Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(92 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6188 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Couleur et forme :Odour SolidAc-AAVALLPAVLLALLAP-LEHD-CHO
CAS :Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated withFormule :C97H162N22O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2036.46Ac-FEID-CMK TFA
Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.Formule :C29H38ClF3N4O11Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :711.08PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Couleur et forme :Odour SolidPolyphyllin G
CAS :Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.21LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formule :C53H59Cl2N3O7S2Couleur et forme :SolidMasse moléculaire :985.09Ac-VDQQD-pNA
CAS :Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formule :C31H43N9O14Couleur et forme :SolidMasse moléculaire :765.73NOD1/2-IN-1
NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.Couleur et forme :Odour SolidBcl-2-IN-22
Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.Couleur et forme :Odour SolidFW-1
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.
Formule :C24H27N7OCouleur et forme :SolidMasse moléculaire :429.517Jacaric Acid
CAS :Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436PROTAC PD-1/PD-L1 degrader-1
CAS :PROTAC PD-1/PD-L1 degrader-1, a Cereblon-based inhibitor, blocks PD-1/PD-L1 with 39.2 nM IC50, boosting immune response and reducing PD-L1 via lysosomes.Formule :C59H58ClN7O11Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :1076.59RIP2 Kinase Inhibitor 4
CAS :RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.Formule :C50H66F2N14O7SCouleur et forme :SolidMasse moléculaire :1045.23LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFormule :C27H27N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.59Satratoxin H
CAS :Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.Formule :C29H36O9Couleur et forme :SolidMasse moléculaire :528.598Anti-inflammatory agent 95
Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.Formule :C16H21NO4Couleur et forme :SolidMasse moléculaire :291.34GGTI298 Trifluoroacetate
CAS :GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formule :C27H33N3O3S·C2HF3O2Degré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :593.66ECDD-S18
ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.Formule :C35H31BrO12Couleur et forme :SolidMasse moléculaire :723.52Compound TPX-0046
CAS :Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formule :C21H21FN6O3Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :424.43PD-1/PD-L1-IN-9
CAS :PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Formule :C22H24N2O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T9651
1mg57,00€2mg85,00€5mg127,00€1mL*10mM (DMSO)140,00€10mg178,00€25mg298,00€50mg405,00€100mg535,00€500mg1.063,00€CQ-ER
CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).Formule :C33H33N7O6SCouleur et forme :SolidMasse moléculaire :655.72EGFR-IN-131
EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0/G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.Formule :C26H23FN4O2SCouleur et forme :SolidMasse moléculaire :474.55Quercetin-d3
Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.Formule :C15H9D3O8Couleur et forme :SolidMasse moléculaire :323.27Apoptosis inducer 30
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.Formule :C52H69BrNO4PCouleur et forme :SolidMasse moléculaire :882.99MK-4166
MK-4166 is a humanized IgG1 agonistic monoclonal antibody targeting GITR. It is capable of enhancing the proliferation of both naive T lymphocytes and tumor-infiltrating T lymphocytes.PLD-IN-1
PLD-IN-1 (Compound 3r) is an orally effective inhibitor of phospholipase D (phospholipaseD) with an IC50 of 1.97 μM. It reduces the expression of CD24, CD47, and PD-L1 while enhancing the expression of calreticulin, thereby modulating the immune evasion mechanisms of lung cancer cells by promoting the phagocytosis of cancer cells by macrophages. PLD-IN-1 inhibits the viability of lung cancer cell lines A549, HCC44, H460, and HCC15 with IC50 values of 18.44, 22.31, 24.85, and 21.45 μM, respectively. It induces apoptosis (apoptosis) in A549 cells and inhibits cell migration. Additionally, PLD-IN-1 increases pro-inflammatory M1 macrophage levels and decreases anti-inflammatory M2 macrophage levels, exhibiting anti-tumor activity in mouse models.Formule :C19H14F6N2OCouleur et forme :SolidMasse moléculaire :400.32Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS :Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formule :C56H81N13O10SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :1128.39Ref: TM-T75720
1mg49,00€5mg105,00€10mg172,00€1mL*10mM (DMSO)200,00€25mg268,00€50mg416,00€100mg600,00€Estradiol (cypionate)
CAS :Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.Formule :C26H36O3Degré de pureté :99.53% - >99.99%Couleur et forme :White Or Off-White Crystalline PowderMasse moléculaire :396.56PROTAC ERα Degrader-9
PROTACERα Degrader-9 (Compound 18c) is a dual-targeting PROTAC degrader designed to diminish estrogen receptor α (ERα) and aromatase (ARO). It demonstrates a Ki of 0.25 μM for ERα binding and an IC50 of 4.6 μM for ARO inhibition. This compound curbs proliferation in wild-type MCF-7 cells (IC50=0.54 μM) and ERα mutant variants MCF-7EGFR (IC50=0.075 μM), MCF-7D538G (IC50=0.31 μM), and MCF-7Y537S (IC50=2.3 μM), while also downregulating ERS1 and MYC expression. PROTACERα Degrader-9 arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 cells, exhibiting antitumor efficacy in mouse models.Formule :C58H64F3N7O9S2Masse moléculaire :1123.4159EGFR-IN-151
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.Couleur et forme :Odour SolidAP1867-2-(carboxymethoxy)
CAS :AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAGFormule :C38H47NO11Couleur et forme :SolidMasse moléculaire :693.785,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin
CAS :5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a capable of forming complexes with metal ions and exhibit phototoxicity towards Hep-2 cells.Formule :C48H38N4O4Couleur et forme :SolidMasse moléculaire :734.84PROTAC FLT-3 degrader 4
CAS :PROTACFLT-3degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that efficiently induces the degradation of FLT3-ITD via the ubiquitin-proteasome system. It demonstrates high selectivity for FLT3-ITD mutant acute myeloid leukemia (AML) cells. [Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor].Formule :C39H41FN8O6Couleur et forme :SolidMasse moléculaire :736.79Thalidomide-NH-(CH2)2-NH2 TFA
CAS :Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified derivative of Thalidomide serving as a Cereblon ligand to recruit CRBN proteins and a pivotal intermediate inFormule :C17H17F3N4O6Couleur et forme :SolidMasse moléculaire :430.34WKYMVM TFA
CAS :WKYMVm is a selective FPR2 agonist with high affinity, which was identified through screening of a synthetic peptide library.Formule :C43H62F3N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :970.13KGYY15
CAS :KGYY15 (Mouse KGYY15), a peptide that targets CD40, exhibits weak inhibition of the CD40-CD40L interaction, with an IC50 exceeding 1 mM. At a concentration of 100 μM, KGYY15 activates the NF-κB pathway by 33%.Formule :C84H129N21O22SCouleur et forme :SolidMasse moléculaire :1817.12Nemorosone
CAS :Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.Formule :C33H42O4Couleur et forme :SolidMasse moléculaire :502.695D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formule :C58H66N2O12Couleur et forme :SolidMasse moléculaire :983.15Fluorene
CAS :Compound PDK0379, with CAS No. 86-73-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0379 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C13H10Masse moléculaire :166.21Lisaftoclax
CAS :Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.42Ref: TM-T10483
1mg177,00€5mg394,00€1mL*10mM (DMSO)558,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€Src Inhibitor 4
Src Inhibitor4 (Compound 18) is a derivative of KX-01 and functions as a Src inhibitor. It effectively disrupts tumor cells, damages microtubules, and induces cell cycle arrest, apoptosis, and immunogenic cell death. After introducing phenol or aniline functional groups, Src Inhibitor4 serves as a payload conjugation site for antibody-drug conjugates, showcasing antitumor activity.Formule :C33H34N4O3Couleur et forme :SolidMasse moléculaire :534.648PD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.Formule :C22H22N2O3Couleur et forme :SolidMasse moléculaire :362.42Ferroptosis inducer-6
CAS :Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formule :C69H78F12N12P2RuCouleur et forme :SolidMasse moléculaire :1466.44Diazepinomicin
CAS :Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.Formule :C28H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.58Euphjatrophane M
Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that reduces NF-κBp65 phosphorylation and exhibits anti-inflammatory properties. It can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in LPS-induced RAW 264.7 macrophages.Formule :C20H28O4Couleur et forme :SolidMasse moléculaire :332.43BWA-522
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)Formule :C43H51ClN4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.34[Au(L4)(CyJohnPhos)]SbF6
[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.Formule :C44H56AuF6NO4PSSbCouleur et forme :SolidMasse moléculaire :1158.68NLRP3-IN-62
CAS :NLRP3-IN-62 (Compound 1) is an inhibitor of NLRP3. It effectively inhibits pyroptosis in THP-1 cells with an IC50 of 0.7 nM and suppresses IL-β release with an IC50 of 108.5 nM.Formule :C21H15F3N4O3Masse moléculaire :428.36Amiloride hydrochloride dihydrate
CAS :Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.Formule :C6H8ClN7O·HCl·2H2ODegré de pureté :99.07% - >99.99%Couleur et forme :SolidMasse moléculaire :302.12LWY713
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.Formule :C43H54N10O8Masse moléculaire :838.41261NFh-NMe-2
NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.
Formule :C32H33IN2OCouleur et forme :SolidMasse moléculaire :588.522ATPase-IN-3
CAS :ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3MC-25B
MC-25B is a selective FKBP12 PROTAC degrader. It effectively degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a mechanism dependent on DCAF16.Formule :C65H92ClN7O14Couleur et forme :SolidMasse moléculaire :1230.92HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Formule :C57H75N3O15Couleur et forme :SolidMasse moléculaire :1042.22Mitochondria modulator-2
Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.Formule :C63H50F12IrN6OP3Couleur et forme :SolidMasse moléculaire :1420.23FF2049
FF2049 is a selective HDAC PROTAC degrader with a DC50 of 257 nM for HDAC1. It facilitates the ubiquitination and degradation of HDAC and promotes apoptosis (Apoptosis). FF2049 is applicable in research involving hematological and solid tumors.Formule :C31H38ClN7O7Couleur et forme :SolidMasse moléculaire :656.129FLT3-IN-28
FLT3-IN-28 (Compound 12y) is an orally active FLT3 inhibitor with antitumor properties. It selectively targets cancer cells with FLT3 internal tandem duplication (ITD) mutations, demonstrating IC50 values of 85, 290, 130, 65, and 220 nM against BaF3-FLT3-ITD, BaF3-TEL-VEGFR2, MV4-11, MOLM-13, and MOLM-14 cell lines, respectively. These lines include acute myeloid leukemia (AML) cells harboring FLT3-ITD mutations such as MV4-11 and MOLM-13/14. The compound also reduces phosphorylation levels of FLT3 and STAT5 in MOLM-13 cells, leading to cell cycle arrest and apoptosis. With an oral bioavailability of 19.2% in SD rats, FLT3-IN-28 extends survival in a dose-dependent manner in MOLM-13 xenografted NSG mouse models. It holds promise for research in FLT3-ITD-related cancer studies.Formule :C23H19FN8O4Couleur et forme :SolidMasse moléculaire :490.447Methylene Violet 3RAX
CAS :Methylene Violet 3RAX is a cationic dye that is a potential photosensitizer in photodynamic therapy and has antitumor activity.Formule :C22H23ClN4Degré de pureté :97.03% - 97.17%Couleur et forme :SolidMasse moléculaire :378.9UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formule :C15H19N3OCouleur et forme :SolidMasse moléculaire :257.33HDAC-IN-88
HDAC-IN-88 (Compound HJ-9) is a potent inhibitor of HDAC, effectively targeting HDAC6, HDAC1, HDAC2, HDAC8, and HDAC3 with IC50 values of 0.226, 1.103, 2.308, 3.255, and 3.864 μM, respectively. This compound suppresses the proliferation of cancer cells HepG2, HCT116, and MV4-11 with IC50 values of 5.47, 9.78, and 0.38 μM, respectively. Additionally, it inhibits the migration of HCT116 cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis and autophagy in MV4-11 cells. HDAC-IN-88 reduces ROS levels and mitochondrial membrane potential and demonstrates antimalarial activity by inhibiting Plasmodium falciparum 3D7 with an EC50 of 165 nM. Furthermore, HDAC-IN-88 exhibits anti-angiogenic properties.Formule :C23H36N4O4Couleur et forme :SolidMasse moléculaire :432.56ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formule :C110H210N52O26Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :2677.18Anticancer agent 205
Anticanceragent 205 (compound 9) is an effective anticancer agent that binds to the G4-mtDNA target, inhibiting the replication, transcription, and translation of mtDNA (mitochondrial genome). It induces mitochondrial dysfunction, increases ROS production, and triggers DNA damage and cellular senescence. Anticanceragent 205 also promotes apoptosis and causes cell cycle arrest at the G0/G1 phase, showing potential for research in colorectal cancer.Formule :C52H60I2N4Masse moléculaire :994.29074RET ligand-1
CAS :RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.Formule :C28H24F2N6O3Couleur et forme :SolidMasse moléculaire :530.525Fuscin
CAS :Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).Formule :C15H16O5Couleur et forme :SolidMasse moléculaire :276.288PK7088
CAS :PK7088, a pyrazole-based peptide, selectively reactivates mutant p53 to a conformation with wild-type characteristics, demonstrating anticancer activity inFormule :C14H13N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :223.27Thalidomide-O-C8-Boc
CAS :Thalidomide-O-C8-Boc: CRBN ligand for PROTAC creation, derived from Thalidomide.Formule :C26H34N2O7Couleur et forme :SolidMasse moléculaire :486.565AB-3PRGD2
CAS :AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32(R)-Q-VD-OPh
(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.Formule :C26H25F2N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.49C8 D-threo Ceramide (d18:1/8:0)
CAS :C8 D-threo Ceramide, a potent bioactive sphingolipid, is cytotoxic with IC50=17µM, enhances DNA fragmentation and pore formation, and activates CAPK.Formule :C26H51NO3Couleur et forme :SolidMasse moléculaire :425.698TMX1
CAS :TMX1 is a molecular glue degrader targeting BRD4, selectively recruiting the ubiquitin ligase CUL4-DCAF16 complex to BRD4 (BD2.Formule :C26H28N4O3SDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :476.59PROTAC BRD4 Degrader-33
PROTACBRD4 Degrader-33 is an enzyme-activated, click-responsive BRD4 PROTAC degrader designed with effective tumor microenvironment responsiveness. This compound exhibits exceptional penetration into tumor tissues and effectively inhibits PD-L1 protein expression. In the 4T1 tumor mouse model, PROTACBRD4 Degrader-33 demonstrates potent antitumor immunomodulatory activity.Couleur et forme :Odour SolidPROTAC KSP-IN-1
PROTACKSP-IN-1 (Compound 21) is a spindle protein (KSP) degrader as a PROTAC, effectively degrading KSP in HCT-116 cells with a DC50 value of 114.8 nM. It inhibits the proliferation of HCT-116 with an IC50 of 10 nM, causes G2/M phase cell cycle arrest, and induces apoptosis in HCT-116. Additionally, PROTACKSP-IN-1 demonstrates antitumor activity in mouse models.Formule :C48H51N5O8SCouleur et forme :SolidMasse moléculaire :858.01p38-α MAPK-IN-8
p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892KRN 5500
CAS :KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.Formule :C28H43N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :589.68Cathepsin B
CAS :Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.Couleur et forme :SolidBTK ligand 12
CAS :BTK ligand 12 is a PROTAC target protein ligand serving as an active control for NRX-0492 (a BTK degradator).Formule :C25H34N8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :478.59Mcl-1 inhibitor 3
CAS :Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activateFormule :C40H52ClF2N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.39HNPMI
CAS :HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Formule :C22H20N2O3Degré de pureté :97.19%Couleur et forme :SoildMasse moléculaire :360.41BAD (103-127) (human)
CAS :BAD (103-127) human peptide from BH3 domain, blocks Bcl-xL, 800x more binding than 16-mer.Formule :C137H212N42O39SCouleur et forme :SolidMasse moléculaire :3103.52[Ru(DIP)2TAP]Cl2
[Ru(DIP)2TAP]Cl2, a Ruthenium(II) polypyridyl compound, serves as a photosensitizer and is utilized in photodynamic therapy (PDT) research.Couleur et forme :Odour SolidL-Glutamic-5-14C acid
CAS :L-Glutamic-5-14C acid is a bioactive chemical.Formule :C5H9NO4Couleur et forme :SolidMasse moléculaire :149.12GNE-1567
GNE-1567 is a potent ERα PROTAC degrader and a selective antagonist of XIAP, with a Kd of 0.03 μM. It is applicable in breast cancer research.Couleur et forme :Odour SolidHydrocinchonine
CAS :Hydrocinchonine is an Alkaloid from Olea europaea and is found in fruits.Formule :C19H24N2OCouleur et forme :SolidMasse moléculaire :296.41Biotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Couleur et forme :Odour Solidcpm-1285
CAS :CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.Formule :C153H240N44O42SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3399.88Diafenthiuron
CAS :Diafenthiuron is a widely utilized thiourea-based pesticide that effectively hinders mitochondrial activity in insect pests.Formule :C23H32N2OSCouleur et forme :SolidMasse moléculaire :384.58KWCN-41
CAS :KWCN-41, Selective RIPK1 inhibitor (IC50=88 nM), inhibits necrosis specifically, anti-inflammatory effects.Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35FKBP12 ligand-2
FKBP12 ligand-2 (compound d) is a high-affinity ligand that targets FKBP12. This compound is utilized to selectively enhance the binding of heterobifunctional molecules to BRD4, facilitating the intracellular accumulation of drugs through the "CellTrap" effect. It forms a ternary complex of FKBP12-ligand-BRD4, which inhibits BRD4, suppresses the expression of BRD4 target genes such as MYC, and induces tumor cell death. FKBP12 ligand-2 is applicable in selective cancer research based on the differential levels of presenter proteins within cells.Couleur et forme :Odour SolidKinamycin C
CAS :Kinamycin C is a bacterial metabolite used as an anticancer agent.Formule :C24H20N2O10Couleur et forme :SolidMasse moléculaire :496.428MB-314
MB-314 is a humanized IgG1 monoclonal antibody (mAb) targeting Lewis Y. This compound enhances antibody-dependent cell-mediated cytotoxicity (ADCC) activity and increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 is applicable in cancer research.Couleur et forme :Odour LiquidNMC-001
NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.Couleur et forme :Odour Liquidc-MYC/BCL2 ligand 1 iodide
c-MYC/BCL2 ligand 1 iodide is a dual-target ligand that specifically interacts with the G-quadruplex (G4) regions of the c-MYC and Bcl-2 promoters, exhibiting Kd values of 0.90 μM for c-MYCG4 and 0.56 μM for Bcl-2G4. It works by binding to these G4-forming sequences to inhibit transcription of the c-MYC and Bcl-2 genes, leading to reduced protein expression. This compound effectively suppresses MCF-7 cell proliferation and migration, induces G1 phase cell cycle arrest, and triggers apoptosis. Additionally, it significantly hampers tumor growth in the 4T1 homogenous model with negligible toxicity. c-MYC/BCL2 ligand 1 iodide is applicable in breast cancer research.Couleur et forme :Odour SolidPerfluorodecanoic acid
CAS :Perfluorodecanoic acid is a biochemical.Formule :C10HF19O2Couleur et forme :Physical Description Liquid (Ntp 1992)Masse moléculaire :514.08ElteN378
CAS :ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formule :C23H26N2O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :378.46Ref: TM-T9950
1mg167,00€1mL*10mM (DMSO)295,00€5mg356,00€10mg528,00€25mg848,00€50mg1.153,00€100mg1.603,00€200mg2.142,00€PARP1-IN-16
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.Degré de pureté :98%Couleur et forme :Odour SolidNEP162
CAS :NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 μM in SW480 cells and 1.6 μM in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.Formule :C50H56ClN11O3SCouleur et forme :SolidMasse moléculaire :926.57PQ401
CAS :PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79NF-κB-IN-19
NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. It effectively induces DNA damage in tumor cells through the NF-κB signaling pathway and promotes the production of reactive oxygen species (ROS), as well as induces autophagy and apoptosis. Additionally, NF-κB-IN-19 inhibits levels of VEGF and HIF-1α, exerting antiproliferative effects in tumor cells through the PI3K/AKT and STAT-3 pathways. It is also effective in overcoming cisplatin resistance and exhibits antitumor activity.Formule :C24H26Cl3F2N3O4PtCouleur et forme :SolidMasse moléculaire :759.92ZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Formule :C25H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.53FLT3/HDAC-IN-1
FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.Couleur et forme :Odour Solid
