Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5598 produits trouvés pour "Apoptose"
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Anti-inflammatory agent 45
<p>Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies,</p>Formule :C25H22BrNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.35NMC-001
<p>NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidPROTAC 20S proteasome subunit β5 degrader 1
<p>PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.</p>Couleur et forme :Odour SolidEGFR/VEGFR2-IN-1
<p>EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.</p>Couleur et forme :Odour SolidTRBP-IN-1
<p>TRBP-IN-1 (Compound 13j) is an orally active inhibitor of TAR RNA-binding protein 2 (TRBP) with an IC50 of 12.72 μM. It exhibits significant anti-hepatocellular carcinoma (HCC) activity, effectively suppressing proliferation and metastasis of HCC cells [HCCLM3 cells (IC50: 18.96 μM) and SK-Hep-1 cells (IC50: 16.45 μM)]. TRBP-IN-1 modulates miRNA biosynthesis by targeting TRBP, inhibiting the expression of oncogenic miRNAs. It induces apoptosis and pyroptosis in HCC cells by decreasing miRNA levels. TRBP-IN-1 is suitable for research on targeted HCC therapy.</p>Formule :C25H23F3N2O5SCouleur et forme :SolidMasse moléculaire :520.12798UZH1a
CAS :<p>UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.</p>Formule :C32H42N6O3Couleur et forme :SoildMasse moléculaire :558.71Thalidomide-5-PEG2-Cl
CAS :<p>Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.</p>Formule :C17H17ClN2O6Couleur et forme :SolidMasse moléculaire :380.78Apoptosis inducer 11
<p>Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within</p>Formule :C27H28N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.52GLP-2(rat)
CAS :<p>intestinal epithelium-specific growth factor</p>Formule :C166H256N44O56SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3796.17Pro-GA
CAS :<p>Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.</p>Formule :C12H19NO7Couleur et forme :SolidMasse moléculaire :289.28Latikafusp
CAS :<p>Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.</p>Degré de pureté :97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :LiquidPQ401
CAS :<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79Monensin
CAS :<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>Formule :C36H62O11Degré de pureté :98%Couleur et forme :Crystals White Or Off-White CrystalsMasse moléculaire :670.87FLT3/HDAC-IN-1
<p>FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.</p>Couleur et forme :Odour SolidAcrixolimab
CAS :<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Degré de pureté :98%Couleur et forme :LiquidKTX-582
CAS :<p>KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.</p>Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93TAT-NEP1-40 acetate
<p>TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose</p>Formule :C268H438N88O77·xC2H4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6124.89 (free base)VEGFR-2-IN-53
<p>VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.</p>Couleur et forme :Odour SolidHexapeptide-11
CAS :<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formule :C36H48N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :676.8GPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Formule :C33H57N9O12Degré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :771.86Indinavir
CAS :<p>Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.</p>Formule :C36H47N5O4Couleur et forme :SolidMasse moléculaire :613.79TS-24
CAS :<p>TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.</p>Formule :C20H15NO2Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :301.34Lw13
<p>Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.</p>Formule :C46H55F3N8O8Masse moléculaire :904.4095Feladilimab
CAS :<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDaChlopynostat
<p>Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.</p>Formule :C22H17ClN4O2Masse moléculaire :404.104NCA029
<p>NCA029 is a potent activator of human caseinolytic protease P (HsClpP) with an EC50 of 0.15 μM. It targets HsClpPP and triggers an ATF3-dependent integrated stress response, resulting in the death of colon cancer cells.</p>Formule :C22H20F3N3OMasse moléculaire :399.15585RIPK2-IN-4
<p>RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.</p>Formule :C16H10N6S2Masse moléculaire :350.04084Pidilizumab
CAS :<p>Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic</p>Degré de pureté :98%Couleur et forme :LiquidThalidomide-N-C3-O-C4-O-C3-OH
<p>Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.</p>Formule :C23H31N3O7Masse moléculaire :461.2162Thalidomide-O-C8-NH2
CAS :<p>Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.</p>Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.463GPX4-IN-5
CAS :<p>GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.</p>Formule :C18H17ClFNO5Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :381.78PRDX1-IN-2
<p>PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.</p>FKBP12 PROTAC dTAG-7
CAS :<p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>Formule :C63H79N5O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1210.32Ferroptosis inducer-6
CAS :<p>Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.</p>Formule :C69H78F12N12P2RuCouleur et forme :SolidMasse moléculaire :1466.44dFKBP-1
CAS :<p>dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].</p>Formule :C53H64N6O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1009.11Oligomycin B
CAS :<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>Formule :C45H72O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :805.05TNF-α-IN-6
CAS :<p>TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).</p>Formule :C26H25N9O2Couleur et forme :SolidMasse moléculaire :495.547LC-1-40
<p>LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). In mouse models, LC-1-40 selectively inhibits tumor growth induced by MYCN and induces nucleotide damage and apoptosis (cell death) in MYCN-associated tumors. It is applicable for cancer research.</p>Formule :C49H48N8O6Masse moléculaire :844.36968Solanidine
CAS :<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>Formule :C27H43NODegré de pureté :96.83%Couleur et forme :SolidMasse moléculaire :397.64PROTAC PD-L1 degrader-1
<p>PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.</p>Ferumoxytol
CAS :<p>Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.</p>Couleur et forme :SolidMinocycline
CAS :<p>Minocycline is a useful organic compound for research related to life sciences. The catalog number is T131626 and the CAS number is 10118-90-8.</p>Formule :C23H27N3O7Couleur et forme :SolidMasse moléculaire :457.48PROTAC GPX4 degrader-2
<p>PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.</p>Formule :C50H61ClN8O9Masse moléculaire :952.425Apoptosis inducer 33
<p>Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.</p>Formule :C16H13N3O2Couleur et forme :SolidMasse moléculaire :279.293DB2313
CAS :<p>DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.</p>Formule :C42H41FN8O2Degré de pureté :98.63% - 99.29%Couleur et forme :SolidMasse moléculaire :708.83PROTAC Mcl1 degrader-1
CAS :<p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>Formule :C45H45BrN6O8SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :909.84ICy-OH
CAS :<p>ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.</p>Formule :C26H25I2NO2Couleur et forme :SolidMasse moléculaire :637.29USP7-IN-9
<p>USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.</p>Formule :C32H33ClF6N6O8Couleur et forme :SolidMasse moléculaire :779.08WEE1-IN-7
<p>WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.</p>WD6305
<p>WD6305 is an effective and selective METTL3-METTL14 PROTAC degrader, with DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. It inhibits m6A modification and the proliferation of acute myeloid leukemia cells while inducing apoptosis. WD6305 also exhibits antitumor activity.</p>Formule :C61H75F2N11O5SMasse moléculaire :1111.56414Ru-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Formule :C89H75Cl2N11O11Ru·7H2OTopoisomerase II inhibitor 17
<p>TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.</p>Formule :C25H22Cl3N3O5SMasse moléculaire :581.03458Maceneolignan A
CAS :<p>Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibiting</p>Formule :C21H24O5Couleur et forme :SolidMasse moléculaire :356.41Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Formule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52YL5084
CAS :<p>YL5084 is a selective JNK2/3 inhibitor with IC50s: JNK2 (70 nM), JNK3 (84 nM), and antiproliferative, apoptosis-inducing effects.</p>Formule :C35H36N8O2Couleur et forme :SolidMasse moléculaire :600.71TD52 dihydrochloride
<p>TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.</p>Formule :C24H18Cl2N4Degré de pureté :97.23%Couleur et forme :SoildMasse moléculaire :433.33Anticancer agent 204
<p>Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.</p>Formule :C26H18FN5O3SMasse moléculaire :499.11144eIF4E-IN-3
CAS :<p>eIF4E-IN-3: potent eIF4e inhibitor with promise for cancer study.</p>Formule :C34H30ClF3N6O4SCouleur et forme :SolidMasse moléculaire :711.16CBI1
<p>CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.</p>Formule :C15H19BrN4OS2Masse moléculaire :414.01837DB818 dihydrochloride
<p>DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).</p>Couleur et forme :Odour Solidp53 and MDM2 proteins-interaction-inhibitor dihydrochloride
<p>p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.</p>Formule :C40H51Cl4N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :807.68Thalidomide-5-propoxyethanamine
CAS :<p>Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.</p>Formule :C18H21N3O5Couleur et forme :SolidMasse moléculaire :359.38CDK-IN-14
<p>CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.</p>Couleur et forme :Odour SolidCDK/HDAC-IN-4
<p>CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.</p>Couleur et forme :Odour Solid(Rac)-AMXT-1501 4HCl
CAS :<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Formule :C32H72Cl4N6O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :714.77Cathepsin B
CAS :<p>Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.</p>Couleur et forme :SolidOPBP-1
<p>OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.</p>Formule :C64H92N20O19SMasse moléculaire :1476.65683CV-4-26
<p>CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).</p>Couleur et forme :Odour SolidJAK/HDAC-IN-2
<p>JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.</p>Formule :C28H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.7Echitamine chloride
CAS :<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Formule :C22H29ClN2O4Couleur et forme :SolidMasse moléculaire :420.93Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS :<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Formule :C17H19ClN4O6Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :410.81Opnurasib
CAS :<p>Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small</p>Formule :C29H28ClN7ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :526.03PRMT5-IN-33
<p>PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.</p>Formule :C25H24BrN5O3SMasse moléculaire :553.07832TNF-α (31-45), human
CAS :<p>TNF-α (31-45), human is a peptide of tumor necrosis factor-α.</p>Formule :C69H122N26O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1667.895Anti-inflammatory agent 42
CAS :<p>Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.</p>Formule :C20H12N2OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :328.39CDK2-IN-41
<p>CDK2-IN-41 (Compound 7a) is a CDK2 inhibitor that impedes the cell cycle by binding to CDK2, leading to cytotoxicity, increased ROS production, and apoptosis (Apoptosis). It exhibits anticancer activity with an IC50 of 10 µM against acute myeloid leukemia (AML) HL-60 cells. CDK2-IN-41 is applicable in research related to AML-associated cancers.</p>Formule :C19H21N3SCouleur et forme :SolidMasse moléculaire :323.461,2,3,4-Tetrahydronaphthalen-2-ol
CAS :<p>1,2,3,4-Tetrahydronaphthalen-2-ol exhibits weak inhibitory activity against Bcl-xL and is widely used in biochemical experiments and drug synthesis research.</p>Formule :C10H12OCouleur et forme :SolidMasse moléculaire :148.2NSC 295642
CAS :<p>NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.</p>Formule :C15H14ClCuN3S2Couleur et forme :SolidMasse moléculaire :399.42PD-1/PD-L1-IN-39
<p>PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.</p>Formule :C23H20ClFN2O3Masse moléculaire :426.11465S-Adenosyl-L-methionine
CAS :<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Jacaric Acid
CAS :<p>Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.</p>Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436HEMTAC CDK4/6 degrader 1
CAS :<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.49C188
CAS :<p>C188, a naphthol-based STAT3 inhibitor, blocks IL-6-induced STAT3 activity in HepG2 cells, sparing STAT1.</p>Formule :C19H15NO7S2Couleur et forme :SolidMasse moléculaire :433.45Calcimycin hemicalcium salt
CAS :<p>Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.</p>Formule :C58H72CaN6O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1085.3223MB-PP1
CAS :<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Formule :C17H21N5Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :295.38β-Glucuronide-dPBD-PEG5-NH2
CAS :<p>β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate</p>Formule :C78H101N7O35Couleur et forme :SolidMasse moléculaire :1696.66PB28
CAS :<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Formule :C24H38N2OCouleur et forme :SolidMasse moléculaire :370.581(-)-Irofulven
CAS :<p>Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.</p>Formule :C15H18O3Couleur et forme :SolidMasse moléculaire :246.30Sincalide ammonium
CAS :<p>Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.</p>Formule :C49H65N11O16S3Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :1160.3Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formule :C38H56N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.86RIPK1-IN-17
CAS :<p>RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.</p>Formule :C26H19F4N3O3SDegré de pureté :95.22%Couleur et forme :SolidMasse moléculaire :529.51Tubulin/AKT1-IN-1
<p>Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and</p>Formule :C38H34ClNO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :716.13Antiproliferative agent-25
<p>Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.</p>Formule :C20H21BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.3FPR1 antagonist 1
<p>Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.</p>Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49AZD5582 TFA
<p>AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA</p>Formule :C60H79F3N8O10Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :1129.31ARD-61
CAS :<p>ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.</p>Formule :C61H71ClN8O7SCouleur et forme :SolidMasse moléculaire :1095.8RIPK1-IN-30
<p>RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.</p>Formule :C27H25FN2O4Couleur et forme :SolidMasse moléculaire :460.17984DA5-HTL
<p>DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.</p>Formule :C39H58Cl2N8O8SMasse moléculaire :868.34754CIGB-300 acetate
<p>CIGB-300 acetate (P15-Tat acetate) is a peptide that acts as an inhibitor of casein kinase 2 (CK2). It exhibits anticancer properties by disrupting the phosphorylation activity of CK2. CIGB-300 acetate induces apoptosis in various tumor cell lines and is applicable for cancer research.</p>Couleur et forme :Odour SolidicFSP1
CAS :<p>icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.</p>Formule :C26H25N3O5Degré de pureté :99.87% - 99.93%Couleur et forme :SoildMasse moléculaire :459.49
