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Apoptose

Apoptose

Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.

Sous-catégories appartenant à la catégorie "Apoptose"

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6222 produits trouvés pour "Apoptose"

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  • Polyinosinic-polycytidylic acid potassium

    CAS :
    Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.
    Formule :(C10H13N4O8P)x·(C9H14N3O8P)x·xK
    Couleur et forme :Solid

    Ref: TM-T74052

    5mg
    À demander
    50mg
    À demander
  • PTD-p65-P1 Peptide TFA


    Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.
    Formule :C170H276F3N57O46S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :3943.52

    Ref: TM-TP1395

    1mg
    138,00€
    5mg
    409,00€
    10mg
    705,00€
  • Tubulin inhibitor 34


    Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.
    Formule :C21H22N4O3S
    Couleur et forme :Solid
    Masse moléculaire :410.49

    Ref: TM-T78761

    5mg
    À demander
    50mg
    À demander
  • PUMA BH3


    PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.
    Formule :C128H202N42O43S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :3049.3

    Ref: TM-TP1724

    1mg
    112,00€
    5mg
    259,00€
    10mg
    409,00€
  • JPS014 TFA


    JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC
    Formule :C48H60F3N7O9S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :968.09

    Ref: TM-T77937

    5mg
    À demander
    50mg
    À demander
  • ZC0109


    ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.
    Formule :C22H20BrFN8O4S
    Couleur et forme :Solid
    Masse moléculaire :591.41

    Ref: TM-T73512

    5mg
    404,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Conglobatin

    CAS :
    Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.
    Formule :C28H38N2O6
    Couleur et forme :Solid
    Masse moléculaire :498.62

    Ref: TM-T36494

    2500µg
    2.052,00€
  • WEHI-3773


    WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.
    Couleur et forme :Odour Solid

    Ref: TM-T206161

    10mg
    À demander
    50mg
    À demander
  • c-JUN peptide

    CAS :

    Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.

    Formule :C121H210N36O34S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :2743.55

    Ref: TM-TP2134

    1mg
    1.008,00€
  • EGFR/BRAFV600E-IN-3


    EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.
    Formule :C25H18N4O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :422.44

    Ref: TM-T78850

    5mg
    À demander
    50mg
    À demander
  • BRD4 Inhibitor-39


    BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.
    Formule :C24H19BrFN9
    Couleur et forme :Solid
    Masse moléculaire :532.37

    Ref: TM-T204232

    10mg
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    50mg
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  • DiPT-4


    DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to
    Formule :C32H22FN5O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :591.61

    Ref: TM-T78747

    5mg
    À demander
    50mg
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  • Pralnacasan

    CAS :
    Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).
    Formule :C26H29N5O7
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :523.54

    Ref: TM-T16570

    25mg
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    50mg
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    100mg
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  • NCT-58

    CAS :
    NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.
    Formule :C27H34N2O5
    Degré de pureté :99.55%
    Couleur et forme :Solid
    Masse moléculaire :466.57

    Ref: TM-T9996

    2mg
    43,00€
    5mg
    80,00€
    10mg
    119,00€
    1mL*10mM (DMSO)
    197,00€
    25mg
    245,00€
    50mg
    394,00€
    100mg
    627,00€
    200mg
    842,00€
  • AS-99 TFA


    AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.
    Couleur et forme :Solid

    Ref: TM-T36978

    5mg
    482,00€
    10mg
    818,00€
  • Thalidomide-O-amido-PEG4-azide

    CAS :
    Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].
    Formule :C25H32N6O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :576.56

    Ref: TM-T18821

    2mg
    62,00€
    5mg
    90,00€
    10mg
    130,00€
    25mg
    212,00€
    50mg
    339,00€
    100mg
    532,00€
  • CRA-026440 hydrochloride

    CAS :
    CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.
    Formule :C23H25ClN4O4
    Degré de pureté :99.78%
    Couleur et forme :Soild
    Masse moléculaire :456.92

    Ref: TM-T10883L

    1mL*10mM (DMSO)
    47,00€
    1mg
    115,00€
    5mg
    274,00€
    10mg
    432,00€
    25mg
    735,00€
    50mg
    1.159,00€
    100mg
    1.568,00€
  • VEGFR-2-IN-36


    VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated
    Formule :C24H23N7O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :489.48

    Ref: TM-T79403

    5mg
    À demander
    50mg
    À demander
  • ICy-OH

    CAS :
    ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.
    Formule :C26H25I2NO2
    Couleur et forme :Solid
    Masse moléculaire :637.29

    Ref: TM-T74922

    5mg
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    50mg
    À demander
  • PZ703b TFA


    PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for
    Formule :C82H103ClF6N10O13S4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1714.46

    Ref: TM-T77913

    5mg
    À demander
    50mg
    À demander
  • SL-01

    CAS :
    SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.
    Formule :C18H18ClNO3
    Degré de pureté :98%
    Couleur et forme :White Powder
    Masse moléculaire :331.79

    Ref: TM-T19779

    250mg
    172,00€
    500mg
    265,00€
    1g
    404,00€
  • KTX-582

    CAS :
    KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.
    Formule :C45H51F3N8O7
    Couleur et forme :Solid
    Masse moléculaire :872.93

    Ref: TM-T74664

    5mg
    À demander
    50mg
    À demander
  • Thalidomide-O-C7-NH2

    CAS :
    Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.
    Formule :C20H25N3O5
    Couleur et forme :Solid
    Masse moléculaire :387.436

    Ref: TM-T39511

    25mg
    1.369,00€
  • Halenaquinone

    CAS :
    Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.
    Formule :C20H12O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :332.31

    Ref: TM-T27526

    25mg
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    50mg
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    100mg
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  • p53 and MDM2 proteins-interaction-inhibitor (racemic)

    CAS :
    p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.
    Formule :C40H49Cl2N5O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :734.75

    Ref: TM-T12351

    25mg
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    50mg
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    100mg
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  • CALP1

    CAS :
    Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.
    Formule :C40H75N9O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :842.09

    Ref: TM-TP1910

    1mg
    159,00€
  • Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

    CAS :

    Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly

    Formule :C25H34N4O9
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :534.566

    Ref: TM-T40094

    100mg
    À demander
    500mg
    À demander
  • Galloflavin Potassium

    CAS :
    Galloflavin Potassium is an inhibitor of lactate dehydrogenase.
    Formule :C12H5KO8
    Couleur et forme :Solid
    Masse moléculaire :316.26

    Ref: TM-T70203

    10mg
    747,00€
  • Antitumor agent-100 hydrochloride

    CAS :
    Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].
    Formule :C17H15Cl2N3O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :348.23

    Ref: TM-T79138

    5mg
    À demander
    50mg
    À demander
  • PI3K/HDAC-IN-4


    PI3K/HDAC-IN-4 (Compound 31f) is a dual inhibitor targeting PI3K and HDAC, with an IC50 of 0.2μM. It demonstrates high selectivity for HDAC1-3, with IC50 values of 75.5 nM, 70.9 nM, and 1.9 nM, respectively. As a potent pan-PI3K inhibitor, PI3K/HDAC-IN-4 has IC50 values of 2.5 nM, 80.5 nM, 10.0 nM, and 57.2 nM for PI3Kα, β, δ, and γ, respectively. This compound effectively induces apoptosis in tumor cells by concurrently inhibiting the PI3K/AKT/mTOR signaling pathway and HDAC1-3. It shows significant antiproliferative activity across various tumor cell lines, such as MV4-11, Jeko-1, HL60, and MCF-7, with IC50 values of 0.2, 0.9, 0.8, and 1.5 μM, respectively. PI3K/HDAC-IN-4 is applicable in the study of lymphoma and leukemia.
    Formule :C28H35F3N12O3
    Couleur et forme :Solid
    Masse moléculaire :644.29072

    Ref: TM-T207683

    10mg
    À demander
    50mg
    À demander
  • VTP50469 fumarate

    CAS :
    VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
    Formule :C76H106F2N12O20S2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1609.86

    Ref: TM-T13336L

    25mg
    1.084,00€
  • Thalidomide-O-amido-PEG4-propargyl


    Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
    Formule :C26H31N3O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :545.54

    Ref: TM-T18823

    100mg
    À demander
    500mg
    À demander
  • CRM1-IN-2


    CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibiting
    Formule :C29H48N2O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :504.7

    Ref: TM-T79655

    5mg
    À demander
    50mg
    À demander
  • Thalidomide-O-amido-C3-PEG3-C1-NH2

    CAS :
    Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.
    Formule :C27H35F3N4O11
    Couleur et forme :Solid
    Masse moléculaire :648.589

    Ref: TM-T39215

    200mg
    À demander
    500mg
    À demander
    25mg
    411,00€
    50mg
    672,00€
    100mg
    898,00€
  • 7-epi-Isogarcinol

    CAS :
    7-epi-Isogarcinol, a PPAP, hinders STAT3 to induce apoptosis and curbs cell migration with moderate antiproliferative effects.
    Formule :C38H50O6
    Couleur et forme :Solid
    Masse moléculaire :602.8

    Ref: TM-T75609

    5mg
    À demander
    50mg
    À demander
  • CSF1R-IN-26

    CAS :
    CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.
    Formule :C20H22ClN5O3
    Couleur et forme :Soild
    Masse moléculaire :415.87

    Ref: TM-T206224

    10mg
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    50mg
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  • Nauclefine

    CAS :
    Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.
    Formule :C18H13N3O
    Degré de pureté :99.92%
    Couleur et forme :Solid
    Masse moléculaire :287.32

    Ref: TM-TN6120

    25mg
    À demander
    50mg
    À demander
    1mg
    110,00€
    2mg
    166,00€
    5mg
    241,00€
    10mg
    355,00€
  • BRD4 Inhibitor-38


    BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.
    Formule :C19H18N2O4
    Couleur et forme :Solid
    Masse moléculaire :338.357

    Ref: TM-T204812

    10mg
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    50mg
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  • HDSI-18


    HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.
    Formule :C28H28N4O5
    Couleur et forme :Solid
    Masse moléculaire :500.20597

    Ref: TM-T207650

    10mg
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    50mg
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  • Poly(I:C):Kanamycin (1:1) sodium


    Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.

    Degré de pureté :99%
    Couleur et forme :Solid

    Ref: TM-T74067

    5mg
    506,00€
  • EGFR-IN-153


    EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.
    Couleur et forme :Odour Solid

    Ref: TM-T206404

    10mg
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    50mg
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  • DL-Sulforaphane N-acetyl-L-cysteine

    CAS :
    DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).
    Formule :C11H20N2O4S3
    Degré de pureté :99%
    Couleur et forme :Solid
    Masse moléculaire :340.48

    Ref: TM-T36614

    1mg
    194,00€
  • DCZ3301

    CAS :
    DCZ3301 is a novel aryl-guanidino inhibitor.
    Formule :C20H16ClF3N6O2
    Degré de pureté :99.89%
    Couleur et forme :Solid
    Masse moléculaire :464.83

    Ref: TM-T9658

    1mg
    73,00€
    5mg
    149,00€
    1mL*10mM (DMSO)
    166,00€
    10mg
    213,00€
    25mg
    319,00€
    50mg
    450,00€
    100mg
    605,00€
    200mg
    802,00€
  • RD-23

    CAS :
    RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.
    Formule :C52H56N12O4
    Couleur et forme :Solid
    Masse moléculaire :913.079

    Ref: TM-T204442

    10mg
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    50mg
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  • FeTPPS

    CAS :
    FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.
    Formule :C44H28ClFeN4O12S4
    Couleur et forme :Solid
    Masse moléculaire :1024.27

    Ref: TM-T35996

    5mg
    37,00€
    10mg
    54,00€
    25mg
    90,00€
    50mg
    148,00€
    100mg
    213,00€
    200mg
    315,00€
  • Top1-IN-2


    Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.
    Couleur et forme :Odour Solid

    Ref: TM-T206637

    10mg
    À demander
    50mg
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  • p53 (17-26)

    CAS :
    Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.
    Formule :C60H90N12O17
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1251.43

    Ref: TM-TP1794

    100mg
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    500mg
    À demander
  • PD-L1/LpxC-IN-1


    PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.
    Couleur et forme :Odour Solid

    Ref: TM-T206624

    10mg
    À demander
    50mg
    À demander
  • D-Trimannuronic acid

    CAS :
    D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.
    Formule :C18H26O19
    Couleur et forme :Solid
    Masse moléculaire :546.387

    Ref: TM-T35614

    5mg
    207,00€
  • AB-3PRGD2

    CAS :

    AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.

    Formule :C137H215IN30O45S
    Couleur et forme :Solid
    Masse moléculaire :3161.32

    Ref: TM-T206427

    10mg
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    50mg
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  • ATPase-IN-3

    CAS :
    ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.
    Formule :C10H6N2O3S2
    Degré de pureté :97.76%
    Couleur et forme :Soild
    Masse moléculaire :266.3

    Ref: TM-T83967

    2mg
    35,00€
    5mg
    52,00€
    10mg
    74,00€
    25mg
    140,00€
    50mg
    210,00€
    100mg
    309,00€
    200mg
    462,00€
  • Thalidomide-O-C8-COOH

    CAS :
    Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment
    Formule :C22H26N2O7
    Couleur et forme :Solid
    Masse moléculaire :430.45

    Ref: TM-T77918

    2mg
    75,00€
  • Eciskafusp alfa

    CAS :
    Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific
    Degré de pureté :98%
    Couleur et forme :Solid

    Ref: TM-T82508

    5mg
    À demander
    50mg
    À demander
  • AP1867-2-(carboxymethoxy)

    CAS :
    AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG
    Formule :C38H47NO11
    Couleur et forme :Solid
    Masse moléculaire :693.78

    Ref: TM-T18611

    2mg
    255,00€
  • Nemorosone

    CAS :
    Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.
    Formule :C33H42O4
    Couleur et forme :Solid
    Masse moléculaire :502.695

    Ref: TM-T36954

    1mg
    148,00€
    5mg
    494,00€
    10mg
    838,00€
  • Humulone


    Humulone is a natural product and has a wide range of applications in life science related research.
    Formule :C21H30O5
    Couleur et forme :Solid
    Masse moléculaire :362.47

    Ref: TM-TSP-42478394

    1mg
    À demander
    5mg
    À demander
  • [1,1'-Biphenyl]-3-amine

    CAS :
    [1,1'-Biphenyl]-3-amine is an inhibitor of MAO-A and MAO-B and can inhibit the cell viability of HT-29, HEK 293, and MCF-7 cells.
    Formule :C12H11N
    Degré de pureté :99.78%
    Couleur et forme :Solid
    Masse moléculaire :169.22

    Ref: TM-TN9371

    50mg
    39,00€
    100mg
    52,00€
  • ChoKα inhibitor-3


    ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to
    Formule :C50H54Br2Cl2N4S2
    Couleur et forme :Solid
    Masse moléculaire :1005.83

    Ref: TM-T75024

    5mg
    À demander
    50mg
    À demander
  • Mumefural

    CAS :

    Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.

    Formule :C12H12O9
    Couleur et forme :Solid
    Masse moléculaire :300.22

    Ref: TM-T75689

    5mg
    À demander
    50mg
    À demander
  • Tubulysin B

    CAS :
    Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.
    Formule :C42H63N5O10S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :830.04

    Ref: TM-T13937

    100mg
    À demander
    500mg
    À demander
  • Diazepinomicin

    CAS :
    Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.
    Formule :C28H34N2O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :462.58

    Ref: TM-T15113

    50mg
    À demander
    100mg
    À demander
    25mg
    9.487,00€
  • anti-TNBC agent-9


    Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.
    Couleur et forme :Odour Solid

    Ref: TM-T206779

    10mg
    À demander
    50mg
    À demander
  • Reveromycin A

    CAS :
    Reveromycin A from Streptomyces sp. inhibits epidermal growth, tumors, and C. albicans; affects osteoclasts. IC50: 0.7-1.9 μg/ml; MIC: 2 μg/ml.
    Formule :C36H52O11
    Couleur et forme :Solid
    Masse moléculaire :660.79

    Ref: TM-T37008

    250µg
    795,00€
    1mg
    1.584,00€
  • Opamtistomig

    CAS :
    Opamtistomig is a humanized monoclonal antibody immunoglobulin (H-γ1-scFv-L-κ) dimer targeting human programmed death-ligand 1 (PD-L1), CD274, and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). It is anticipated for use in research on various solid tumors and hematologic malignancies.
    Couleur et forme :Liquid

    Ref: TM-T9901A-869

    1mg
    À demander
    5mg
    À demander
  • INF200


    INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-
    Formule :C13H13ClN2O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :296.71

    Ref: TM-T79446

    5mg
    À demander
    50mg
    À demander
  • (R)-MIK665

    CAS :
    (R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).
    Formule :C47H44ClFN6O6S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :875.41

    Ref: TM-T12629

    25mg
    9.565,00€
  • PROTAC RIPK degrader-2

    CAS :
    PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
    Formule :C52H65N7O11S3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1060.31

    Ref: TM-T13846

    100mg
    À demander
    500mg
    À demander
  • Secalonic acid D

    CAS :
    Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.
    Formule :C32H30O14
    Couleur et forme :Solid
    Masse moléculaire :638.57

    Ref: TM-T75621

    5mg
    À demander
    50mg
    À demander
  • Thalidomide-NH-C8-NH2 hydrochloride

    CAS :
    Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.
    Formule :C21H29ClN4O4
    Couleur et forme :Solid
    Masse moléculaire :436.94

    Ref: TM-T40104

    25mg
    682,00€
  • MET/PDGFRA-IN-1


    MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.
    Formule :C26H23N7O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :449.51

    Ref: TM-T78843

    5mg
    À demander
    50mg
    À demander
  • RIP1-IN-1


    RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.
    Couleur et forme :Odour Solid

    Ref: TM-T206258

    10mg
    À demander
    50mg
    À demander
  • SDH-IN-26


    SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.
    Couleur et forme :Odour Solid

    Ref: TM-T206770

    10mg
    À demander
    50mg
    À demander
  • PI3Kα-IN-14


    PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in
    Degré de pureté :98%
    Couleur et forme :Odour Solid

    Ref: TM-T81469

    5mg
    À demander
    50mg
    À demander
  • Ac-VDVAD-CHO TFA


    Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.
    Couleur et forme :Odour Solid

    Ref: TM-T206392

    10mg
    À demander
    50mg
    À demander
  • PZ703b

    CAS :
    PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.
    Formule :C80H102ClF3N10O11S4
    Couleur et forme :Solid
    Masse moléculaire :1600.44

    Ref: TM-T40135

    25mg
    1.369,00€
  • PL120131


    PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.
    Formule :C62H105N19O18
    Couleur et forme :Solid
    Masse moléculaire :1404.61

    Ref: TM-TP3086

    10mg
    À demander
    50mg
    À demander
  • RIPK3-IN-3


    RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.
    Formule :C16H11N5S
    Couleur et forme :Solid
    Masse moléculaire :305.36

    Ref: TM-T78784

    5mg
    À demander
    50mg
    À demander
  • Z-VEID-FMK

    CAS :
    Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.
    Formule :C31H45FN4O10
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :652.71

    Ref: TM-T23555

    1mg
    99,00€
    5mg
    254,00€
    10mg
    421,00€
    25mg
    672,00€
  • (±)-Enterodiol

    CAS :
    "(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."
    Formule :C18H22O4
    Couleur et forme :Solid
    Masse moléculaire :302.36

    Ref: TM-TN7345

    10mg
    À demander
    50mg
    À demander
  • Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

    CAS :
    Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.
    Formule :C21H27ClN4O8
    Degré de pureté :98.09%
    Couleur et forme :Solid
    Masse moléculaire :498.914

    Ref: TM-T18819

    5mg
    47,00€
    10mg
    62,00€
    25mg
    96,00€
    50mg
    164,00€
    100mg
    266,00€
    200mg
    386,00€
  • XZ739

    CAS :
    XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.
    Formule :C65H76ClF3N8O12S3
    Couleur et forme :Solid
    Masse moléculaire :1349.99

    Ref: TM-T39909

    5mg
    1.153,00€
    10mg
    1.900,00€
  • MSU-42011

    CAS :
    MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.
    Formule :C24H34N2O2
    Degré de pureté :99.6%
    Couleur et forme :Soild
    Masse moléculaire :382.54

    Ref: TM-T77499

    5mg
    46,00€
    10mg
    67,00€
    25mg
    112,00€
    50mg
    175,00€
    100mg
    281,00€
    200mg
    394,00€
  • MAO-B-IN-30

    CAS :
    MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.
    Formule :C15H10BrN3O2
    Degré de pureté :98.31%
    Couleur et forme :Soild
    Masse moléculaire :344.16

    Ref: TM-T84309

    5mg
    46,00€
    10mg
    63,00€
    25mg
    105,00€
    50mg
    160,00€
    100mg
    234,00€
  • G-Glu-Val

    CAS :

    G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".

    Formule :C10H18N2O5
    Couleur et forme :Solid
    Masse moléculaire :246.26

    Ref: TM-T31927

    1g
    1.550,00€
  • PG-11047 2HCl


    PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.
    Formule :C14H34Cl2N4
    Degré de pureté :99.51%
    Couleur et forme :Solid
    Masse moléculaire :329.35

    Ref: TM-T73400L

    1mg
    70,00€
    5mg
    180,00€
    10mg
    289,00€
    25mg
    469,00€
    50mg
    680,00€
    100mg
    954,00€
    200mg
    1.288,00€
  • IC 86621

    CAS :
    IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.
    Formule :C12H15NO3
    Degré de pureté :99.68%
    Couleur et forme :Solid
    Masse moléculaire :221.25

    Ref: TM-T9760

    5mg
    38,00€
    1mL*10mM (DMSO)
    40,00€
    10mg
    50,00€
    25mg
    84,00€
    50mg
    110,00€
    100mg
    162,00€
  • β-Apopicropodophyllin

    CAS :
    β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,
    Formule :C22H20O7
    Couleur et forme :Solid
    Masse moléculaire :396.39

    Ref: TM-T75622

    5mg
    À demander
    50mg
    À demander
  • Tengonermin

    CAS :
    Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.
    Couleur et forme :Liquid

    Ref: TM-T76983

    5mg
    À demander
    50mg
    À demander
  • ChoKα inhibitor-5


    ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.
    Formule :C54H68Br2N4S4
    Couleur et forme :Solid
    Masse moléculaire :1061.21

    Ref: TM-T75025

    5mg
    À demander
    50mg
    À demander
  • PEAQX tetrasodium hydrate


    PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).
    Formule :C17H15BrN3Na4O6P
    Degré de pureté :99%
    Couleur et forme :Solid
    Masse moléculaire :560.15

    Ref: TM-T16451

    1mg
    964,00€
  • PD-1-IN-20


    PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.
    Formule :C12H20N6O7
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :360.32

    Ref: TM-T12378

    25mg
    À demander
    50mg
    À demander
    100mg
    À demander
  • Mechercharmycin A

    CAS :
    Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.
    Formule :C35H32N8O7S
    Couleur et forme :Solid
    Masse moléculaire :708.75

    Ref: TM-T40929

    25mg
    1.369,00€
  • AS-99 free base

    CAS :
    AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.
    Formule :C27H30F3N5O3S2
    Couleur et forme :Solid
    Masse moléculaire :593.68

    Ref: TM-T36977

    5mg
    785,00€
  • 7,3′,5′-Trihydroxyflavanone

    CAS :
    7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.
    Formule :C15H12O5
    Couleur et forme :Solid
    Masse moléculaire :272.25

    Ref: TM-T40940

    25mg
    1.369,00€
  • Inuviscolide

    CAS :
    Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.
    Formule :C15H20O3
    Couleur et forme :Solid
    Masse moléculaire :248.32

    Ref: TM-T72965

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • EGFR T790M/L858R-IN-2


    EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.
    Formule :C28H28FN7O
    Couleur et forme :Solid
    Masse moléculaire :497.57

    Ref: TM-T74833

    5mg
    À demander
    50mg
    À demander
  • Chol-CTPP


    Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.
    Formule :C144H263N3O53
    Couleur et forme :Solid
    Masse moléculaire :2884.62

    Ref: TM-T74365

    5mg
    À demander
    50mg
    À demander
  • Metronidazole hydrochloride

    CAS :
    Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.
    Formule :C6H10ClN3O3
    Couleur et forme :Solid
    Masse moléculaire :207.62

    Ref: TM-T75285

    5mg
    À demander
    50mg
    À demander
  • HEMTAC CDK4/6 degrader 1

    CAS :
    HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.
    Formule :C48H53ClN16O4
    Couleur et forme :Solid
    Masse moléculaire :953.49

    Ref: TM-T75029

    5mg
    À demander
    50mg
    À demander
  • Delmitide

    CAS :
    Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.
    Formule :C59H105N17O11
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :1228.57

    Ref: TM-T27142

    25mg
    1.369,00€