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Apoptose

Apoptose

Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.

Sous-catégories appartenant à la catégorie "Apoptose"

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6170 produits trouvés pour "Apoptose"

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  • Pantoprazole Sodium Hydrate

    CAS :
    Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus
    Formule :C16H14F2N3NaO4SH2O
    Degré de pureté :98.32%
    Couleur et forme :Solid
    Masse moléculaire :432.37

    Ref: TM-T0161

    1g
    119,00€
    100mg
    34,00€
    500mg
    92,00€
  • TNF-α-IN-11


    TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.
    Formule :C24H26N2O5
    Couleur et forme :Solid
    Masse moléculaire :422.47

    Ref: TM-T78730

    5mg
    À demander
    50mg
    À demander
  • Pro-GA

    CAS :
    Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.
    Formule :C12H19NO7
    Couleur et forme :Solid
    Masse moléculaire :289.28

    Ref: TM-T203386

    10mg
    À demander
    50mg
    À demander
  • Petromurin C

    CAS :
    Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).
    Formule :C26H24N2O5
    Couleur et forme :Solid
    Masse moléculaire :444.487

    Ref: TM-T35910

    2500µg
    1.215,00€
  • Finotonlimab


    Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].
    Couleur et forme :Odour Liquid

    Ref: TM-T77008

    5mg
    À demander
  • Topoisomerase I/II inhibitor 6


    TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.
    Formule :C31H28F2N4O6S
    Couleur et forme :Solid
    Masse moléculaire :622.64

    Ref: TM-T201278

    10mg
    À demander
    50mg
    À demander
  • Ac-AAVALLPAVLLALLAP-YVAD-CHO

    CAS :
    Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].
    Formule :C97H160N20O24
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1990.43

    Ref: TM-T80532

    5mg
    À demander
    50mg
    À demander
  • MBC-11 trisodium

    CAS :
    MBC-11 trisodium, a bisphosphonate-Ara-C conjugate, may treat TIBD.
    Formule :C11H17N3Na3O14P3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :577.16

    Ref: TM-T11957

    25mg
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    50mg
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    100mg
    À demander
  • TAT-NEP1-40 TFA


    TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.
    Formule :C268H438N88O77·xC2HF3O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :6124.89 (free base)

    Ref: TM-T80419

    5mg
    À demander
    50mg
    À demander
  • Rozanolixizumab

    CAS :

    Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.

    Degré de pureté :SDS-PAGE:97.2%;SEC-HPLC:95.9%
    Couleur et forme :Liquid
    Masse moléculaire :145.19 kDa

    Ref: TM-T39057

    1mg
    216,00€
    5mg
    472,00€
    10mg
    755,00€
    25mg
    1.121,00€
    50mg
    1.501,00€
  • GPX4-IN-7


    GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.
    Formule :C25H23ClN4O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :478.93

    Ref: TM-T79777

    5mg
    À demander
    50mg
    À demander
  • EMB-02


    EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.
    Couleur et forme :Odour Liquid

    Ref: TM-T9901A-799

    1mg
    À demander
    5mg
    À demander
  • Taltirelin acetate

    CAS :
    Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an
    Formule :C19H27N7O7
    Degré de pureté :99.21%
    Couleur et forme :Solid
    Masse moléculaire :465.46

    Ref: TM-T13072

    2mg
    34,00€
    5mg
    49,00€
    10mg
    80,00€
    25mg
    141,00€
    50mg
    230,00€
    100mg
    358,00€
    200mg
    530,00€
    1mL*10mM (DMSO)
    54,00€
  • Ferroptosis-IN-14


    Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.
    Couleur et forme :Odour Solid

    Ref: TM-T200679

    10mg
    À demander
    50mg
    À demander
  • Z-VEID-FMK

    CAS :
    Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.
    Formule :C31H45FN4O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :652.71

    Ref: TM-T23555

    1mg
    99,00€
    5mg
    254,00€
    10mg
    421,00€
    25mg
    672,00€
  • Avotaciclib hydrochloride


    Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including
    Formule :C13H12ClN7O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :317.73

    Ref: TM-T78137

    5mg
    À demander
    50mg
    À demander
  • RET ligand-3


    RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.
    Formule :C38H42N10O3
    Couleur et forme :Solid
    Masse moléculaire :686.81

    Ref: TM-T205712

    10mg
    À demander
    50mg
    À demander
  • Beclin1-Bcl-2 interaction inhibitor 1


    Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].
    Couleur et forme :Odour Solid

    Ref: TM-T82902

    5mg
    À demander
    50mg
    À demander
  • IRF1-IN-1

    CAS :
    IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.
    Formule :C22H24N4O4S
    Degré de pureté :99.88%
    Couleur et forme :Solid
    Masse moléculaire :440.52

    Ref: TM-T203129

    25mg
    51,00€
    50mg
    À demander
    1mL*10mM (DMSO)
    33,00€
  • Macrophage-activating lipopeptide 2 TFA


    Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,
    Formule :C99H167N19O30S·xC2HF3O2
    Degré de pureté :97.56%
    Couleur et forme :Solid
    Masse moléculaire :2135.56 (free base)

    Ref: TM-TP2905

    1mg
    111,00€
    5mg
    274,00€
    10mg
    444,00€
    25mg
    739,00€
  • Anticancer agent 39

    CAS :
    Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.
    Formule :C50H65N5O10
    Couleur et forme :Solid
    Masse moléculaire :896.08

    Ref: TM-T73833

    5mg
    À demander
    50mg
    À demander
  • EGFR-IN-78


    EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer.
    Formule :C23H32BrN7O2S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :550.51

    Ref: TM-T78940

    5mg
    À demander
    50mg
    À demander
  • Mcl-1 inhibitor 15


    Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].
    Formule :C40H42ClFN6O4S
    Couleur et forme :Solid
    Masse moléculaire :757.32

    Ref: TM-T79216

    5mg
    À demander
    50mg
    À demander
  • LSD1-IN-24

    CAS :
    LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response
    Formule :C18H20N2OS
    Degré de pureté :99.61%
    Couleur et forme :Soild
    Masse moléculaire :312.43

    Ref: TM-T67871

    1mg
    34,00€
    5mg
    77,00€
    10mg
    110,00€
    25mg
    212,00€
    50mg
    349,00€
    100mg
    532,00€
    200mg
    705,00€
    1mL*10mM (DMSO)
    84,00€
  • Liensinine Perchlorate

    CAS :

    Liensinine is the active constituent of plumula nelambinis with anti-hypertension.

    Formule :C37H43ClN2O10
    Degré de pureté :99.80%
    Couleur et forme :Solid
    Masse moléculaire :711.2

    Ref: TM-T3055

    5mg
    60,00€
    10mg
    99,00€
    25mg
    172,00€
  • Tyroserleutide hydrochloride

    CAS :
    Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.
    Formule :C18H28ClN3O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :417.88

    Ref: TM-TP1598

    5mg
    170,00€
    10mg
    295,00€
    25mg
    558,00€
    50mg
    858,00€
    100mg
    1.441,00€
  • 2'-epi-2'-O-Acetylthevetin B

    CAS :
    2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.
    Formule :C44H68O19
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :901

    Ref: TM-T79982

    5mg
    À demander
    50mg
    À demander
  • Ac-FEID-CMK TFA


    Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.
    Formule :C29H38ClF3N4O11
    Degré de pureté :95%
    Couleur et forme :Solid
    Masse moléculaire :711.08

    Ref: TM-T76251L

    1mg
    152,00€
    5mg
    326,00€
    10mg
    522,00€
    25mg
    837,00€
  • PROTAC PD-1/PD-L1 degrader-1

    CAS :
    PROTAC PD-1/PD-L1 degrader-1, a Cereblon-based inhibitor, blocks PD-1/PD-L1 with 39.2 nM IC50, boosting immune response and reducing PD-L1 via lysosomes.
    Formule :C59H58ClN7O11
    Degré de pureté :99.07%
    Couleur et forme :Solid
    Masse moléculaire :1076.59

    Ref: TM-T40112

    1mg
    227,00€
    5mg
    557,00€
    10mg
    888,00€
    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.493,00€
    200mg
    3.357,00€
  • IMMH 010 maleate

    CAS :
    IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.
    Formule :C36H36BrClN2O9
    Couleur et forme :Soild
    Masse moléculaire :756.04

    Ref: TM-T83970

    1mg
    175,00€
    5mg
    434,00€
    10mg
    622,00€
    25mg
    973,00€
    50mg
    1.341,00€
    100mg
    1.773,00€
  • Chloranil

    CAS :
    Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.
    Formule :C6Cl4O2
    Degré de pureté :98.03%
    Couleur et forme :Solid
    Masse moléculaire :245.88

    Ref: TM-T80673

    1g
    33,00€
  • Z-DQMD-FMK

    CAS :

    Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.

    Formule :C29H40FN5O11S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :685.72

    Ref: TM-TP2037

    1mg
    309,00€
  • Ara-SH


    Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded Cytarabine
    Formule :C12H17N3O6S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :331.34

    Ref: TM-T79224

    5mg
    À demander
    50mg
    À demander
  • Ferroptosis-IN-3


    Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).
    Degré de pureté :98%
    Couleur et forme :Odour Solid

    Ref: TM-T82408

    5mg
    À demander
    50mg
    À demander
  • Caerin 1.1 TFA


    Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells
    Degré de pureté :98%
    Couleur et forme :Odour Solid

    Ref: TM-T82793

    5mg
    À demander
    50mg
    À demander
  • CYP51/PD-L1-IN-3


    CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM
    Formule :C27H28N6O2
    Couleur et forme :Solid
    Masse moléculaire :468.55

    Ref: TM-T79740

    5mg
    À demander
    50mg
    À demander
  • Asparanin A

    CAS :
    Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.
    Formule :C39H64O13
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :740.92

    Ref: TM-T79971

    5mg
    À demander
    50mg
    À demander
  • Chol-CTPP


    Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.
    Formule :C144H263N3O53
    Couleur et forme :Solid
    Masse moléculaire :2884.62

    Ref: TM-T74365

    5mg
    À demander
    50mg
    À demander
  • Metronidazole hydrochloride

    CAS :
    Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.
    Formule :C6H10ClN3O3
    Couleur et forme :Solid
    Masse moléculaire :207.62

    Ref: TM-T75285

    5mg
    À demander
    50mg
    À demander
  • Lon-TK


    Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.
    Formule :C24H28Cl2N2O3S2
    Couleur et forme :Solid
    Masse moléculaire :527.53

    Ref: TM-T203042

    10mg
    À demander
    50mg
    À demander
  • 2-Methylbiphenyl-oxadiazole-NH-Ph-CHO

    CAS :
    2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.
    Formule :C22H17N3O2
    Couleur et forme :Solid
    Masse moléculaire :355.39

    Ref: TM-T203314

    10mg
    À demander
    50mg
    À demander
  • Anticancer agent 130


    Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].
    Formule :C38H46FN5O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :671.8

    Ref: TM-T78941

    5mg
    À demander
    50mg
    À demander
  • Pim-1 kinase inhibitor 4


    Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and
    Formule :C19H12ClN3O
    Degré de pureté :97.37%
    Couleur et forme :Solid
    Masse moléculaire :333.77

    Ref: TM-T77526

    1mg
    115,00€
    2mg
    169,00€
    5mg
    275,00€
    10mg
    394,00€
    25mg
    615,00€
    50mg
    848,00€
    100mg
    1.121,00€
    200mg
    1.510,00€
  • Z-LEHD-fmk

    CAS :
    Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and
    Formule :C32H43FN6O10
    Degré de pureté :96.13%
    Couleur et forme :Solid
    Masse moléculaire :690.72

    Ref: TM-T21835

    1mg
    178,00€
    5mg
    557,00€
    10mg
    790,00€
    25mg
    1.153,00€
    50mg
    1.575,00€
  • PTD-p65-P1 Peptide


    PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.
    Formule :C168H275N57O44S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :3829.5

    Ref: TM-TP1608

    100mg
    À demander
    500mg
    À demander
  • Dapirolizumab


    Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.
    Degré de pureté :>95%
    Couleur et forme :Liquid
    Masse moléculaire :150 kDa

    Ref: TM-T77363

    1mg
    323,00€
    5mg
    955,00€
    10mg
    1.513,00€
    25mg
    2.489,00€
  • PD-1/PD-L1-IN-9

    CAS :
    PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.
    Formule :C22H24N2O2
    Degré de pureté :99.92%
    Couleur et forme :Solid
    Masse moléculaire :348.44

    Ref: TM-T9651

    1mg
    57,00€
    2mg
    85,00€
    5mg
    127,00€
    10mg
    178,00€
    25mg
    298,00€
    50mg
    405,00€
    100mg
    535,00€
    500mg
    1.063,00€
    1mL*10mM (DMSO)
    140,00€
  • AZT triphosphate TEA


    AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.
    Couleur et forme :Solid

    Ref: TM-T36490

    1mg
    540,00€
  • Collismycin A

    CAS :
    Collismycin A, from Streptomyces, has antibacterial, antiproliferative, and neuroprotective effects. It inhibits various cancer cells and is iron-complexing.
    Formule :C13H13N3O2S
    Couleur et forme :Solid
    Masse moléculaire :275.33

    Ref: TM-T35687

    1mg
    940,00€
  • Mofarotene

    CAS :
    Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of
    Formule :C29H39NO2
    Degré de pureté :99.96%
    Couleur et forme :Solid
    Masse moléculaire :433.63

    Ref: TM-T68104

    1mg
    50,00€
    5mg
    111,00€
    10mg
    165,00€
    25mg
    266,00€
    50mg
    379,00€
    100mg
    540,00€
    200mg
    757,00€
  • XM-U-14


    XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.
    Couleur et forme :Odour Solid

    Ref: TM-T89347

    10mg
    À demander
    50mg
    À demander
  • HX009


    HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).
    Couleur et forme :Odour Liquid

    Ref: TM-T9901A-797

    1mg
    À demander
    5mg
    À demander
  • XIAP BIR2/BIR2-3 inhibitor-1

    CAS :
    XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].
    Formule :C72H96N16O14
    Couleur et forme :Solid
    Masse moléculaire :1409.63

    Ref: TM-T87640

    10mg
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    50mg
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  • GGTI298 Trifluoroacetate

    CAS :
    GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.
    Formule :C27H33N3O3S·C2HF3O2
    Degré de pureté :98.07% - >99.99%
    Couleur et forme :Solid
    Masse moléculaire :593.66

    Ref: TM-T6844

    1mg
    82,00€
    5mg
    150,00€
    10mg
    227,00€
    25mg
    442,00€
    50mg
    615,00€
    1mL*10mM (DMSO)
    192,00€
  • BY13


    BY13 is an SRC-3 PROTAC degrader with a DC50 of 0.031 μM. It selectively obstructs the ER signaling pathway by downregulating ERα levels, showing greater selectivity over the androgen receptor (AR). BY13 effectively addresses endocrine resistance in breast cancer by inducing cell cycle arrest at the G1 phase and triggering apoptosis. Additionally, it surpasses Fulvestrant in efficacy and significantly inhibits the growth of resistant breast tumors in LCC2 xenograft mouse models, exhibiting no noticeable toxicity.
    Couleur et forme :Odour Solid

    Ref: TM-T210784

    10mg
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  • Azurin p28 peptide

    CAS :

    Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.

    Formule :C122H197N31O47S2
    Couleur et forme :Solid
    Masse moléculaire :2914.18

    Ref: TM-T80523

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  • Mcl-1 inhibitor 12

    CAS :
    Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].
    Formule :C47H45ClFN7O6
    Couleur et forme :Solid
    Masse moléculaire :858.35

    Ref: TM-T75143

    5mg
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  • BRD9 ligand-5

    CAS :
    BRD9 Ligand-5 (Compound 172-11) serves as a ligand for the target protein in PROTAC applications. It is utilized in the synthesis of CFT8634.
    Formule :C17H19NO4
    Couleur et forme :Solid
    Masse moléculaire :301.34

    Ref: TM-T201421

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  • Amino-PEG6-Thalidomide


    Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
    Formule :C27H39N3O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :565.61

    Ref: TM-T17439

    100mg
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  • Bfl-1-IN-5


    Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor of Bfl-1, demonstrating an IC50 of 0.022 μM. This compound enhances the activity of caspase-3/7, with an EC50 of 0.37 μM, and also inhibits the viability of SU-DHL-1 cells, showing an EC50 of 1.3 μM.
    Formule :C24H24F3N3O2
    Couleur et forme :Solid
    Masse moléculaire :443.46

    Ref: TM-T201041

    10mg
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  • PROTAC c-Met degrader-6


    PROTACc-Met degrader-6 is a potent and orally active c-Met PROTAC degrader. It effectively promotes the degradation of c-Met protein, with DC50 values of 0.52 nM in EBC-1 cells and 0.45 nM in Hs746T cells. This compound almost completely abolishes the migration and invasion capabilities of tumor cells, significantly induces apoptosis (apoptosis), and arrests the cell cycle at the G0/G1 phase. PROTACc-Met degrader-6 is useful for studying various cancers, including non-small cell lung cancer and gastric cancer.
    Couleur et forme :Odour Solid

    Ref: TM-T212285

    10mg
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  • STAT3-IN-40

    CAS :
    STAT3-IN-40 (Compound 8b) is an anticancer agent. It initiates immune responses in CD4+ and CD8+ T lymphocytes by inhibiting the expression and phosphorylation of STAT3, and induces ferroptosis and apoptosis in tumor cells. STAT3-IN-40 is valuable for research into cancer chemoimmunotherapy drugs.
    Formule :C34H40ClN3O10Pt
    Couleur et forme :Solid
    Masse moléculaire :881.232

    Ref: TM-T205098

    10mg
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  • LBM22


    LBM22, a CLK2 inhibitor, exhibits an IC50 value of 3.9 nM. It possesses anti-proliferative properties by inhibiting the phosphorylation of SR proteins. Additionally, LBM22 downregulates the expression of Wnt-related proteins and anti-apoptotic proteins, making it applicable in the study of non-small cell lung cancer.
    Formule :C28H22F2N6O2
    Couleur et forme :Solid
    Masse moléculaire :512.51

    Ref: TM-T201198

    10mg
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  • Apoptosis inducer 31


    Apoptosisinducer 31 (compound 19) triggers caspase-dependent apoptosis (cell death). It plays a crucial role in cancer research.
    Formule :C14H10N4O3
    Couleur et forme :Solid
    Masse moléculaire :282.254

    Ref: TM-T204870

    10mg
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  • CDK2-IN-32


    CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.
    Formule :C18H13Cl2N5O2
    Couleur et forme :Solid
    Masse moléculaire :402.23

    Ref: TM-T201108

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  • STK17A/B-IN-1 hydrochloride


    STK17A/B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A/B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.
    Formule :C26H28ClN7O
    Couleur et forme :Solid
    Masse moléculaire :490.00

    Ref: TM-T201324

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  • PROTAC NCOA4 degrader-1


    PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.
    Couleur et forme :Odour Solid

    Ref: TM-T89280

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  • OBHSA

    CAS :
    OBHSA(Oxabicycloheptane sulfonamide) is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.
    Formule :C27H24F3NO6S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :547.54

    Ref: TM-T77724

    1mg
    175,00€
    5mg
    434,00€
    10mg
    622,00€
    25mg
    973,00€
    50mg
    1.341,00€
    100mg
    1.773,00€
    500mg
    3.537,00€
  • SZU-B6

    CAS :
    SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.
    Formule :C29H32FN7O6
    Couleur et forme :Solid
    Masse moléculaire :593.61

    Ref: TM-T200927

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  • (-)-Mcl-1 inhibitor 21

    CAS :

    (-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.

    Formule :C32H33N3O4
    Couleur et forme :Solid
    Masse moléculaire :523.622

    Ref: TM-T204636

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  • KGYY15

    CAS :
    KGYY15 (Mouse KGYY15), a peptide that targets CD40, exhibits weak inhibition of the CD40-CD40L interaction, with an IC50 exceeding 1 mM. At a concentration of 100 μM, KGYY15 activates the NF-κB pathway by 33%.
    Formule :C84H129N21O22S
    Couleur et forme :Solid
    Masse moléculaire :1817.12

    Ref: TM-TP2671

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  • Bcl-2-IN-21


    Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.
    Formule :C45H33F6IrN5P
    Masse moléculaire :980.96

    Ref: TM-T89910

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  • Obestatin (human)

    CAS :
    Obestatin (human) is an endogenous ligand for G-protein eurythmic entity 39 formed by shearing of preproghrelin and can be used to study obesity.
    Formule :C116H176N32O33
    Degré de pureté :99.75%
    Couleur et forme :Solid
    Masse moléculaire :2546.83

    Ref: TM-T38470

    1mg
    80,00€
    5mg
    215,00€
    10mg
    323,00€
    25mg
    505,00€
    50mg
    675,00€
    100mg
    909,00€
  • JAK-IN-40


    JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.
    Formule :C26H32N8O3S
    Couleur et forme :Solid
    Masse moléculaire :536.65

    Ref: TM-T205062

    10mg
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    50mg
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  • PROTAC EGFR degrader 14


    PROTACEGFRdegrader 14 is a potent and selective EGFR PROTAC degrader with a DC50 value of approximately 2.9 nM against EGFRL858R/T790M/C797S and a Dmax of 93.1%. It induces the selective degradation of EGFRC797S via a VHL and proteasome-dependent mechanism, downregulating EGFR-related transcriptomes. PROTACEGFRdegrader 14 exhibits high selectivity for EGFRWT, induces cell cycle arrest and apoptosis, and effectively inhibits tumor growth. It is applicable for research on non-small cell lung cancer (NSCLC).
    Couleur et forme :Odour Solid

    Ref: TM-T211487

    10mg
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  • XY221


    XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.
    Formule :C32H34FN3O5
    Couleur et forme :Solid
    Masse moléculaire :559.628

    Ref: TM-T204924

    10mg
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    50mg
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  • VEGFR-2-IN-61


    VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.
    Formule :C27H25N5O
    Couleur et forme :Solid
    Masse moléculaire :435.52

    Ref: TM-T204905

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  • DP-15

    CAS :
    DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]
    Formule :C42H44ClN9O5S
    Couleur et forme :Solid
    Masse moléculaire :822.374

    Ref: TM-T205043

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  • SZUH280

    CAS :
    SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.
    Formule :C36H34N8O8
    Couleur et forme :Solid
    Masse moléculaire :706.7

    Ref: TM-T75021

    5mg
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    50mg
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  • MEDI-7352


    MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.
    Couleur et forme :Odour Liquid

    Ref: TM-T9901A-1108

    1mg
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    5mg
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  • SL-01

    CAS :
    SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.
    Formule :C18H18ClNO3
    Degré de pureté :98%
    Couleur et forme :White Powder
    Masse moléculaire :331.79

    Ref: TM-T19779

    1g
    404,00€
    250mg
    172,00€
    500mg
    265,00€
  • BC13


    BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.
    Formule :C37H39N7O5
    Couleur et forme :Solid
    Masse moléculaire :661.75

    Ref: TM-T204938

    10mg
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    50mg
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  • Tat-ASIC1a (1-20) (mouse, rat)


    Tat-ASIC1a (1-20) (mouse, rat) is a competitive ASIC1a transmembrane peptide with significant neuroprotective effects. It alleviates acidotoxic neuronal damage by targeting the ASIC1a-RIPK1 pathway and an auto-inhibition mechanism. This compound effectively safeguards the brain in ischemic stroke mouse models against damage from ischemia and is applicable in research on neurodegenerative diseases, such as Huntington's disease and Parkinson’s disease.
    Couleur et forme :Odour Solid

    Ref: TM-TP3781

    10mg
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    50mg
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  • RET Ligand-Linker Conjugate-1


    RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.
    Formule :C40H44N10O
    Couleur et forme :Solid
    Masse moléculaire :680.84

    Ref: TM-T205264

    10mg
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    50mg
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  • Necroptosis-IN-5


    Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.
    Couleur et forme :Odour Solid

    Ref: TM-T89312

    10mg
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  • 5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin

    CAS :
    5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a capable of forming complexes with metal ions and exhibit phototoxicity towards Hep-2 cells.
    Formule :C48H38N4O4
    Couleur et forme :Solid
    Masse moléculaire :734.84

    Ref: TM-T202942

    5mg
    40,00€
    10mg
    50,00€
    25mg
    79,00€
    50mg
    99,00€
    100mg
    150,00€
  • Topoisomerase I inhibitor 17

    CAS :
    TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1). It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and γH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.
    Formule :C28H21FN2O7
    Couleur et forme :Solid
    Masse moléculaire :516.47

    Ref: TM-T203609

    10mg
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  • XY077


    XY077 (compound 14a) is a RORγ inverse agonist with an IC50 value of 0.004 μM. It induces cell apoptosis (cellapoptosis) and exhibits antiproliferative activity both in vitro and in vivo.
    Formule :C27H27F3N2O5S2
    Masse moléculaire :580.13135

    Ref: TM-T209894

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  • Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

    CAS :
    Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.
    Formule :C20H14ClFeN2O2
    Couleur et forme :Solid
    Masse moléculaire :405.64

    Ref: TM-T37851

    5mg
    128,00€
    10mg
    208,00€
    50mg
    775,00€
    100mg
    1.423,00€
  • CDK4/6/HDAC-IN-1


    CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.
    Formule :C35H39N9O5
    Couleur et forme :Solid
    Masse moléculaire :665.742

    Ref: TM-T204833

    10mg
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    50mg
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  • EGFR/DHFR-IN-2


    EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 μM for h-DHFR and 0.109 μM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.
    Formule :C24H16N4O5
    Couleur et forme :Solid
    Masse moléculaire :440.11207

    Ref: TM-T207349

    10mg
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  • Sec61-IN-4


    Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].
    Couleur et forme :Odour Solid

    Ref: TM-T81184

    5mg
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    50mg
    À demander
  • dASK1-VHL


    dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.
    Couleur et forme :Odour Solid

    Ref: TM-T210975

    10mg
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    50mg
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  • SB-T-1214

    CAS :
    SB-T-1214 (SBT) is a taxane-based drug known for its ability to effectively suppress the expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induce apoptosis in drug-resistant tumorigenic CD133+/CD44+ colon cancer spheroids. In Pgp+ DLD-1 human colon tumor xenograft mouse models, SB-T-1214 successfully inhibits tumor growth. This compound is relevant for anti-tumor research, particularly against drug-resistant tumors such as colon, pancreatic, and renal cancers.
    Formule :C45H59NO15
    Couleur et forme :Solid
    Masse moléculaire :853.95

    Ref: TM-T210736

    10mg
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    50mg
    À demander
  • Caspase-3/7 activator 1


    Caspase-3/7 activator 1 is an effective activator of Caspase-3/7 that exhibits tumor-selective, antiproliferative activity and high apoptosis (Apoptosis) induction capability.
    Formule :C26H28N2O5
    Masse moléculaire :448.19982

    Ref: TM-T209473

    10mg
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    50mg
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  • Thujopsene

    CAS :
    Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 µM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 µg/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 µg/cm2, respectively.
    Formule :C15H24
    Couleur et forme :Solid
    Masse moléculaire :204.35

    Ref: TM-TN7505

    10mg
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  • PROTAC PI3Kδ degrader-1


    PROTACPI3Kδ degrader-1 is a covalent PI3Kδ-targeting PROTAC degrader that targets lysine, with a DC50 of 3.98 nM. It exhibits potent antiproliferative activity and selective PI3Kδ inhibition (IC50: 8 nM). Additionally, PROTACPI3Kδ degrader-1 effectively degrades p-AKT, induces cell cycle arrest in the G1 phase, and promotes apoptosis and autophagy. It also significantly suppresses tumor growth in the SU-DHL-6 xenograft mouse model.
    Couleur et forme :Odour Solid

    Ref: TM-T211083

    10mg
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    50mg
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  • HMGB1-IN-2


    HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in
    Formule :C53H71N3O11
    Couleur et forme :Soild
    Masse moléculaire :926.14

    Ref: TM-T82189

    5mg
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    50mg
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  • Thiocolchicine

    CAS :
    Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.
    Formule :C22H25NO5S
    Degré de pureté :98.19%
    Couleur et forme :Solid
    Masse moléculaire :415.5

    Ref: TM-T41248

    5mg
    46,00€
    10mg
    66,00€
    25mg
    120,00€
    50mg
    192,00€
    100mg
    308,00€
    1mL*10mM (DMSO)
    55,00€
  • Trimebutine

    CAS :
    Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid
    Formule :C22H29NO5
    Degré de pureté :99.49% - 99.86%
    Couleur et forme :Solid
    Masse moléculaire :387.47

    Ref: TM-T0918

    1g
    34,00€
    1mL*10mM (DMSO)
    33,00€