Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
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6222 produits trouvés pour "Apoptose"
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MD-265
CAS :MD-265 is a PROTAC degrader that targets and degrades MDM2, leading to the activation of p53 in cancer cells with wild-type p53. MD-265 achieves complete tumor regression and enhances long-term survival in leukemic mice.Formule :C50H51Cl2FN6O6Masse moléculaire :921.88ATPase-IN-3
CAS :ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3Vonlerizumab
Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.22 kDaDesmethyl-WEHI-345 analog
CAS :Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.Formule :C22H23N7OCouleur et forme :SolidMasse moléculaire :401.474Os30
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK andDegré de pureté :98%Couleur et forme :Odour SolidPROTAC FLT-3 degrader 4
CAS :PROTACFLT-3degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that efficiently induces the degradation of FLT3-ITD via the ubiquitin-proteasome system. It demonstrates high selectivity for FLT3-ITD mutant acute myeloid leukemia (AML) cells. [Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor].Formule :C39H41FN8O6Couleur et forme :SolidMasse moléculaire :736.79PROTAC ERα Degrader-9
PROTACERα Degrader-9 (Compound 18c) is a dual-targeting PROTAC degrader designed to diminish estrogen receptor α (ERα) and aromatase (ARO). It demonstrates a Ki of 0.25 μM for ERα binding and an IC50 of 4.6 μM for ARO inhibition. This compound curbs proliferation in wild-type MCF-7 cells (IC50=0.54 μM) and ERα mutant variants MCF-7EGFR (IC50=0.075 μM), MCF-7D538G (IC50=0.31 μM), and MCF-7Y537S (IC50=2.3 μM), while also downregulating ERS1 and MYC expression. PROTACERα Degrader-9 arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 cells, exhibiting antitumor efficacy in mouse models.Formule :C58H64F3N7O9S2Masse moléculaire :1123.415915-Acetoxyscirpenol
CAS :15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.Formule :C17H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.373Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75Ac-Pro-Gly-Pro-OH
CAS :Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.Formule :C14H21N3O5Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :311.33Eriosematin
CAS :Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.Formule :C19H20O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.36Thalidomide-O-PEG4-amine
CAS :Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Formule :C23H31N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.51Antitumor photosensitizer-5
Antitumor photosensitizer-5 (Ru2) is an effective photosensitizing agent that targets tumor mitochondria, with an IC50 of 0.3 μM for phototoxicity against A549 cells. Upon exposure to 460 nm light, it induces reactive oxygen species production and NADH depletion, leading to mitochondrial damage, caspase-3 activation, apoptosis induction, and inhibition of cell migration. Antitumor photosensitizer-5 shows potential for preventing malignant tumor growth and may be applicable in photodynamic therapy.Formule :C53H43F12N11O2P2RuSMasse moléculaire :1289.1649PTD-p65-P1 Peptide TFA
Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.Formule :C170H276F3N57O46SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3943.52Tubulin inhibitor 34
Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.Formule :C21H22N4O3SCouleur et forme :SolidMasse moléculaire :410.49Aluminum phthalocyanine disulfonate disodium
CAS :AlPcS2 disodium: a photosensitizer for cancer therapies, isomeric mix, and used as a dye, reagent, and luminescent agent.Formule :C32H14AlClN8Na2O6S2Couleur et forme :SolidMasse moléculaire :779.05Polyphyllin G
CAS :Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.21Tomatine hydrochloride
CAS :Tomatine hydrochloride halts fungi/bacteria growth, is extracted from wild tomato leaves, and precipitates steroids.Formule :C50H84ClNO21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1070.65Thiocolchicine
CAS :Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Formule :C22H25NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :415.5JPS014 TFA
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDACFormule :C48H60F3N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :968.09FA4-Cu
FA4-Cu is a compound formed from the effective pancreatic cancer inhibitor FA4 and Cu(II), which can induce apoptosis by triggering ER and mitochondrial stress.Formule :C27H33Cl2CuN5O2SCouleur et forme :SolidMasse moléculaire :626.1HL435
HL435 is a heterobifunctional molecule that degrades BRD4 by linking with JQ1, with DC50 values of 11.9 nM and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. It inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1, and A549 cells, arrests the cell cycle, and induces apoptosis. Additionally, HL435 exhibits antitumor activity in mouse models.Formule :C47H48BrClF3N7O7SMasse moléculaire :1025.21599ZC0109
ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.Formule :C22H20BrFN8O4SCouleur et forme :SolidMasse moléculaire :591.41Suc-Ala-Leu-Pro-Phe-pNA
CAS :Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], showcases the intricate interactions necessary for specificFormule :C33H42N6O9Couleur et forme :SolidMasse moléculaire :666.72Conglobatin
CAS :Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62Anticancer agent 137
Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5JNK-1-IN-3
CAS :JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36CDK9-Cyclin T1 PPI-IN-1
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBCDegré de pureté :98%Couleur et forme :Odour SolidBRD4 Inhibitor-39
BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.Formule :C24H19BrFN9Couleur et forme :SolidMasse moléculaire :532.37Fluorene
CAS :Compound PDK0379, with CAS No. 86-73-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0379 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C13H10Masse moléculaire :166.21DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential toFormule :C32H22FN5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.6122-SLF
22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).ZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.Formule :C54H67ClN8O9SMasse moléculaire :1039.69PH14
PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.Degré de pureté :98%Couleur et forme :Odour SolidTrehalose-6,6'-dibehenate
CAS :Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formule :C56H106O13Couleur et forme :SolidMasse moléculaire :987.43Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Formule :C31H23BrN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.51Emavusertib Phosphate
CAS :Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.Formule :C24H28N7O9PMasse moléculaire :589.49Disitertide diammonium
Disitertide (P144) is a TGF-β1 receptor blocker, PI3K inhibitor, and apoptosis inducer.Formule :C68H115N19O22S2Couleur et forme :SolidMasse moléculaire :1614.88PDL1 degrader-2
PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.Formule :C45H48N8O5Couleur et forme :SolidMasse moléculaire :780.91EP5-1
EP5-1 is an antimicrobial peptide with antibacterial, antifungal, antitumor, and antiviral properties, notably inducing apoptosis in cancer cells andFormule :C16H27N5O8SCouleur et forme :SolidMasse moléculaire :449.48Emavusertib Tosylate
CAS :Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.Formule :C31H33N7O8SMasse moléculaire :663.7PARP-1/2-IN-2
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repairFormule :C25H23IN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.41Amiloride hydrochloride dihydrate
CAS :Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.Formule :C6H8ClN7O·HCl·2H2ODegré de pureté :99.07% - >99.99%Couleur et forme :SolidMasse moléculaire :302.12AS-99 TFA
AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.Couleur et forme :SolidThalidomide-O-amido-PEG4-azide
CAS :Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56CRA-026440 hydrochloride
CAS :CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.Formule :C23H25ClN4O4Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :456.92Ref: TM-T10883L
1mL*10mM (DMSO)47,00€1mg115,00€5mg274,00€10mg432,00€25mg735,00€50mg1.159,00€100mg1.568,00€NFh-NMe-2
NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.
Formule :C32H33IN2OCouleur et forme :SolidMasse moléculaire :588.5223MB-PP1
CAS :3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formule :C17H21N5Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :295.38Ref: TM-T21678
500mgÀ demander5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg166,00€50mg255,00€100mg374,00€MDM2 ligand 4
MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].Formule :C31H33Cl2FN2O4Couleur et forme :SolidMasse moléculaire :587.509VEGFR-2-IN-36
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstratedFormule :C24H23N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.48Cannflavin A
CAS :Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation andFormule :C26H28O6Couleur et forme :SolidMasse moléculaire :436.5SL-01
CAS :SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.Formule :C18H18ClNO3Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :331.79Hexapeptide-11
CAS :Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formule :C36H48N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :676.8KTX-582
CAS :KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93EGFR-IN-143
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.Formule :C20H21ClN6O3Couleur et forme :SolidMasse moléculaire :428.872PROTAC LZK-IN-1
CAS :PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formule :C51H64F2N10O5SCouleur et forme :SolidMasse moléculaire :967.18TRF2-IN-1
TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.Formule :C18H17BrO4Couleur et forme :SolidMasse moléculaire :377.229Thalidomide-O-C7-NH2
CAS :Thalidomide-O-C7-NH2 is a cereblon ligand-linked E3 ligase for PROTAC use.Formule :C20H25N3O5Couleur et forme :SolidMasse moléculaire :387.436P1D-34
P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).Couleur et forme :Odour SolidSTAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.Couleur et forme :Odour Solidp53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS :p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.Formule :C40H49Cl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.75Δ8-Tetrahydrocannabinoquinone
CAS :Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.Formule :C21H28O3Couleur et forme :SolidMasse moléculaire :328.45TS-IN-5
TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.Formule :C16H17N5OSCouleur et forme :SolidMasse moléculaire :327.404CALP1
CAS :Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.Formule :C40H75N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :842.09L 683519
CAS :L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein.Formule :C43H67NO12Couleur et forme :SolidMasse moléculaire :789.99C8 D-threo Ceramide (d18:1/8:0)
CAS :C8 D-threo Ceramide, a potent bioactive sphingolipid, is cytotoxic with IC50=17µM, enhances DNA fragmentation and pore formation, and activates CAPK.Formule :C26H51NO3Couleur et forme :SolidMasse moléculaire :425.698PK7088
CAS :PK7088, a pyrazole-based peptide, selectively reactivates mutant p53 to a conformation with wild-type characteristics, demonstrating anticancer activity inFormule :C14H13N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :223.27Tizanidine
CAS :Tizanidine, an α2-adrenergic receptor agonist, suppresses the release of neurotransmitters from central nervous system (CNS) noradrenergic neurons.Formule :C9H8ClN5SDegré de pureté :99.11%Couleur et forme :White SolidMasse moléculaire :253.71JGB1741
CAS :JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.
Formule :C27H24N2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :440.56Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS :Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly
Formule :C25H34N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.566Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS :Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.Formule :C28H39F3N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :688.662ZS3-046
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.Formule :C49H57N9O7Couleur et forme :SolidMasse moléculaire :883.4381A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormule :C27H28N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.55HDAC-IN-84
HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.Formule :C17H21N3O5SCouleur et forme :SolidMasse moléculaire :379.431F1324
F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.Formule :C83H121N21O20SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1765.04GR-1405
GR-1405 is a human monoclonal antibody (mAb) that targets B7-H1/PD-L1/CD274. It enhances the antitumor immune response mediated by cytotoxic T lymphocytes (CTL) against tumor cells expressing PD-L1. GR-1405 is applicable in research related to lymphomas and solid tumors.Couleur et forme :Odour LiquidThalidomide-O-amido-C3-PEG3-C1-NH2
CAS :Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.Formule :C27H35F3N4O11Couleur et forme :SolidMasse moléculaire :648.589Mcl-1 inhibitor 3
CAS :Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activateFormule :C40H52ClF2N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.397-epi-Isogarcinol
CAS :7-epi-Isogarcinol, a PPAP, hinders STAT3 to induce apoptosis and curbs cell migration with moderate antiproliferative effects.Formule :C38H50O6Couleur et forme :SolidMasse moléculaire :602.8ACP-0052
CAS :ACP-0052(SL-052, ACP-SL-052) is a photosensitizer based on hypoclintin that may be used in the treatment of prostate cancer.Formule :C35H32N2O7Couleur et forme :SolidMasse moléculaire :592.648c-MYC/BCL2 ligand 1 iodide
c-MYC/BCL2 ligand 1 iodide is a dual-target ligand that specifically interacts with the G-quadruplex (G4) regions of the c-MYC and Bcl-2 promoters, exhibiting Kd values of 0.90 μM for c-MYCG4 and 0.56 μM for Bcl-2G4. It works by binding to these G4-forming sequences to inhibit transcription of the c-MYC and Bcl-2 genes, leading to reduced protein expression. This compound effectively suppresses MCF-7 cell proliferation and migration, induces G1 phase cell cycle arrest, and triggers apoptosis. Additionally, it significantly hampers tumor growth in the 4T1 homogenous model with negligible toxicity. c-MYC/BCL2 ligand 1 iodide is applicable in breast cancer research.Couleur et forme :Odour SolidPROTAC BRD4 Degrader-33
PROTACBRD4 Degrader-33 is an enzyme-activated, click-responsive BRD4 PROTAC degrader designed with effective tumor microenvironment responsiveness. This compound exhibits exceptional penetration into tumor tissues and effectively inhibits PD-L1 protein expression. In the 4T1 tumor mouse model, PROTACBRD4 Degrader-33 demonstrates potent antitumor immunomodulatory activity.Couleur et forme :Odour SolidGDC-0152-acetamide
GDC-0152-acetamide is a pan-antagonist of apoptosis inhibiting proteins (IAPs). It induces the autoubiquitination and subsequent degradation of cIAP1/2, activates the non-canonical NF-κB pathway, and promotes the secretion of TNF-α, leading to apoptosis in tumor cells. GDC-0152-acetamide holds potential for research in ERα-positive breast cancer.Couleur et forme :Odour SolidCSF1R-IN-26
CAS :CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Formule :C20H22ClN5O3Couleur et forme :SoildMasse moléculaire :415.87FLT3/IRAK4-IN-1
FLT3/IRAK4-IN-1 is a selective inhibitor of FLT3 and IRAK4, exhibiting significant activity against FLT3-WT (IC50= 1.95 nM), FLT3-D835Y (IC50= 3.22 nM), and IRAK4 (IC50= 53.72 nM). It demonstrates low cytotoxicity towards normal bone marrow cells, effectively promotes apoptosis, and has potential to overcome resistance. FLT3/IRAK4-IN-1 can be utilized in studies of acute myeloid leukemia (AML).Couleur et forme :Odour SolidThalidomide-O-amido-C8-NH2
CAS :Thalidomide-O-amido-C8-NH2 is a thalidomide-based ligand-linker for PROTAC synthesis.Formule :C23H30N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51PRLX-93936 HCL
CAS :PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formule :C21H26Cl2N4O2Degré de pureté :98.4% - 99.94%Couleur et forme :SolidMasse moléculaire :437.37Poly(I:C):Kanamycin (1:1) sodium
Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.
Degré de pureté :99%Couleur et forme :SolidEGFR-IN-153
EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.Couleur et forme :Odour SolidDL-Sulforaphane N-acetyl-L-cysteine
CAS :DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formule :C11H20N2O4S3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :340.48(±)-Indoxacarb
CAS :(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.
Formule :C22H17ClF3N3O7Couleur et forme :SolidMasse moléculaire :527.83α-Tubulin polymerization-IN-1
α-Tubulin polymerization-IN-1 (Compound 8l) functions as an inhibitor of α-tubulin polymerization. This compound modulates the NRF2/KEAP-1 signaling pathway and induces ROS production in PC-3 cells, leading to apoptosis. It inhibits the proliferation of PC-3 cells with a GI50 of 0.17 µM, causing cell cycle arrest in the G2/M phase. Additionally, α-Tubulin polymerization-IN-1 demonstrates antitumor activity in mouse models.Couleur et forme :Odour SolidPROTAC AR-NTD degrader 1
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminalFormule :C41H47ClN6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.3DCZ3301
CAS :DCZ3301 is a novel aryl-guanidino inhibitor.Formule :C20H16ClF3N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :464.83Ref: TM-T9658
1mg73,00€5mg149,00€1mL*10mM (DMSO)166,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€RD-23
CAS :RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.Formule :C52H56N12O4Couleur et forme :SolidMasse moléculaire :913.079VCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Couleur et forme :Odour SolidBTK ligand 12
CAS :BTK ligand 12 is a PROTAC target protein ligand serving as an active control for NRX-0492 (a BTK degradator).Formule :C25H34N8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :478.59FeTPPS
CAS :FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.Formule :C44H28ClFeN4O12S4Couleur et forme :SolidMasse moléculaire :1024.27Tubulin polymerization-IN-79
Tubulin polymerization-IN-79 (Compound C20) acts as an inhibitor of microtubule polymerization. It exhibits significant antiproliferative activity against esophageal cancer cells, such as KYSE450 (IC50=0.36 μM) and EC-109 (IC50=0.63 μM). In esophageal cancer cells, Tubulin polymerization-IN-79 occupies the colchicine binding site, disrupting the microtubule network's integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP, and inducing G2/M phase arrest and apoptosis. This compound shows promise for esophageal cancer research.Couleur et forme :Odour SolidThalidomide-5-PEG2-Cl
CAS :Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.Formule :C17H17ClN2O6Couleur et forme :SolidMasse moléculaire :380.78
