Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
STM3006
CAS :STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).Formule :C25H27BrN8Degré de pureté :97.16%Couleur et forme :SoildMasse moléculaire :519.44Didocosahexaenoin
CAS :Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formule :C25H40O5Couleur et forme :SolidMasse moléculaire :420.58Antitumor agent-61
CAS :Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.Formule :C54H63FN5O10PCouleur et forme :SolidMasse moléculaire :992.083-Hydroxykynurenine
CAS :3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.Formule :C10H12N2O4Degré de pureté :98.83% - 99.69%Couleur et forme :SolidMasse moléculaire :224.21Nargenicin
CAS :Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.Formule :C28H37NO8Couleur et forme :SolidMasse moléculaire :515.6Thalidomide-PEG4-NH2 hydrochloride
CAS :Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.Formule :C21H28ClN3O8Couleur et forme :SolidMasse moléculaire :485.92Thalidomide-O-C8-NH2 hydrochloride
CAS :Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.Formule :C21H28ClN3O5Couleur et forme :SolidMasse moléculaire :437.92Satratoxin G
CAS :Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.Formule :C29H36O10Couleur et forme :SolidMasse moléculaire :544.597AZD5582 dihydrochloride
CAS :Dimeric Smac mimetic inhibits XIAP, cIAP1/2 (IC50: 15/15/21 nM); binds BIR3 domain; degrades cIAPs; induces apoptosis in cancer cells; shrinks tumors in mice.Formule :C58H80Cl2N8O8Couleur et forme :SolidMasse moléculaire :1088.23Antitumor agent-41
Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities.Formule :C64H109IN2O21Couleur et forme :SolidMasse moléculaire :1369.46Thalidomide-O-amido-PEG2-C2-NH2
CAS :Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.Formule :C21H26N4O8Couleur et forme :SolidMasse moléculaire :462.459LSD1-IN-26
LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.Formule :C27H25Cl2F2N3OCouleur et forme :SolidMasse moléculaire :516.41NecroIr1
NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.Formule :C40H29ClIrN5OCouleur et forme :SolidMasse moléculaire :823.36Peginterferon β-1a
CAS :Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.Couleur et forme :SoliddTAGV-1-NEG TFA
dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].Formule :C70H91F3N6O16SCouleur et forme :SolidMasse moléculaire :1361.56RA-XII
CAS :RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.Formule :C46H58N6O14Couleur et forme :SolidMasse moléculaire :918.998Thalidomide-O-C2-acid
CAS :Thalidomide-O-C2-acid: E3 ligase ligand-linker for PROTAC, with cereblon-derived Thalidomide component.Formule :C16H14N2O7Couleur et forme :SolidMasse moléculaire :346.2916Schisandronic acid
CAS :Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.68Fascaplysin chloride
CAS :Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.Formule :C18H11ClN2OCouleur et forme :SolidMasse moléculaire :306.75Antitumor photosensitizer-3
Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laserFormule :C48H34N4O4Couleur et forme :SolidMasse moléculaire :730.81Bursehernin
CAS :Bursehernin is a useful organic compound for research related to life sciences and the catalog number is T124894.Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.401FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.45605Ilicicolin A
CAS :Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.Formule :C23H31ClO3Couleur et forme :SolidMasse moléculaire :390.95Canfosfamide
CAS :Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formule :C26H40Cl4N5O10PSCouleur et forme :SolidMasse moléculaire :787.47Milademetan tosylate hydrate
CAS :Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.Formule :C37H44Cl2FN5O8SCouleur et forme :SolidMasse moléculaire :808.74Chloranthalactone B
CAS :Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formule :C15H16O3Couleur et forme :SolidMasse moléculaire :244.29RET-IN-4
CAS :RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.Formule :C27H31FN10O2Couleur et forme :SolidMasse moléculaire :546.611Anagrelide hydrochloride monohydrate
CAS :Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.Formule :C10H10Cl3N3O2Couleur et forme :SolidMasse moléculaire :310.56Ganglioside GD3 disodium salt
CAS :Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.Formule :C70H123N3Na2O29Couleur et forme :SolidMasse moléculaire :1516.71ERK-IN-6
ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.Formule :C19H18BrN3O3SCouleur et forme :SolidMasse moléculaire :448.33Thalidomide-5-propargyne-NH2 hydrochloride
CAS :Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.Formule :C16H14ClN3O4Couleur et forme :SolidMasse moléculaire :347.753Anticancer agent 104
Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis [1] .Formule :C34H47F3N2O2S2Couleur et forme :SolidMasse moléculaire :636.87TAS-117
CAS :TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.Formule :C26H24N4O2Couleur et forme :SolidMasse moléculaire :424.49Odoroside A
CAS :Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.Formule :C30H46O7Couleur et forme :SolidMasse moléculaire :518.68Xylopine
CAS :Xylopine: an aporphine alkaloid, cytotoxic to cancer cells, induces oxidative stress, G2/M arrest, and apoptosis.Formule :C18H17NO3Couleur et forme :SolidMasse moléculaire :295.33MRIA9
CAS :MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.Formule :C24H22ClFN6O3Couleur et forme :SolidMasse moléculaire :496.92Bim BH3, Peptide IV
CAS :This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.Formule :C145H222N44O41SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3269.65cis-Clovamide
CAS :cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.Formule :C18H17NO7Couleur et forme :SolidMasse moléculaire :359.334Fludarabine triphosphate
CAS :Fludarabine triphosphate inhibits key enzymes, causing cell death.Formule :C10H15FN5O13P3Couleur et forme :SolidMasse moléculaire :525.17ARI-1
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrantCouleur et forme :Odour SolidTNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47LL-K9-3
CAS :LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM forFormule :C31H49N5O6S3Couleur et forme :SolidMasse moléculaire :683.94BODIPY FL thalidomide
CAS :BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].Formule :C37H43BF2N6O7Couleur et forme :SolidMasse moléculaire :732.58fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.Formule :C25H17N6O8ReCouleur et forme :SolidMasse moléculaire :715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS :Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].Formule :C17H18ClFN4O4Couleur et forme :SolidMasse moléculaire :396.8CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μMFormule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55XM-U-14
XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.Couleur et forme :Odour SolidXIAP BIR2/BIR2-3 inhibitor-1
CAS :XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Formule :C72H96N16O14Couleur et forme :SolidMasse moléculaire :1409.63Azurin p28 peptide
CAS :Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.
Formule :C122H197N31O47S2Couleur et forme :SolidMasse moléculaire :2914.18PD-1/PD-L1-IN-48
PD-1/PD-L1-IN-48 (compound HD10) is an effective inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 3.1 nM. It plays a vital role in cancer research.Couleur et forme :Odour SolidPROTAC NCOA4 degrader-1
PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.Couleur et forme :Odour SolidBMSpep-57
CAS :BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.Formule :C89H126N24O19SCouleur et forme :SolidMasse moléculaire :1868.2Human PD-L1 inhibitor II
CAS :Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.Formule :C103H151N25O30Couleur et forme :SolidMasse moléculaire :2219.486Human PD-L1 inhibitor I
CAS :Human PD-L1 inhibitor I, a peptide, blocks PD-L1/PD-1 interaction with 3.39 μM affinity.Formule :C110H152N26O32Couleur et forme :SolidMasse moléculaire :2350.576RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell migration and induces apoptosis (increasing the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). It reduces mitochondrial membrane potential and activates autophagy (Autophagy) through the PI3K-Akt-mTOR signaling pathway, damaging mitochondria and lysosomes within the cell and causing endoplasmic reticulum stress. RPS6-IN-1 also inhibits the phosphorylation of RPS6. Notably, RPS6-IN-1 is a low systemic toxicity anticancer agent.Couleur et forme :Odour SolidPROTAC CDK4/6 degrader 1
CAS :PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis).Formule :C41H47N11O6Couleur et forme :SolidMasse moléculaire :789.88DAPK Substrate Peptide TFA
DAPK Substrate Peptide TFA is a synthetic peptide that serves as a substrate for the enzyme death-associated protein kinase (DAPK), exhibiting a MichaelisFormule :C72H116F3N25O19Couleur et forme :SolidMasse moléculaire :1692.84TPP-1 TFA
TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.Formule :C109H151F3N34O34S2Couleur et forme :SolidMasse moléculaire :2602.69Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Formule :C51H67F3N12O8SCouleur et forme :SolidMasse moléculaire :1065.21(E/Z)-Eltrombopag 13C4
CAS :(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.Formule :C25H22N4O4Couleur et forme :SolidMasse moléculaire :446.444PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52Antitumor agent-145
CAS :Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].Formule :C44H34IrN5OSCouleur et forme :SolidMasse moléculaire :873.06XIAP BIR2/BIR2-3 inhibitor-3
CAS :XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].Formule :C86H106N18O16S2Couleur et forme :SolidMasse moléculaire :1712GSK-1070916
CAS :GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formule :C30H33N7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :507.63p-MPPF
CAS :p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Formule :C25H27FN4O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :434.51CIGB-300
CAS :CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.Formule :C127H215N53O30S3Couleur et forme :SolidMasse moléculaire :3060.6Ac-Trp-Glu-His-Asp-Aldehyde
CAS :Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formule :C28H33N7O9Couleur et forme :SolidMasse moléculaire :611.6CDK2-IN-45
CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.Formule :C25H16ClN5SCouleur et forme :SolidMasse moléculaire :453.95FAK-IN-25
FAK-IN-25 (4c) is an inhibitor of FAK with an IC50 value of 50.98 nM. It induces apoptosis and causes cell cycle arrest in the G1 phase, making it relevant for cancer research.Formule :C22H13ClN4OS2Couleur et forme :SolidMasse moléculaire :448.95Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride blocks TPL-2 kinase (IC50=28nM) and TNF-α synthesis (IC50=5.7nM) in human blood.Formule :C27H28Cl3FN8Degré de pureté :98.37%Couleur et forme :SoildMasse moléculaire :589.92Ref: TM-T10865L
1mg118,00€5mg227,00€1mL*10mM (DMSO)268,00€10mg359,00€25mg598,00€50mg852,00€100mg1.153,00€TNF-α Antagonist
CAS :TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction withFormule :C58H71N11O15S2Couleur et forme :SolidMasse moléculaire :1226.39PBE-AMF
PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.Couleur et forme :Odour SolidTrilexium
CAS :Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].Formule :C24H23FO6Couleur et forme :SolidMasse moléculaire :426.43Ac-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formule :C27H37ClN4O9Couleur et forme :SolidMasse moléculaire :597.06Tubulin polymerization-IN-67
Tubulin polymerization-IN-67 (Compound 5h) serves as an inhibitor of microtubule protein polymerization at the colchicine binding site, exhibiting an IC50 value of 2.92 μM. It effectively inhibits the proliferation of various cancer cell lines including HT29, A549, U2OS, MG-63, and HeLa, with IC50 values ranging from 0.12 to 4.13 μM. Additionally, Tubulin polymerization-IN-67 induces cell cycle arrest at the G2/M phase and triggers apoptosis in U2OS cells. It also inhibits cell migration in A549 and reduces mitochondrial membrane potential (MMP) while increasing intracellular ROS levels, thereby suppressing angiogenesis in HUVEC cells. Furthermore, this compound demonstrates antitumor activity in mice.Couleur et forme :Odour SolidVinepidine sulfate
CAS :Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Formule :C46H58N4O13SCouleur et forme :SolidMasse moléculaire :907.04MKC-1
CAS :MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Formule :C22H16N4O4Degré de pureté :99.63% - 99.85%Couleur et forme :SolidMasse moléculaire :400.39Ref: TM-T9831
500mgÀ demander1mg54,00€5mg118,00€1mL*10mM (DMSO)127,00€10mg168,00€25mg293,00€50mg423,00€100mg588,00€FR900359
CAS :FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.Formule :C49H75N7O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.16PROTAC GPX4 degrader-4
CAS :PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Formule :C43H58N2O13Couleur et forme :SolidMasse moléculaire :810.93YX-02-030
CAS :YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.
Formule :C66H85Cl2N9O10SMasse moléculaire :1267.41CBI1
CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.Formule :C15H19BrN4OS2Masse moléculaire :415.37Antimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.Formule :C25H34ClN3OMasse moléculaire :427.23904Ru-Poma
Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.Formule :C89H75Cl2N11O11Ru·7H2O155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Formule :C79H120FN19O23SMasse moléculaire :1753.85092RIP1 kinase inhibitor 9
RIP1 kinase inhibitor 9 (compound SY-1) is a selective inhibitor of RIP kinase. It effectively reduces central inflammatory responses caused by seizures. RIP1 kinase inhibitor 9 also obstructs Z-VAD-FMK-induced necroptosis in HT-29 cells, with an EC50 of 7.04 nM.Formule :C25H21N3O3Masse moléculaire :411.15829PROTAC PD-L1 degrader-1
PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.MX106-4C
MX106-4C is a survivin inhibitor that selectively targets ABCB1-positive colorectal cancer cells. It can work synergistically with Doxorubicin for enhanced anticancer effects or restore Doxorubicin sensitivity in drug-resistant ABCB1 cells.Formule :C23H25BrN2O2Masse moléculaire :440.10994ECDD-S16
ECDD-S16 is a potent inhibitor of pyroptosis. It effectively suppresses pyroptosis in Raw264.7 cells activated by surface and endosomal TLR ligands.Formule :C35H31FO12Masse moléculaire :662.17995Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formule :C24H26ClN5O5Masse moléculaire :499.16225PRDX1-IN-2
PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.HDAC6-IN-28
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.Formule :C23H16FN3O2Masse moléculaire :385.12265LC-1-40
LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). In mouse models, LC-1-40 selectively inhibits tumor growth induced by MYCN and induces nucleotide damage and apoptosis (cell death) in MYCN-associated tumors. It is applicable for cancer research.Formule :C49H48N8O6Masse moléculaire :844.36968NCA029
NCA029 is a potent activator of human caseinolytic protease P (HsClpP) with an EC50 of 0.15 μM. It targets HsClpPP and triggers an ATF3-dependent integrated stress response, resulting in the death of colon cancer cells.Formule :C22H20F3N3OMasse moléculaire :399.15585RIPK2-IN-4
RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.Formule :C16H10N6S2Masse moléculaire :350.04084MALT1-IN-13
MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.Formule :C20H15BrClN3O3S2Masse moléculaire :522.94267Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formule :C21H28ClN5O5Masse moléculaire :465.1779Camrelizumab
CAS :Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up
Degré de pureté :95% - 98.6%Couleur et forme :LiquidMasse moléculaire :143.7 kDaSB 699551
CAS :SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formule :C34H45N3ODegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :511.74Ref: TM-T23325L
1mg190,00€5mg471,00€10mg662,00€25mg1.036,00€50mg1.429,00€100mg1.821,00€200mg2.489,00€Feladilimab
CAS :Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.
Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDaPacmilimab
CAS :Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Degré de pureté :98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :153.3 kDa
