Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
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Thalidomide-O-C8-NH2
CAS :Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.463UM4118
CAS :UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.27Zalypsis
CAS :Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.Formule :C37H38F3N3O8Couleur et forme :SolidMasse moléculaire :709.71Tubulin/MMP-IN-3
Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.Formule :C38H41N2O12PCouleur et forme :SolidMasse moléculaire :748.712PROTAC Bcl2 degrader-1
CAS :PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formule :C45H45BrN6O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.84HG-7-85-01
CAS :HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formule :C31H31F3N6O2SDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :608.68GPLGIAGQ
CAS :GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Formule :C31H53N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :711.81EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormule :C20H21N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.49(-)-Mcl-1 inhibitor 21
CAS :(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622Anticancer agent 102
CAS :Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formule :C20H19F6N3OCouleur et forme :SolidMasse moléculaire :431.37Cyanoacetamide
CAS :Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1Formule :C3H4N2ODegré de pureté :97.04%Couleur et forme :Needles From Alcohol White To Light Cream Crystalline PowderMasse moléculaire :84.08HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formule :C23H23N5O3Couleur et forme :SolidMasse moléculaire :417.46Apoptolidin
CAS :Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.Formule :C58H96O21Couleur et forme :SolidMasse moléculaire :1129.385Z-VDVA-(DL-Asp)-FMK
CAS :Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formule :C32H46FN5O11Couleur et forme :SolidMasse moléculaire :695.742Thalidomide-O-amido-C6-NH2
CAS :Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.Formule :C21H26N4O6Couleur et forme :SolidMasse moléculaire :430.45Enpp/Carbonic anhydrase-IN-1
CAS :Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Formule :C23H25NO4SDegré de pureté :99.96%Couleur et forme :SoildMasse moléculaire :411.51Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterated form of quercetin hydrate, known as a flavonoid that stimulates recombinant SIRT1 and acts as a PI3K inhibitor. It has IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM for PI3Kγ, PI3K δ, and PI3Kβ, respectively.Couleur et forme :Odour SolidGanoderic acid Mk
CAS :GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.Formule :C34H50O7Couleur et forme :SolidMasse moléculaire :570.76YW-N-7 TFA
YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.Formule :C58H63F3N12O9Couleur et forme :SolidMasse moléculaire :1129.19Vincristine-d3 sulfate
CAS :Vincristine-d3 (sulfate) is the deuterated form of Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid that inhibits the formation of microtubules in the mitotic spindle, resulting in the arrest of dividing cells at metaphase. It binds to microtubules with a Ki of 85 nM.Formule :C46H58N4O14SCouleur et forme :SolidMasse moléculaire :926.06Adenosine-13C10
CAS :Adenosine-13C10 (Adenine riboside-13C10; D-Adenosine-13C10) is the 13C-labeled form of adenosine. Adenosine (Adenine riboside) is a widely occurring endogenous secretion that operates through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects nearly every aspect of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.Formule :C10H13N5O4Couleur et forme :SolidMasse moléculaire :277.17Ferumoxytol
CAS :Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.Couleur et forme :SolidGemcitabine-13C,15N2 hydrochloride
CAS :Gemcitabine-13C,15N2(hydrochloride) is the 13C and 15N labeled version of Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) functions as a nucleoside antimetabolite analog and antineoplastic agent. It interrupts DNA synthesis and repair, which leads to autophagy and apoptosis in cells.Formule :C9H12ClF2N3O4Couleur et forme :SolidMasse moléculaire :302.64Lenalidomide-d5
CAS :Lenalidomide-d5 is a deuterated form of Lenalidomide. Lenalidomide (CC-5013) is a derivative of Thalidomide and acts as an orally active immunomodulator in a molecular glue manner. It serves as a ligand for the ubiquitin E3 ligase cereblon (CRBN). Through the CRBN-CRL4 ubiquitin ligase complex, Lenalidomide selectively ubiquitinates and degrades the lymphocyte transcription factors IKZF1 and IKZF3. It effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and induces T cells to release interleukin-2 (IL-2).Formule :C13H13N3O3Couleur et forme :SolidMasse moléculaire :264.29Simvastatin-d3
CAS :Simvastatin-d3 is the deuterated form of Simvastatin. Simvastatin (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).Formule :C25H38O5Couleur et forme :SolidMasse moléculaire :421.59(R,R)-S63845
(R,R)-S63845 is the isomer of S63845 and serves as a control compound in experiments. S63845 is a potent and selective inhibitor of myeloid cell leukemia 1 (MCL1), binding to human MCL1 with a dissociation constant (Kd) of 0.19 nM.Couleur et forme :Odour SolidPROTAC RIPK degrader-6
CAS :PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linkerFormule :C43H48N6O11S2Couleur et forme :SolidMasse moléculaire :889.01Rosamultic acid
Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.Formule :C30H46O5Couleur et forme :SolidMasse moléculaire :486.693Adenosine-d2
CAS :Adenosine-d2 is the deuterated analog of Adenosine. Adenosine (Adenine riboside) is a widely found endogenous compound, acting through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.Formule :C10H13N5O4Couleur et forme :SolidMasse moléculaire :269.25JST-TfR09
JST-TfR09 (PPMX-T003) is a human monoclonal antibody (mAb) targeting CD71. It reduces ferritin levels in ATLL cell lines to induce ferroptosis, increases the production of ferrous ions and reactive oxygen species (ROS), and induces lipid peroxidation through malondialdehyde. JST-TfR09 is applicable in leukemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control.Couleur et forme :Odour LiquidHematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.265-Fluorouracil-15N2
CAS :5-Fluorouracil-15N2 is a nitrogen-15 labeled form of 5-Fluorouracil (5-FU), a uracil analog (nucleoside antimetabolite/analog) and potent antitumor agent. It hampers pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool, inducing apoptosis, acting as a chemotherapeutic sensitizer, inhibiting HIV, and damaging exosome-specific rRNA.Formule :C4H3FN2O2Couleur et forme :SolidMasse moléculaire :132.06PROTAC Bcl-xL degrader-3
CAS :PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.Formule :C82H105ClF3N11O11S4Couleur et forme :SolidMasse moléculaire :1641.49MD-222
CAS :MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.Formule :C48H47Cl2FN6O6Couleur et forme :SolidMasse moléculaire :893.84Propylparaben-d7
CAS :Propylparaben-d7 (Propyl parahydroxybenzoate-d7) is a deuterium-labeled form of Propylparaben. This compound serves as an antimicrobial preservative and is naturally produced by plants and bacteria. Propylparaben is extensively utilized in cosmetics, pharmaceuticals, and food products. It disrupts follicular development and steroidogenesis by altering the cell cycle, apoptosis, and steroidogenic pathways. Additionally, Propylparaben reduces sperm count and motility in rats.Formule :C10H12O3Couleur et forme :SolidMasse moléculaire :187.24Curcumin 5-8
CAS :CUR5-8: potent, oral CUR analog, reduces lipid droplets, boosts autophagy, hinders apoptosis, enhances insulin sensitivity.Formule :C20H21NO4Couleur et forme :SolidMasse moléculaire :339.39Ac-Pro-Gly-Pro-OH
CAS :Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.Formule :C14H21N3O5Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :311.33Garivulimab
CAS :Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Couleur et forme :LiquidLH1307
CAS :LH1307 blocks PD-1/PD-L1 interaction, IC50 = 3 nM (HTRF assay), activates Jurkat cells, EC50s: 79 nM (U2OS), 763 nM (CHO).
Formule :C54H58N8O6Couleur et forme :SolidMasse moléculaire :915.108FF2039
FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.Formule :C43H56Cl3N5O6Couleur et forme :SolidMasse moléculaire :845.29Tebentafusp
CAS :Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Degré de pureté :97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :76.14 kDaARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99.38%Couleur et forme :SoildMasse moléculaire :568.68(Free base）UBX1325
CAS :UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.
Formule :C53H59ClF3N6O10PS3Couleur et forme :SolidMasse moléculaire :1159.69Valproic acid sodium salt
CAS :Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formule :C8H15NaO2Degré de pureté :98% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.2PROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formule :C46H48N10O6Couleur et forme :SolidMasse moléculaire :836.94Bak BH3
Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.Formule :C72H125N25O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1724.9CAY10678
CAS :CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormule :C23H34N4ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :382.548-Aminoadenosine
CAS :8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formule :C10H14N6O4Couleur et forme :SolidMasse moléculaire :282.26BCMA72-80
CAS :BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.Formule :C59H97N13O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1196.55Boc-AEVD-CHO
CAS :Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].Formule :C22H36N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.54Spiroplatin
CAS :Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Formule :C8H18N2O4PtSDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :433.39Linsidomine
CAS :Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.Formule :C6H10N4O2Couleur et forme :Solid Off-WhiteMasse moléculaire :170.17BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Couleur et forme :Odour LiquidAnticancer agent 130
Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].Formule :C38H46FN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :671.8S-Adenosyl-L-methionine
CAS :S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Thalidomide-NH-C8-NH2
CAS :Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.Formule :C21H28N4O4Couleur et forme :SolidMasse moléculaire :400.479GB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Couleur et forme :Odour LiquidAnti-inflammatory agent 42
CAS :Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.Formule :C20H12N2OSDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :328.39Oxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26GSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Couleur et forme :Odour LiquidEGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Degré de pureté :98%Couleur et forme :Odour SolidABBV-167
CAS :ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formule :C46H53ClN7O11PSCouleur et forme :SolidMasse moléculaire :978.45Moflerafusp alfa
CAS :Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.Couleur et forme :LiquidBesufetamig
CAS :Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Couleur et forme :LiquidBK60106
BK60106 is a selective and direct inhibitor of the transmembrane protein CD99, which causes cell death in Ewing Sarcoma cells.Formule :C15H15FN6O3Degré de pureté :99.30% - >99.99%Couleur et forme :SolidMasse moléculaire :346.32Enniatin A1
CAS :Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formule :C35H61N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.885Placulumab
CAS :Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Couleur et forme :LiquidTNF/IFNγ-IN-1
CAS :TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formule :C20H23N3O6Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :401.41Baminercept
CAS :Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Degré de pureté :95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :46.88 kDaPAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formule :C14H8Au5B2F8N2Couleur et forme :SolidMasse moléculaire :1348.66Polyphyllin G
CAS :Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formule :C51H84O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1049.215-LOX-IN-2
CAS :5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.Formule :C17H16O4Degré de pureté :98.74%Couleur et forme :SoildMasse moléculaire :284.31Dazodalibep
CAS :Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Couleur et forme :LiquidPERK-IN-6
CAS :PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formule :C23H22N6ODegré de pureté :99.62% - 99.92%Couleur et forme :SolidMasse moléculaire :398.46Thalidomide-NH-PEG7
Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.Formule :C27H39N3O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.61Lodapolimab
CAS :Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Couleur et forme :LiquidAsunercept
CAS :Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Couleur et forme :LiquidAnti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) represents a chimeric antibody of mouse IgG2b, κ type, specifically targeting human PD-L1/B7-H1. The recommended isotype control for this antibody is Mouse IgG2b kappa, Isotype Control.Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting and inhibiting mouse PD-L1/B7-H1.Couleur et forme :Odour LiquidAtibuclimab
CAS :Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.28 kDaEldecalcitol
CAS :Eldecalcitol, orally active vitamin D analog, boosts bone density and treats osteoporosis.Formule :C30H50O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.72Izuralimab
CAS :Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].Couleur et forme :LiquidLIB3S0280
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).Couleur et forme :Odour SolidPamrevlumab
CAS :FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.Degré de pureté :100% (SEC-HPLC) - >95.0% (SDS-PAGE)Couleur et forme :LiquidMasse moléculaire :150 kDaEfaprinermin alfa
CAS :Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].Couleur et forme :LiquidThalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS :Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.Formule :C17H19ClN4O6Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :410.81Apoptosis inducer 33
Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.Formule :C16H13N3O2Couleur et forme :SolidMasse moléculaire :279.293Latikafusp
CAS :Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.Degré de pureté :97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :159.55 kDaJAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Formule :C28H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.74-Epianhydrotetracycline hydrochloride
CAS :EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.Formule :C22H23ClN2O7Couleur et forme :SolidMasse moléculaire :462.88Lenercept
CAS :Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].Couleur et forme :LiquidManelimab
CAS :Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .Couleur et forme :LiquidReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formule :C110H210N52O26Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :2677.18Onercept
CAS :Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].Couleur et forme :LiquidZ-Asp-CH2-DCB
CAS :Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.Formule :C20H17Cl2NO7Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :454.26Finotonlimab
Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].Couleur et forme :Odour Liquid2,2'-Dihydroxy chalcone
CAS :2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.Formule :C15H12O3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :240.25PROTAC GPX4 degrader-1
CAS :PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080Formule :C50H57ClN10O10Couleur et forme :SolidMasse moléculaire :993.5Anti-Mouse CD44 Antibody (IM7)
Anti-Mouse CD44 Antibody (IM7) is a monoclonal antibody targeting CD44 in mice.Degré de pureté :99%Couleur et forme :Odour LiquidMasse moléculaire :150 kDaPROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.Formule :C68H80N8O14S3Couleur et forme :SolidMasse moléculaire :1329.6
