Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Simvastatin-d3
CAS :Simvastatin-d3 is the deuterated form of Simvastatin. Simvastatin (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).Formule :C25H38O5Couleur et forme :SolidMasse moléculaire :421.59Resveratrol-13C6
Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.Couleur et forme :Odour SolidBetifisolimab
CAS :Betifisolimab (MSB-2311) is a humanized antibody targeting PD-L1 for solid tumors and blood cancer research.Couleur et forme :Liquid2-Deoxy-D-glucose-d
CAS :2-Deoxy-D-glucose-d is the deuterated form of 2-Deoxy-D-glucose. This compound is a glucose analogue that acts as a glucose metabolism inhibitor by targeting hexokinase to hinder glycolysis.Formule :C6H12O5Couleur et forme :SolidMasse moléculaire :165.16Lenalidomide-d5
CAS :Lenalidomide-d5 is a deuterated form of Lenalidomide. Lenalidomide (CC-5013) is a derivative of Thalidomide and acts as an orally active immunomodulator in a molecular glue manner. It serves as a ligand for the ubiquitin E3 ligase cereblon (CRBN). Through the CRBN-CRL4 ubiquitin ligase complex, Lenalidomide selectively ubiquitinates and degrades the lymphocyte transcription factors IKZF1 and IKZF3. It effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and induces T cells to release interleukin-2 (IL-2).Formule :C13H13N3O3Couleur et forme :SolidMasse moléculaire :264.29Tebentafusp
CAS :Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Degré de pureté :97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :76.14 kDaTNF/IFNγ-IN-1
CAS :TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formule :C20H23N3O6Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :401.41ARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99.38%Couleur et forme :SoildMasse moléculaire :568.68(Free base）BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Couleur et forme :Odour LiquidEnniatin A1
CAS :Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formule :C35H61N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.885Spiroplatin
CAS :Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Formule :C8H18N2O4PtSDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :433.39Sudubrilimab
Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.Couleur et forme :Odour LiquidZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Formule :C25H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.53Besufetamig
CAS :Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Couleur et forme :LiquidChloranthalactone B
CAS :Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formule :C15H16O3Couleur et forme :SolidMasse moléculaire :244.29Moflerafusp alfa
CAS :Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.Couleur et forme :LiquidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Couleur et forme :Odour LiquidKRAS inhibitor-40
CAS :KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.Formule :C53H66ClF4N9O8SCouleur et forme :SolidMasse moléculaire :1100.66PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Degré de pureté :98%Couleur et forme :Odour SolidBaminercept
CAS :Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Degré de pureté :95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :46.88 kDaDazodalibep
CAS :Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Couleur et forme :LiquidGB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Couleur et forme :Odour LiquidAMPK-IN-6
AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.Formule :C18H20FN5OCouleur et forme :SolidMasse moléculaire :341.383DB2313
CAS :DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Formule :C42H41FN8O2Degré de pureté :98.63% - 99.29%Couleur et forme :SolidMasse moléculaire :708.83MMRi62
CAS :MMRi62, a MDM2-MDM4 inhibitor, induces ferroptosis and autophagy in PDAC, degrades FTH1 and mutant p53, and inhibits KRAS/TP53 mutant PDAC in mice.Formule :C21H15Cl2N3ODegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :396.27Ref: TM-T60202
1mg35,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg104,00€25mg202,00€50mg329,00€100mg525,00€500mg1.121,00€Lodapolimab
CAS :Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Couleur et forme :LiquidGemcitabine-13C,15N2 hydrochloride
CAS :Gemcitabine-13C,15N2(hydrochloride) is the 13C and 15N labeled version of Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) functions as a nucleoside antimetabolite analog and antineoplastic agent. It interrupts DNA synthesis and repair, which leads to autophagy and apoptosis in cells.Formule :C9H12ClF2N3O4Couleur et forme :SolidMasse moléculaire :302.64Fuscin
CAS :Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).Formule :C15H16O5Couleur et forme :SolidMasse moléculaire :276.288Anti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) represents a chimeric antibody of mouse IgG2b, κ type, specifically targeting human PD-L1/B7-H1. The recommended isotype control for this antibody is Mouse IgG2b kappa, Isotype Control.Oxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26Anti-ETBR Antibody (DEDN6526A Naked Antibody)
DEDN6526A (RG-7636) is a humanized ADC compound targeting endothelin B receptor (ETBR), which can be used to study melanoma.Couleur et forme :LiquidMasse moléculaire :145.54 kDaAnti-inflammatory agent 42
CAS :Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.Formule :C20H12N2OSDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :328.39Lipustobart
CAS :Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticDegré de pureté :98%Couleur et forme :LiquidMet-12
CAS :Met-12 is a peptide inhibitor of the Fas receptor. It suppresses Fas receptor-mediated apoptosis in photoreceptor cells and reduces Caspase activation, making it a potential candidate for research on photoreceptor protectants.Formule :C71H99N17O17Couleur et forme :SolidMasse moléculaire :1462.65Pamrevlumab
CAS :FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.Degré de pureté :100% (SEC-HPLC) - >95.0% (SDS-PAGE)Couleur et forme :LiquidMasse moléculaire :150 kDaEfaprinermin alfa
CAS :Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].Couleur et forme :LiquidIzuralimab
CAS :Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].Couleur et forme :Liquid4-Nitrothalidomide
CAS :4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.Formule :C13H9N3O6Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :303.23Pexelizumab
CAS :Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.Couleur et forme :Liquidp-MPPF
CAS :p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Formule :C25H27FN4O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :434.51Atibuclimab
CAS :Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.28 kDaAntiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formule :C20H21BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.3Manelimab
CAS :Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .Couleur et forme :LiquidHMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Formule :C57H75N3O15Couleur et forme :SolidMasse moléculaire :1042.22AZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFormule :C60H79F3N8O10Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :1129.31Ref: TM-T36201L
1mg55,00€5mg96,00€1mL*10mM (DMSO)144,00€10mg149,00€25mg259,00€50mg442,00€100mg647,00€8-Aminoadenosine
CAS :8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formule :C10H14N6O4Couleur et forme :SolidMasse moléculaire :282.26Onercept
CAS :Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].Couleur et forme :LiquidASK1-IN-4
CAS :ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.Formule :C18H14BrNO4S2Degré de pureté :99.756%Couleur et forme :SolidMasse moléculaire :452.34Lenercept
CAS :Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].Couleur et forme :LiquidAnticancer agent 272
Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.Formule :C26H34Br2Cl4Cu2N8Couleur et forme :SolidMasse moléculaire :881.86192Bak BH3
Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.Formule :C72H125N25O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1724.9Anti-Mouse CD44 Antibody (IM7)
Anti-Mouse CD44 Antibody (IM7) is a monoclonal antibody targeting CD44 in mice.Degré de pureté :99%Couleur et forme :Odour LiquidMasse moléculaire :150 kDaBoc-AEVD-CHO
CAS :Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].Formule :C22H36N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.54Atacicept
CAS :Atacicept (TACI-Ig) is a homodimeric fusion protein that inhibits B cell stimulation.Degré de pureté :97.9% (SDS-PAGE); 98.7% (SEC-HPLC) - 97.9% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :35.36 kDaPB28
CAS :PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formule :C24H38N2OCouleur et forme :SolidMasse moléculaire :370.581PROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formule :C46H48N10O6Couleur et forme :SolidMasse moléculaire :836.94Balstilimab
CAS :Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .Couleur et forme :LiquidAsunercept
CAS :Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Couleur et forme :LiquidLinsidomine
CAS :Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.Formule :C6H10N4O2Couleur et forme :Solid Off-WhiteMasse moléculaire :170.17CIGB-300
CAS :CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.Formule :C127H215N53O30S3Couleur et forme :SolidMasse moléculaire :3060.6Finotonlimab
Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].Couleur et forme :Odour LiquidS-Adenosyl-L-methionine
CAS :S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Thalidomide-NH-C8-NH2
CAS :Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.Formule :C21H28N4O4Couleur et forme :SolidMasse moléculaire :400.479Thalidomide-NH-C4-NH2 TFA
CAS :Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.Formule :C19H21F3N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.39UBX1325
CAS :UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.
Formule :C53H59ClF3N6O10PS3Couleur et forme :SolidMasse moléculaire :1159.69BRD-810
CAS :BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.Formule :C39H44ClFN4O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :703.24Ref: TM-T89869
1mL*10mM (DMSO)À demander1mg665,00€5mg1.935,00€10mg3.087,00€25mg4.609,00€50mg6.201,00€Latikafusp
CAS :Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.Degré de pureté :97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :159.55 kDaArisostatin A
CAS :Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.Formule :C69H100N2O24Couleur et forme :SolidMasse moléculaire :1341.53VEGFR-2-IN-68
VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.Formule :C27H25N5O2SCouleur et forme :SolidMasse moléculaire :483.1729Furazolidone
CAS :Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formule :C8H7N3O5Degré de pureté :99.96%Couleur et forme :Yellow Crystals From Dmf (N N-Dimethylformamide) SolidMasse moléculaire :225.16Thalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.Formule :C23H31ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.97Ac-AAVALLPAVLLALLAP-YVAD-CHO
CAS :Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formule :C97H160N20O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1990.43MEDI-7352
MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.Couleur et forme :Odour LiquidA947
CAS :A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.Formule :C61H76N12O7SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :1121.4HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Formule :C25H33FO3Couleur et forme :SolidMasse moléculaire :400.53EGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Degré de pureté :98%Couleur et forme :Odour SolidFF2039
FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.Formule :C43H56Cl3N5O6Couleur et forme :SolidMasse moléculaire :845.29LH1307
CAS :LH1307 blocks PD-1/PD-L1 interaction, IC50 = 3 nM (HTRF assay), activates Jurkat cells, EC50s: 79 nM (U2OS), 763 nM (CHO).
Formule :C54H58N8O6Couleur et forme :SolidMasse moléculaire :915.108Anti-Mouse PD-1 Antibody (D265A) Antibody (RMP1-14)
Anti-MousePD-1Antibody (D265A) is an antibody inhibitor targeting the PD-1 protein in mice.Couleur et forme :Odour LiquidAMG-7209
CAS :AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.Formule :C37H41Cl2FN2O7SCouleur et forme :SolidMasse moléculaire :747.7Curcumin 5-8
CAS :CUR5-8: potent, oral CUR analog, reduces lipid droplets, boosts autophagy, hinders apoptosis, enhances insulin sensitivity.Formule :C20H21NO4Couleur et forme :SolidMasse moléculaire :339.39Oligomycin B
CAS :Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formule :C45H72O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :805.05Placulumab
CAS :Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Couleur et forme :LiquidXIAP BIR2/BIR2-3 inhibitor-3
CAS :XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].Formule :C86H106N18O16S2Couleur et forme :SolidMasse moléculaire :1712ABBV-167
CAS :ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formule :C46H53ClN7O11PSCouleur et forme :SolidMasse moléculaire :978.45Thymidine 3',5'-disphosphate
CAS :pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formule :C10H16N2O11P2Couleur et forme :SolidMasse moléculaire :402.19PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inDegré de pureté :98%Couleur et forme :Odour SolidMD-222
CAS :MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.Formule :C48H47Cl2FN6O6Couleur et forme :SolidMasse moléculaire :893.84PROTAC Bcl-xL degrader-3
CAS :PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.Formule :C82H105ClF3N11O11S4Couleur et forme :SolidMasse moléculaire :1641.49TopoII/tubulin-IN-1
TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.Formule :C21H18ClN5O3Couleur et forme :SolidMasse moléculaire :423.85Cardanol (C15:1)
CAS :Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Formule :C21H34ODegré de pureté :98.48% - 99.77%Couleur et forme :SolidMasse moléculaire :302.49Ref: TM-TN3594
100mgÀ demander1mg92,00€2mg135,00€5mg259,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg583,00€50mg800,00€AFMK
CAS :AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.Formule :C13H16N2O4Degré de pureté :98.34% - 99.81%Couleur et forme :SolidMasse moléculaire :264.281,2-Naphthoquinone
CAS :1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.Formule :C10H6O2Degré de pureté :98.01%Couleur et forme :Golden Yellow Needles Color On Standing (Ntp 1992)Masse moléculaire :158.15Hematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.26(-)-Rasfonin
CAS :Rasfonin, a fungal metabolite from T. terrophilus, halts mouse splenocyte growth; IC50: 0.7 μg/ml (ConA), 0.5 μg/ml (LPS).Formule :C25H38O6Couleur et forme :SolidMasse moléculaire :434.57TS-24
CAS :TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formule :C20H15NO2Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :301.34PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formule :C14H8Au5B2F8N2Couleur et forme :SolidMasse moléculaire :1348.66PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formule :C80H103Cl2F3N10O11S4Couleur et forme :SolidMasse moléculaire :1636.9Thiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Couleur et forme :Odour SolidMS1943
CAS :MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€
