Estándares farmacéuticos

Applications 9-Chlorophenazine-1-carboxylic Acid is an intermediate in the synthesis of Endophenazine A which is a new phenazine antibiotic isolated from the arthropod associated endosymbiont Streptomyces anulatus and shows antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).
References Gebhardt, K., et al.: J. Antibiot., 55, 794 (2002)

Applications Guanosine-13C5 5’-Monophosphate is an isotope labelled version of Guanosine 5’-Monophosphate (G844708), a nucleotide with an umami taste.
References Charve, Josephine, et al.: J. of Agric. and Food Chem., 66(8), 1863-1871 (2018)

Applications 2-Bromo-5-nitropyridine (cas# 4487-59-6) is a compound useful in organic synthesis.

Applications Intermediate in the synthesis of polycyclic aromatic systems.

Applications α-(Phenylmethylene)-1-naphthaleneacetic Acid is an intermediate in the synthesis of chrysene based polycyclic aromatic ketones found in environmental gas samples of wood and coal combustion gasses, municipal incineration waste gases, diesel exhaust, Al plant workplace and urban ambient air.
References Dai, W., et al.: Org. Prep. Proc. Int., 29, 347 (1997);

Stability Readily Polymerizes
Applications A precursor of polynuclear aromatic hydrocarbons in tobacco smoke.

Stability Hygroscopic
Applications Dihydroxyacetone Phosphate Lithium Salt, is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.
References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);

Applications Acetophenone-13C8 is an intermediate in synthesizing Mandelic Acid-13C8 (M162523). It is a C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers.
References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications 1,2-Dimethylisothiourea-HI (cas# 41306-45-0) is a useful research chemical.

Applications 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 >95% is a compound useful in organic synthesis.

Applications N,​N-​Dimethyl-​5-​(phenylmethoxy)​-1H-​indole-​3-​ethan-​α,​α,​β,​β-​d4-​amine is an intermediate in the synthesis of Bufotenine-d4 Hydrochloride (B689467), which is labelled bufotenine Hydrochloride (B689465) which is a weak hallucinogenic agent active by intravenous injection. It is a constituent of toad poison.
References Stoll, et al.: Helv. Chim. Acta, 38, 1452 (1955), Bhattacharya, S., et al.: Indian. J. Physiol. Pharmacol., 15, 133 (1971), Falkenberg, G., et al.: Acta Crystallogr., 28B, 3219 (1972)

Applications N1,O2'-Dimethyladenosine-d3 Monohydriodide is an intermediate in the synthesis of N6,O2'-Dimethyladenosine-d3 (D447417). N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007)

Applications 9,10-Dichloro-2,6-dimethylanthracene (cas# 887354-46-3) is a compound useful in organic synthesis.

Applications 2-Fluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile is an intermediate in synthesizing 1-Cyclopropyl-2-(2-fluorophenyl)-2-hydroxy-ethanone (C989465), a useful synthetic intermediate in the synthesis of Prasugrel (P701150, HCl); an antiplatelet agent.
References Wiviott, S.D., et al.: Circulation, 116, 2923 (2007); Xu, X., et al. Faming Zhuanli Shenqing. CN 102718642 A 20121010. Oct 10, 2012; Wang, G., et al. Faming Zhuanli Shenqing. CN 101402556 A 20090408. Apr 8, 2009

Applications Used as an animal glue liquifier, silver tarnish remover, fixing agents, manufactured resins and vulcanization accelerators. It is a known carcinogen, also causes bone marrow depression and goiters.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Butola, J., et al.: J. Plant Biol., 35, 75 (2008), Roux-Dalvai, F., et al.: Mol. Cell. Proteom., 7, 2254 (2008), Ansari, F., et al.: J. Enz. Inhibit. Med. Chem., 24, 151 (2009),

Applications 4,4,4-Trimethoxybutanoic Acid Methyl Ester is an substituent in the synthesis of Methyl Prednisolone (M325934).
References Ueno, H., et al.: J. Med. Chem., 34, 2468 (1991);

Applications (3aα,4β,7aα)-4-(Acetyloxy)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of (3aα,4β,7aα)-3a,4,7,7a-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione (T293630), which is a metabolite of Captan (C175725), a fungicide, often added to pesticide mixtures used to control diseases among fruits, vegetables.
References Kukla, D. et al.: J. Agri. Food Chem., 43, 1224 (1995); Afful, S., et al.: Res. J. App. Sci., Eng. Technol., 2, 592 (2010), Engelen, K., et al.: J. Prot. Res., 9, 4919 (2010), Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010),

Applications Propylthiouracil N-β-D-Glucuronide Methyl Ester is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications An unknown impurity from the synthesis of Telmisartan (T017000).
References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998);

Applications (1S,2R)-1-((2S,3R,4S,6R)-3-Acetamido-4,6-diacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl Triacetate is an intermediate in synthesizing 2-O-Methyl-α-D-N-acetylneuraminic Acid (M275400), which is a model compound for studies of binding of influenza virus hemagglutinin and metal ions.
References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989); Sharon, N., et al.: Science, 246, 227 (1989); Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992); Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)

Applications Texas Red 2’-Propargyl Sulfonamide 4’-Sulfate is an intermediate in the synthesis of Texas Red-5-dUTP (T320100), a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.

Applications (E)-(5,6-Dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-Methyloxime-d4 is an intermediate used in the synthesis of Fluoxastrobin-d4 (F596702), which is labelled Fluoxastrobin (F596700). Leaf-systemic broad-spectrum fungicide for use in cereal and food crops; member of methoxy-imiodihydro-dioxazines. Agricultural fungicide.
References Milus, E., et al.: Plant Dis., 78, 697 (1994), D'Mello, J., et al.: Eur. J. Plant Pathol., 104, 745 (1998), Domijan, A., et al.: Food Addit. Contam., 22, 677 (2005),

Applications An intermediate in the synthesis of the Daspone metabolite.

Applications 3-Methylphosphinicopropionic Acid Diethyl Ester is a derivative of 3-Methylphosphinicopropionic Acid Sodium Salt (M326160), a metabolite of Glufosinate (G596950). 3-Methylphosphinicopropionic Acid Diethyl Ester is used in the preparation of the naturally occurring amino acid, Phosphinothricin.
References Zeiss, H.: J. Org. Chem., 56, 1783 (1991)

Applications 5-Acetamidonaphthalene-1-sulfonamide (cas# 32327-48-3) is a compound useful in organic synthesis.

Applications 3',5'-Bis(Trifluoromethyl)acetophenone is a reactant that has been used in the preparation of pyrazole carboxamide derivatives with antibacterial and antifungal activity.
References Patil, A., et. al.: J. Chem. Pharmaceut. Res., 6, 218 (2014)

Applications (5-Chloro-2-nitrophenyl)(phenyl)carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of Clobazam (C582500), a benzodiazepine psychotherapeutic agent and anxiolytic agent.

Impurity Candesartan Impurity
Applications A byproduct formed during the synthesis of labelled Candesartan.
References Kubo, K., et al.: J. Med. Chem., 36, 2182 (1993)

Applications 4-Phthalimidoacetoacetic Acid Ethyl Ester-13C is an intermediate in the synthesis of 5-Aminolevulinic Acid-3-13C Hydrochloride which is a naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).
References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),

Applications Propylene Glycol 2-β-Glucopyranosiduronic Acid Benzyl Ester-d6 is an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.
References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);

Applications 1-[(4-Chlorophenyl)methyl]-2-oxocyclopentanecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Isotope labelled Metconazole (M225795), an conazole based fungicide used for the control of black sigatoka disease on banana.
References Kato, A., et al.: Chem. Pharma. Bull., 43, 2152 (1995);

Applications (Z)-3-Methylpent-2-en-4-yn-1-ol is used as a reagent in organic synthesis of many compounds including that of prolycopene which is a tangerine-colored tetra-Z-isomer of lycopene that is found in fruits of the tangerine tomato. Z)-3-Methylpent-2-en-4-yn-1-ol is also used in the synthesis of Leucosceptroids A and B which have potent antifungal properties.
References Pattenden, G., et al.: Tetrahedron Lett., 28, 5751 (1987); Guo, S., et al.: Angew. Chem. Int. Edit., 54, 1298 (2015);

5-Chloro-2-nitrocinnamic acid is a fine chemical with a CAS number of 20357-28-2. It is a versatile building block that can be used as a reaction component or intermediate in the synthesis of more complex compounds. The high purity and quality of 5-Chloro-2-nitrocinnamic acid makes it an ideal reagent for research purposes, and it can be used as a building block for the synthesis of useful scaffolds.

3,3'-Dimethoxyazoxybenzene is a nitroarene that has electron-donating properties. It reacts with primary amines to form azoxy groups in the presence of alkoxide. 3,3'-Dimethoxyazoxybenzene can be used for the synthesis of nitrophenyl and aniline derivatives by reaction with nitroarenes, alcohols, or amines. It can also serve as a photoreduced molecule in mechanistic studies.

4-Methyl-5,7-dimethoxycoumarin is a coumarin derivative that has been synthesized from acetonitrile and aluminium. It is used as an antiplatelet drug in the treatment of cardiovascular diseases such as unstable angina, myocardial infarction, and transient ischemic attack. 4-Methyl-5,7-dimethoxycoumarin reversibly inhibits platelet aggregation by blocking the platelet receptor P2Y12 on the surface of platelets. This drug also has antioxidant effects and can be used to identify markers associated with cardiovascular disease.

1-(3-Fluorophenyl)-2-nitropropene is a versatile building block that can be used as a reagent, speciality chemical, or a reaction component. This compound is also useful for the synthesis of complex compounds. 1-(3-Fluorophenyl)-2-nitropropene has been shown to react with various electrophiles, including carbonyl compounds and nitro compounds, to give substituted products. This chemical is classified as a high quality compound and can be used in the synthesis of pharmaceuticals and other fine chemicals.

3,3'-Dipropylthiadicarbocyanine iodide (3DTI) is a proton-carrying compound that has been used extensively as a probe for measuring the cytosolic calcium concentration ([Ca2+]c). This agent binds to the cyclic lipopeptide cation channel in the bacterial cell membrane, inhibiting the uptake of organic anions. 3DTI can also be used to measure mitochondrial membrane potential by monitoring changes in its fluorescence intensity. The antimicrobial activity of 3DTI is due to its ability to inhibit bacteria that are resistant to antibiotics and other antimicrobial peptides. 3DTI binds to DNA at specific sites in the genome and targets intracellular targets such as mitochondria.

2'-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole trihydrochloride (EPMB) is a DNA binding agent that is used in tumor detection and research into apoptosis. It has been shown to inhibit the activity of p-glycoprotein, which is an efflux pump protein, and Bcl-2 protein. EPMB has also been shown to cause apoptosis in human squamous cell carcinoma cells in a concentration dependent manner. This compound has shown potential as a treatment for cancer because it inhibits the ability of cancer cells to proliferate by binding to the NMDA receptor.

4-Acetamido-2'-nitro-4'-(trifluoromethyl)phenyl sulphone is a fine chemical that has versatile building block properties. It is a complex compound that has been used in research chemicals and as a reagent. 4-Acetamido-2'-nitro-4'-(trifluoromethyl)phenyl sulphone is also useful for the production of speciality chemicals and as an intermediate for the synthesis of high quality compounds, such as pharmaceuticals, agrochemicals and other industrial products. This product can be used as a reaction component or scaffold for the synthesis of new compounds.

1-Naphthalene ethanol is a stabilizer that is used in the alkaline hydrolysis of primary amines. It has been shown to have fluorescence activity and has been used as a dye intermediate and chemical intermediate. 1-Naphthalene ethanol has also been shown to be an acetylation, ethylene, and dehydration agent. The compound is also a particle stabilizer and can be used as an additive for fuels. 1-Naphthalene ethanol is also a reagent that can transfer amines onto acidic chloride or chloral compounds.

Vanillylacetone is a natural compound that belongs to the group of phenolic compounds. It is an inhibitor of the enzyme cyclase, which is involved in the biosynthesis of fatty acids and sterols. Vanillylacetone has been shown to have anti-tumor effects in mice with induced tumors. It also inhibits the growth of bacteria, fungi, and protozoa by inhibiting DNA synthesis. Vanillylacetone has been shown to inhibit nuclear DNA replication and toll-like receptor signaling pathways.

6-Acetyl-1,2,3,4-tetrahydronaphthalene is a β-unsaturated ketone that has been shown to have anticancer activity in vitro. It can be used as an analgesic and has a low safety profile. This compound interacts with thiourea and sodium hypochlorite, which are compounds commonly used in the laboratory to induce DNA damage. 6-Acetyl-1,2,3,4-tetrahydronaphthalene also inhibits viral replication through interaction with iminium groups of nucleotide bases.

4'-Chloro-3'-methylacetophenone, 95% is a white crystalline solid that is soluble in alcohols and ethers. It has been used as a reagent for the synthesis of acetophenones. The compound exhibits moderate solubility in water and reacts with aqueous alkalis to form salts. 4'-Chloro-3'-methylacetophenone, 95% also reacts with strong oxidizing agents to form peroxides and with acid chlorides to form esters.