Apoptose

LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.

PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells

Durvalumab is a humanized antibody for cancer, inhibiting PD-L1/PD-1 and CD80 interactions at very low concentrations.

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Chlorhexidine dihydrochloride (NSC-185) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Isatuximab targets CD38 in blood cancers, with high expression in multiple myeloma, inducing apoptosis and impairing cellular functions.

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.

Monobenzone (Benoquin) is a Depigmenting Agent.

Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.

Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.

Flurbiprofen is an anti-inflammatory, analgesic, antipyretic that reduces bone resorption by inhibiting carbonic anhydrase.

Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

D-(-)-3-Phosphoglyceric acid disodium: a key glycolysis/gluconeogenesis intermediate, inhibits yeast enolase, crucial in serine, glycine, threonine synthesis.

Conatumumab (AMG 655) targets DR5 to induce apoptosis in tumors, with Kd of 1 nM (long DR5) and 0.8 nM (short DR5).

Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.

VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.

Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors.

Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.

Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II HDACs resulting in a global increase in gene expression.

STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.

Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.

N-Oleoyl-L-Serine (N-Oleoylserine) is a lipid modulator of bone remodeling and stimulates osteoclast apoptosis for the study of osteoporosis.

(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera.

Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea.

WJ-39 is an AR inhibitor that may be used to ameliorate renal insufficiency and fibrosis.

Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in

Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity.

Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.

Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.

Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class.

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.

Penfluridol (TLP-607) is a highly potent antipsychotic.

GCN2iB is an ATP-competitive inhibitor of serine/threonine protein kinase, stress-responsive kinase (GCN2).Cost-effective and quality-assured.

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11.

BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.

Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.

Letolizumab (BMS-986004) is a dimeric antibody that targets CD40L.

Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.

Cinchonine (LA40221), a potent amide local anesthetic for surface use, is toxic and limited to spinal anesthesia.

Adarotene (ST1926) induces apoptosis, causes DNA damage, and has strong antiproliferative effects on human tumors.

Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain

MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.

Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2,

C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BAG2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BAG2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BAG2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BAG2 in the samples is then determined by comparing the OD of the samples to the standard curve.

MN58b is a selective inhibitor of choline kinase α (CHKα).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PDCD1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PDCD1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat PDCD1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PDCD1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.

Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor.

Benazepril hydrochloride (CGS 14824A HCl) is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension.

BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.

ABT-510 acetate: a TSP peptide mimicking anti-angiogenic, anti-inflammatory, and anti-cancer agent, inhibits tumor growth and angiogenesis in cancer and IBD.

Isoliquiritigenin (ISL) is a natural flavonoid that inhibits influenza virus and aldose reductase. Isoliquiritigenin has antitumor effect. Cost-effective and quality-assured.

Acesulfame potassium is a non-nutritive sweetener.

NVS-ZP7-4 is a inhibitor of Zinc transporter SLC39A7 (ZIP7).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GZMB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GZMB. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human GZMB, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GZMB in the samples is then determined by comparing the OD of the samples to the standard curve.

Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive

Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.

FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM.

Semaglutide Acetate is a GLP-1R agonist (EC50=6.2 pM) with long-acting, selective, competitive, and oral efficacy. High-Quality, Low-Cost!

Piceatannol (Astringenin) is a synthetic anti-inflammatory that blocks p56lck, syk kinases, and NF-κB, made from resveratrol.

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.

PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.

Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.

Tetraethylenepentamine Pentahydrochloride is a high affinity copper and zinc chelator.