Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(127 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6170 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
BDK-IN-1
BDK-IN-1 (compound (-)-43) is a BDK inhibitor with an IC50 of 0.23 μM and a maximum inhibition rate of 90%. It reduces phosphorylated-E1 levels and is useful in the study of cardiac metabolic diseases.Formule :C18H14F2N2O3SCouleur et forme :SolidMasse moléculaire :376.38Apoptosis inducer 29
Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.Formule :C33H46ClN3O3Couleur et forme :SolidMasse moléculaire :568.19Fludioxonil
CAS :Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.Formule :C12H6F2N2O2Degré de pureté :99.971%Couleur et forme :SolidMasse moléculaire :248.18Aspochalasin D
CAS :Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.
Formule :C24H35NO4Couleur et forme :SolidMasse moléculaire :401.54RET-IN-28
CAS :RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formule :C26H29N9Couleur et forme :SolidMasse moléculaire :467.57Azadirone
CAS :Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.
Formule :C9H15N3O5Couleur et forme :SolidMasse moléculaire :245.23Resolvin D2 n-3 DPA
CAS :RvD2 n-3 DPA is an SPM made from docosapentaenoic acid in human leukocytes, inhibiting neutrophil chemotaxis and adhesion.
Formule :C22H34O5Couleur et forme :SolidMasse moléculaire :378.509Rozanolixizumab
CAS :Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.
Degré de pureté :SDS-PAGE:97.2%;SEC-HPLC:95.9%Couleur et forme :LiquidMasse moléculaire :145.19 kDaTaltirelin acetate
CAS :Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating anFormule :C19H27N7O7Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :465.46Ref: TM-T13072
2mg34,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg80,00€25mg141,00€50mg230,00€100mg358,00€200mg530,00€Ferroptosis-IN-14
Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.Couleur et forme :Odour SolidAc-IEPD-AFC
CAS :Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formule :C32H38F3N5O11Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :725.67KC01
CAS :KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formule :C22H39NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.558Tralokinumab
CAS :Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144.14 kDa5α-dihydro Levonorgestrel
CAS :5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .Formule :C21H30O2Couleur et forme :SolidMasse moléculaire :314.469Tyroserleutide hydrochloride
CAS :Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.Formule :C18H28ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.88Hellebrin
CAS :Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.Formule :C36H52O15Couleur et forme :SolidMasse moléculaire :724.79Epoprostenol sodium
CAS :Epoprostenol sodium (Prostaglandin I2 sodium salt) is a vasodilator and a synthetic prostacyclin that can be used to study pulmonary hypertension.Formule :C20H31NaO5Degré de pureté :98%Couleur et forme :White Crystalline PowderMasse moléculaire :374.45BOC-D-FMK
CAS :Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formule :C11H18FNO5Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)132,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€HPOB
CAS :HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formule :C17H18N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :314.34(Iso)-Z-VAD(OMe)-FMK
CAS :(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.49GPI-1485
CAS :GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formule :C12H19NO4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54TNF-α/IL-1β-IN-1
TNF-α/IL-1β-IN-1 (compound 11a) is an anti-inflammatory agent that effectively reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and myocardial cell apoptosis, and demonstrates significant activity against septic myocardial injury. Additionally, it improves myocardial blood flow in vivo.Formule :C41H58N2O7Couleur et forme :SolidMasse moléculaire :690.911D09C3
CAS :1D09C3 is a fully humanized anti-HLA-DR monoclonal antibody. It induces cell apoptosis (apoptosis) and death through a cascade of reactions, including reactive oxygen species (ROS) production, JNK activation, mitochondrial membrane depolarization, and the release of AIF from mitochondria. In xenograft models with JVM-2 cells and GRANTA-519 cells in mice, 1D09C3 demonstrated significant antitumor activity, improving overall survival and median survival time. This compound is applicable in cancer research, including studies on chronic lymphocytic leukemia (CLL).Couleur et forme :LiquidPROTAC c-Met degrader-6
PROTACc-Met degrader-6 is a potent and orally active c-Met PROTAC degrader. It effectively promotes the degradation of c-Met protein, with DC50 values of 0.52 nM in EBC-1 cells and 0.45 nM in Hs746T cells. This compound almost completely abolishes the migration and invasion capabilities of tumor cells, significantly induces apoptosis (apoptosis), and arrests the cell cycle at the G0/G1 phase. PROTACc-Met degrader-6 is useful for studying various cancers, including non-small cell lung cancer and gastric cancer.Couleur et forme :Odour SolidWR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52E3 ligase Ligand 36
CAS :E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Formule :C25H30N4O5SCouleur et forme :SolidMasse moléculaire :498.6LY 219703
CAS :LY 219703 is a photoactivatable diarylsulfonylurea.Formule :C13H10ClN5O3SCouleur et forme :SolidMasse moléculaire :351.77RIPK1 ligand-Linker Conjugate-1
RIPK1ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that consists of a RIPK1 ligand and a PROTAC linker, designed to recruit E3 ligase. It is utilized in the synthesis of PROTACRIPK1Degrader-1.Couleur et forme :Odour SolidSodium fluoride
CAS :Sodium fluoride is a fluorinated inorganic salt. With wide range of applications. Sodium fluoride is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose, it can also act as an insectcide, herbicide and fungicide.Formule :FnaCouleur et forme :SolidMasse moléculaire :41.99Iturin A
CAS :Iturin A: antifungal compound targeting cell membranes, forms ion pores in yeast/fungi.Couleur et forme :SolidGLPG4970
GLPG4970 is a potent, selective, orally active dual inhibitor of salt-inducible kinases 2 and 3 (SIK2/SIK3), with IC50 values of 0.3 nM and 0.7 nM, respectively. It exhibits weak inhibition of the hERG channel, with an IC50 value of 29 μM. GLPG4970 reduces the release of tumor necrosis factor α (TNFα) and increases the release of interleukin 10 (IL-10). This compound is applicable for research in inflammation and immunology, such as studies on colitis.Couleur et forme :Odour SoliddPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Couleur et forme :Odour SolidPI3Kδ-IN-25
PI3Kδ-IN-25 is an orally active and selective PI3Kδ inhibitor with an IC50 of 2.1 nM. It exhibits IC50 values of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. In B16F10 cells, PI3Kδ-IN-25 inhibits the phosphorylation of AKTSer473, suppresses Treg cell proliferation, and downregulates the expression of PD-L1. In mouse models of B16F10 melanoma and Lewis lung cancer, PI3Kδ-IN-25 demonstrates anticancer activity by reducing tumor-infiltrating Treg cells and enhancing immune responses. This compound is applicable for research on cancers such as melanoma and lung cancer.Couleur et forme :Odour SolidVTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Couleur et forme :Odour LiquidAMPK-IN-6
AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.Formule :C18H20FN5OCouleur et forme :SolidMasse moléculaire :341.383VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Formule :C27H25N5OCouleur et forme :SolidMasse moléculaire :435.52DP-15
CAS :DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]Formule :C42H44ClN9O5SCouleur et forme :SolidMasse moléculaire :822.374CGP-74514
CAS :CGP-74514,CDK1 inhibitor (IC50=25 nM). Induces G2/M arrest, apoptosis. Used in bladder cancer research.Formule :C19H24ClN7Degré de pureté :98.54%Couleur et forme :SoildMasse moléculaire :385.89PROTAC PI3K/110β degrader-2
CAS :PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.Formule :C51H65N9O7SCouleur et forme :SolidMasse moléculaire :948.18YTHu78
YTHu78 is a KDM5B PROTAC-based degrader. It induces the degradation of KDM5B through the ubiquitin-proteasome system and triggers apoptosis in MV-4-11 and MM.1S cell lines. YTHu78 demonstrates significant antiproliferative activity against various hematologic tumor cell lines and is useful for studying hematological malignancies.Couleur et forme :Odour SolidTopoisomerase IIα-IN-10
TopoisomeraseIIα-IN-10 (Compound 13r) is a topoisomerase IIα inhibitor that binds to the active site of DNA when complexed with topoisomerase IIα. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIα-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 μM. It is applicable for cancer research studies.Formule :C32H27N3O3Couleur et forme :SolidMasse moléculaire :501.575CDK4/6/HDAC-IN-1
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.Formule :C35H39N9O5Couleur et forme :SolidMasse moléculaire :665.7421R,3R-RSL3
CAS :1R,3R-RSL3 is a negative control for1S, 3R-RSL3.Formule :C23H21ClN2O5Couleur et forme :SolidMasse moléculaire :440.88Ferroptosis-IN-20
Ferroptosis-IN-20 (Compound 34a) is an inhibitor of ferroptosis targeting voltage-dependent anion channels (VDAC) with an EC50 of 24.2 nM. It prevents VDAC oligomerization and lipid peroxidation. Additionally, Ferroptosis-IN-20 reduces ROS levels, diminishes TFR1-mediated iron uptake, inhibits Fe2+ levels, and restores glutathione (GSH) levels. It also alleviates acute kidney injury (AKI) caused by folic acid.Couleur et forme :Odour SolidGarlic oil
CAS :Garlic oil can inhibit lung tumors caused by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by inducing second-phase drug metabolizing enzymes.Formule :C18H32OS7Couleur et forme :SolidMasse moléculaire :488.87Chetomin
CAS :Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar
Formule :C31H30N6O6S4Degré de pureté :98%Couleur et forme :Off-White To Fawn SolidMasse moléculaire :710.87Insect repellent M 3535
CAS :Insect repellent M 3535 is a bug repellant.Formule :C11H21NO3Couleur et forme :Colorless To Slightly Yellowish Liquid SolidMasse moléculaire :215.29ZLDI-8
CAS :ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Formule :C24H23N3O3SDegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :433.52Perfluorodecanoic acid
CAS :Perfluorodecanoic acid is a biochemical.Formule :C10HF19O2Couleur et forme :Physical Description Liquid (Ntp 1992)Masse moléculaire :514.08GNE-1567
GNE-1567 is a potent ERα PROTAC degrader and a selective antagonist of XIAP, with a Kd of 0.03 μM. It is applicable in breast cancer research.Couleur et forme :Odour SolidFASN/SCD-IN-1
FASN/SCD-IN-1 is a Silybin derivative and an orally active inhibitor of fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD). In vitro, FASN/SCD-IN-1 demonstrates the ability to inhibit lipid deposition, reduce the transcription levels of FASN and SCD, and exhibits antioxidant, anti-inflammatory, and antifibrotic activities. It shows significant hepatoprotective effects in rat models of acute liver injury and improves pathological features such as steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative-associated steatohepatitis (MASH). FASN/SCD-IN-1 can be used for MASH research.Couleur et forme :Odour SolidPROTAC RIPK1 Degrader-1
PROTACRIPK1Degrader-1 is a selective RIPK1 PROTAC degrader. This compound degrades RIPK1 in various cancer cell lines, such as A375 and B16F10 cells. It enhances the anticancer effects of radiotherapy in both syngeneic and humanized mouse models. PROTACRIPK1Degrader-1 is applicable for research in cancers like melanoma.Couleur et forme :Odour SolidS-Acetyl-L-glutathione
CAS :S-Acetyl-L-glutathione boosts intracellular GSH, induces lymphoma cell apoptosis, and inhibits HSV-1 replication, improving survival in HSV-1 mice.Formule :C12H19N3O7SCouleur et forme :SolidMasse moléculaire :349.36Thymocartin
CAS :Thymocartin (RGH 0206) is a fragment 32-35 of the naturally occurring thymic factor (thymopoietin).Thymocartin is used in the study of immunodeficiency diseasesFormule :C21H40N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.59MST3-IN-1
MST3-IN-1 is a selective and orally active MST3 inhibitor with an IC50 of 122.4 nM. It exhibits antiproliferative activity in HepG2 cells, effectively induces apoptosis, and causes cell cycle arrest at the G2/M phase. In HepG2 xenograft mouse models, MST3-IN-1 significantly suppresses tumor growth, making it useful for liver cancer research.Couleur et forme :Odour SolidGPX4-AUTAC
GPX4-AUTAC is an autophagy-mediated degrader (AUTAC) targeting GPX4. It consists of the inhibitor ML162-yne, a degradation tag FBnG, and a glycol linker. GPX4-AUTAC facilitates the ubiquitination of GPX4 by the E3 ligase TRAF6 and enhances its interaction with GPX4 and p62, leading to selective autophagy-dependent degradation of GPX4. This compound significantly induces ferroptosis and demonstrates potent anticancer activity in breast cancer cells, patient-derived organoids (PDOs), and MDA-MB-231 tumor xenograft mouse models. It shows strong synergy when used in combination with Sulfasalazine (SAS) or chemotherapy drugs (Paclitaxel or Cisplatin).Couleur et forme :Odour SolidVEGFR-2-IN-50
VEGFR-2-IN-50 (Compound 10f) is a VEGFR-2 inhibitor and apoptosis inducer with an IC50 of 0.33 μM. It exhibits growth inhibitory activity against the MCF-7 and MDA-MB-231 breast cancer cell lines, with IC50 values of 19.86 μM and 10.88 μM, respectively, making it a promising agent for breast cancer research.Couleur et forme :Odour SolidAM0001
AM0001 is a human monoclonal antibody (mAb) that targets PDCD1/PD-1/CD279. It is applicable in cancer research.Couleur et forme :Odour LiquidS9-CMC1 TFA
S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 2.53 μM. It selectively targets the active site Cys360 of the enzyme. By inhibiting LSD1 activity, S9-CMC1 TFA elevates H3K4me1 and H3K4me2 levels, inducing G1 cell cycle arrest and apoptosis, thereby suppressing cell proliferation. In addition, S9-CMC1 TFA markedly inhibits tumor growth in A549 xenograft animal models.Formule :C97H151F3N32O17S2Couleur et forme :SolidMasse moléculaire :2158.57ISB2001
ISB2001 is a human trispecific antibody targeting CD38, CD3, and BCMA. It is applicable for research on relapsed/refractory multiple myeloma (RRMM). The recommended isotype control is IgG1-kappa-IgG1-Fab.Couleur et forme :Odour LiquidBTK ligand 12
CAS :BTK ligand 12 is a PROTAC target protein ligand serving as an active control for NRX-0492 (a BTK degradator).Formule :C25H34N8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :478.59MB-314
MB-314 is a humanized IgG1 monoclonal antibody (mAb) targeting Lewis Y. This compound enhances antibody-dependent cell-mediated cytotoxicity (ADCC) activity and increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 is applicable in cancer research.Couleur et forme :Odour LiquidACP-0052
CAS :ACP-0052(SL-052, ACP-SL-052) is a photosensitizer based on hypoclintin that may be used in the treatment of prostate cancer.Formule :C35H32N2O7Couleur et forme :SolidMasse moléculaire :592.648Bim BH3
CAS :Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.Formule :C108H170N32O31SCouleur et forme :SolidMasse moléculaire :2444.77RTX-002
RTX-002 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. This compound is applicable in the research of autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.Couleur et forme :Odour LiquidTubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Couleur et forme :Odour SolidNSC243928 mesylate
CAS :NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity.Formule :C23H25N3O6S2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :503.595-hydroxy Diclofenac
CAS :5-hydroxy Diclofenac, a CYP3A4-formed NSAID diclofenac metabolite, inhibits COX-1/2 with varying IC50 values.Formule :C14H11Cl2NO3Couleur et forme :SolidMasse moléculaire :312.15TrxR-IN-7
TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).Formule :C22H21NO3Couleur et forme :SolidMasse moléculaire :347.407Antioxidant agent-20
Antioxidant agent-20 (Compound 3d) exhibits potent anti-inflammatory and antioxidant activities. It reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 demonstrates photoprotective effects on UVB-exposed human skin keratinocytes (HaCaT) (IC50=5.13 µM) by activating Nrf2/HO-1 signaling and inhibiting the NF-κB pathway.Formule :C18H24O4Couleur et forme :SolidMasse moléculaire :304.381Mitochondria modulator-2
Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.Formule :C63H50F12IrN6OP3Couleur et forme :SolidMasse moléculaire :1420.23Amiloride hydrochloride dihydrate
CAS :Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.Formule :C6H8ClN7O·HCl·2H2ODegré de pureté :99.07% - >99.99%Couleur et forme :SolidMasse moléculaire :302.12Emavusertib Tosylate
CAS :Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.Formule :C31H33N7O8SMasse moléculaire :663.7EP5-1
EP5-1 is an antimicrobial peptide with antibacterial, antifungal, antitumor, and antiviral properties, notably inducing apoptosis in cancer cells andFormule :C16H27N5O8SCouleur et forme :SolidMasse moléculaire :449.48PDL1 degrader-2
PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.Formule :C45H48N8O5Couleur et forme :SolidMasse moléculaire :780.91Disitertide diammonium
Disitertide (P144) is a TGF-β1 receptor blocker, PI3K inhibitor, and apoptosis inducer.Formule :C68H115N19O22S2Couleur et forme :SolidMasse moléculaire :1614.88Thyrotropin
CAS :Thyrotropin (TSH), a thyroid-stimulating hormone, is synthesized by thyrotrope cells in the anterior pituitary gland and modulates the endocrine activity of theCouleur et forme :SolidDiethyl phthalate
CAS :Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.Formule :C12H14O4Degré de pureté :99.68% - 99.8%Couleur et forme :SolidMasse moléculaire :222.24Sec61-IN-4
Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].Couleur et forme :Odour SolidChlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS :Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Formule :C20H14ClFeN2O2Couleur et forme :SolidMasse moléculaire :405.64XY077
XY077 (compound 14a) is a RORγ inverse agonist with an IC50 value of 0.004 μM. It induces cell apoptosis (cellapoptosis) and exhibits antiproliferative activity both in vitro and in vivo.Formule :C27H27F3N2O5S2Masse moléculaire :580.13135Antitumor photosensitizer-5
Antitumor photosensitizer-5 (Ru2) is an effective photosensitizing agent that targets tumor mitochondria, with an IC50 of 0.3 μM for phototoxicity against A549 cells. Upon exposure to 460 nm light, it induces reactive oxygen species production and NADH depletion, leading to mitochondrial damage, caspase-3 activation, apoptosis induction, and inhibition of cell migration. Antitumor photosensitizer-5 shows potential for preventing malignant tumor growth and may be applicable in photodynamic therapy.Formule :C53H43F12N11O2P2RuSMasse moléculaire :1289.1649Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75Bcl-2-IN-21
Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.Formule :C45H33F6IrN5PMasse moléculaire :980.965-Methoxysterigmatocystin
CAS :5-Methoxysterigmatocystin is a mycotoxin characterized by its cytotoxic and genotoxic properties. It exhibits cytotoxic effects on cancer cell lines A549 and HepG2, with IC50 values of 5.5 μM and 0.7 μM, respectively. Additionally, it induces DNA damage. 5-Methoxysterigmatocystin acts as a photosensitizer, generating singlet oxygen (1O2) under visible light.Formule :C19H14O7Masse moléculaire :354.31PAR4 antagonist 8
PAR4 antagonist8 (Compound 20f) is an effective oral and selective PAR4 antagonist with an IC50 of 15.32 nM, boasting favorable pharmacokinetic properties. It effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50=6.39 nM) and also suppresses platelet aggregation in mice. PAR4 antagonist8 is utilized in anti-thrombotic research.Formule :C28H19F2N5O4SMasse moléculaire :559.54c-Fos-IN-1
c-Fos-IN-1 (Compound P16) acts as a c-Jun inhibitor, effectively reducing the mRNA and protein levels of c-Fos. It also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. This compound demonstrates anticancer properties through the inhibition of the ERK/c-Fos/Jun pathway. c-Fos-IN-1 curbs the proliferation and migration of gastric cancer cells, with an IC50 of 2.31 μM for MGC-803 cells, causing cell cycle arrest at the G2/M phase and inducing apoptosis in cancer cells. Additionally, c-Fos-IN-1 hampers the growth of gastric cancer tumors.Formule :C28H35NO3Couleur et forme :SolidMasse moléculaire :433.582Antiproliferative agent-59
Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.Formule :C26H22N2O3Couleur et forme :SolidMasse moléculaire :410.46LSD1-IN-36
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.Formule :C22H25N3O6SCouleur et forme :SolidMasse moléculaire :459.52BCL-XL-IN-1
BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.Formule :C46H55N7O6SCouleur et forme :SolidMasse moléculaire :834.04PIM-1/CK2-IN-2
PIM-1/CK2-IN-2 (compound 3aA) is an inhibitor of the PIM-1/CK2 enzymes. This compound can induce the mitochondrial apoptosis pathway in CCRF-CEM cells and is utilized in cancer research.Formule :C15H8Br4N2OCouleur et forme :SolidMasse moléculaire :551.85CDK2-IN-32
CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.Formule :C18H13Cl2N5O2Couleur et forme :SolidMasse moléculaire :402.23Quercetin-d3
Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.Formule :C15H9D3O8Couleur et forme :SolidMasse moléculaire :323.27Apoptosis inducer 30
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.Formule :C52H69BrNO4PCouleur et forme :SolidMasse moléculaire :882.99Tubulin polymerization-IN-70
Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47ECDD-S18
ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.Formule :C35H31BrO12Couleur et forme :SolidMasse moléculaire :723.52[Au(L4)(CyJohnPhos)]SbF6
[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.Formule :C44H56AuF6NO4PSSbCouleur et forme :SolidMasse moléculaire :1158.68GGTI298 Trifluoroacetate
CAS :GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formule :C27H33N3O3S·C2HF3O2Degré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :593.66
![Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT37851.webp&w=3840&q=75)
