Ácidos y reactivos sintéticos

<p>Applications ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate.<br>References Feng, J. et al.: Brain Res., 1469, 144 (2012); Zuo, D. et al.: J. Biol. Chem., 287, 21773 (2012); Feng, J. et al.: Brain Res., 1395, 62 (2011)<br></p>

<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Bromotripyrrolidinophosphonium Hexafluorophosphate is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs.<br>References Li, S., et. al.: Chem. Commun., 47, 12840 (2011); Lee, J., et. al.: Bioorg. Med. Chem. Lett., 25, 2849 (2015)<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Pentadecanoic acid is a saturated fatty acid. Pentadecanoic acid was utilized as a biomarker to examine for the intake of milk fat in relation to its metabolic risk factors. Pentadecanoic Acid that is also produced by certain plant species and acts as an toxic essential oil, which is known to exhibits potential anxiolytic, antinociceptive and antimicrobial properties.<br>References Smedman, A.EM., et al.: Am. J. Clin. Nutr., 69, 22 (1999); Radulovic, N.S., et al.: Food. Chem. Toxiol., 50, 2016 (2012);<br></p>

<p>Applications A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Misumi, Y., et al.: J. Biol. Chem., 261 (1986), Mordente, J.A., et al.: J. Urol., 159, 275 (1998), Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999), Nojiri, H., et al.: FEBS Letters, 453, 140 (1999),<br></p>

<p>Stability Moisture Sensitive<br>Applications O-Acetylsalicyloyl chloride is used in the derivatisation of amines, and also improve electrochemical detection of these amines when they are run through high-performance liquid chromatography. O-Acetylsalicyloyl chloride is also used as a reagent to synthesize benzimidazole derivatives, compounds that inhibit leukotriene synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banoglu, E., et al.: Bioorg. Med. Chem., 20, 3728 (2012); Smith, R., et al.: J. Chromatogr. A, 455, 349 (1988)<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetragedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002);<br></p>

<p>Applications Inhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.<br>References Shimomura, K., et al.: J. Biochem., 78, 269 (1975), Ambler, J., et al.: Bioorg. Med. Chem. Lett., 9, 737 (1999),<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications Sodium Perborate Tetrahydrate acts as a bleaching agent using oxygen causing less degradation to dyes and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, L. et al.: J. Am. Oil Chem. Soc., 45, 493 (1968);<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.<br>References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)<br></p>

<p>Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.<br>References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),<br></p>

<p>Applications Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor.<br>References Pilar, G. et al.: J. Phycol., 52, 1085 (2016);<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.<br>References Lau, O.D. et al.: Mol. Cell, 5, 589 (2000);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Indium(III) trifluoromethanesulfonate is a catalyst that is used for hetero Diels-Alder reactions including intermolecular Diels-Alder reactions. It is also a catalyst for efficient acylation of alcohols, phenols and amines.<br>References Kamlesh, K.C., et al.: Synlett, 1999, 1743 (1999), Ali, T., et al.: Tetrahedron Lett., 40, 5621 (1999)<br></p>

<p>Applications Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.<br></p>

<p>Applications (R)-tert-Butyl 2-hydroxypropanoate is an intermediate used in the stereo controlled synthesis of hydroxy carboxylic acids from L-amino acids.<br>References Kunz, H., et al.: Tetrahedron Lett., 28, 1873 (1987)<br></p>

<p>Applications (R,R)-1,2-Cyclohexanedicarboxylic Acid (cas# 46022-05-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Fluoro-3-nitrobenzenesulfonyl chloride is a used in the preparation of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.<br>References Zhou, Haibin., et al.: J. Med. Chem., 55, 6149 (2012);<br></p>

<p>Applications Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.<br>References Ren, J. et al.: Eur. J. Med. Chem., 44, 4259 (2009)<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Applications Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.<br>References Gavine, P., et al.: Mol. Oncol., 9, 323 (2015); Jia, H., et al.: J. Med. Chem., 57, 7577 (2014);<br></p>

<p>Applications 4-Chlorophenyl Isocyanate, is an intermediate used for the synthesis of novel pyrimido[5,4-c]quinolin-4(3H)-one derivatives, having antibacterial and antifungal activities. It is also shown to have anti tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Yu., et al.: Youji Huaxue, 33(5), 1074 (2013); Moos, G. E., et al.: Cancer Res., 31(7), 937 (1971);<br></p>

<p>Applications 1,3-Diiodopropane is a useful research chemical. A reagent used in the preparation of synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial properties.<br>References Ellis, G. L., et al.: Bioorg. Med. Chem. Lett., 18, 1720 (2008)<br></p>

<p>Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors<br>References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)<br></p>

<p>Applications Di-p-toluoyl-d-tartaric Acid Monohydrate is a useful intermediate in the preparation of chiral rivastigmine hydrogen tartrate.<br>References Feng, J., et al.; Nanfang Yike Daxue Xuebao, 27, 177 (2007)<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Applications 2-Isobutyrylcyclohexanone (cas# 39207-65-3) is a useful research chemical.<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications 2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.<br>References Wolfe, J., et al.: J. Am. Chem. Soc., 121, 9550 (1999);<br></p>

<p>Stability Hygroscopic<br>Applications Indium(III) chloride tetrahydrate (cas# 22519-64-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications rac 2-Lauroyl-3-chloropropanediol-d5 (cas# 1330055-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications SU11652 is a cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor &amp; angiogenic inhibitor.<br></p>

<p>Applications 2-Acrylamide-2-methylpropanesulfonic Acid is used in preparation of PAMPS/PHEMA/PEDOT Hydrogel Polyelectrolyte for activated carbon electrode.<br>References Zhang, X., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications A phopshine ligand used in transition-metal mediated organic synthesis, in particular in wittig reactions to improved (Z) selectivity.<br>References Andersen N.G. et al.: Chem. Rev., 101, 997 (2001); Appel M. et al.: Eur. J. Org. Chem., 1143, (2002);<br></p>

<p>Applications D-Glyceraldehyde is the simplest of all aldoses and have been shown to be the one of the carbonyl metabolite of dietary fructose.<br>References Yang, K., et al.: Chem-Biol. Interact., 191, 315 (2011); Zheng, X.H., et al.: Chem. Med. Chem., 7, 1921 (2012);<br></p>

<p>Applications Hypotaurine is a metabolite of taurine and affects the regulation of the inflammatory aspects of the immune response. It is also converted into taurine in the body.<br>References Grove, R. et al.: Free Radical. Biol. med., 108, 575 (2017);<br></p>

<p>Applications Aziridine carboxylic acid ester derivative used for the synthetic application of chiral aziridine via esterification.<br>References Minakata, S., et al.: Chem. Commun., 47, 6363 (2008); Li, Y.X., et al.: Tetrahedron. Lett., 49, 1480 (2008);<br></p>

<p>Applications WAY-100135 is a selective and potent 5-HT1A receptor antagonist.<br></p>

<p>Applications trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile (cas# 300364-84-5) is a useful research chemical.<br></p>

<p>Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC).<br>References Guo, Y., et. al.: Am. J. Phys.: 276, L1018 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.<br>References Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);<br></p>

<p>Applications Trimethylphenylammonium tribromide is a brominating agent, and is also used as an oxidizing agent in the preparation of disulfides and sulfoxides from thiols and sulfides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghorbani-Choghamarani, A., et al.: Phosphorus Sulfur, 186, 1665 (2011); Gonzalez, A., et al.: Phytochemistry, 12, 1113 (1973)<br></p>

<p>Applications (R)-3-(Boc-amino)piperidine is Boc protected (R)-3-Aminopiperidine (A627920, Dihydrochloride salt) which has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.<br>References Xie, Hui., et. al.: Eur. J. Med. Chem., 68, 312 (2013)<br></p>

<p>Applications Ammonium Vanadium Oxide is used in pharmaceutical composition of metformin decavanadate for prevention and treatment of metabolic syndrome, obesity and diabetes. Chimeric design, synthesis, and biological assays of new nonpeptide insulin-mimetic vanadium compounds to inhibit protein tyrosine phosphatase 1B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scior, T., et al.: Drug Des. Devel. Ther., 4, 231 (2010); Gonzalez V., et al.: Pat. Appl. (2016), MX 2015003461 A 20160919;<br></p>

<p>Applications Copper(II) Chloride Dihydrate is a substance used in the release of copper complexes from a nanostructured sol-gel titania for cancer treatment. Also in the solubilization of thymol in Tween 80 micelle to study solubilization mechanism of thymol and effect of solubilization on its antioxidant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, L., et al.: Scientific Reports, 6, 38160 (2016); Lopez, T., et al.: J. Mater. Sci., 50, 2410 (2015)<br></p>

<p>Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.<br>References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);<br></p>

<p>Applications α-Acetoxyacetic Acid, is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Appleton, D., et al.: J. Chem. Soci., Perkin Transactions , 1, 89 (1998);<br></p>

<p>Stability No Data available<br>Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.<br>References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma<br>References Burger, J.A., et al.: Leuke. Lympho.,53. 3 (2012); Lam, A.R., et al.: J. Chem. Info. Model., 51, 139 (2011); De Clercq. E., et al.: Pharmacol. Therap., 128. 509 (2010);<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications Cyclopropylacetylene is used in a variety of chemical reactions in organic syntheses. Used in the synthesis of BACE1 inhibitors used in the treatment of Alzheimer’s disease. It is also used in cycloaddition reactions and the synthesis of fluoromethylsydnones.<br>References Xu, Y. et al.: Bioorg. Med. Chem. Lett., 23, 3075 (2013); Foster, R. et al.: J. Org. Chem., 78, 4049 (2013);<br></p>