Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5599 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Iratumumab
CAS :<p>Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.</p>Couleur et forme :LiquidVisilizumab
CAS :<p>Visilizumab is a humanized anti-CD3 IgG2 mAb with low Fc binding, modulating T-cell function for ulcerative colitis and Crohn's.</p>Degré de pureté :95%Couleur et forme :LiquidVisugromab
CAS :<p>Visugromab (CTL-002) is a monoclonal antibody that targets and neutralises GDF-15.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
<p>Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.</p>Couleur et forme :Odour LiquidRemtolumab
CAS :<p>Remtolumab (ABT-122) is a dual inhibitor of TNFα and IL-17A for rheumatoid arthritis research.</p>Couleur et forme :LiquidToralizumab
CAS :<p>Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.</p>Couleur et forme :LiquidMasse moléculaire :148.43 (kD)Licaminlimab
<p>Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.</p>Couleur et forme :Odour LiquidLinvoseltamab
CAS :<p>Linvoseltamab, a bispecific antibody, targets both BCMA (TNFRSF17) and CD3 epsilon, demonstrating a favorable safety profile and promising efficacy in relapsed/</p>Couleur et forme :LiquidBenazepril
CAS :<p>Benazepril inhibits the activity of circulating angiotensin-converting enzyme (ACE) in horses.</p>Formule :C24H28N2O5Couleur et forme :SolidMasse moléculaire :424.49Gilvetmab
CAS :<p>Gilvetmab is a caninized anti-PD-1 antibody approved for veterinary use, researched for stage I-III mast cell tumors and stage II-III melanoma in dogs.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidFrexalimab
CAS :<p>Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].</p>Couleur et forme :LiquidVonsetamig
CAS :<p>Vonsetamig, a humanized immunoglobulin G4-kappa monoclonal antibody, targets both TNFRSF17 and CD3E. It serves as an antineoplastic agent.</p>Couleur et forme :LiquidGeptanolimab
CAS :<p>Geptanolimab (CBT-501) is a humanized IgG4κ antibody against PD-1, blocking PD-L1/PD-L2 binding to reactivate T cell activity.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidTecaginlimab
CAS :<p>Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.</p>Couleur et forme :LiquidTagitanlimab
CAS :<p>Tagitanlimab (HBM-9167) is a humanized IgG1κ anti-PD-L1 antibody, potentially for recurrent/metastatic NPC.</p>Couleur et forme :LiquidCadonilimab
CAS :<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidTabalumab
CAS :<p>Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.</p>Degré de pureté :95%Couleur et forme :LiquidIvuxolimab
CAS :<p>Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidCifurtilimab
CAS :<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Degré de pureté :95%Couleur et forme :LiquidAHR agonist 3
CAS :<p>AHR agonist 3 is an agent with therapeutic activity.</p>Formule :C18H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :270.28Afimkibart
CAS :<p>Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.</p>Degré de pureté :95% - 95%Couleur et forme :SoildRulonilimab
CAS :<p>Rulonilimab, a human IgG1 monoclonal antibody, inhibits PD-1 to enhance immune response and exhibit anti-tumor effects.</p>Couleur et forme :LiquidTuvonralimab
CAS :<p>Tuvonralimab, a combo of anti-PD-1/IgG4 and anti-CTLA-4/IgG1 antibodies, blocks dual immune checkpoints.</p>Couleur et forme :LiquidQuilizumab
CAS :<p>Quilizumab (Anti-Human NGcGM3 Recombinant Antibody) is a humanised monoclonal antibody ,the M1-prime fragment of membrane-bound IgE, depleting memory B cells</p>Degré de pureté :95%Couleur et forme :LiquidRavagalimab
CAS :<p>Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidMicrotubule inhibitor 8
CAS :<p>Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].</p>Formule :C21H15N3O2SCouleur et forme :SolidMasse moléculaire :373.43Acasunlimab
CAS :<p>Acasunlimab (GEN1046) is a bsAb that targets PD-L1 and 4-1BB, boosting T/NK cells and blocking PD-1/PD-L1 in cancer research.</p>Couleur et forme :LiquidNeihulizumab
CAS :<p>Neihulizumab is an anti-CD162 antibody that induces apoptosis in activated T cells for treating GVHD and psoriasis.</p>Degré de pureté :95%Couleur et forme :LiquidAzintuxizumab
CAS :<p>Azintuxizumab, an IgG4 bispecific antibody, targets BCMA, offering dual-action immunotherapy for relapsed/refractory multiple myeloma in preclinical studies.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidToripalimab
CAS :<p>Toripalimab is a humanized anti-PD-1 monoclonal antibody used as an immune checkpoint inhibitor in research for advanced malignancies like nasopharyngeal carcinoma.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidPeresolimab
CAS :<p>Peresolimab is a humanized antibody targeting PD-1, potentially stimulating immune inhibitory pathways for autoimmune disease research.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidTriethanolamine oleate
CAS :<p>Triethanolamine oleate is a nonionic surfactant</p>Formule :C24H49NO5Degré de pureté :98%Couleur et forme :LiquidMasse moléculaire :431.65Dalotuzumab
CAS :<p>Dalotuzumab (MK-0646) is an anti-IGF-1R mAb that inhibits oncogenic signaling, inducing tumor cell apoptosis.</p>Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :146.4 (kDa)Cosibelimab
CAS :<p>Cosibelimab, a fully human monoclonal antibody, blocks PD-L1, enabling ADCC and CDC against cancer cells.</p>Couleur et forme :LiquidPucotenlimab
CAS :<p>Pucotenlimab (HX008) is an anti-PD-1 mAb that blocks PD-1/PD-L1/2 interactions, restoring immune function against solid tumours.</p>Degré de pureté :95%Couleur et forme :LiquidAfelimomab
CAS :<p>Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].</p>Couleur et forme :LiquidRosnilimab
CAS :<p>Rosnilimab is a PD-1 agonist that inhibits T cell proliferation and depletes T cells, enabling research into inflammatory diseases.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidSugemalimab
CAS :<p>Sugemalimab: human anti-PD-L1 IgG4 mAb with anticancer properties for non-small cell lung cancer.</p>Couleur et forme :LiquidPifithrin-β
CAS :<p>potent p53 inhibitor</p>Formule :C16H16N2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.38RMC5127
<p>RMC5127 is an oral and mutation-selective inhibitor of RASG12V (ON) that inhibits the GTP-bound (ON) form of RAS G12V with CNS and brain permeability.</p>Formule :C57H75N9O9SCouleur et forme :SolidMasse moléculaire :1062.32Inezetamab
CAS :<p>Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] .</p>Degré de pureté :95% - 95%Couleur et forme :LiquidVudalimab
CAS :<p>Vudalimab: humanized antibody, blocks PD-1 & CTLA-4, boosts selective T-cell tumor response.</p>Couleur et forme :LiquidCephalotaxine
CAS :Formule :C18H21NO4Degré de pureté :>98.0%(GC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :315.37L-Selenocystine
CAS :Formule :C6H12N2O4Se2Degré de pureté :>97.0%(T)Couleur et forme :Light yellow to Brown powder to crystalMasse moléculaire :334.09Meloxicam-d3
CAS :<p>Meloxicam D4: deuterium-labeled, non-steroidal anti-inflammatory; COX-1 inhibitor (IC50: 36.6μM), COX-2 inhibitor (IC50: 0.49μM).</p>Formule :C14H13N3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.42Pioglitazone-d4
CAS :<p>Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .</p>Formule :C19H20N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46Galanthamine-O-methyl-d3
CAS :Galanthamine-O-methyl-d3 is a deuterated compound of Galanthamine-O-methyl. Galanthamine-O-methyl has a CAS number of 357-70-0. Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.Formule :C17H18D3NO3Couleur et forme :SolidMasse moléculaire :290.37Dasatinib-d8
CAS :<p>Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.</p>Formule :C22H26ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.06Limonin glucoside
CAS :<p>Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.</p>Formule :C32H42O14Couleur et forme :SolidMasse moléculaire :650.6745'-Deoxy-5'-methylthioadenosine-d3
CAS :<p>5'-Deoxy-5'-methylthioadenosine-d3 is a deuterated MTA analog used as an internal standard in metabolomic studies.</p>Formule :C11H15N5O3SCouleur et forme :SolidMasse moléculaire :300.35Propylparaben-d4
CAS :<p>Propylparaben-d4 is a deuterated compound of Propylparaben. Propylparaben has a CAS number of 94-13-3. Propylparaben is an antimicrobial agent, preservative, flavouring agent</p>Formule :C10H8D4O3Couleur et forme :SolidMasse moléculaire :184.23Stavudine-α,α,α,6-d4
CAS :<p>Stavudine-α,α,α,6-d4 is a deuterated compound of Stavudine. Stavudine has a CAS number of 3056-17-5. Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.</p>Formule :C10H8D4N2O4Couleur et forme :SolidMasse moléculaire :228.24Talaporfin sodium
CAS :<p>Talaporfin is a photosensitizer used in photodynamic therapy.</p>Formule :C38H41N5NaO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.762MCL-1/BCL-2-IN-1
CAS :<p>MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].</p>Formule :C31H27BrN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.53GZD856 formic
CAS :<p>GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.</p>Formule :C30H29F3N6O3Couleur et forme :SolidMasse moléculaire :578.58Esmolol hydrochloride
CAS :Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Formule :C16H25NO4·HClDegré de pureté :98.72% - 99.48%Couleur et forme :White SolidMasse moléculaire :331.15EGFR-IN-109
CAS :<p>EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].</p>Formule :C12H16N4OSCouleur et forme :SolidMasse moléculaire :264.35SM1044
CAS :<p>SM1044 is a dimer of dihydroartemisinin (DHA). It activates caspase, inducing apoptosis in RL95-2 and KLE cells. SM1044 inhibits the proliferation of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, and AN3CA, with an IC50 of less than 3.6 μM. Additionally, SM1044 suppresses tumor growth in RL95-2 xenograft mouse models.</p>Formule :C34H55NO10Couleur et forme :SolidMasse moléculaire :637.80IA-14069
CAS :<p>IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.</p>Formule :C20H15ClF2O4Couleur et forme :SoildMasse moléculaire :392.78Asobamast
CAS :<p>Asobamast is a biochemical.</p>Formule :C13H15N3O5SCouleur et forme :SolidMasse moléculaire :325.34EGFR-IN-117
CAS :<p>EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.</p>Formule :C25H30BrN7O2SCouleur et forme :SolidMasse moléculaire :572.52Desethylamiodarone
CAS :<p>Diethylamiodarone is the main metabolite of amiodarone in vivo.</p>Formule :C23H25I2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :617.26Dalbinol
CAS :<p>Dalbinol is a useful organic compound for research related to life sciences. The catalog number is T124857 and the CAS number is 41993-79-7.</p>Formule :C23H22O8Couleur et forme :SolidMasse moléculaire :426.421Diquafosol Free Base
CAS :<p>Diquafosol Free Base is a purinoceptor P2Y(2) receptor agonist.</p>Formule :C18H26N4O23P4Couleur et forme :SolidMasse moléculaire :790.31Xevinapant hydrochloride
CAS :<p>Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.</p>Formule :C32H44ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.19nor-NOHA acetate
CAS :<p>nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction,</p>Formule :C9H20N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.28Quinacrine methanesulfonate
CAS :<p>Quinacrine methanesulfonate is a bioactive chemical.</p>Formule :C25H38ClN3O7S2Couleur et forme :SolidMasse moléculaire :592.17CPTH6 hydrobromide
CAS :<p>CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.</p>Formule :C15H16ClN3SHBrCouleur et forme :SolidMasse moléculaire :386.7Prosultiamine
CAS :<p>Prosultiamine is commonly used for treatment of beriberi, nutritional disorders caused by lack of vitamin B1, etc.</p>Formule :C15H24N4O2S2Degré de pureté :98%Couleur et forme :White Crystalline Or Crystalline PowderMasse moléculaire :356.51Kaolin
CAS :<p>Kaolin (Bolus alba) is a clay dominated by minerals of the kaolinite family. Kaolin increased the sensitivity of this method for monitoring hemophilia therapy.</p>Formule :Al2H8O9Si2Degré de pureté :98%Couleur et forme :White Or Yellowish-White Earhty Mass Or White Powder; Unctuous When Moist (Al2O3(Sio2)2(H2O)2) A Hydrous Aluminosilicate Kaolinite Has Mp 740-1785°C And Density 2 65Masse moléculaire :262.188Avenanthramide A
CAS :<p>Avenanthramide A is a biochemical.</p>Formule :C16H13NO5Couleur et forme :SolidMasse moléculaire :299.28Ionomycin calcium
CAS :<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07Zibotentan
CAS :<p>Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.</p>Formule :C19H16N6O4SDegré de pureté :97.00% - 97.02%Couleur et forme :SolidMasse moléculaire :424.43p-Decylaminophenol
CAS :<p>p-Decylaminophenol is a melanogenesis inhibitor.</p>Formule :C16H27NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :249.394-(6-Bromo-2-benzothiazolyl)benzenamine
CAS :<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Formule :C13H9BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.19AC-4-130
CAS :<p>AC-4-130 inhibits STAT5 SH2 domain, blocks gene transcription, induces apoptosis in FLT3-ITD leukemia, and shows anti-AML potential.</p>Formule :C37H36ClF5N2O5SCouleur et forme :SolidMasse moléculaire :751.2Mollugin
CAS :Produit contrôlé<p>Applications Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.<br>References Zhang, L. et al.: Biochem. Biophys. Res. Comm., 450, 247 (2014); Idhayadhulla, A. et al.: Bioorg. Chem., 52, 77 (2014);<br></p>Formule :C17H16O4Couleur et forme :NeatMasse moléculaire :284.31Selonsertib
CAS :Produit contrôlé<p>Applications Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.<br>References Nelson, C. H. et al.: Clin Pharmacol Ther. 98, 630 (2015); Lin, J. H., et al.: Nephron. 129, 29 (2015)<br></p>Formule :C24H24FN7OCouleur et forme :NeatMasse moléculaire :445.492',5'-Dimethoxyacetophenone
CAS :Produit contrôléFormule :C10H12O3Couleur et forme :NeatMasse moléculaire :180.2Graveoline
CAS :Produit contrôlé<p>Applications Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells.<br></p>Formule :C17H13NO3Couleur et forme :NeatMasse moléculaire :279.29C4 Ceramide-1-phosphate
Produit contrôlé<p>Applications Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages.<br></p>Formule :C22H44NO6PCouleur et forme :NeatMasse moléculaire :449.562(R)-Irofulven
CAS :Produit contrôlé<p>Applications Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.<br>References Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997), Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (2004), Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (2005),<br></p>Formule :C15H18O3Couleur et forme :NeatMasse moléculaire :246.31Apogossypolone
CAS :Produit contrôlé<p>Applications Apogossypolone is an anticancer agent that induces apoptosis in carcinoma cells. Antiproliferative.<br>References Zubair, H. et al.: Eur J. Pharm. Sci., 47, 280 (2012);<br></p>Formule :C28H26O8Couleur et forme :NeatMasse moléculaire :490.50Aurintricarboxylic Acids (Technical Grade)
CAS :Produit contrôlé<p>Applications Aurintricarboxylic Acid is a cell-permeable apoptosis inhibitor.<br></p>Formule :C22H14O9Couleur et forme :NeatMasse moléculaire :422.344-Methyl-1H-Imidazole-5-Carboxylic Acid Hydrate
CAS :Produit contrôlé<p>Applications 4-Methyl-1H-imidazole-5-carboxylic Acid is used in preparation of Cyclohexyl Benzamide compounds for treatment of type II diabetes. Also, used in preparation of Triazolylphenyl substituted Amides as apoptosis signal-regulating kinase inhibitors.<br>References Hu, Z., et al.: PCT Int. Appl.,(2018); Corkey, B., et al.: U.S., (2015);<br></p>Formule :C5H6N2O2·xH2OCouleur et forme :NeatMasse moléculaire :126.11 + x(18.02)6-(2-Hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine
CAS :Produit contrôlé<p>Applications An analogue of Olomoucine (Cat. # O567000) that acts as a potent inhibitor of Cdk 1 (IC50=100nm) and Cdk2 (IC50=80nm). Also displays antiproliferative and proapoptotic effects.<br>References Wermeulen, K., et al.: Leukemia, 16, 299(2002)<br></p>Formule :C18H24N6O2Couleur et forme :NeatMasse moléculaire :356.42tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate
CAS :Produit contrôléFormule :C18H17BrN2O3Couleur et forme :NeatMasse moléculaire :389.24Delanzomib
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.<br>References Piva, R. et al.: Blood, 111, 2765 (2008); Sanchez, E. et al.: Br. J. Haematol., 148, 569 (2010);<br></p>Formule :C21H28BN3O5Couleur et forme :NeatMasse moléculaire :413.28Lucidenic Acid B
CAS :Produit contrôléFormule :C27H38O7Couleur et forme :Off-WhiteMasse moléculaire :474.59N-Benzyloxycarbonyl-4-[(3R)-3-amino-1-oxo-4-(phenylthio)butyl]morpholine
CAS :<p>Applications Intermediate in the production of cell death regulators and apoptosis promoters.<br></p>Formule :C22H26N2O4SCouleur et forme :Off White OilyMasse moléculaire :414.524-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid
CAS :Produit contrôlé<p>Applications Intermediate in the production of cell death regulators and apoptosis promoters.<br>References Park, C., et al.: J. Med. Chem., 51, 6902 (2008),<br></p>Formule :C26H31ClN2O2Couleur et forme :NeatMasse moléculaire :438.99Monosialoganglioside GM3 Sodium Salt
CAS :Produit contrôlé<p>Applications Monosialoganglioside GM3 can have anti-tumor effects by regulating cell apoptosis, angiogenesis. Monosialoganglioside GM3 can also regulate peripheral insulin receptor signaling and increases in GM3 in adipose tissue of obese humans may contribute to insulin resistance.<br>References Zhu, Y., et al.: Zhongliu Fangzhi Yanjiu, 42, 450 (2015); Herzer, S., et al.: Diabetes, 64, 3363 (2015); Wentworth, J., et al.: ?Int. J. Obes., 40, 706 (2016)<br></p>Formule :C59H107N2NaO21Couleur et forme :NeatMasse moléculaire :1203.47tert-Butyl 4-Bromo-2-fluorobenzoate
CAS :Produit contrôlé<p>Applications tert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>Formule :C11H12BrFO2Couleur et forme :NeatMasse moléculaire :275.11(3a,5b,7a,12a,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid
CAS :Produit contrôlé<p>Applications (3α,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.<br>References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)<br></p>Formule :C27H44O5Couleur et forme :NeatMasse moléculaire :448.64(3S,4S)-(+)-1-Benzyl-3,4-pyrrolidinediol
CAS :Produit contrôlé<p>Applications (3S,4S)-(+)-1-Benzyl-3,4-pyrrolidinediol is used as a reagent in organic synthesis including that of pyrrolidine iminocyclitol α-glucosidase inhibitors and (-)-(1R,2R,7S,8aR)-1,2,7-Trihydroxyindolizidine ((-)-7S-OH-Lentiginosine) which has potential proapoptotic properties.<br>References Guerreiro, L., et al.: Bioorg. Med. Chem., 21, 1911 (2013); Cordero, F., et al.: ChemPlusChem, 77, 224 (2012);<br></p>Formule :C11H15NO2Couleur et forme :NeatMasse moléculaire :193.24N-(Ethoxycarbonylmethyl)piperazine
CAS :Produit contrôlé<p>Applications N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents.<br>References Nakagawara, A., et al.: Cancer Res., 57, 4578 (1997), Denault, J., et al.: J. Biol. Chem., 278, 34042 (2003), Traven, A., et al.: Cancer Cell, 5, 107 (2004), Becattini, B., et al.: Chem. Biol., 11, 389 (2004),<br></p>Formule :C8H16N2O2Couleur et forme :NeatMasse moléculaire :172.22PHA 767491 Dihydrochloride Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).<br>References Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);<br></p>Formule :C12H11N3O·2ClHCouleur et forme :Light Yellow PowderMasse moléculaire :286.162-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde
CAS :Produit contrôlé<p>Applications 2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde is an intermediate in various reactions. For example, its an intermediate in preparation of N-(phenylsulfonyl)benzamides and N-(3-pyridylsulfonyl)benzamides as apoptosis-inducing agents for the treatment of cancer and immune diseases and autoimmune diseases.<br>References Bruncko, M., et al.: PCT Int. Appl. (2010), WO 2010138588 A2 20101202.<br></p>Formule :C15H17ClOCouleur et forme :NeatMasse moléculaire :248.75
![tert-Butyl 4-Bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB694160.webp&w=3840&q=75)
![N-Benzyloxycarbonyl-4-[(3R)-3-amino-1-oxo-4-(phenylthio)butyl]morpholine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB286060.webp&w=3840&q=75)
![4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FC377880.webp&w=3840&q=75)
