Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(128 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
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6172 produits trouvés pour "Apoptose"
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S-Adenosyl-L-methionine iodide
CAS :S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formule :C15H23IN6O5SCouleur et forme :SolidMasse moléculaire :526.35Syringolin A
CAS :Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formule :C24H39N5O6Couleur et forme :SolidMasse moléculaire :493.605CSF1R-IN-26
CAS :CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Formule :C20H22ClN5O3Couleur et forme :SoildMasse moléculaire :415.87Tubulin polymerization-IN-70
Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS :Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formule :C56H81N13O10SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :1128.39Ref: TM-T75720
1mg49,00€5mg105,00€10mg172,00€1mL*10mM (DMSO)200,00€25mg268,00€50mg416,00€100mg600,00€Apoptosis inducer 30
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.Formule :C52H69BrNO4PCouleur et forme :SolidMasse moléculaire :882.99Tyroserleutide hydrochloride
CAS :Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.Formule :C18H28ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.88DL-Sulforaphane N-acetyl-L-cysteine
CAS :DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formule :C11H20N2O4S3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :340.48Jacaric Acid
CAS :Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436RBN013209
CAS :RBN013209 is a potent CD38 inhibitor. RBN013209 is useful in the treatment of cancer.Formule :C19H24N6O3Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :384.43Ref: TM-T60099
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg178,00€25mg356,00€50mg512,00€100mg713,00€AVJ16
CAS :AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formule :C28H27N3O4Degré de pureté :98.87% - 99.72%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T9980
1mg130,00€5mg313,00€1mL*10mM (DMSO)323,00€10mg500,00€25mg807,00€50mg1.108,00€100mg1.485,00€200mg1.998,00€DC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).
Formule :C14H10N2O2SDegré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :270.31Sorafenib-d4
CAS :Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.Formule :C21H16ClF3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.85RIPK3-IN-3
RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36c-Fos-IN-1
c-Fos-IN-1 (Compound P16) acts as a c-Jun inhibitor, effectively reducing the mRNA and protein levels of c-Fos. It also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. This compound demonstrates anticancer properties through the inhibition of the ERK/c-Fos/Jun pathway. c-Fos-IN-1 curbs the proliferation and migration of gastric cancer cells, with an IC50 of 2.31 μM for MGC-803 cells, causing cell cycle arrest at the G2/M phase and inducing apoptosis in cancer cells. Additionally, c-Fos-IN-1 hampers the growth of gastric cancer tumors.Formule :C28H35NO3Couleur et forme :SolidMasse moléculaire :433.582Ferroptosis-IN-13
Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.Formule :C32H30F2N4O3Couleur et forme :SolidMasse moléculaire :556.602Waltonitone
CAS :Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.Formule :C30H48O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.7A-1248767
CAS :A-1248767, a derivative of A-1210477, is an MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) known for its anticancer properties. It binds to MCL-1 with high affinity, induces an increase in MCL-1 protein levels inside cells, and promotes apoptosis in tumor cells.Formule :C47H55N7O6Couleur et forme :SolidMasse moléculaire :813.98Opnurasib
CAS :Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-smallFormule :C29H28ClN7ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :526.03Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Couleur et forme :Odour Solidc-Met/HDAC-IN-4
c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.Formule :C37H36N8OCouleur et forme :SolidMasse moléculaire :608.73LS-106
LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.Formule :C24H28BrClN5OPCouleur et forme :SolidMasse moléculaire :548.84Apoptosis inducer 26
Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.Formule :C40H36AgClN4P2SCouleur et forme :SolidMasse moléculaire :810.07Nrf2 activator 19
Nrf2 activator 19 is a compound capable of crossing the blood-brain barrier and acts as an NRF2/HO-1 activator, offering potent antioxidant and neuroprotective effects. It effectively reduces brain damage and minimizes the accumulation of Reactive Oxygen Species (ROS). Additionally, Nrf2 activator 19 inhibits neuronal apoptosis, aiding in the recovery of neural function and motor skills. It has demonstrated significant potential in ischemic stroke research.Couleur et forme :Odour SolidPG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formule :C14H34Cl2N4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :329.35PZ703b
CAS :PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formule :C80H102ClF3N10O11S4Couleur et forme :SolidMasse moléculaire :1600.44ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formule :C39H48ClN5O8Couleur et forme :SolidMasse moléculaire :750.28Aloeresin G
CAS :Aloeresin G, a chromone glycoside isolated from Aloe, exhibits a moderate inhibitory effect on TNFα-induced NF-κB transcriptional activity, evidenced by an IC50Formule :C29H30O10Couleur et forme :SolidMasse moléculaire :538.54NMC-001
NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidEnniatin complex
CAS :Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.Degré de pureté :98%Couleur et forme :SolidFPR1 antagonist 2
Compound 25b, an FPR1 antagonist, exhibits potent inhibition of the formyl peptide receptor 1 with an IC50 of 70 nM.Formule :C25H25F3O5Couleur et forme :SolidMasse moléculaire :462.46Ch282-5
CAS :Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.Formule :C34H34N2Na2O14S2Couleur et forme :SolidMasse moléculaire :804.75ROS inducer 4
Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.89PL120131
PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formule :C22H26N4O2SCouleur et forme :SolidMasse moléculaire :410.53Antagonist G
CAS :Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inDegré de pureté :98%Couleur et forme :Odour SolidDB0614
CAS :DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95ADH-6 TFA
ADH-6 TFA disrupts mutant p53 self-assembly in cancer, restores function, and induces cell cycle arrest and apoptosis.Formule :C31H37F3N8O11Couleur et forme :SolidMasse moléculaire :754.67PRLX-93936 HCL
CAS :PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formule :C21H26Cl2N4O2Degré de pureté :98.4% - 99.94%Couleur et forme :SolidMasse moléculaire :437.37Apoptosis inducer 24
CAS :Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2/M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg/kg.Formule :C55H70BNO9Couleur et forme :SolidMasse moléculaire :899.96RET-IN-26
RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].Couleur et forme :Odour SolidFGFR1/VEGFR2-IN-2
FGFR1/VEGFR2-IN-2 (compound 6) is a dual inhibitor targeting both VEGFR2 and FGFR1 with IC50 values of 0.025 µM and 0.026 µM, respectively. This compound also exhibits inhibitory effects on EGFR and PDGFR-β, with IC50 values of 0.106 µM and 0.077 µM, respectively. FGFR1/VEGFR2-IN-2 demonstrates significant anticancer activity in the NCI-60 cell lines, showing a growth inhibition (GI) of 60.38%. In T-47D cell lines, it achieves an IC50 of 8.51 µM, exhibits anti-migratory properties, induces cell cycle arrest in the G1 phase, and promotes both apoptosis and necrosis. Additionally, while it has an IC50 greater than 100 µM in MCF-7 cell lines, it does so with an IC50 of 69.17 µM in MDA-MB-231 cell lines and shows no toxicity to normal cells.Formule :C21H15ClF3NO4SCouleur et forme :SolidMasse moléculaire :469.86PROTAC FGFR2 degrader 1
PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.Couleur et forme :Odour SolidIC 86621
CAS :IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25(+)-Mcl-1 inhibitor 22
CAS :(+)-Mcl-1 inhibitor 22 (Example 37) is an MCL-1 inhibitor that impedes the anti-apoptotic function of MCL-1 by blocking its interaction with pro-apoptotic proteins. It demonstrates antiproliferative activity against various cancer cell lines and is applicable for cancer research.Formule :C33H33ClFN3O4Couleur et forme :SolidMasse moléculaire :590.084ElteN378
CAS :ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formule :C23H26N2O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :378.46Ref: TM-T9950
1mg167,00€1mL*10mM (DMSO)295,00€5mg356,00€10mg528,00€25mg848,00€50mg1.153,00€100mg1.603,00€200mg2.142,00€Ub4ix
CAS :Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.Formule :C84H106N18O23SCouleur et forme :SolidMasse moléculaire :1767.91VEGFR2/HDAC1-IN-1
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC.Degré de pureté :98%Couleur et forme :Odour Solid7-Methoxy-1-tetralone
CAS :7-Methoxy-1-tetralone may have insecticidal activity.Formule :C11H12O2Degré de pureté :99.85% - 99.89%Couleur et forme :White CrystalMasse moléculaire :176.21Cefatrizine
CAS :Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.Formule :C18H18N6O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.5Biotin-PEG6-Thalidomide
CAS :Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.Formule :C37H53N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.91PROTAC FLT-3 degrader 1
CAS :PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formule :C52H61N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1020.238-hydroxy Efavirenz
CAS :8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.68Nrf2 activator-11
Nrf2 activator-11 (compound M11) is a Nrf2 activator that possesses blood-brain barrier permeability and offers anti-oxidation, anti-inflammation, anti-ferroptosis, and anti-apoptosis properties. It is applicable for use in studying cerebral ischemia-reperfusion (CI/R) injury models.Formule :C20H23N3O2Couleur et forme :SolidMasse moléculaire :337.42Tubulin inhibitor 34
Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.Formule :C21H22N4O3SCouleur et forme :SolidMasse moléculaire :410.49EAD1
CAS :EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.
Formule :C24H27Cl2N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.42QZ2135
QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.Formule :C53H54N12O4Couleur et forme :SolidMasse moléculaire :923.07Z-VEID-FMK
CAS :Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.Formule :C31H45FN4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.71AM-8553
CAS :AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.Formule :C25H29Cl2NO4Couleur et forme :SolidMasse moléculaire :478.41(R)-Q-VD-OPh
(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.Formule :C26H25F2N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.49Humulone
Humulone is a natural product and has a wide range of applications in life science related research.Formule :C21H30O5Couleur et forme :SolidMasse moléculaire :362.47NL13
NL13, a Polo-like kinase 4 (PLK4) inhibitor, exhibits an IC 50 value of 2.32 μM. It demonstrates the ability to suppress the viability of PC3 and DU145 prostate cancer cells with respective IC 50 values of 3.51 μM and 2.53 μM. NL13 also inhibits tumor growth in prostate cancer mice. Additionally, it deactivates the AKT signaling pathway by reducing CCNB1/CDK1 levels, leading to G2/M cell cycle arrest and initiating apoptosis through caspase-9/caspase-3 cleavage.Formule :C22H19Cl2NO2Couleur et forme :SolidMasse moléculaire :400.3PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formule :C80H103Cl2F3N10O11S4Couleur et forme :SolidMasse moléculaire :1636.9PTP1B-IN-30
PTP1B-IN-30 (Compound 3j) is an inhibitor of PTP1B with an IC50 of 0.51 µM. It suppresses the proliferation of T47D cancer cells with an IC50 of 21.21 µM, induces cell cycle arrest at the S phase, and triggers apoptosis in T47D cells.Formule :C22H21N3O5SCouleur et forme :SolidMasse moléculaire :439.48MET/PDGFRA-IN-1
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.Formule :C26H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.51Ajoene
CAS :Ajoene from garlic has antibacterial, anticancer, antiplatelet, and antioxidant effects; it combats various bacteria, yeasts, and cancer cells.
Formule :C9H14OS3Couleur et forme :SolidMasse moléculaire :234.39Apoptosis inducer 32
Apoptosisinducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, demonstrating antitumor activity by causing significant morphological changes, such as membrane blebbing, nuclear fragmentation, and apoptotic body formation, in MDA-MB-231 cells. The IC50 values for Apoptosisinducer 32 are 4.77 μM in MCF-7 cells, 6.56 μM in MDA-MB-231 cells, and 337.8 μM in HEK cells.Formule :C29H27Cl2N3O8Couleur et forme :SolidMasse moléculaire :616.45CQ-Mito
CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.Formule :C45H42BrN6O4PCouleur et forme :SolidMasse moléculaire :841.73TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Formule :C57H66ClF3N11O3PSCouleur et forme :SolidMasse moléculaire :1108.69P53R3
CAS :P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53Formule :C32H35Cl2N5O2Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :592.56PF-543
CAS :PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formule :C27H31NO4SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :465.6Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.Couleur et forme :Odour LiquidAc-LEHD-AMC
CAS :Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formule :C33H41N7O11Couleur et forme :SolidMasse moléculaire :711.729TRBP-IN-1
TRBP-IN-1 (Compound 13j) is an orally active inhibitor of TAR RNA-binding protein 2 (TRBP) with an IC50 of 12.72 μM. It exhibits significant anti-hepatocellular carcinoma (HCC) activity, effectively suppressing proliferation and metastasis of HCC cells [HCCLM3 cells (IC50: 18.96 μM) and SK-Hep-1 cells (IC50: 16.45 μM)]. TRBP-IN-1 modulates miRNA biosynthesis by targeting TRBP, inhibiting the expression of oncogenic miRNAs. It induces apoptosis and pyroptosis in HCC cells by decreasing miRNA levels. TRBP-IN-1 is suitable for research on targeted HCC therapy.Formule :C25H23F3N2O5SCouleur et forme :SolidMasse moléculaire :520.12798Suramin
CAS :Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.Formule :C51H40N6O23S6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :1297.28MPT0B014
CAS :MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.
Formule :C19H17NO4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :323.34Secalonic acid D
CAS :Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.Formule :C32H30O14Couleur et forme :SolidMasse moléculaire :638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS :Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.Formule :C21H29ClN4O4Couleur et forme :SolidMasse moléculaire :436.94CPTH2 (hydrochloride) (357649-93-5 free base)
CAS :CPTH2 is an inhibitor of the HAT activity of Gcn5.Formule :C14H15Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.26MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Formule :C41H42Cl2FN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.71NDI-Lyso
CAS :NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).Formule :C71H100N22O13Couleur et forme :SolidMasse moléculaire :1469.69HDAC3-IN-2
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37SCR7
CAS :SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Formule :C18H14N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.4PROTAC HIF-1α degrader-1
PROTAC HIF-1α degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1α (HIF-1α), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1α protein expression, and induces apoptosis.Formule :C51H72N6O7SCouleur et forme :SolidMasse moléculaire :913.22Ferroptosis inducer-4
Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.Formule :C33H64NO7PCouleur et forme :SolidMasse moléculaire :617.8412-Deoxyphorbol 13-palmitate
CAS :12-Deoxyphorbol 13-palmitate, a monomer derived from the roots of Euphorbia fischeriana, exhibits notable antitumor activity. This compound induces cell cycle arrest and apoptosis in gastric cancer cells by modulating key cell cycle regulators, such as cyclin B, cyclin A, and CDC2. Additionally, 12-Deoxyphorbol 13-palmitate significantly diminishes liver fibrosis by targeting APOL2 and impairing the APOL2–SERCA2–PERK–HES1 signaling pathway.Formule :C36H58O6Couleur et forme :SolidMasse moléculaire :586.84MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.78AKN-028
CAS :AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formule :C17H14N6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :302.33ROCK/HDAC-IN-2
ROCK/HDAC-IN-2 (Compound C-9) is a dual inhibitor of ROCK/HDAC, characterized by IC50 values of 0.185 µM for HDAC6, 0.8 µM for ROCK1, and 0.7 µM for ROCK2. It effectively induces apoptosis and mitochondrial membrane potential alterations in cancer cells and demonstrates notable antitumor activity, making it useful for research in pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC).Formule :C22H32N4O4SCouleur et forme :SolidMasse moléculaire :448.58EGFR/COX-2-IN-1
EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.Formule :C20H17FN6O2S2Couleur et forme :SolidMasse moléculaire :456.52Daporinad hydrochloride
CAS :Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Formule :C24H30ClN3O2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :427.97VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Formule :C72H123N9O6Couleur et forme :SolidMasse moléculaire :1210.8HDAC-IN-88
HDAC-IN-88 (Compound HJ-9) is a potent inhibitor of HDAC, effectively targeting HDAC6, HDAC1, HDAC2, HDAC8, and HDAC3 with IC50 values of 0.226, 1.103, 2.308, 3.255, and 3.864 μM, respectively. This compound suppresses the proliferation of cancer cells HepG2, HCT116, and MV4-11 with IC50 values of 5.47, 9.78, and 0.38 μM, respectively. Additionally, it inhibits the migration of HCT116 cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis and autophagy in MV4-11 cells. HDAC-IN-88 reduces ROS levels and mitochondrial membrane potential and demonstrates antimalarial activity by inhibiting Plasmodium falciparum 3D7 with an EC50 of 165 nM. Furthermore, HDAC-IN-88 exhibits anti-angiogenic properties.Formule :C23H36N4O4Couleur et forme :SolidMasse moléculaire :432.56UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formule :C15H19N3OCouleur et forme :SolidMasse moléculaire :257.33Minocycline
CAS :Minocycline is a useful organic compound for research related to life sciences. The catalog number is T131626 and the CAS number is 10118-90-8.Formule :C23H27N3O7Couleur et forme :SolidMasse moléculaire :457.4812-HETE
CAS :12-HETE ((±)12-HETE) is a regulator of PGE2, having both antithrombotic and prothrombotic effects.Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47Nrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFormule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Formule :C20H22ClN5ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :383.88Photosensitizer-5
Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.Formule :C35H26BF2IN4O2Couleur et forme :SolidMasse moléculaire :710.32
