Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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Polyinosinic-polycytidylic acid potassium
CAS :Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.Formule :(C10H13N4O8P)x·(C9H14N3O8P)x·xKCouleur et forme :SolidPTD-p65-P1 Peptide TFA
Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.Formule :C170H276F3N57O46SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3943.52Tubulin inhibitor 34
Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.Formule :C21H22N4O3SCouleur et forme :SolidMasse moléculaire :410.49PUMA BH3
PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.Formule :C128H202N42O43SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3049.3JPS014 TFA
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDACFormule :C48H60F3N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :968.09ZC0109
ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.Formule :C22H20BrFN8O4SCouleur et forme :SolidMasse moléculaire :591.41Conglobatin
CAS :Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62WEHI-3773
WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.Couleur et forme :Odour Solidc-JUN peptide
CAS :Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.
Formule :C121H210N36O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2743.55EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formule :C25H18N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :422.44BRD4 Inhibitor-39
BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.Formule :C24H19BrFN9Couleur et forme :SolidMasse moléculaire :532.37DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential toFormule :C32H22FN5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.61Pralnacasan
CAS :Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54NCT-58
CAS :NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formule :C27H34N2O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :466.57Ref: TM-T9996
2mg43,00€5mg80,00€10mg119,00€1mL*10mM (DMSO)197,00€25mg245,00€50mg394,00€100mg627,00€200mg842,00€AS-99 TFA
AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.Couleur et forme :SolidThalidomide-O-amido-PEG4-azide
CAS :Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56CRA-026440 hydrochloride
CAS :CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.Formule :C23H25ClN4O4Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :456.92Ref: TM-T10883L
1mL*10mM (DMSO)47,00€1mg115,00€5mg274,00€10mg432,00€25mg735,00€50mg1.159,00€100mg1.568,00€VEGFR-2-IN-36
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstratedFormule :C24H23N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.48ICy-OH
CAS :ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.Formule :C26H25I2NO2Couleur et forme :SolidMasse moléculaire :637.29PZ703b TFA
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound forFormule :C82H103ClF6N10O13S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1714.46SL-01
CAS :SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.Formule :C18H18ClNO3Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :331.79KTX-582
CAS :KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93Thalidomide-O-C7-NH2
CAS :Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.Formule :C20H25N3O5Couleur et forme :SolidMasse moléculaire :387.436Halenaquinone
CAS :Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.Formule :C20H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31p53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS :p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.Formule :C40H49Cl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.75CALP1
CAS :Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.Formule :C40H75N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :842.09Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS :Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly
Formule :C25H34N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.566Galloflavin Potassium
CAS :Galloflavin Potassium is an inhibitor of lactate dehydrogenase.Formule :C12H5KO8Couleur et forme :SolidMasse moléculaire :316.26Antitumor agent-100 hydrochloride
CAS :Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].Formule :C17H15Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.23PI3K/HDAC-IN-4
PI3K/HDAC-IN-4 (Compound 31f) is a dual inhibitor targeting PI3K and HDAC, with an IC50 of 0.2μM. It demonstrates high selectivity for HDAC1-3, with IC50 values of 75.5 nM, 70.9 nM, and 1.9 nM, respectively. As a potent pan-PI3K inhibitor, PI3K/HDAC-IN-4 has IC50 values of 2.5 nM, 80.5 nM, 10.0 nM, and 57.2 nM for PI3Kα, β, δ, and γ, respectively. This compound effectively induces apoptosis in tumor cells by concurrently inhibiting the PI3K/AKT/mTOR signaling pathway and HDAC1-3. It shows significant antiproliferative activity across various tumor cell lines, such as MV4-11, Jeko-1, HL60, and MCF-7, with IC50 values of 0.2, 0.9, 0.8, and 1.5 μM, respectively. PI3K/HDAC-IN-4 is applicable in the study of lymphoma and leukemia.Formule :C28H35F3N12O3Couleur et forme :SolidMasse moléculaire :644.29072VTP50469 fumarate
CAS :VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.Formule :C76H106F2N12O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1609.86Thalidomide-O-amido-PEG4-propargyl
Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].Formule :C26H31N3O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :545.54CRM1-IN-2
CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibitingFormule :C29H48N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.7Thalidomide-O-amido-C3-PEG3-C1-NH2
CAS :Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.Formule :C27H35F3N4O11Couleur et forme :SolidMasse moléculaire :648.5897-epi-Isogarcinol
CAS :7-epi-Isogarcinol, a PPAP, hinders STAT3 to induce apoptosis and curbs cell migration with moderate antiproliferative effects.Formule :C38H50O6Couleur et forme :SolidMasse moléculaire :602.8CSF1R-IN-26
CAS :CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Formule :C20H22ClN5O3Couleur et forme :SoildMasse moléculaire :415.87Nauclefine
CAS :Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.Formule :C18H13N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :287.32BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.Formule :C19H18N2O4Couleur et forme :SolidMasse moléculaire :338.357HDSI-18
HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.Formule :C28H28N4O5Couleur et forme :SolidMasse moléculaire :500.20597Poly(I:C):Kanamycin (1:1) sodium
Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.
Degré de pureté :99%Couleur et forme :SolidEGFR-IN-153
EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.Couleur et forme :Odour SolidDL-Sulforaphane N-acetyl-L-cysteine
CAS :DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formule :C11H20N2O4S3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :340.48DCZ3301
CAS :DCZ3301 is a novel aryl-guanidino inhibitor.Formule :C20H16ClF3N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :464.83Ref: TM-T9658
1mg73,00€5mg149,00€1mL*10mM (DMSO)166,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€RD-23
CAS :RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.Formule :C52H56N12O4Couleur et forme :SolidMasse moléculaire :913.079FeTPPS
CAS :FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.Formule :C44H28ClFeN4O12S4Couleur et forme :SolidMasse moléculaire :1024.27Top1-IN-2
Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.Couleur et forme :Odour Solidp53 (17-26)
CAS :Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Formule :C60H90N12O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1251.43PD-L1/LpxC-IN-1
PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.Couleur et forme :Odour SolidD-Trimannuronic acid
CAS :D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.Formule :C18H26O19Couleur et forme :SolidMasse moléculaire :546.387AB-3PRGD2
CAS :AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32ATPase-IN-3
CAS :ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3Thalidomide-O-C8-COOH
CAS :Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitmentFormule :C22H26N2O7Couleur et forme :SolidMasse moléculaire :430.45Eciskafusp alfa
CAS :Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specificDegré de pureté :98%Couleur et forme :SolidAP1867-2-(carboxymethoxy)
CAS :AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAGFormule :C38H47NO11Couleur et forme :SolidMasse moléculaire :693.78Nemorosone
CAS :Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.Formule :C33H42O4Couleur et forme :SolidMasse moléculaire :502.695Humulone
Humulone is a natural product and has a wide range of applications in life science related research.Formule :C21H30O5Couleur et forme :SolidMasse moléculaire :362.47[1,1'-Biphenyl]-3-amine
CAS :[1,1'-Biphenyl]-3-amine is an inhibitor of MAO-A and MAO-B and can inhibit the cell viability of HT-29, HEK 293, and MCF-7 cells.Formule :C12H11NDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :169.22ChoKα inhibitor-3
ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability toFormule :C50H54Br2Cl2N4S2Couleur et forme :SolidMasse moléculaire :1005.83Mumefural
CAS :Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22Tubulysin B
CAS :Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.Formule :C42H63N5O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :830.04Diazepinomicin
CAS :Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.Formule :C28H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.58anti-TNBC agent-9
Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.Couleur et forme :Odour SolidReveromycin A
CAS :Reveromycin A from Streptomyces sp. inhibits epidermal growth, tumors, and C. albicans; affects osteoclasts. IC50: 0.7-1.9 μg/ml; MIC: 2 μg/ml.Formule :C36H52O11Couleur et forme :SolidMasse moléculaire :660.79Opamtistomig
CAS :Opamtistomig is a humanized monoclonal antibody immunoglobulin (H-γ1-scFv-L-κ) dimer targeting human programmed death-ligand 1 (PD-L1), CD274, and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). It is anticipated for use in research on various solid tumors and hematologic malignancies.Couleur et forme :LiquidINF200
INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-Formule :C13H13ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.71(R)-MIK665
CAS :(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).Formule :C47H44ClFN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :875.41PROTAC RIPK degrader-2
CAS :PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.Formule :C52H65N7O11S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1060.31Secalonic acid D
CAS :Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.Formule :C32H30O14Couleur et forme :SolidMasse moléculaire :638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS :Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.Formule :C21H29ClN4O4Couleur et forme :SolidMasse moléculaire :436.94MET/PDGFRA-IN-1
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.Formule :C26H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.51RIP1-IN-1
RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.Couleur et forme :Odour SolidSDH-IN-26
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.Couleur et forme :Odour SolidPI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inDegré de pureté :98%Couleur et forme :Odour SolidAc-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Couleur et forme :Odour SolidPZ703b
CAS :PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formule :C80H102ClF3N10O11S4Couleur et forme :SolidMasse moléculaire :1600.44PL120131
PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61RIPK3-IN-3
RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36Z-VEID-FMK
CAS :Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.Formule :C31H45FN4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.71(±)-Enterodiol
CAS :"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.36Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS :Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.Formule :C21H27ClN4O8Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :498.914XZ739
CAS :XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.Formule :C65H76ClF3N8O12S3Couleur et forme :SolidMasse moléculaire :1349.99MSU-42011
CAS :MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.Formule :C24H34N2O2Degré de pureté :99.6%Couleur et forme :SoildMasse moléculaire :382.54MAO-B-IN-30
CAS :MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.Formule :C15H10BrN3O2Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :344.16G-Glu-Val
CAS :G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".
Formule :C10H18N2O5Couleur et forme :SolidMasse moléculaire :246.26PG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formule :C14H34Cl2N4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :329.35IC 86621
CAS :IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25β-Apopicropodophyllin
CAS :β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,Formule :C22H20O7Couleur et forme :SolidMasse moléculaire :396.39Tengonermin
CAS :Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.Couleur et forme :LiquidChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21PEAQX tetrasodium hydrate
PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).Formule :C17H15BrN3Na4O6PDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :560.15PD-1-IN-20
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.Formule :C12H20N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.32Mechercharmycin A
CAS :Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.Formule :C35H32N8O7SCouleur et forme :SolidMasse moléculaire :708.75AS-99 free base
CAS :AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formule :C27H30F3N5O3S2Couleur et forme :SolidMasse moléculaire :593.687,3′,5′-Trihydroxyflavanone
CAS :7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.Formule :C15H12O5Couleur et forme :SolidMasse moléculaire :272.25Inuviscolide
CAS :Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formule :C15H20O3Couleur et forme :SolidMasse moléculaire :248.32EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57Chol-CTPP
Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62Metronidazole hydrochloride
CAS :Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.Formule :C6H10ClN3O3Couleur et forme :SolidMasse moléculaire :207.62HEMTAC CDK4/6 degrader 1
CAS :HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.49Delmitide
CAS :Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.Formule :C59H105N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1228.57
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