Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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Microtubule inhibitor 8
CAS :Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].Formule :C21H15N3O2SCouleur et forme :SolidMasse moléculaire :373.43Reozalimab
CAS :Reozalimab (LY3434172) is a bispecific monoclonal antibody targeting PD-1/PD-L1, antitumour and enhances T-cell activation in vitro.Degré de pureté :95% - 98.1% (SDS-PAGE); 96.2% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.16 kDaTagitanlimab
CAS :Tagitanlimab, Humanized anti-PD-L1 mAb, blocks PD-L1-PD-1 interaction, for nasopharyngeal carcinoma (NPC) research.Degré de pureté :95% - 95%Couleur et forme :LiquidQuilizumab
CAS :Quilizumab (Anti-Human NGcGM3 Recombinant Antibody) is a humanised monoclonal antibody ,the M1-prime fragment of membrane-bound IgE, depleting memory B cellsDegré de pureté :95%Couleur et forme :LiquidMasse moléculaire :~150 kDaCosibelimab
CAS :Cosibelimab, a fully human monoclonal antibody, blocks PD-L1, enabling ADCC and CDC against cancer cells.Couleur et forme :LiquidExlinkibart
CAS :Exlinkibart (LVGN-6051) is a humanised monoclonal antibody and agonist targeting CD137/TNFRSF9, inducing cytotoxic T lymphocyte (CTL) proliferation.Degré de pureté :95% - 97.7% (SDS-PAGE); 99.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.44 kDaAfelimomab
CAS :Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].Couleur et forme :LiquidIratumumab
CAS :Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.Couleur et forme :LiquidTavolixizumab
CAS :Tavolixizumab (also known as MEDI 0562 and Tavolimab) is a human monoclonal antibody targeting TNFRSF4 (TNF receptor superfamily member 4), utilized in cancerCouleur et forme :LiquidGilvetmab
CAS :Gilvetmab is a caninized anti-PD-1 antibody approved for veterinary use, researched for stage I-III mast cell tumors and stage II-III melanoma in dogs.Degré de pureté :95% - 97.9% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.95 kDaSugemalimab
CAS :Sugemalimab, Anti-PD-L1 mAb, induces ADCC, for EGFR/ALK-negative metastatic NSCLC, solid tumors, and lymphoma research.Degré de pureté :95% - 95%Couleur et forme :LiquidPQA-18
CAS :PQA-18, an inhibitor of p21-activated kinase 2 (PAK2; IC50 = 10 nM), is derived from Ppc-1 (product number 42352) and exhibits immunosuppressive properties. It inhibits IL-2 production in Jurkat T cells induced by Concanavalin A (product number 14951) with an IC50 of 400 nM. Topically applied at 0.1%, PQA-18 reduces the severity of atopic dermatitis, serum IgE levels, and skin thickness in the NC/Nga mouse model. A lower concentration of 0.05% also decreases skin nerve fiber density in NC/Nga mice. Additionally, PQA-18 administered at 4 mg/kg improves graft survival in a rat small intestine transplantation model.Formule :C25H31NO4Couleur et forme :SolidMasse moléculaire :409.52MDM2-p53-IN-18
CAS :MDM2-p53-IN-18, also known as Compd A-7b, is an inhibitor of the MDM2-p53 interaction [1].Formule :C19H16Cl2FN3O4Couleur et forme :SolidMasse moléculaire :440.25Ivuxolimab
CAS :Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.Degré de pureté :95% - 96.0% (SDS-PAGE); 96.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.18 kDaFrataxin-IN-1
CAS :Frataxin-IN-1 inhibits the mitochondrial protein Frataxin with IC50 45 μM and is used in Friedreich’s ataxia research linked to mitochondrial defects.Formule :C20H23NO6Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :373.4Anti-Mouse VEGFR-2 Antibody (DC101)
Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab.Degré de pureté :99%Couleur et forme :LiquidMasse moléculaire :150 kDaPifithrin-β
CAS :potent p53 inhibitorFormule :C16H16N2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.38Remtolumab
CAS :Remtolumab (ABT-122) is a dual inhibitor of TNFα and IL-17A for rheumatoid arthritis research.Couleur et forme :LiquidLicaminlimab
Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.Couleur et forme :Odour LiquidRosnilimab
CAS :Rosnilimab is a PD-1 agonist that inhibits T cell proliferation and depletes T cells, enabling research into inflammatory diseases.Degré de pureté :95% - 98.9% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.57 kDaBAY 249716
CAS :BAY 249716 stabilizes three variants of the p53 protein and shows antitubercular activity with an IC90 against Mycobacterium tuberculosis of less than 0.10 μg/mL.Formule :C13H9ClN4SMasse moléculaire :288.76Inezetamab
CAS :Inezetamab is a bispecific monoclonal antibody functioning as an MSLN inhibitor and CD40 agonist, suitable for investigating solid tumours.Degré de pureté :95% - 99.1% (SDS-PAGE); 99.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :195.98 kDaLinvoseltamab
CAS :Linvoseltamab, a bispecific antibody, targets both BCMA (TNFRSF17) and CD3 epsilon, demonstrating a favorable safety profile and promising efficacy in relapsed/Couleur et forme :LiquidVonsetamig
CAS :Vonsetamig, a humanized immunoglobulin G4-kappa monoclonal antibody, targets both TNFRSF17 and CD3E. It serves as an antineoplastic agent.Couleur et forme :LiquidBenazepril
CAS :Benazepril inhibits the activity of circulating angiotensin-converting enzyme (ACE) in horses.Formule :C24H28N2O5Couleur et forme :SolidMasse moléculaire :424.49Anti-Mouse PD-1 Antibody (S-5001)
Anti-MousePD-1Antibody (S-5001) is an IgG1 antibody inhibitor that targets mouse PD-1.Couleur et forme :Odour LiquidToripalimab
CAS :Toripalimab is a humanized anti-PD-1 monoclonal antibody used as an immune checkpoint inhibitor in research for advanced malignancies like nasopharyngeal carcinoma.Degré de pureté :95% - 95.2% (SDS-PAGE); 96.8% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.29 kDaFosinopril
CAS :Fosinopril, a prodrug ACE inhibitor for hypertension, converts to active fosinoprilat.Formule :C30H46NO7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.6625Pucotenlimab
CAS :Pucotenlimab (HX008) is an anti-PD-1 mAb that blocks PD-1/PD-L1/2 interactions, restoring immune function against solid tumours.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.77 kDaAHR agonist 3
CAS :AHR agonist 3 is an agent with therapeutic activity.Formule :C18H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :270.28RMC5127
CAS :RMC5127 is an orally available RAS G12V inhibitor, CNS and brain permeability, induces apoptosis in KRAS G12V mutant cancer cells, antitumour.Formule :C57H75N9O9SDegré de pureté :97.54%Couleur et forme :SolidMasse moléculaire :1062.32Toralizumab
CAS :Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.Couleur et forme :LiquidMasse moléculaire :148.43 (kD)Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12)
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is an IgG2a, κ antibody inhibitor derived from mice, targeting phosphorylated PD-1/CD279 in both mice and humans.Couleur et forme :Odour LiquidCifurtilimab
CAS :Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.10 kDaCadonilimab
CAS :Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.Degré de pureté :95% - 95%Couleur et forme :LiquidMasse moléculaire :198.64 kDaBoserolimab
CAS :Boserolimab, Humanized anti-CD27 agonistic mAb, blocks CD70 binding to CD27, used for lung cancer research.Degré de pureté :95% - 95%Couleur et forme :LiquidVisugromab
CAS :Visugromab (CTL-002) is a monoclonal antibody that targets and neutralises GDF-15.Degré de pureté :95% - 98.8% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.50 kDaRavagalimab
CAS :Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.Degré de pureté :95% - 96.9% (SDS-PAGE); 99.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.95 kDaVudalimab
CAS :Vudalimab: humanized antibody, blocks PD-1 & CTLA-4, boosts selective T-cell tumor response.Degré de pureté :98.93%Couleur et forme :LiquidPeresolimab
CAS :Peresolimab is a humanized antibody targeting PD-1, potentially stimulating immune inhibitory pathways for autoimmune disease research.Degré de pureté :95% - 97.8% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.14 kDaVisilizumab
CAS :Visilizumab is a humanized anti-CD3 IgG2 mAb with low Fc binding, modulating T-cell function for ulcerative colitis and Crohn's.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.64 kDaAmantadine sulfate
CAS :Amantadine: antiviral, anti-Parkinson's, blocks NMDA receptors, boosts dopamine/norepinephrine release.Formule :C20H36N2O4SCouleur et forme :White Fine Crystalline PowderMasse moléculaire :400.58Tabalumab
CAS :Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :146.24 kDaAfimkibart
CAS :Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.Degré de pureté :95% - 99.2% (SDS-PAGE); 95.3% (SEC-HPLC)Couleur et forme :SoildMasse moléculaire :146.20 kDaTuvonralimab
CAS :Tuvonralimab, a combo of anti-PD-1/IgG4 and anti-CTLA-4/IgG1 antibodies, blocks dual immune checkpoints.Degré de pureté :95% - 95%Couleur et forme :LiquidRulonilimab
CAS :Rulonilimab, a human IgG1 monoclonal antibody, inhibits PD-1 to enhance immune response and exhibit anti-tumor effects.Couleur et forme :LiquidDalnicastobart
CAS :Dalnicastobart (LVGN-7409) is a humanized monoclonal antibody targeting CD40/TNFRSF5 with agonist activity, immunostimulatory and antitumor.Degré de pureté :95% - 97.4% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.33 kDaLesabelimab
CAS :Lesabelimab (LDP) is an anti-CD274 monoclonal antibody of the immunoglobulin G1-kappa subclass.Couleur et forme :LiquidAnti-Mouse IL-1b Antibody (B122)
Anti-Mouse IL-1b Antibody (B122) is a mab inhibitor, blocks IL-1β signaling, reducing monocyte infiltration and alleviating T cell exhaustion.Couleur et forme :Odour LiquidTecaginlimab
CAS :Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.Couleur et forme :LiquidAcasunlimab
CAS :Acasunlimab (GEN1046) is a bsAb that targets PD-L1 and 4-1BB, boosting T/NK cells and blocking PD-1/PD-L1 in cancer research.Couleur et forme :LiquidMG-132
CAS :Formule :C26H41N3O5Degré de pureté :>95.0%(qNMR)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :475.63Cephalotaxine
CAS :Formule :C18H21NO4Degré de pureté :>98.0%(GC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :315.37L-Selenocystine
CAS :Formule :C6H12N2O4Se2Degré de pureté :>97.0%(T)Couleur et forme :Light yellow to Brown powder to crystalMasse moléculaire :334.09Oncrasin 1
CAS :Formule :C16H12ClNODegré de pureté :>95.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :269.73Dasatinib-d8
CAS :Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.Formule :C22H26ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.06Limonin glucoside
CAS :Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.Formule :C32H42O14Couleur et forme :SolidMasse moléculaire :650.6745'-Deoxy-5'-methylthioadenosine-d3
CAS :5'-Deoxy-5'-methylthioadenosine-d3 is a deuterated MTA analog used as an internal standard in metabolomic studies.Formule :C11H15N5O3SCouleur et forme :SolidMasse moléculaire :300.35Stavudine-α,α,α,6-d4
CAS :Stavudine-α,α,α,6-d4 is a deuterated compound of Stavudine. Stavudine has a CAS number of 3056-17-5. Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Formule :C10H8D4N2O4Couleur et forme :SolidMasse moléculaire :228.24Meloxicam-d3
CAS :Meloxicam D4: deuterium-labeled, non-steroidal anti-inflammatory; COX-1 inhibitor (IC50: 36.6μM), COX-2 inhibitor (IC50: 0.49μM).Formule :C14H13N3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.42Galanthamine-O-methyl-d3
CAS :Galanthamine-O-methyl-d3 is a deuterated compound of Galanthamine-O-methyl. Galanthamine-O-methyl has a CAS number of 357-70-0. Galanthamine is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.Formule :C17H18D3NO3Couleur et forme :SolidMasse moléculaire :290.37Pioglitazone-d4
CAS :Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .Formule :C19H20N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46D-F07
CAS :D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.Formule :C18H21NO6Degré de pureté :98.31% - 99.31%Couleur et forme :SoildMasse moléculaire :347.36Propylparaben-d4
CAS :Propylparaben-d4 is a deuterated compound of Propylparaben. Propylparaben has a CAS number of 94-13-3. Propylparaben is an antimicrobial agent, preservative, flavouring agentFormule :C10H8D4O3Couleur et forme :SolidMasse moléculaire :184.23GZD856 formic
CAS :GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.Formule :C30H29F3N6O3Couleur et forme :SolidMasse moléculaire :578.58nor-NOHA acetate
CAS :nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction,Formule :C9H20N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.28Prosultiamine
CAS :Prosultiamine is commonly used for treatment of beriberi, nutritional disorders caused by lack of vitamin B1, etc.Formule :C15H24N4O2S2Degré de pureté :98%Couleur et forme :White Crystalline Or Crystalline PowderMasse moléculaire :356.51Quinacrine methanesulfonate
CAS :Quinacrine methanesulfonate is a bioactive chemical.Formule :C25H38ClN3O7S2Couleur et forme :SolidMasse moléculaire :592.174-(6-Bromo-2-benzothiazolyl)benzenamine
CAS :4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.Formule :C13H9BrN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.19Diquafosol Free Base
CAS :Diquafosol Free Base is a purinoceptor P2Y(2) receptor agonist.Formule :C18H26N4O23P4Couleur et forme :SolidMasse moléculaire :790.31Ionomycin calcium
CAS :Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.
Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07EGFR-IN-117
CAS :EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.Formule :C25H30BrN7O2SCouleur et forme :SolidMasse moléculaire :572.52CPTH6 hydrobromide
CAS :CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.Formule :C15H16ClN3SHBrCouleur et forme :SolidMasse moléculaire :386.7IA-14069
CAS :IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.Formule :C20H15ClF2O4Couleur et forme :SoildMasse moléculaire :392.78Talaporfin sodium
CAS :Talaporfin is a photosensitizer used in photodynamic therapy.Formule :C38H41N5NaO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.762AC-4-130
CAS :AC-4-130 is a direct STAT5 SH2 domain inhibitor, inducing cell cycle arrest and apoptosis in leukemia cells, acute myeloid leukemia (AML).Formule :C37H36ClF5N2O5SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :751.2Ref: TM-T35429
1mgÀ demander5mgÀ demander10mgÀ demander1mL*10mM (DMSO)À demander25mg557,00€50mg898,00€100mg1.674,00€Esmolol hydrochloride
CAS :Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Formule :C16H25NO4·HClDegré de pureté :98.72% - 99.48%Couleur et forme :White SolidMasse moléculaire :331.15SM1044
CAS :SM1044 is a dimer of dihydroartemisinin (DHA). It activates caspase, inducing apoptosis in RL95-2 and KLE cells. SM1044 inhibits the proliferation of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, and AN3CA, with an IC50 of less than 3.6 μM. Additionally, SM1044 suppresses tumor growth in RL95-2 xenograft mouse models.Formule :C34H55NO10Couleur et forme :SolidMasse moléculaire :637.80Zibotentan
CAS :Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.Formule :C19H16N6O4SDegré de pureté :97.00% - 97.02%Couleur et forme :SolidMasse moléculaire :424.43Xevinapant hydrochloride
CAS :Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.Formule :C32H44ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.19MCL-1/BCL-2-IN-1
CAS :MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].Formule :C31H27BrN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.53Dalbinol
CAS :Dalbinol is a useful organic compound for research related to life sciences. The catalog number is T124857 and the CAS number is 41993-79-7.Formule :C23H22O8Couleur et forme :SolidMasse moléculaire :426.421p-Decylaminophenol
CAS :p-Decylaminophenol is a melanogenesis inhibitor.Formule :C16H27NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :249.39Asobamast
CAS :Asobamast is a biochemical.
Formule :C13H15N3O5SCouleur et forme :SolidMasse moléculaire :325.34Desethylamiodarone
CAS :Diethylamiodarone is the main metabolite of amiodarone in vivo.Formule :C23H25I2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :617.26LY 303511
CAS :LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formule :C19H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.36EGFR-IN-109
CAS :EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].Formule :C12H16N4OSCouleur et forme :SolidMasse moléculaire :264.35Kaolin
CAS :Kaolin (Bolus alba) is a clay dominated by minerals of the kaolinite family. Kaolin increased the sensitivity of this method for monitoring hemophilia therapy.Formule :Al2H8O9Si2Degré de pureté :98%Couleur et forme :White Or Yellowish-White Earhty Mass Or White Powder; Unctuous When Moist (Al2O3(Sio2)2(H2O)2) A Hydrous Aluminosilicate Kaolinite Has Mp 740-1785°C And Density 2 65Masse moléculaire :262.188Melittin Trifluoroacetic Acid Salt (~80%)
CAS :Produit contrôléStability Hygroscopic
Applications MelittinTrifluoroacetic Acid Salt is the Trifluoroacetic Acid Salt version of Melittin which is an apoptosis inducer, a NF-κB inhibitor, and a PLA2 activator.
References Han, S., et al.: J Asian Nat Prod Res. 11, 796-804 (2009); Park, C., et al.: Biochem. Biophys. Res. Commun., 394, 170-172 (2010); Park, J.H., et al.: Mol. Cells., 29, 209-215 (2010);Formule :C131H229N39O31·x(C2HF3O2)Degré de pureté :~80%Couleur et forme :NeatMasse moléculaire :2846.5Mollugin
CAS :Produit contrôléApplications Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.
References Zhang, L. et al.: Biochem. Biophys. Res. Comm., 450, 247 (2014); Idhayadhulla, A. et al.: Bioorg. Chem., 52, 77 (2014);Formule :C17H16O4Couleur et forme :NeatMasse moléculaire :284.31Lucidenic Acid B
CAS :Produit contrôléFormule :C27H38O7Couleur et forme :Off-WhiteMasse moléculaire :474.59(3a,5b,7a,12a,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid
CAS :Produit contrôléApplications (3α,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.
References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)Formule :C27H44O5Couleur et forme :NeatMasse moléculaire :448.64Pyocyanin (Technical Grade)
CAS :Produit contrôléApplications Pyocyanin is an antibiotic accelerator of neutrophil apoptosis.
Formule :C13H10N2OCouleur et forme :NeatMasse moléculaire :210.23(3S,4S)-(+)-1-Benzyl-3,4-pyrrolidinediol
CAS :Produit contrôléApplications (3S,4S)-(+)-1-Benzyl-3,4-pyrrolidinediol is used as a reagent in organic synthesis including that of pyrrolidine iminocyclitol α-glucosidase inhibitors and (-)-(1R,2R,7S,8aR)-1,2,7-Trihydroxyindolizidine ((-)-7S-OH-Lentiginosine) which has potential proapoptotic properties.
References Guerreiro, L., et al.: Bioorg. Med. Chem., 21, 1911 (2013); Cordero, F., et al.: ChemPlusChem, 77, 224 (2012);Formule :C11H15NO2Couleur et forme :NeatMasse moléculaire :193.24Aurintricarboxylic Acids (Technical Grade)
CAS :Produit contrôléApplications Aurintricarboxylic Acid is a cell-permeable apoptosis inhibitor.
Formule :C22H14O9Couleur et forme :NeatMasse moléculaire :422.34Belinostat Amide
CAS :Produit contrôléFormule :C15H14N2O3SCouleur et forme :NeatMasse moléculaire :302.3520(R)-Ginsenoside Rg3
CAS :Produit contrôléApplications 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.
References Liu, Y., et al.: Chengdu Yixueyuan Xuebao, 9, 4 (2014); Liu, Y., et al.: Linchuang Junyi Zazhi, 42, 1138 (2014), Kim, D., et al.: Toxicol. Lett., 259, 1 92016); Geng, L., et al.: Zhonghua Zhongyiyao Zazhi, 29, 601 (2014)Formule :C42H72O13Couleur et forme :NeatMasse moléculaire :785.01N-(Ethoxycarbonylmethyl)piperazine
CAS :Produit contrôléApplications N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents.
References Nakagawara, A., et al.: Cancer Res., 57, 4578 (1997), Denault, J., et al.: J. Biol. Chem., 278, 34042 (2003), Traven, A., et al.: Cancer Cell, 5, 107 (2004), Becattini, B., et al.: Chem. Biol., 11, 389 (2004),Formule :C8H16N2O2Couleur et forme :NeatMasse moléculaire :172.224-Methyl-1H-Imidazole-5-Carboxylic Acid Hydrate
CAS :Produit contrôléApplications 4-Methyl-1H-imidazole-5-carboxylic Acid is used in preparation of Cyclohexyl Benzamide compounds for treatment of type II diabetes. Also, used in preparation of Triazolylphenyl substituted Amides as apoptosis signal-regulating kinase inhibitors.
References Hu, Z., et al.: PCT Int. Appl.,(2018); Corkey, B., et al.: U.S., (2015);Formule :C5H6N2O2·xH2OCouleur et forme :NeatMasse moléculaire :144.13
