Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(128 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6172 produits trouvés pour "Apoptose"
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SB-1295
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.Formule :C23H22ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.88MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Formule :C28H25Cl3FN3O3Couleur et forme :SolidMasse moléculaire :576.87β-Glucuronide-dPBD-PEG5-NH2
CAS :β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugateFormule :C78H101N7O35Couleur et forme :SolidMasse moléculaire :1696.66HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Formule :C25H33FO3Couleur et forme :SolidMasse moléculaire :400.53p53 (17-26)
CAS :Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Formule :C60H90N12O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1251.43(±)-Indoxacarb
CAS :(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.
Formule :C22H17ClF3N3O7Couleur et forme :SolidMasse moléculaire :527.83CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Formule :C27H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.55BM-1244
CAS :BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively.Formule :C54H59ClF4N6O8S4Couleur et forme :SolidMasse moléculaire :1159.78Sincalide ammonium
CAS :Sincalide ammonium, a CCK analog, stimulates bile release, gallbladder contraction, and sphincter relaxation, aiding in diagnoses.Formule :C49H65N11O16S3Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :1160.3JC2-11
CAS :JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.
Formule :C17H15FO4Degré de pureté :98.6%Couleur et forme :SoildMasse moléculaire :302.3PG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formule :C14H34Cl2N4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :329.35(-)-Irofulven
CAS :Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.Formule :C15H18O3Couleur et forme :SolidMasse moléculaire :246.30BGC4
BGC4 is a gold(III) complex based on biphenyl. It inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity with an IC50 of 5.4 μM in MDA-MB-231 cells, and induces apoptosis. Additionally, BGC4 demonstrates antitumor activity in mouse models.Formule :C30H32AuClF3N3Couleur et forme :SolidMasse moléculaire :724.01Thalidomide-PEG2-C2-NH2 hydrochloride
CAS :Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formule :C19H25ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.88ZYH-23
ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.Formule :C41H50N4O3Couleur et forme :SolidMasse moléculaire :646.38829Ac-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formule :C27H37ClN4O9Couleur et forme :SolidMasse moléculaire :597.06ZS3-046
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.Formule :C49H57N9O7Couleur et forme :SolidMasse moléculaire :883.4381Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Formule :C21H26N4O5SCouleur et forme :SolidMasse moléculaire :446.52Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Formule :C38H56N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.86FW-1
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.
Formule :C24H27N7OCouleur et forme :SolidMasse moléculaire :429.517ARD-61
CAS :ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formule :C61H71ClN8O7SCouleur et forme :SolidMasse moléculaire :1095.8ZMF-24
ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent that exhibits IC50 values of 0.22 μM and 0.44 μM against BT-549 and MDA-MB-231 TNBC cell proliferation, respectively. It targets the eukaryotic translation initiation factor 3 subunit D (EIF3D), disrupting TNBC's energy supply by inhibiting glycolysis. Additionally, ZMF-24 induces TNBC cell apoptosis (apoptosis) by stimulating sustained endoplasmic reticulum stress.Couleur et forme :Odour SolidIC 86621
CAS :IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25Vinepidine sulfate
CAS :Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Formule :C46H58N4O13SCouleur et forme :SolidMasse moléculaire :907.04PARP1/BRD4-IN-3
PARP1/BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0/G1 phase. Additionally, PARP1/BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.Couleur et forme :Odour SolidEriosematin
CAS :Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.Formule :C19H20O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.36N-Acetylpsychosine
CAS :N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties.
Formule :C26H49NO8Couleur et forme :SolidMasse moléculaire :503.67FPR1 antagonist 1
Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49Thailanstatin D
CAS :Thailanstatin D blocks AR-V7 splicing, disrupts U2AF65/SAP155 binding, and induces apoptosis in CRPC xenografts.
Formule :C28H41NO8Couleur et forme :SolidMasse moléculaire :519.635SH-5
CAS :SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene productsFormule :C29H59O10PCouleur et forme :SolidMasse moléculaire :598.75Stem bromelain
CAS :Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.Couleur et forme :SolidFerroptosis-IN-12
Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.Couleur et forme :Odour SolidPROTAC AR-NTD degrader 1
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminalFormule :C41H47ClN6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.3Thalidomide-O-PEG4-amine
CAS :Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Formule :C23H31N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.51Tubulin/AKT1-IN-1
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation andFormule :C38H34ClNO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :716.13NA-Ir
CAS :NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.Formule :C49H36F6IrN8O4PCouleur et forme :SolidMasse moléculaire :1138.04DL-Sulforaphane N-acetyl-L-cysteine
CAS :DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formule :C11H20N2O4S3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :340.48Polyinosinic-polycytidylic acid potassium
CAS :Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.Formule :(C10H13N4O8P)x·(C9H14N3O8P)x·xKCouleur et forme :Solidp38-α MAPK-IN-8
p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892FKBP12 Ligand-Linker Conjugate 1
CAS :FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.Formule :C42H63N3O11Couleur et forme :SolidMasse moléculaire :785.963Xerophilusin B
CAS :Xerophilusin B from Isodon xerophilus halts ESCC cell growth, causes G2/M arrest, and induces apoptosis.Formule :C20H26O5Couleur et forme :SolidMasse moléculaire :346.428-hydroxy Efavirenz
CAS :8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.68Claturafenib
CAS :Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formule :C18H15Cl2F2N5O3SDegré de pureté :98.68% - 99.85%Couleur et forme :SolidMasse moléculaire :490.31PTD-p65-P1 Peptide TFA
Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.Formule :C170H276F3N57O46SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3943.52GD3 Ganglioside sodium
GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.Couleur et forme :SolidBetamethasone
CAS :Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formule :C22H29FO5Degré de pureté :98% - 99.71%Couleur et forme :White Or Almost White Powder Solid CrystallineMasse moléculaire :392.46MitoTam bromide, hydrobromide
CAS :MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Formule :C52H60Br2NOPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :905.82MS41
CAS :MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.Formule :C56H70N8O9SCouleur et forme :SolidMasse moléculaire :1031.27Pep19-2.5
CAS :Pep19-2.5: Synthetic antitoxin peptide inhibits LP/LPS signals via PRRs, preventing inflammation and pyroptosis.Formule :C135H187N37O22SCouleur et forme :SolidMasse moléculaire :2712.23Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formule :C21H28ClN5O5Masse moléculaire :465.1779HDAC3-IN-2
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37Azalamellarin N
CAS :Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].Formule :C28H22N2O7Couleur et forme :SolidMasse moléculaire :498.48Poly(I:C):Kanamycin (1:1) sodium
Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.
Degré de pureté :99%Couleur et forme :SolidRWJ-56110 dihydrochloride
CAS :RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.Formule :C41H44Cl3F2N7O3Couleur et forme :SolidMasse moléculaire :827.2Apoptosis inducer 37
Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.Formule :C27H37BrN2O4SCouleur et forme :SolidMasse moléculaire :564.16574AChE-IN-81
AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.Formule :C37H54ClNO5Couleur et forme :SolidMasse moléculaire :628.28Poly (I:C):Kanamycin (1:1)
Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.
Couleur et forme :SolidThalidomide-5-PEG2-Cl
CAS :Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.Formule :C17H17ClN2O6Couleur et forme :SolidMasse moléculaire :380.78KRASG12C IN-16
KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.Formule :C28H35ClN8O2Couleur et forme :SolidMasse moléculaire :551.08PARP1-IN-15
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.Formule :C16H12N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :264.28TCF4/β-catenin-IN-1
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.Formule :C23H15N7O3Couleur et forme :SolidMasse moléculaire :437.41HDAC-IN-57
CAS :HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formule :C21H19N3O4Degré de pureté :98.62%Couleur et forme :SoildMasse moléculaire :377.39DHFR-IN-23
DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.Couleur et forme :Odour SolidCDK-IN-14
CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.Couleur et forme :Odour Solidp53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.Formule :C40H51Cl4N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :807.68DB818 dihydrochloride
DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).Couleur et forme :Odour SolidSotigalimab
CAS :Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Degré de pureté :98.50% - 98.50%Couleur et forme :LiquidMasse moléculaire :144.35 kDaAntiproliferative agent-42
Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54Couleur et forme :Odour Solid2-aminobenzo[d]thiazol-6-ol
CAS :2-aminobenzo[d]thiazol-6-ol: antimicrobial, antioxidant, anticancer; may trigger cancer cell apoptosis.Formule :C7H6N2OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :166.2(±)-Enterodiol
CAS :"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.36Dazodalibep
CAS :Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Couleur et forme :LiquidCSF1R-IN-26
CAS :CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Formule :C20H22ClN5O3Couleur et forme :SoildMasse moléculaire :415.87JAK05
JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.Formule :C27H27ClN4O9SCouleur et forme :SolidMasse moléculaire :619.043Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.Formule :C27H35F3N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :648.582-Chloronaphthalene
CAS :2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.Formule :C10H7ClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :162.62HNPMI
CAS :HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Formule :C22H20N2O3Degré de pureté :97.19%Couleur et forme :SoildMasse moléculaire :360.41Carbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).Formule :C19H15FN6O2SCouleur et forme :SolidMasse moléculaire :410.09612PPA-904 FA
PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.Formule :C29H43N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.74Anticancer agent 153
Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial MembraneFormule :C16H11Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.18Uvarigrin
CAS :Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.Formule :C37H68O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.93Anticancer agent 132
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities.Formule :C24H16Cl3F3N5ORhDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :656.68HDAC6 degrader-5
HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.Formule :C21H22N4O3Couleur et forme :SolidMasse moléculaire :378.424Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cellFormule :C21H22ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.95Antitumor agent-112
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35Formule :C18H17ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.87TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.Formule :C159H268N58O45·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3712.19 (free acid)Thalidomide-O-C8-NH2
CAS :Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.463Vallesiachotamine
CAS :Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].Formule :C21H22N2O3Couleur et forme :SolidMasse moléculaire :350.41GSPT1 degrader-1
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and inducesFormule :C28H33ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :541.04Antagonist G
CAS :Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19Lisaftoclax
CAS :Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.42Ref: TM-T10483
1mg177,00€5mg394,00€1mL*10mM (DMSO)558,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€Ferroptosis inducer-6
CAS :Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formule :C69H78F12N12P2RuCouleur et forme :SolidMasse moléculaire :1466.44Bcl-2-IN-22
Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.Couleur et forme :Odour SolidFAK-IN-24
CAS :FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formule :C39H45Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :801.728Antitumor agent-96
"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing theFormule :C27H32N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.56IRF1-IN-2
CAS :IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formule :C18H20N2O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :360.43Flaccidoside II
CAS :Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral NerveFormule :C59H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1205.38Antimycin A2c
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.Formule :C28H40N2O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.63CPTH2 (hydrochloride) (357649-93-5 free base)
CAS :CPTH2 is an inhibitor of the HAT activity of Gcn5.Formule :C14H15Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.26C-Reactive Protein (CRP) (174-185)
CAS :CRP protein and its fragment (174-185, RS-83277) boost human monocyte and macrophage cancer-killing effects in vitro.Formule :C62H93N13O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1276.48RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell migration and induces apoptosis (increasing the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). It reduces mitochondrial membrane potential and activates autophagy (Autophagy) through the PI3K-Akt-mTOR signaling pathway, damaging mitochondria and lysosomes within the cell and causing endoplasmic reticulum stress. RPS6-IN-1 also inhibits the phosphorylation of RPS6. Notably, RPS6-IN-1 is a low systemic toxicity anticancer agent.Couleur et forme :Odour Solid
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