Péptidos

Applications N-tert-Boc-L-alanine is the protected form of L-Alanine (A481500), a non-essential amino acid that can be found naturally in the human body and is obtained by our diet.
References Anderson, H., et al.: J. Nutr., 99, 82 (1969)

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 6000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013)

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Applications Urolithin A is a major metabolite of ellagitannin and exhibits anti-inflammatory and antioxidant properties.
References Ishimoto, H., et. al.: Bioorg. Med. Chem. Lett., 21, 5901 (2011);

Applications Insulin (Human) is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.
References Lai, Y. et al.: Biochem. J., 460, 363 (2014); Hedman, C. et al.: Clin. Endocrinol., 81, 58 (2014);

Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).
References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Applications N-L-GAMMA-GLUTAMYL-L-LEUCINE (cas# 2566-39-4) is a useful research chemical.

Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);

Stability Hygroscopic
Applications gamma-Polyglutamic acid - sodium salt (cas# 25513-46-6) is a useful research chemical.

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.

Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.
References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);

Applications H-GAMMA-GLU-GLU-OH (cas# 1116-22-9) is a useful research chemical.

Applications DOTA-tris (t-Bu ester), is a Bifunctional chelator, that can be used in the preparation of gadolinium complexes as MRI blood contrast agents.

Applications N-Glycylproline was found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia.
References Bashun, Z.N., et al.: Neurochem. J., 7, 39 (2013);

Applications Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.

Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),

Applications L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include actions as neurotransmitters, modulation of enzymic activities and chelation of heavy metals.
References Quinn, P.J., et al.: Mol. Aspects. Med., 13, 379 (1992); Aruoma, O.I., et al.: Biochem. J., 264, 863 (1989);

Applications MG-101 (ALLN) is a potent inhibitor of cysteine proteases including caplains and cathespins. Used in the treatment of genotoxic agents or replication stress of cells. Neuroprotective product.
References Wang, H. et al.: Biochem., 54, 5781 (2015); Fukunaga, Y. et al.: Neurosci. Res., 101, 6 (2014);

Applications AEBSF Hydrochloride is an irreversible serine protease inhibitor.
References Diatchuk, V., et. al.: J. Biol. Chem., 272, 13292 (1997)

Applications L-Alanyl-L-alanyl-L-alanine (cas# 5874-90-8) is a useful research chemical.

Stability Moisture Sensitive
Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)

Applications D-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.
References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)

Applications N-Boc-L-proline is a useful synthetic intermediate. It is used to synthesize Daclatasvir (D101500) which nhibits the HCV protein NS5A. Daclatasvir (D101500) can be used as a drug candidate for the treatment of hepatitis C (HCV).
References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Stability Moisture Sensitive
Applications L-Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. L-Cysteine is commonly used as a precursor in the food and pharmaceutical industries. L-Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.
References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);

Applications An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.
References Horiuchi, T., et al.: Agric. Biol. Chem., 55, 333 (1991), Sosnovsky, G., et al.: J. Pharm. Sci., 82, 649 (1993), Glinsky, G., et al.: Cancer Res., 56, 5319 (1996),

Applications [Leu5]-Enkephalin is a neurotransmitter used in molecular dynamics studies for the insertion of neurotransmitters into lipid bilayer membranes and their implication on membrane stability.
References Shen, C., et al.: ChemPhysChem, pages ahead of print (2017)

Applications H-Glu(Val-OH)-OH (CAS# 2746-34-1) is a useful research chemical compound.

Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.
References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);

Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),

Stability Moisture Sensitive
Applications Amino reactive biotin reagent for preparing biotinylated surfaces or polypeptides.
References Ngo, T.T., et al.: Applied Biochem. Biotech, 7, 443 (1982), Wojchowski, D.M., et al.: J. Immunol. Methods, 90, 173 (1986);

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2).
References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 2000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);

Applications H-GLU-LYS-OH (cas# 5891-53-2) is a useful research chemical.

Applications 6-Azidohexanoic Acid is a reagent that is useful for click chemistry.
References Alleti, R.,et al.: J. Org. Chem., 75, 5895 (2010); Daumar, P., et al.: Bioconjug. Chem., 23, 1557 (2012)

Applications An obstetric drug used to control postpartum hemorrhaging.
References Sanz-Nebot, V., et al.: Anal. Bioanal. Chem., 377, 306 (2003), Gimpl, G., et al.: Eur. J. Pharmacol., 510, 9 (2005), Handler, J., et al.: Theriogenol., 66, 1397 (2006), Klenerova, V., et al.: J. Physiol. Pharmacol., 60, 57 (2009),

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 600. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 1000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);