Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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sEH inhibitor-19
sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.Formule :C28H28F3N3O4Couleur et forme :SolidMasse moléculaire :527.535Inuviscolide
CAS :Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formule :C15H20O3Couleur et forme :SolidMasse moléculaire :248.32NSC90616
NSC90616 is a mutant p53 rescue compound [1] .Formule :C23H30FNa2O9PCouleur et forme :SolidMasse moléculaire :546.43AKN-028
CAS :AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formule :C17H14N6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :302.33Canfosfamide
CAS :Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formule :C26H40Cl4N5O10PSCouleur et forme :SolidMasse moléculaire :787.47Thalidomide-5-propoxyethanamine
CAS :Thalidomide-5-propoxyethanamine acts as a cereblon (CRBN) ligand derived from Thalidomide, and it serves the purpose of recruiting the CRBN protein.Formule :C18H21N3O5Couleur et forme :SolidMasse moléculaire :359.38CST626
CAS :CST626 is a PROTAC degrader that targets XIAP, cIAP1, and cIAP2.Formule :C61H82N8O9SDegré de pureté :95.87%Couleur et forme :SolidMasse moléculaire :1103.42AUNP-12
CAS :AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.Formule :C142H226N40O48Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3261.55K-252c
CAS :K-252c is a staurosporine analog isolated from Nocardiopsis sp.Formule :C20H13N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.34CNDAC hydrochloride
CAS :CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.Formule :C10H13ClN4O4Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :288.69Ref: TM-T13621
1mg108,00€1mL*10mM (DMSO)236,00€5mg259,00€10mg404,00€25mg578,00€50mg745,00€100mg1.189,00€200mg1.603,00€BCL6-IN-6
CAS :BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma.Formule :C27H31FN6O2SDegré de pureté :98.90%Couleur et forme :SolidMasse moléculaire :522.64PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formule :C48H62N12O7Couleur et forme :SolidMasse moléculaire :919.08GR-1405
GR-1405 is a human monoclonal antibody (mAb) that targets B7-H1/PD-L1/CD274. It enhances the antitumor immune response mediated by cytotoxic T lymphocytes (CTL) against tumor cells expressing PD-L1. GR-1405 is applicable in research related to lymphomas and solid tumors.Couleur et forme :Odour LiquidDehydrobruceine B
CAS :Dehydrobruceine B, from Brucea javanica, enhances Cisplatin-induced apoptosis by affecting AIF, Bax, and Keap1-Nrf2.Formule :C23H26O11Couleur et forme :SolidMasse moléculaire :478.45Bax inhibitor peptide, negative control
CAS :The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.Formule :C28H52N6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.81AKT-IN-18
AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity.Formule :C19H14ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.86Mangafodipir trisodium
CAS :Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously.Formule :C22H27MnN4Na3O14P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :757.32Tauro-β-muricholic acid
CAS :Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptoticFormule :C26H45NO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.78-Bromo-cAMP
CAS :8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.Formule :C10H11BrN5O6PDegré de pureté :97.30%Couleur et forme :SolidMasse moléculaire :408.12,4,6-trichloroanisole
CAS :2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.Formule :C7H5Cl3ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :211.47ASR-488
CAS :ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].Formule :C33H40O7SCouleur et forme :SolidMasse moléculaire :580.73Ilicicolin A
CAS :Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.Formule :C23H31ClO3Couleur et forme :SolidMasse moléculaire :390.95PCC0208017
CAS :PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.
Formule :C19H20F3N7Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :403.4YL5084
CAS :YL5084 is a selective JNK2/3 inhibitor with IC50s: JNK2 (70 nM), JNK3 (84 nM), and antiproliferative, apoptosis-inducing effects.Formule :C35H36N8O2Couleur et forme :SolidMasse moléculaire :600.717,3′,5′-Trihydroxyflavanone
CAS :7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.Formule :C15H12O5Couleur et forme :SolidMasse moléculaire :272.25S65487 sulfate
CAS :S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y.Formule :C41H43ClN6O8SCouleur et forme :SolidMasse moléculaire :815.34Mitochondria modulator-2
Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.Formule :C63H50F12IrN6OP3Couleur et forme :SolidMasse moléculaire :1420.23AS-99 free base
CAS :AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formule :C27H30F3N5O3S2Couleur et forme :SolidMasse moléculaire :593.68EGFR/BRAFV600E-IN-4
EGFR/BRAFV600E-IN-4 (Compound 10f) is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 61 nM and 43 nM, respectively. It halts the cell cycle, induces apoptosis in both early and late stages, and inhibits cancer cell growth in vitro, showing broad-spectrum anticancer activity.Formule :C22H16N4OSCouleur et forme :SolidMasse moléculaire :384.45(E/Z)-Squalene
CAS :(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.Formule :C30H50Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :410.72Bcl-2-IN-15
Bcl-2-IN-15 (Compound 13d) is a Bcl-2 inhibitor with an IC50 of 363 nM, which impedes the proliferation of the NCI leukemia cancer cell line [1].Couleur et forme :Odour SolidRaptinal
CAS :Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
Formule :C28H18O2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :386.44CPTH2 (hydrochloride) (357649-93-5 free base)
CAS :CPTH2 is an inhibitor of the HAT activity of Gcn5.Formule :C14H15Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.26BM-1244
CAS :BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively.Formule :C54H59ClF4N6O8S4Couleur et forme :SolidMasse moléculaire :1159.78FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.45605Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Formule :C26H23N5OCouleur et forme :SolidMasse moléculaire :421.49Mcl-1 inhibitor 16
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.Formule :C25H29Cl2N3PtCouleur et forme :SolidMasse moléculaire :637.51HDAC-IN-84
HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.Formule :C17H21N3O5SCouleur et forme :SolidMasse moléculaire :379.431Mechercharmycin A
CAS :Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.Formule :C35H32N8O7SCouleur et forme :SolidMasse moléculaire :708.75Antitumor agent-36
Antitumor agent-36: potent anti-cancer; causes DNA damage, triggers apoptosis, enhances immune response by upregulating T cells.Formule :C32H30Cl2N2O6PtCouleur et forme :SolidMasse moléculaire :804.58BAY1082439
CAS :BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formule :C25H30N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.54HG-7-85-01
CAS :HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formule :C31H31F3N6O2SDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :608.68GPLGIAGQ
CAS :GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Formule :C31H53N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :711.81Polyphyllin G
CAS :Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.21Thailanstatin D
CAS :Thailanstatin D blocks AR-V7 splicing, disrupts U2AF65/SAP155 binding, and induces apoptosis in CRPC xenografts.
Formule :C28H41NO8Couleur et forme :SolidMasse moléculaire :519.635CGP 3466B maleate
CAS :CGP 3466B (Omigapil) is an oral drug inhibiting GAPDH nitrosylation and apoptosis, potentially treating Alzheimer's and CMD.Formule :C23H21NO5Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :391.42EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormule :C20H21N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.49Fascaplysin chloride
CAS :Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.Formule :C18H11ClN2OCouleur et forme :SolidMasse moléculaire :306.75NCT-58
CAS :NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formule :C27H34N2O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :466.57Ref: TM-T9996
2mg43,00€5mg80,00€10mg119,00€1mL*10mM (DMSO)197,00€25mg245,00€50mg394,00€100mg627,00€200mg842,00€PF-543
CAS :PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formule :C27H31NO4SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :465.6Thalidomide-NH-PEG3-COOH
CAS :Thalidomide-NH-PEG3-COOH is a cereblon-based E3 ligase ligand-linker for PROTAC synthesis.Formule :C22H27N3O9Couleur et forme :SolidMasse moléculaire :477.47Anticancer agent 102
CAS :Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formule :C20H19F6N3OCouleur et forme :SolidMasse moléculaire :431.37eIF4E-IN-1
CAS :eIF4E-IN-1 inhibits eIF4E and boosts immunity by targeting PD-1, PD-L1, LAG3, TIM3, IDO, aiding cancer and infection treatment.Formule :C33H28ClF3N6O4SCouleur et forme :SolidMasse moléculaire :697.13HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formule :C23H23N5O3Couleur et forme :SolidMasse moléculaire :417.46Z-VDVA-(DL-Asp)-FMK
CAS :Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formule :C32H46FN5O11Couleur et forme :SolidMasse moléculaire :695.742Schisandronic acid
CAS :Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.68Thalidomide-O-amido-C6-NH2
CAS :Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.Formule :C21H26N4O6Couleur et forme :SolidMasse moléculaire :430.45PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].Formule :C32H29IN4O4S2Couleur et forme :SolidMasse moléculaire :724.63Ganoderic acid Mk
CAS :GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.Formule :C34H50O7Couleur et forme :SolidMasse moléculaire :570.76YW-N-7 TFA
YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.Formule :C58H63F3N12O9Couleur et forme :SolidMasse moléculaire :1129.19PD-1-IN-20
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.Formule :C12H20N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.32JAK-IN-40
JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.Formule :C26H32N8O3SCouleur et forme :SolidMasse moléculaire :536.65Kurzipene D
CAS :Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.Formule :C26H36O8Couleur et forme :SolidMasse moléculaire :476.56Cefatrizine
CAS :Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.Formule :C18H18N6O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.5PROTAC RIPK degrader-6
CAS :PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linkerFormule :C43H48N6O11S2Couleur et forme :SolidMasse moléculaire :889.01PROTAC FLT-3 degrader 1
CAS :PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formule :C52H61N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1020.23Rosamultic acid
Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.Formule :C30H46O5Couleur et forme :SolidMasse moléculaire :486.693MK-0731
CAS :MK-0731 inhibits kinesin spindle protein, disrupting mitosis and triggering apoptosis in KSP-overexpressing tumor cells.Formule :C25H28F3N3O2Couleur et forme :SolidMasse moléculaire :459.5(+)-Mcl-1 inhibitor 21
CAS :(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622Thalidomide-O-C10-NH2
CAS :Thalidomide-O-C10-NH2: synthetic cereblon-based E3 ligase ligand-linker for PROTACs.Formule :C23H31N3O5Couleur et forme :SolidMasse moléculaire :429.517Hematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.26TTQ-SA
TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.Formule :C78H53N7SCouleur et forme :SolidMasse moléculaire :1120.3727-O-(tert-Butyldimethylsilyl)withaferin A
CAS :Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Formule :C34H52O6SiCouleur et forme :SolidMasse moléculaire :584.86PROTAC Bcl-xL degrader-3
CAS :PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.Formule :C82H105ClF3N11O11S4Couleur et forme :SolidMasse moléculaire :1641.49MD-222
CAS :MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.Formule :C48H47Cl2FN6O6Couleur et forme :SolidMasse moléculaire :893.84rac-CCT-250863 HCl
rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.Formule :C24H26ClF3N4O2SDegré de pureté :98.21%Couleur et forme :SoildMasse moléculaire :527LH1307
CAS :LH1307 blocks PD-1/PD-L1 interaction, IC50 = 3 nM (HTRF assay), activates Jurkat cells, EC50s: 79 nM (U2OS), 763 nM (CHO).
Formule :C54H58N8O6Couleur et forme :SolidMasse moléculaire :915.108FF2039
FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.Formule :C43H56Cl3N5O6Couleur et forme :SolidMasse moléculaire :845.29BRD4 Inhibitor-39
BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.Formule :C24H19BrFN9Couleur et forme :SolidMasse moléculaire :532.37Curzerene
CAS :Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties.Formule :C15H20ODegré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :216.32SPOP-IN-6lc
CAS :SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Formule :C26H31N7O2SDegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :505.64Pomalidomide-PEG3-CO2H
CAS :Pomalidomide-PEG3-CO2H is a cereblon ligand-PEG3 linker for PROTACs.Formule :C22H27N3O9Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :477.46PEAQX tetrasodium hydrate
PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).Formule :C17H15BrN3Na4O6PDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :560.15BU 224 hydrochloride
CAS :BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.Formule :C12H12ClN3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :233.7PROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formule :C46H48N10O6Couleur et forme :SolidMasse moléculaire :836.94M24
CAS :M24 inhibits Mcl-1 (Ki = 0.33μM), blocks HepG2 cell growth, and triggers apoptosis.Formule :C44H40Cl3N5O11SCouleur et forme :SolidMasse moléculaire :953.24PK7088
CAS :PK7088, a pyrazole-based peptide, selectively reactivates mutant p53 to a conformation with wild-type characteristics, demonstrating anticancer activity inFormule :C14H13N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :223.27Bak BH3
Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.Formule :C72H125N25O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1724.9Antagonist G
CAS :Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19dTAGV-1-NEG TFA
dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].Formule :C70H91F3N6O16SCouleur et forme :SolidMasse moléculaire :1361.56Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formule :C20H21BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.3PB28
CAS :PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formule :C24H38N2OCouleur et forme :SolidMasse moléculaire :370.581PROTAC ROR1 degrader-1
PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]Formule :C55H74BrN11O5SCouleur et forme :SolidMasse moléculaire :1081.22Thalidomide-PEG2-C2-NH2 hydrochloride
CAS :Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formule :C19H25ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.88C8 D-threo Ceramide (d18:1/8:0)
CAS :C8 D-threo Ceramide, a potent bioactive sphingolipid, is cytotoxic with IC50=17µM, enhances DNA fragmentation and pore formation, and activates CAPK.Formule :C26H51NO3Couleur et forme :SolidMasse moléculaire :425.698L 683519
CAS :L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein.Formule :C43H67NO12Couleur et forme :SolidMasse moléculaire :789.99ChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21S-Adenosyl-L-methionine
CAS :S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Tubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Couleur et forme :Odour SolidOxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26
