Apoptose

Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride: sensitizing, induces HepG2/SK-Hep1 apoptosis, inhibits PP2A. IC50: HepG2=62μM, SK-Hep1=151μM.

LNnT is a metabolite that reduces IL-8, has anti-inflammatory effects, and aids in wound healing.

Vitamin E succinate (D-alpha-Tocopherol Succinate) is an antioxidant tocopherol with antitumor activity that induces apoptosis.

Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.

Galantamin-d6 is a deuterated compound of Galantamin.

Devazepide is a competitive, selective, orally available non-peptide CCK1 receptor antagonist that inhibits proliferation, induce apoptosis.

BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2.

Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a

Batabulin sodium, an antitumor compound, disrupts microtubules, alters cell shape, halts cell cycle, and induces apoptosis.

Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.

Cl-amidine TFA: oral PAD inhibitor, induces cancer cell apoptosis, IC50s: PAD1 - 0.8μM, PAD3 - 6.2μM, PAD4 - 5.9μM.

GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.

COX-2 expression inhibitor

ML291 triggers UPR, causing apoptosis in solid cancers by activating PERK/eIF2a/CHOP pathway and reducing leukemia cells.

Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α) and also inhibits CDK7 (TFIIH) and CDK9 (P-TEFb). It induces apoptosis in leukemia cells, exhibiting substantial anti-leukemic effects.

Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.

Traumatic Acid aids wound healing in plants by stimulating cell division to create a callus.

SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit.

Metronidazole-d4 is a deuterium labeled compound isotopic tracing.Metronidazole is an antibiotic and antiprotozoal oral and BBB penetration anaerobic bacteria.

IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.

Isoscabertopin has anticancer activity.

Tegaserod is a 5-HT4R agonist and 5-HT2B receptor antagonist with antitumor activity used in the treatment of irritable bowel syndrome (IBS).

RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].

6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.

Thalidomide-based cereblon ligand linked to PEG-C2-NH2 for use in PROTAC E3 ligase conjugates.

RKI 1447 dihydrochloride: selective ROCK inhibitor, inhibits colorectal cancer growth, promotes apoptosis (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM).

Furazolidone (Standard) is the standard substance of Furazolidone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,

Diphenyl disulfide fights breast cancer by inducing cell death and stopping growth.

Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.

TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in MCF.

Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2

YZ129, an HSP90-calcineurin-NFAT inhibitor with 820 nM IC50, halts GBM growth, arrests G2/M phase, and induces apoptosis.

Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity and induces apoptosis.

TZ9 is a Rad6 inhibitor with anticancer activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.

Thalidomide-5-CH2-NH2 (HCl) recruits CRBN protein, used to create PROTACs via a linker.

4-Vinylcyclohexene Dioxide. Affordable Excellence: Reliable Quality You Can Trust

Niacinamide ascorbate is a vitamin complex that combines niacinamide (vitamin B3) and ascorbic acid (vitamin C). This compound is known to reduce the risks associated with exposure to ionizing radiation, including radiation-induced acute leukemia, breast cancer, thyroid cancer, and other somatic and genetic mutations.

Terfenadine (Standard) is the standard substance of Terfenadine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.

PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits the growth of breast cancer cells.

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.

CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.

Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.

Phenoxyethanol (Standard) is the standard substance of Phenoxyethanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

Compound PDK0035, with CAS No. 119-65-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0035 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).

Sildenafil-d8 is a deuterated compound of Sildenafil. Sildenafil has a CAS number of 139755-83-2. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).

Compound Fr16683 is a natural product for research related to life sciences. The catalog number is Fr16683 and the CAS number is 699-83-2.

5-NIdR is a Nucleoside Derivative - Indole nucleoside.

Teneligliptin hydrobromide hydrate: potent, long-lasting DPP-4 inhibitor with ~1 nM IC50.

KPT-6566 is a covalent PIN1 inhibitor that selectively targets cancer cells by a dual mechanism of action.

Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.

Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.

AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.

TDE is an organochlorine insecticide with slightly irritating to the skin.

Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.

MM-401 (TFA), an MLL1 H3K4 methylation inhibitor (IC50 = 0.32 µM), blocks MLL1-WDR5, causing cell cycle arrest and apoptosis, for MLL leukemia studies.

Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.

Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.

Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in

trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).

Bucladesine calcium: PDE inhibitor, boosts cAMP, activates PKA.

Melrilimab (GSK 3772847) is an IgG antibody targeting IL-33R with high affinity for IL1RL1/ST2/DER4/FIT-1 and can be used in asthma research.

Busulfan-d8 (Sulphabutin-d8) is the 2H-labeled Busulfan. Busulfan is an anticancer agent with immunosuppressive and myeloablative chemotherapy activities.

Methopterin shows the activation and bone resorption function of murine osteoclasts.

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.

Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.

AZT triphosphate is a Nucleoside Triphosphate.

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.

Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].

Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.

TBHQ (Standard) is the standard substance of TBHQ, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.

Gallic acid (Standard) is the standard substance of Gallic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gallic acid (Benzoic acid) is a natural polyhydroxyphenol, which can inhibit the free radical scavenging effect of COX-2. Gallic acid has a wide range of physiological activities such as antioxidant, anti-inflammatory, anti-tumor and antibacterial.

Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).

MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.

Pancratistatin, an isoquinoline from Hymenocallis littoralis, triggers apoptosis in melanoma and is studied for neuroblastoma, leukemia, and breast cancer.

Alternariol (Standard) is the standard substance of Alternariol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.

Diafenthiuron (Standard) is the standard substance of Diafenthiuron, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Diafenthiuron is a widely utilized thiourea-based pesticide that effectively hinders mitochondrial activity in insect pests.

N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].

Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

GO-203 is a useful organic compound for research related to life sciences. The catalog number is T35351 and the CAS number is 1222186-26-6.