Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(145 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(86 produits)
- Src(78 produits)
- Syk(38 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1414 produits trouvés pour "Angiogenèse"
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NS309
CAS :<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04E-4031 dihydrochloride
CAS :<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44Gusacitinib HCl
CAS :<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formule :C24H29ClN8O2Couleur et forme :SolidMasse moléculaire :497CAY10594
CAS :<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53Filgotinib
CAS :<p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>Formule :C21H23N5O3SDegré de pureté :98.03% - ≥95%Couleur et forme :SolidMasse moléculaire :425.5Blu-782
CAS :<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formule :C31H42N6O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :562.7(Z)-SU4312
CAS :<p>(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).</p>Formule :C17H16N2ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :264.32AST5902 mesylate(2412155-74-7 free base)
CAS :<p>AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.</p>Formule :C28H33F3N8O5SDegré de pureté :97.04% - 99.46%Couleur et forme :SolidMasse moléculaire :650.67CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Formule :C29H39ClN6O6SCouleur et forme :SolidMasse moléculaire :635.17KHS 101
CAS :<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Formule :C18H21N5SDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :339.46Tesevatinib
CAS :<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formule :C24H25Cl2FN4O2Degré de pureté :97.89% - 98.66%Couleur et forme :SolidMasse moléculaire :491.39VH-298
CAS :<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Formule :C27H33N5O4SDegré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :523.65Regorafenib monohydrate
CAS :<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83Benidipine hydrochloride
CAS :<p>Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.</p>Formule :C28H32ClN3O6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :542.03Xanthinol Nicotinate
CAS :<p>Xanthinol Nicotinate (Complamin) is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased</p>Formule :C13H21N5O4·C6H5NO2Degré de pureté :99.91%Couleur et forme :White Crystalline PowderMasse moléculaire :434.45SPHINX31
CAS :<p>SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).</p>Formule :C27H24F3N5O2Degré de pureté :98.81% - 99.3%Couleur et forme :SolidMasse moléculaire :507.51N-Desethylsunitinib hydrochloride
CAS :<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Formule :C20H24ClFN4O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :406.88Regorafenib mesylate
CAS :<p>Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.</p>Formule :C22H19ClF4N4O6SCouleur et forme :SolidMasse moléculaire :578.92Takeda-6d
CAS :<p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>Formule :C27H19ClFN5O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :547.99Midostaurin
CAS :<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formule :C35H30N4O4Degré de pureté :97.61% - >99.99%Couleur et forme :SolidMasse moléculaire :570.64Momelotinib HCl
CAS :<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38Bisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48Avitinib
CAS :<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53Pantoprazole sodium
CAS :<p>Pantoprazole sodium is a proton pump inhibitor that irreversibly blocks gastric acid secretion by bonding with H+/K+-ATPase.</p>Formule :C16H14F2N3NaO4SDegré de pureté :96.92% - 99.81%Couleur et forme :White To Off-White SolidMasse moléculaire :405.35NVP-BAW2881
CAS :<p>NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.</p>Formule :C22H15F3N4O2Degré de pureté :98.19% - 99.97%Couleur et forme :SolidMasse moléculaire :424.38UF010
CAS :<p>UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.</p>Formule :C11H15BrN2ODegré de pureté :98.03% - 99.68%Couleur et forme :SolidMasse moléculaire :271.15Dasatinib N-oxide
CAS :<p>Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.</p>Formule :C22H26ClN7O3SDegré de pureté :98.54% - 99.94%Couleur et forme :SolidMasse moléculaire :504Cabozantinib
CAS :<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formule :C28H24FN3O5Degré de pureté :99.68% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51N-piperidine Ibrutinib
CAS :<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45Isoliquiritin apioside
CAS :<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51(S)-Sunvozertinib
CAS :<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08HG-14-10-04
CAS :<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08Trastuzumab
CAS :<p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>Degré de pureté :98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Couleur et forme :LiquidMasse moléculaire :Approximately 145.53 kDaAtopaxar hydrochloride
CAS :<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Formule :C29H39ClFN3O5Couleur et forme :SolidMasse moléculaire :564.1Afatinib Dimaleate
CAS :<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formule :C32H33ClFN5O11Degré de pureté :98.11% - 99.87%Couleur et forme :SolidMasse moléculaire :718.08Silymarin
CAS :<p>Silymarin, a liver-aiding polyphenolic flavonoid, is extracted from milk thistle seeds.</p>Formule :C25H22O10Degré de pureté :98%Couleur et forme :Yellow And Brown PowderMasse moléculaire :482.44GN44028
CAS :<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formule :C18H15N3O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :305.33KRCA-0008
CAS :<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Formule :C30H37ClN8O4Degré de pureté :96.19%Couleur et forme :SolidMasse moléculaire :609.12MCB-613
CAS :<p>MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.</p>Formule :C20H20N2ODegré de pureté :98.17% - 99.754%Couleur et forme :SolidMasse moléculaire :304.39BMS817378
CAS :<p>BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).</p>Formule :C24H18ClF2N4O7PDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :578.85Filgotinib maleate
CAS :<p>Filgotinib maleate, a selective oral JAK1 inhibitor, treats RA and Crohn's. IC50s: JAK1-10nM, JAK2-28nM, JAK3-810nM, TYK2-116nM.</p>Formule :C25H27N5O7SCouleur et forme :SolidMasse moléculaire :541.58PRT062607 hydrochloride
CAS :<p>PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.</p>Formule :C19H23N9O·HClDegré de pureté :97.7% - 99.81%Couleur et forme :SolidMasse moléculaire :429.91A-176120
CAS :<p>A-176120: potent FPP analog, inhibits farnesyltransferase, anti-angiogenic, may curb H-ras NIH3T3 tumor growth.</p>Formule :C33H29NO9Couleur et forme :SolidMasse moléculaire :583.58Bafetinib
CAS :<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Formule :C30H31F3N8ODegré de pureté :94.16% - 99.68%Couleur et forme :SolidMasse moléculaire :576.62OICR-9429
CAS :<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formule :C29H32F3N5O3Degré de pureté :97.07% - 99.93%Couleur et forme :SolidMasse moléculaire :555.59(Z)-Semaxinib
CAS :<p>(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for</p>Formule :C15H14N2ODegré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :238.28Vactosertib Hydrochloride
CAS :<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :435.89R1530
CAS :<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>Formule :C18H14ClFN4ODegré de pureté :98.422%Couleur et forme :SolidMasse moléculaire :356.78Verteporfin
CAS :<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Formule :C41H42N4O8Degré de pureté :95.37% - 99.82%Couleur et forme :Dark Green To Black SolidMasse moléculaire :718.79SU 4313
CAS :<p>SU 4313 is a bioactive chemical.</p>Formule :C18H17NODegré de pureté :99.51% - 99.89%Couleur et forme :SolidMasse moléculaire :263.33Semaxinib
CAS :<p>Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks ATP on VEGFR2, may reduce tumor vessels.</p>Formule :C15H14N2ODegré de pureté :99.84%Couleur et forme :Yellow To Yellow OrangeMasse moléculaire :238.28ZM39923 hydrochloride
CAS :<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91SKLB4771
CAS :<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formule :C25H27N7O3S2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :537.66Zorifertinib
CAS :<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9NVP-BSK805 trihydrochloride
CAS :<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93GDC-0214
CAS :<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formule :C28H28ClF2N9O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :612.03SB-431542
CAS :<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formule :C22H16N4O3Degré de pureté :99.035% - >99.99%Couleur et forme :SolidMasse moléculaire :384.39Epitinib
CAS :<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formule :C24H26N6O2Couleur et forme :SolidMasse moléculaire :430.5Quizartinib HCl
CAS :<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Formule :C29H34Cl2N6O4SCouleur et forme :SolidMasse moléculaire :633.59Gefitinib dihydrochloride
CAS :<p>Gefitinib dihydrochloride: orally active, selective EGFR inhibitor (IC50: 33-54 nM), hinders tumor growth, induces autophagy and apoptosis in cancer research.</p>Formule :C22H26Cl3FN4O3Couleur et forme :SolidMasse moléculaire :519.821-Naphthyl PP1
CAS :<p>1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)</p>Formule :C19H19N5Degré de pureté :99.85%Couleur et forme :White Cyrstalline SolidMasse moléculaire :317.39Epidermal Growth Factor
CAS :<p>EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.</p>Formule :C270H401N73O83S7Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :6222GluR6 antagonist-1
CAS :<p>GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.</p>Formule :C15H11ClN2OSDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :302.78Syk Inhibitor II dihydrochloride
CAS :<p>Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.</p>Formule :C14H17Cl2F3N6ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :413.22Merestinib dihydrochloride
CAS :<p>Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.</p>Formule :C30H24Cl2F2N6O3Couleur et forme :SolidMasse moléculaire :625.45Arnebin 1
CAS :<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Formule :C21H22O6Degré de pureté :98.76% - 99.81%Couleur et forme :SolidMasse moléculaire :370.396Avitinib maleate
CAS :<p>Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.</p>Formule :C30H30FN7O6Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :603.61CZC-8004
CAS :<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Formule :C17H16FN5Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :309.34MGCD-265 analog
CAS :<p>Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM and 10 nM, may treat cancer.</p>Formule :C26H20FN5O2S2Degré de pureté :98.06% - 98.68%Couleur et forme :SolidMasse moléculaire :517.6AMG 925 HCl
CAS :<p>AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).</p>Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02BAY 61-3606 HCl
CAS :<p>BAY 61-3606 HCl: a reversible Syk inhibitor, halts mast cell degranulation, cytokines, and sensitizes MCF-7 cells to TRAIL-induced apoptosis.</p>Formule :C20H19ClN6O3Couleur et forme :SolidMasse moléculaire :426.86BMS 599626 2HCl
CAS :<p>BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100</p>Formule :C27H29FN8O3Cl2Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :603.48Cetuximab
CAS :<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Formule :C107H179N35O36S7Degré de pureté :95 - 98.60%Couleur et forme :LiquidMasse moléculaire :152 kDaLificiguat
CAS :<p>Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha</p>Formule :C19H16N2O2Degré de pureté :98.85% - 99.92%Couleur et forme :SolidMasse moléculaire :304.34WS6
CAS :<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formule :C29H31F3N6O3Degré de pureté :97.65% - 99.95%Couleur et forme :SolidMasse moléculaire :568.59Ibuprofen Lysine
CAS :<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Formule :C19H32N2O4Degré de pureté :99.26%Couleur et forme :CoaMasse moléculaire :352.47EHop-016
CAS :<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Formule :C25H30N6ODegré de pureté :98.99% - >99.99%Couleur et forme :SolidMasse moléculaire :430.55Treprostinil Sodium
CAS :<p>Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).</p>Formule :C23H33NaO5Degré de pureté :99.67% - >99.99%Couleur et forme :SolidMasse moléculaire :412.5Adaphostin
CAS :<p>Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.</p>Formule :C24H27NO4Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :393.48AZ 12799734
CAS :<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formule :C18H18N4O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :370.43Tirabrutinib
CAS :<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Formule :C25H22N6O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :454.48N-Acryloyl Osimertinib (>85%)
CAS :<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Formule :C31H35N7O3Degré de pureté :>85%Couleur et forme :Off White SolidMasse moléculaire :553.653,3-Azo-1-butanol
CAS :Produit contrôléFormule :C4H8N2OCouleur et forme :NeatMasse moléculaire :100.12Amivantamab
CAS :<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Degré de pureté :97.24% (SEC-HPLC) - 99.74%Couleur et forme :LiquidMasse moléculaire :145.88 kDaDapolsertib
CAS :<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Formule :C15H18Br2N4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :446.14Seribantumab
CAS :<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :143.2 (kDa)α-Eudesmol
CAS :<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Formule :C15H26OCouleur et forme :White To Off-WhiteMasse moléculaire :222.37rac-Clopidogrel Hydrochloride
CAS :<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Formule :C16H16ClNO2S·ClHCouleur et forme :NeatMasse moléculaire :358.28AZ 5104
CAS :Produit contrôlé<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Formule :C27H31N7O2Couleur et forme :Off-WhiteMasse moléculaire :485.58TG 100801
CAS :<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formule :C33H30ClN5O3Degré de pureté :99.28% - 99.61%Couleur et forme :SolidMasse moléculaire :580.08Glycerol 1-Monobutyrate (Technical Grade)
CAS :<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Formule :C7H14O4Couleur et forme :NeatMasse moléculaire :162.18Itacnosertib
CAS :<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formule :C26H28N8ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :468.55CCT241161
CAS :<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Formule :C28H27N7O3SDegré de pureté :99.76% - 99.77%Couleur et forme :SolidMasse moléculaire :541.62SB-505124 hydrochloride
CAS :<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.86SB 203580 hydrochloride
CAS :<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Formule :C21H17ClFN3OSDegré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :413.9rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formule :C24H25Cl2N5O2Couleur et forme :NeatMasse moléculaire :486.39Cavutilide
CAS :<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458Donafenib
CAS :<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formule :C21H13ClD3F3N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :467.84Behenamide
CAS :Produit contrôlé<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Formule :C22H45NOCouleur et forme :White To Off-WhiteMasse moléculaire :339.6Cpd27
CAS :<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Formule :C20H13F4N5O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :431.34Syk Inhibitor II
CAS :<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>Formule :C14H15F3N6ODegré de pureté :97.63%Couleur et forme :SolidMasse moléculaire :340.3BIBF 1202
CAS :<p>BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).</p>Formule :C30H31N5O4Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :525.6Canertinib dihydrochloride
CAS :<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formule :C24H27Cl3FN5O3Degré de pureté :99.13% - >99.99%Couleur et forme :SolidMasse moléculaire :558.86BMS-690514
CAS :<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Methyl 6-[[[(2-Chloroethyl)amino]carbonyl]amino]-6-deoxy-α-D-glucopyranoside
CAS :Produit contrôléFormule :C10H19ClN2O6Couleur et forme :NeatMasse moléculaire :298.72(5E)-5-(4-Hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS :Produit contrôlé<p>Applications 5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue of thiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.<br>References Bhanushali, U., et al.: Bioorg. Chem., 67, 139-147 (2016); Chen, Z., et al.: J. Biol. Chem. 287, 23537 (2012); Fukunaga, T., et al.: J. Bone Miner. Res., 30, 508 (2015)<br></p>Formule :C10H7NO3SCouleur et forme :NeatMasse moléculaire :221.23Fidasimtamab
CAS :<p>Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidDepatuxizumab
CAS :<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Degré de pureté :95%Couleur et forme :LiquidBafisontamab
CAS :<p>Bafisontamab (EMB-01) is a bispecific antibody that targets EGFR and cMET, displaying antitumor activity [1].</p>Couleur et forme :LiquidFaricimab
CAS :<p>Faricimab,Bispecific antibody targeting Ang-2/VEGF-A. Prevents retinal I/R injury. Improves vision in w-AMD, DME, RVO.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidZalutumumab
CAS :<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Degré de pureté :95%Couleur et forme :LiquidSolrikitug
CAS :<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Degré de pureté :95%Couleur et forme :LiquidPonezumab
CAS :<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Couleur et forme :LiquidIvonescimab
CAS :<p>Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody with cancer immunotherapy and anti-angiogenic effects, NSCLC).</p>Degré de pureté :95% - 95%Couleur et forme :LiquidVanucizumab
CAS :<p>Vanucizumab is a bispecific humanised monoclonal antibody that simultaneously inhibits the receptor interactions of VEGF-A and Angiopoietin-2 (Ang-2)</p>Degré de pureté :95%Couleur et forme :LiquidIzalontamab
CAS :<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Degré de pureté :95%+ - 95%+Couleur et forme :LiquidTovetumab
CAS :<p>Tovetumab (MEDI-575) is an anti-PDGFRα mAb inhibiting its signaling, in trials for glioblastoma and NSCLC.</p>Degré de pureté :95%Couleur et forme :LiquidAnti-Mouse VEGFR-2 Antibody (DC101)
<p>Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab.</p>Degré de pureté :99%Couleur et forme :Odour LiquidDilpacimab
CAS :<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidBecotatug
CAS :<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Degré de pureté :95% - 95%Couleur et forme :LiquidElgemtumab
CAS :<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Degré de pureté :95%Couleur et forme :LiquidZanidatamab
CAS :<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Couleur et forme :LiquidTarcocimab
CAS :<p>Tarcocimab (OG1953) is a humanized IgG1 monoclonal antibody targeting VEGFA, researched for RVO and wet AMD.</p>Couleur et forme :LiquidSerclutamab
CAS :<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Degré de pureté :98%Couleur et forme :LiquidFutuximab
CAS :<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Degré de pureté :95% - 95%Couleur et forme :LiquidImgatuzumab
CAS :<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Couleur et forme :LiquidMasse moléculaire :145.0 (kDa)Anbenitamab
CAS :<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Couleur et forme :LiquidIbrutinib-d5
CAS :<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Formule :C25H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53Dasatinib-d8
CAS :<p>Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.</p>Formule :C22H26ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.06Erlotinib mesylate
CAS :<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Formule :C23H27N3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.54MAPK-IN-2
<p>MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell</p>Formule :C20H11Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.23ALK5-IN-79
CAS :<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51(3S,4S)-Tofacitinib
CAS :<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37ZM39923
CAS :<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Formule :C23H25NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.45EGFR-IN-117
CAS :<p>EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.</p>Formule :C25H30BrN7O2SCouleur et forme :SolidMasse moléculaire :572.52IGF-1R modulator 1
CAS :<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formule :C22H17N3O4Couleur et forme :SolidMasse moléculaire :387.39EGFR-IN-109
CAS :<p>EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].</p>Formule :C12H16N4OSCouleur et forme :SolidMasse moléculaire :264.35HVH-2930
CAS :<p>HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.</p>Formule :C29H36N4O3Couleur et forme :SolidMasse moléculaire :488.62GZD856 formic
CAS :<p>GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.</p>Formule :C30H29F3N6O3Couleur et forme :SolidMasse moléculaire :578.58AD1058
CAS :<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Formule :C19H20N6O3SDegré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :412.47Tyrphostin AG 1478
CAS :Produit contrôlé<p>Applications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.<br></p>Formule :C16H14ClN3O2Couleur et forme :NeatMasse moléculaire :315.75Pulsatilla Saponin D (90%)
CAS :Produit contrôlé<p>Applications Pulsatilla Saponin D shows antiangiogenic and antitumor activity.<br>References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);<br></p>Formule :C47H76O17Degré de pureté :90%Couleur et forme :NeatMasse moléculaire :913.1Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS :Produit contrôlé<p>Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.<br>References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)<br></p>Formule :C24H20ClN5O2Couleur et forme :NeatMasse moléculaire :445.9Atrasentan
CAS :Produit contrôlé<p>Applications Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.<br>References Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);<br></p>Formule :C29H38N2O6Couleur et forme :Off-WhiteMasse moléculaire :510.62N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS :Produit contrôléFormule :C20H16FN5O3Couleur et forme :Light Yellow To YellowMasse moléculaire :393.374-Fmoc-3(R)-morpholinecarboxylic Acid
CAS :Produit contrôlé<p>Applications 4-Fmoc-3(R)-morpholinecarboxylic Acid is used to prepare 125I-labeled morpholine-containing RGD ligand of αvβ3 integrin as angiogenesis imaging probe.<br>References Bianchini, F., et al.: J. Med. Chem., 55, 5024 (2012)<br></p>Formule :C20H19NO5Couleur et forme :NeatMasse moléculaire :353.37Tyrphostin AG 112
CAS :Produit contrôlé<p>Applications Tyrphostin AG 112 is an EGFR inhibitor.<br></p>Formule :C13H8N4OCouleur et forme :NeatMasse moléculaire :236.232,3-Naphthalic Anhydride
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.<br>References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)<br></p>Formule :C12H6O3Couleur et forme :NeatMasse moléculaire :198.17Dehydrodivanillin (~90%, contains up to 10% unknown inorganics)
CAS :Formule :C16H14O6Couleur et forme :NeatMasse moléculaire :302.2792-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
CAS :Produit contrôlé<p>Applications 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is an intermediate Apatinib 25-N-Oxide (A726160), a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br></p>Formule :C18H16ClN3OCouleur et forme :NeatMasse moléculaire :325.79LB 42708
CAS :Produit contrôlé<p>Applications LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.<br>References Kim, C., et. al.: Mol. Pharmacol., 78, 142 (2010)<br></p>Formule :C30H27BrN4O2Couleur et forme :NeatMasse moléculaire :555.46Bucillamine
CAS :<p>Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF.</p>Formule :C7H13NO3S2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :223.31E3330
CAS :<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formule :C21H30O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :378.46YLT192
CAS :<p>YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.</p>Formule :C21H19N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.39TGFBR1-IN-1
CAS :<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Formule :C23H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.48Antiproliferative agent-30
CAS :<p>Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against</p>Formule :C24H26N4O4Couleur et forme :SolidMasse moléculaire :434.49BTK-IN-24
CAS :<p>BTK-IN-24 is a Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity, and it can be used in the study of myeloproliferative disorders.</p>Formule :C26H19F4N5O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :509.46THS-044
CAS :<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Formule :C11H12F3N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :291.23DMPQ dihydrochloride
CAS :<p>PDGFRβ inhibitor</p>Formule :C16H16Cl2N2O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :339.22EGFR-IN-68
CAS :<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44FM19G11
CAS :<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Formule :C23H17N3O8Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :463.4BKI-1369
CAS :<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51ACP-5862
CAS :<p>ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51NSC114126
CAS :<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39EGFR-IN-50
CAS :<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51FLT3-IN-15
CAS :<p>FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).</p>Formule :C22H23ClFN5O2Couleur et forme :SolidMasse moléculaire :443.91ALK5-IN-30
CAS :<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51AG-183
CAS :<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formule :C13H8N4O3Couleur et forme :Brown SolidMasse moléculaire :268.23NSC81111
CAS :<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33Naphazoline
CAS :<p>Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity.</p>Formule :C14H14N2Degré de pureté :99.79%Couleur et forme :White Crystalline Powder SolidMasse moléculaire :210.27CJ-2360
CAS :<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formule :C27H30FN5O2Couleur et forme :SolidMasse moléculaire :475.56SJF620
CAS :<p>SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).</p>Formule :C41H44N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.84Flonoltinib
CAS :<p>Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.</p>Formule :C25H34FN7ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :467.58J-1048
CAS :<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Formule :C23H17FN6S2Couleur et forme :SolidMasse moléculaire :460.55BTK inhibitor 10
CAS :<p>BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.</p>Formule :C25H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.48Peficitinib hydrochloride
CAS :<p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>Formule :C18H23ClN4O2Couleur et forme :SolidMasse moléculaire :362.86JAK-IN-20
CAS :<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Formule :C28H30FN7O2Couleur et forme :SolidMasse moléculaire :515.58TX-1918
CAS :<p>TX-1918, a tyrphostin, blocks eEF-2K to hinder HepG2, HCT116 cell growth.</p>Formule :C14H12O3Couleur et forme :SolidMasse moléculaire :228.24TK4b
CAS :<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.41FLT3/ITD-IN-2
CAS :<p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>Formule :C23H26F3N7O2Couleur et forme :SolidMasse moléculaire :489.49KL-1156
CAS :<p>KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.</p>Formule :C17H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :299.32DB07107
CAS :<p>DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).</p>Formule :C23H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.45PD180970
CAS :<p>PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit.</p>Formule :C21H15Cl2FN4ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :429.27T338C Src-IN-2
CAS :<p>T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.</p>Formule :C17H18FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.36TK4g
CAS :<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Formule :C19H19N3O4SCouleur et forme :SolidMasse moléculaire :385.44EGFR-IN-67
CAS :<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41Squarunkin A hydrochloride
CAS :<p>Squarunkin A HCl inhibits UNC119-cargo binding, specifically blocks Src kinase activation, IC50=10 nm.</p>Formule :C25H33ClF3N5O4Couleur et forme :SoildMasse moléculaire :560.02JAK-2/3-IN-2
CAS :<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formule :C19H19ClN2OSCouleur et forme :SolidMasse moléculaire :358.89JNJ-47117096 hydrochloride
CAS :<p>JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.</p>Formule :C21H23ClN4O2Couleur et forme :SolidMasse moléculaire :398.89c-ABL-IN-2
CAS :<p>C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.</p>Formule :C21H20N4OCouleur et forme :SolidMasse moléculaire :344.41MS 154N
CAS :<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45Esuberaprost Sodium
CAS :<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Formule :C23H27FN4O2Couleur et forme :SolidMasse moléculaire :410.48OD36 hydrochloride
CAS :<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Formule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23TYK2-IN-12
CAS :<p>TYK2-IN-12: selective oral TYK2 inhibitor (Ki: 0.51 nM), blocks IL-12-induced IFNγ; IC50: human 2.7 µM, mouse 7.0 µM, used for psoriasis research.</p>Formule :C24H20F2N4O2Couleur et forme :SolidMasse moléculaire :434.44PDE5-IN-3
CAS :<p>PDE5-IN-3: Inhibits PDE5 (1.57 nM), EGFR (5.827 μM), Wnt pathway (1286.96 ng/mL), induces apoptosis, and has antitumor effects.</p>Formule :C21H14BrN5O2Couleur et forme :SolidMasse moléculaire :448.27PDGFR-IN-1
CAS :<p>PDGFR-IN-1 is a platelet-derived growth factor receptor (PDGFR) inhibitor, strongly inhibiting PDGFRα and PDGFRβ, useful for studying solid tumors.</p>Formule :C25H30N8ODegré de pureté :99.13% - 99.49%Couleur et forme :SolidMasse moléculaire :458.56IHMT-TRK-284
CAS :<p>IHMT-TRK-284: Oral type II TRK inhibitor; targets TRKA, TRKB, TRKC (IC50s: 10.5, 0.7, 2.6 nM); selective and anti-tumor effective.</p>Formule :C25H27N7OSCouleur et forme :SolidMasse moléculaire :473.59FGFR3-IN-2
CAS :<p>FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).</p>Formule :C28H39N9O4SCouleur et forme :SolidMasse moléculaire :597.73CpCDPK1/TgCDPK1-IN-1
CAS :<p>CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.</p>Formule :C18H17N5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :303.36AG-370
CAS :<p>AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM.</p>Formule :C15H9N5Couleur et forme :SolidMasse moléculaire :259.27
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