>Tetraethyl 2,2'-bipyridine-4,4'-diylbisphosphonate is a chemical that is used as an intermediate in the synthesis of other fine chemicals. Tetraethyl 2,2'-bipyridine-4,4'-diylbisphosphonate can be used as a building block for synthesis of more complex compounds with high chemical and biological activity. Tetraethyl 2,2'-bipyridine-4,4'-diylbisphosphonate can also be used to synthesize speciality chemicals or research chemicals. This compound has many versatile uses due to its ability to react with different substances to form new chemical compounds.</p>

<p>Please enquire for more information about 3-Methylthio-1,2,4-triazino[5,6-b]indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Hydroxyisoquinoline-1,3(2H,4H)-dione (2HIQ) is a potent anti-viral agent that has been shown to inhibit the replication of viruses in cell cultures. 2HIQ inhibits viral replication by binding to the enzyme reverse transcriptase and inhibiting its ability to synthesize DNA from RNA. This drug also has inhibitory properties against human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 2HIQ binds to the active site of the enzyme HIV reverse transcriptase, which is a key enzyme in viral replication. It also binds to HCV NS5B polymerase, which is an essential protein in HCV replication. These interactions lead to inhibition of viral replication and thus prevention of disease progression.</p>

<p>6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.</p>

<p>4,6-Difluoroisatin is a chemical that is useful in the synthesis of complex compounds. It has been used as a reagent for the preparation of 4,6-difluoropyridinium salts and as a reaction component in the synthesis of polymers. 4,6-Difluoroisatin is also one of the building blocks in the synthesis of a number of other compounds. This chemical has been shown to be an effective scaffold for peptides and proteins.</p>

<p>5-Chloroindole-3-Carboxylic Acid is a ring system that is a dimer of two indole rings and one carboxyl group. It has the ability to form hydrogen bonds with itself, which allows it to stack together in an orderly manner. The carboxyl group on the 5-chloroindole-3-carboxylic acid molecule can form hydrogen bonds with water molecules due to its electronegativity. This property enables 5-chloroindole-3-carboxylic acid molecules to be soluble in water, which is why it is used for water treatment and as a corrosion inhibitor.</p>

<p>2,9-Dibromo-1,10-phenanthroline is a molecule that has been shown to be an effective sensitizer for the photochemical conversion of chlorine dioxide to ozone. It has been used as a model compound in molecular orbital calculations and has been shown to enhance the yield of ozone by up to 3%. The emission spectrum of 2,9-dibromo-1,10-phenanthroline displays a peak at 362 nm, which lies in the ultraviolet region. The molecule is orthorhombic and crystallizes in space group P2/c with cell dimensions a = 17.8 Å and c = 18.7 Å.</p>

<p>3,4-Dihydroisoquinolin-1(2H)-one is a potent antagonist of the histamine H1 receptor and has been shown to be safe in animal studies. 3,4-Dihydroisoquinolin-1(2H)-one has also shown efficacy in treating inflammatory diseases, such as asthma and arthritis. This compound was recently tested for its potential to diagnose cancer by targeting the tumor microenvironment. The compound was found to bind to trifluoromethanesulfonic acid (TFMS) with high affinity and selectivity. TFMS is an emerging therapeutic target for cancer therapy because it is highly expressed in the tumor microenvironment and can act as a proton donor for drug delivery systems. 3,4-Dihydroisoquinolin-1(2H)-one has also been observed to have low toxicity profiles in preclinical models, but more research is needed before it can be used clinically.</p>

<p>6-Cyanoindole is a synthetic compound that has been shown to have functional properties. It binds to the receptor of the chemokine, which is a type of protein that regulates inflammatory responses. It also inhibits the activity of coagulation factors, which are proteins involved in blood clotting. 6-Cyanoindole has been shown to inhibit cancer cell growth and induce apoptosis (cell death) in a number of cancer cell lines. The fluorescence properties and lifetimes of 6-cyanoindole have been studied extensively. It has also been used as a monomer in copolymerization reactions and is used as an intermediate in the synthesis of 6-bromoindole.</p>

<p>4-Nitroquinoline-N-oxide is a polymerase chain reaction (PCR) inhibitor that blocks the activity of methyltransferases, which are enzymes involved in DNA replication and repair. The mechanism of action has been shown to be due to the inhibition of the activities of these enzymes in cancer tissues. The efficacy of 4-Nitroquinoline-N-oxide has been demonstrated using an experimental model system composed of cells from Candida glabrata and other cancers, as well as a model system for carcinogenesis in vitro. This compound also shows antiinflammatory activity and can be used as a natural compound for chemotherapy. Chromatographic analysis has revealed that 4-Nitroquinoline-N-oxide is not toxic to wild type strains, but it is toxic to cancer cells with mutations in their DNA repair mechanisms.</p>

<p>The 6-methylcoumarin is a benzalkonium chloride that can be used as a stabilizer for biological samples. It has been shown to inhibit the activity of coumarin derivatives, which are receptors that are involved in the transmission of pain signals in the brain. The 6-methylcoumarin is also able to inhibit signal peptide, which is a protein that is secreted by cells and functions as a messenger between cells. This compound was found to have hypoglycemic effects due to its ability to stimulate glucose uptake in the body.</p>

<p>5-Acetylindole is a synthetic compound that has been shown to have anticancer activity. It inhibits the growth of cancer cells by disrupting their mitochondria, which leads to cell death. 5-Acetylindole was synthesized in an attempt to increase the anticancer efficacy of indole compounds and acetylation of indole rings was found to be an effective strategy for this purpose. Acetylation of the 5 position on the indole ring leads to a more potent antiproliferative agent with decreased potential for resistance development. This compound has been shown to disrupt cellular function in k562 cells, leading to cell death.</p>

<p>4-Fluoroisoquinoline is a synthetic compound that can be produced by the reduction of an acetonitrile-chlorinated isoquinoline compound. It is also possible to produce 4-fluoroisoquinoline by the reaction of chlorinating agents with an aldehyde, followed by the addition of phosphorus oxychloride and fluorine. The reductive sulfonation of 4-fluoroisoquinoline can be achieved by reacting it with sulfur trioxide, which is in turn generated from phosphorous oxychloride and sulfur dioxide. This process produces the desired product in good yields.</p>

<p>8-Nitroquinoline is a nitrogenous compound that has been used as an inhibitor of Leishmania, a parasite that causes leishmaniasis. 8-Nitroquinoline inhibits the growth of Leishmania by inhibiting the enzyme hepg2, which is involved in the synthesis of lipids and cholesterol. The inhibition of this enzyme leads to the accumulation of malonic acid, which inhibits the production of ATP. This inhibition may lead to cell death or inhibitory effects on other enzyme activities. 8-Nitroquinoline has been shown to be effective against Leishmania parasites in vivo.</p>

<p>5-Cyanoindole is a hydrophobic molecule that has been shown to have an inhibitory effect on the trifluoroacetic acid-induced fluorescence in the presence of chloride ions. It is also able to bind peptides and has been used as an antimicrobial peptide. 5-Cyanoindole can be synthesized electrochemically or by electrochemical impedance spectroscopy. The synthesis of 5-cyanoindole can be achieved through a Friedel-Crafts reaction, followed by a hydrolysis with hydrogen peroxide and then a reduction with sodium borohydride.<br>!-- END OF PRODUCT DESCRIPTION --&gt;</p>

<p>4,6-Dichloro-1H-indole-2-carboxylic acid ethyl ester is a synthetic compound that functions as an agonist of the indole 2 receptor. It has been shown to have affinity for cortical and brain membranes, with a greater affinity for acidic regions of the membrane. 4,6-Dichloro-1H-indole-2-carboxylic acid ethyl ester is also capable of binding to the indole 2 receptor and activating it. The carboxyl group in this compound is substituted with benzene rings, which are connected by a moiety containing two carboxylic groups. 4,6-Dichloro-1H-indole-2-carboxylic acid ethyl ester was synthesised from 1H -indole acetic acid and chloroethane in four steps.</p>

<p>2-Phenylquinoline-4-carbohydrazide is an antibacterial agent that binds to bacterial DNA gyrase and topoisomerase, which are enzymes that maintain the integrity of bacterial DNA. It also has significant anti-inflammatory activity and can be used for the treatment of skin disorders, such as acne. 2-Phenylquinoline-4-carbohydrazide has been shown to induce apoptosis in human dermal fibroblast cells. This drug has been shown to have anticancer activity in vitro and in vivo. The anticancer activity of this drug may be due to its ability to inhibit cancer cell proliferation by binding to DNA gyrase and topoisomerase, which are enzymes that maintain the integrity of bacterial DNA.</p>

<p>5-Benzyloxyindole-3-acetic acid is a synthetic chemical that is used as a plant growth regulator. It inhibits the uptake of other plant nutrients, such as nitrates and phosphate ions by roots, which leads to decreased plant growth. This compound also has an inhibitory effect on membranes and morphology. The inhibition of membrane transport can lead to cell death, which can be seen in the case of plants treated with this chemical. 5-Benzyloxyindole-3-acetic acid has been shown to affect the response pathway of plants at temperatures between c1-c3 degrees Celsius.</p>

<p>Dihydro coumarin is a cyclic organic compound, which is a derivative of coumarin primarily obtained through synthetic processes. It possesses the characteristic odor reminiscent of freshly mown hay, contributing to its widespread application in various industries. The primary mode of action of dihydro coumarin involves its role as a fragrance and flavoring agent, capitalizing on its aromatic profile to enhance products’ sensory attributes.</p>

<p>2',6'-Dimethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4'-NHS ester is a chemiluminescent acridinium ester label used widely in clinical diagnostics, particularly in automated immunochemistry analysers. Acridinium ester labels are also useful research tools for the investigation of protein-carbohydrate interactions to characterise the binding affinity between specific carbohydrate and its binding protein. An example of those are lectin-acridinium ester conjugates used as chemiluminescent probes.</p>

<p>7-Methoxycoumarin is a fluorescent compound, which is a derivative of coumarin. It is synthesized through chemical modification processes of natural coumarin, typically sourced from plant extracts of the Apiaceae and Rutaceae families.</p>

<p>5,6-Dihydroxy-1H-indole-2-carboxylic acid (5,6 DHICA) is a photosensitizing agent with a long detection time. It has been used in the treatment of cervical cancer and skin cancer. 5,6 DHICA is an inhibitor of tyrosinase, which is responsible for the synthesis of melanin. 5,6 DHICA prevents the conversion of dopachrome to eumelanin by binding to the active site of tyrosinase and inhibiting its activity. This makes it an important drug for the treatment of hyperpigmentation disorders such as vitiligo and melasma.</p>

<p>5-Hydroxy-6-methoxyindole-carboxylic acid (5-HMICA) is a molecule that is found in the pericardium and urine of patients with cancer. 5-HMICA has been shown to suppress tumor growth and activate cell mediated cytotoxicity in vitro. It also induces T helper type 1 (Th1) immune responses, which are associated with the production of cytokines such as interferon gamma and tumor necrosis factor alpha.</p>

<p>4-Benzyloxyindole-2-carboxylic acid is a synthetic intermediate. It can be prepared from the hydrazide by reaction with benzaldehyde and subsequent reduction. The carboxylic acid moiety of 4-benzyloxyindole-2-carboxylic acid reacts with an electron source to form a class of compounds that can be used as synthetic intermediates. The diazonium salts formed in this process are then reacted with different electrophiles to give other useful products. 4-Benzyloxyindole-2-carboxylic acid has been used for the synthesis of many organic compounds, such as active compounds, intermediates, and synthetic intermediates, by spectroscopic techniques.</p>

<p>7-Ethylindole is a fatty acid with a cationic surfactant that belongs to the group of mesoporous materials. It has been synthesized by using chromatographic method and sample preparation techniques. The synthetic process is based on the protonation of 7-ethylindole. It undergoes dehydrogenation and activation energy, which is programmed in copper chromite. The chemical compositions are chloride, hydrogenated, and activated 7-ethylindole.</p>

<p>Oroselol is an innovative beta-adrenergic blocker, which is a synthetic derivative with unique cardiovascular targeting properties. It is sourced from engineered chemical synthesis, utilizing advanced molecular design to enhance selectivity for beta-adrenergic receptors. The mode of action of Oroselol involves competitive antagonism of beta-1 and beta-2 adrenergic receptors, leading to a decrease in heart rate and myocardial contractility. This blockade of adrenergic stimulation results in reduced cardiac output and lower blood pressure.</p>

<p>4,4'-Dibromo-2,2'-bipyridine is a nucleophilic compound that can react with a wide range of electrophiles. It has been used in medications as a thermally stable and non-toxic ligand for metal ions. 4,4'-Dibromo-2,2'-bipyridine is an efficient ligand for the coordination of many transition metals. This compound also has high values in light emission and is used in crystallography to study protein binding sites. The n-oxide form of 4,4'-dibromo-2,2'-bipyridine has biological properties that have not yet been studied.</p>

<p>5-Fluoroindole-3-acetic acid is a fluorine-containing drug that inhibits the transport of indoleacetic acid (IAA), an auxin, in the peo-iaa system. It has been shown to inhibit cancer cell growth and induce apoptosis in a variety of tumour cells. 5-Fluoroindole-3-acetic acid can be used as a chemotherapeutic agent for cancers such as bladder, breast, and prostate cancers. This drug also activates enzymatic reactions by introducing fluorine atoms into reaction sites.</p>

<p>N,N'-4,4'-Bis(benzyl-2-boronic acid)-bipyridinium dibromide is a high quality reagent that can be used as an intermediate for the synthesis of complex organic compounds. It is a complex compound that contains boronic acid and bipyridinium moieties. N,N'-4,4'-Bis(benzyl-2-boronic acid)-bipyridinium dibromide is useful in the synthesis of fine chemicals and speciality chemicals. It has versatile building block properties and can be used as a reaction component in many chemical reactions.</p>

<p>Indole-3-acetic acid hydrazide is a molecule that has been shown to inhibit the activity of enzymes such as phosphofructokinase, pyruvate kinase, and lactate dehydrogenase. The compound also inhibits hemolytic activity by binding to the red blood cell membrane and inhibiting the enzyme NADH oxidoreductase. Indole-3-acetic acid hydrazide has been shown to bind to divinylbenzene with a hydrogen bond. The compound is also able to inhibit fatty acid synthesis through its interaction with the fatty acid synthase enzyme. In addition, indole-3-acetic acid hydrazide can be used as an inhibitor of SplA2 in cells.</p>

<p>6-Fluoro-5-Methyl-2-[(5-Methyl-1H-Imidazol-4-Yl)Methyl]-2,3,4,5-Tetrahydro-1H-Pyrido[4,3-b]Indol-1-One is a drug that belongs to the class of fatty acid esters. It has been shown to be effective in clinical trials for the treatment of symptoms of dry eye syndrome. 6FMETI has a low safety profile and does not cause any adverse effects in humans. The drug can be administered by intravenous injection or oral administration and has a long elimination half life of 36 hours. 6FMETI is metabolized by hydrolysis to its active form, 5FMTI, which is then conjugated with glucuronic acid or methyl glutaryl coenzyme A to form an inactive metabolite. This drug also has good pharmacokinetic properties</p>

<p>5-Benzyloxyindole-2-carboxylic acid is a versatile compound that has been used as a building block for the synthesis of diverse chemical compounds. It has been shown to be useful in the synthesis of natural products and pharmaceuticals, such as anticancer drugs, antibiotics, and analgesics. 5-Benzyloxyindole-2-carboxylic acid is also used as an intermediate in the production of other chemical compounds. It has a CAS number of 6640-09-1 and is classified as a research chemical.</p>

<p>5-Chloroindole-2-carboxylic acid methyl ester is a potent inhibitor of the enzyme tyrosine kinase in cell culture, with an IC50 value of 0.5 nM. It has been shown to inhibit the growth of cancer cells (e.g., MDA-MB231, MCF-7) in vitro and in vivo. The IC50 values for inhibition of MDA-MB231 and MCF-7 cells are 0.1 and 10 nM, respectively. 5-Chloroindole-2-carboxylic acid methyl ester binds to the ATP binding site on tyrosine kinase, preventing ATP from binding and inhibiting phosphorylation of the receptor protein. This allows the receptor's downstream signaling pathways to be blocked, which leads to cell growth inhibition by arresting cell cycle progression at G0/G1 phase or inducing apoptosis.</p>

<p>6-Azaspiro[2.5]octane hydrochloride is a high quality, reagent, complex compound that is useful as an intermediate in the synthesis of various organic compounds. CAS No. 1037834-62-0 is a fine chemical with many applications including use as a building block and scaffold for speciality chemicals such as research chemicals and versatile building blocks for reactions. 6-Azaspiro[2.5]octane hydrochloride can be used for the synthesis of various compounds including pharmaceuticals, agrochemicals, flavors and fragrances, dyes and pigments, polymers and plasticizers, perfumes and flavorings, agricultural chemicals, surfactants, catalysts and solvents.</p>

<p>7-Hydroxyquinoline-(1H)-2-one is a quinoline derivative that binds to epidermal growth factor (EGF) receptors. It has been shown to inhibit the chloride current in neurons, which may be due to its ability to bind to the dopamine receptors in these cells. 7-Hydroxyquinoline-(1H)-2-one also inhibits DNA and protein synthesis by binding to nucleophilic nitrogen atoms and protonated nitrogen atoms, respectively. It has been shown to have an inhibitory effect on cancer cell growth in control experiments. This drug is not active against normal cells because it does not bind well to them. 7-Hydroxyquinoline-(1H)-2-one binds with high affinity to piperazine and this interaction can be used as a fluorescent probe for the presence of quinoline derivatives.</p>

<p>4,4'-Dimethoxy-2,2'-bipyridine (DMBP) is a reactive compound that can undergo nucleophilic attack on protonated molecules. DMBP has a high value for protonation and is able to react with water vapor in the air to form hydroxide. It has been used as a model protein to study the redox potential of biomolecules and the biological properties of halides. The crystal structure of DMBP has been studied by X-ray crystallography and is found to be related to technetium.</p>

<p>Please enquire for more information about 2,2'-(Methylimino)diquinolin-8-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7H-imidazo[4,5-d]pyrimidine is a small molecule that exhibits receptor activity against toll-like receptors. It has been shown to inhibit the production of proinflammatory cytokines and chemokines in HL60 cells. 7H-imidazo[4,5-d]pyrimidine also inhibits the activities of enzymes involved in purine metabolism and cellular metabolic processes, as well as intracellular targets including protein kinases, phosphatases and transcription factors. 7H-imidazo[4,5-d]pyrimidine has been shown to be effective against solid tumours such as murine sarcoma virus and plant tumors. This drug also inhibits the enzymatic activity of p2y receptors that are involved in inflammation and platelet aggregation.</p>

<p>5,7-Dihydroxy-4-methylcoumarin monohydrate is an organic chemical compound, specifically a type of coumarin derivative. Coumarins are a class of naturally occurring aromatic compounds that are found in various plant sources, such as tonka beans, sweet clover, and other botanicals. This particular compound, with its distinct hydroxyl and methyl groups, falls under the broader category of hydroxycoumarins, which are of significant interest in biochemical research due to their various functional properties.</p>

<p>1-(5-Isoquinolinesulfonyl)piperazine hydrochloride (1-ISOQ-PIP) is a chemical compound that has been shown to inhibit the growth of leukemia cells. It inhibits the expression of leukemia inhibitory factor, which may be due to its ability to introduce modifications into the sequence of DNA. 1-ISOQ-PIP also inhibits pluripotent stem cells and induces adipocyte differentiation. This substance can be used for cancer treatment by inhibiting the growth of leukemia cells and inducing differentiation.</p>

<p>Please enquire for more information about 3-(2,6,6-Trimethyl-4-oxo-5,6,7-trihydroindolyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(8S,10S,11S,13S,14S,17S)-9-Fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (fluorometholone) is a corticosteroid that is used in the treatment of asthma and other respiratory diseases. Fluorometholone has been shown to have strong antiinflammatory activity and inhibit the production of inflammatory cytokines. It also has mineralocorticoid activity and can be used to treat adrenal insufficiency. This drug has potent potencies structurally similar to glucocorticoids and mineralocorticoids.</p>

<p>4,4'-Dihydroxy-2,2'-bipyridine is a metallo-organic compound that can be used as a homogeneous catalyst for the oxidation of hydroxyl groups. It is also used in cancer research because it has been shown to inhibit tumor cell proliferation and induce apoptosis. 4,4'-Dihydroxy-2,2'-bipyridine is an activated form of 2,2'-bipyridyl with a hydroxyl group on its ortho position. It can be prepared by reacting bromine with the metal salt of 2-hydroxybenzaldehyde in the presence of sodium hydroxide. This reaction produces two products: 4,4'-dihydroxy-2,2'-bipyridine and 2-bromoethanol. The deuterium isotope is used for nuclear magnetic resonance spectroscopy studies because it has a spin quantum number of one and does not cause chemical shift</p>

<p>7-Methylindole-3-acetic acid is a metabolite of indomethacin. It is excreted in the urine and has been found to be present in the tissues of monkeys. 7-Methylindole-3-acetic acid is excreted by the kidneys and it is not known how much of this compound is reabsorbed into the body. 7-Methylindole-3-acetic acid can be metabolized to form other metabolites, including 2,4,5,6 tetrahydropyridine (2,4,5,6 THP), which has been shown to produce DNA damage in rats. The metabolites are then excreted from the body through urination and feces.</p>

<p>Isosibiricin is a naturally occurring lignan, which is extracted from certain plant sources. This compound is derived from the genus Daphne, traditionally known for its diverse range of biologically active constituents. Its mode of action is primarily through the modulation of key signaling pathways involved in cell proliferation and apoptosis. Isosibiricin exhibits notable inhibitory effects on specific enzymes and receptors implicated in oncogenic processes, making it a subject of interest for cancer research.</p>

<p>1-Cyanoimidazole is a phosphodiester that is used in the chemical ligation of nucleic acids. It reacts with terminal alkynes to form covalent linkages between DNA molecules, and can be used as a crosslinker for dna duplexes. 1-Cyanoimidazole can be used as a phosphate group replacement in DNA replication. This compound has been shown to react with terminal alkyne groups on DNA templates, forming stable covalent linkages between strands in the presence of an appropriate nucleophile. 1-Cyanoimidazole has been shown to have sequence specificity and efficient method for linking strands of DNA.</p>

<p>4-Methylesculetin is a coumarin derivative, which is a type of organic compound. This compound is primarily sourced from various plant species, where it occurs naturally as a secondary metabolite. Known for its bioactive properties, 4-Methylesculetin exhibits significant antioxidant activity by scavenging free radicals and protecting against oxidative stress.</p>

<p>5,7-Dibromo-8-hydroxyquinoline is a cytotoxic agent that has been shown to inhibit the growth of xenograft tumor cells. It was found to be effective in inhibiting the mitochondrial membrane potential and decrease the rate of cell proliferation. 5,7-Dibromo-8-hydroxyquinoline also showed significant cytotoxicity against carcinoma cell lines, with no effect on normal human fibroblast cells. The drug is an organophosphate compound that inhibits fatty acid synthesis by binding to an enzyme involved in fatty acid biosynthesis. This inhibition causes diarrhoea and sodium salt loss. 5,7-Dibromo-8-hydroxyquinoline can be extracted from hydrochloric acid through a solvent extraction process.</p>