Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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CP-24879 hydrochloride
CAS :<p>CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.</p>Formule :C11H18ClNODegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :215.72BHD
CAS :<p>BHD, a reversible male contraceptive agent, effectively induces spermatogenic cell apoptosis and causes abnormalities in seminiferous tubules in vivo at doses</p>Formule :C21H16Cl2N4OCouleur et forme :SolidMasse moléculaire :411.28PRMT6-IN-3
CAS :<p>PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.</p>Formule :C19H26N4O2SDegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :374.5EGFR kinase inhibitor 1
CAS :<p>Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.</p>Formule :C30H31N7O2Couleur et forme :SolidMasse moléculaire :521.61ST1074
CAS :<p>ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].</p>Formule :C20H36ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.96Falcarindiol
CAS :<p>Falcarindiol: Activates PPARγ, boosts ABCA1, induces apoptosis/autophagy, has anti-inflammatory/anticancer effects.</p>Formule :C17H24O2Couleur et forme :SolidMasse moléculaire :260.37GNE-900
CAS :<p>GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively</p>Formule :C23H21N5Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :367.45TC ASK 10
CAS :<p>TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.</p>Formule :C21H23Cl2N5ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :432.35Anticancer agent 118
CAS :<p>Anticancer Agent 118, an N‑acylated ciprofloxacin derivative, exhibits antibacterial efficacy against Gram-positive strains and antiproliferative effects on</p>Formule :C19H19ClFN3O4Couleur et forme :SolidMasse moléculaire :407.82RUNX-IN-2
CAS :<p>RUNX-IN-2 (Compound Conjugate 3) covalently attaches to RUNX-binding sequences, preventing RUNX proteins from associating with their targets, thereby inhibiting</p>Formule :C71H88Cl2N24O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1524.52Agerafenib hydrochloride
CAS :<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Formule :C24H23ClF3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.92iMAC2 hydrochloride
CAS :<p>iMAC2 hydrochloride, a potent inhibitor of the mitochondrial apoptosis-induced channel (MAC), demonstrates an IC50 of 28 nM and an LD50 of 15000 nM. It exhibits an anti-apoptotic effect by blocking the release of cytochrome c [1].</p>Formule :C19H22Br2Cl2FN3Couleur et forme :SolidMasse moléculaire :542.11NSC 689534
CAS :<p>NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].</p>Formule :C19H18N6SCouleur et forme :SolidMasse moléculaire :362.45Tubulin polymerization-IN-56
CAS :<p>Tubulin Polymerization-IN-56 (compound 8l), an indazole derivative, potently inhibits tubulin polymerization by targeting the colchicine site, which induces</p>Formule :C22H22ClN3O3Couleur et forme :SolidMasse moléculaire :411.88Delmitide acetate
CAS :<p>Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties.</p>Formule :C61H109N17O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1288.62HDAC-IN-59
CAS :<p>HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Formule :C20H25NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.42Ataquimast
CAS :<p>Ataquimast is used in curing advanced receptor-positive breast cancer.</p>Formule :C11H14ClN3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :239.7Thaspine acetate
CAS :<p>Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.</p>Formule :C22H23NO8Couleur et forme :SolidMasse moléculaire :429.425Methyl 12-methyltridecanoate
CAS :<p>Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride), a biosurfactant derived from Brevibacterium casei LS14, enhances the biocompatibility of</p>Formule :C15H30O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :242.4c-Met-IN-10
CAS :<p>c-Met-IN-10: potent kinase inhibitor (IC50=16 nM), halts cancer cell activity/movement, induces apoptosis, for anticancer research.</p>Formule :C26H21FN6O5Couleur et forme :SolidMasse moléculaire :516.48IK-862
CAS :<p>IK-862 is a selective TACE inhibitor with potential anti-inflammatory and anticancer activity for the study of neuritis.</p>Formule :C25H27N3O4Degré de pureté :97.75% - 98.29%Couleur et forme :SolidMasse moléculaire :433.5MTP
CAS :<p>MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation.</p>Formule :C29H23F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.51BMS-561392 formate
CAS :<p>BMS-561392 formate, the formate derivative of BMS-561392, functions as a TNF alpha-converting enzyme (TACE) inhibitor and an ADAM17 blocker. It is utilized in the research of inflammatory bowel disease [1] [2].</p>Formule :C28H34N4O6Couleur et forme :SolidMasse moléculaire :522.59Mezigdomide
CAS :<p>Mezigdomide (CC-92480) is a potent, novel cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue.Cost-effective and quality-assured.</p>Formule :C32H30FN5O4Degré de pureté :97.21% - 99.68%Couleur et forme :SolidMasse moléculaire :567.61TL02-59
CAS :<p>TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.</p>Formule :C32H34F3N5O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :609.64Mcl-1 inhibitor 13
CAS :<p>Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].</p>Formule :C47H45ClFN7O6Couleur et forme :SolidMasse moléculaire :858.35SD 1008
CAS :<p>SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.</p>Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35Bcl-2-IN-13
CAS :<p>Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].</p>Formule :C42H44ClN7O6S3Couleur et forme :SolidMasse moléculaire :874.49ERα antagonist 1
CAS :<p>ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces</p>Formule :C33H32N2O5SCouleur et forme :SolidMasse moléculaire :568.68Boserolimab
CAS :<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Couleur et forme :LiquidBTM-3566
CAS :<p>BTM-3566 triggers ISR via OMA1, induces apoptosis in cancer cells, and is used to research DLBCL.</p>Formule :C24H23F4N3O2S2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :525.58HDAC-IN-46
CAS :<p>HDAC-IN-46 inhibits HDAC1 & HDAC6, affects p-p38, Bcl-xL & cyclin D1, blocks G2 phase & induces apoptosis in TNBC research.</p>Formule :C22H30N8O2Couleur et forme :SolidMasse moléculaire :438.53CPUY201112
CAS :<p>CPUY201112, a novel inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.</p>Formule :C19H23N3O4Couleur et forme :SolidMasse moléculaire :357.4USP7-IN-3
CAS :<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59Nedometinib
CAS :<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Formule :C17H16FIN4O3Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :470.24RET-IN-5
CAS :<p>RET-IN-5 is a potent inhibitor of RET (IC50: 4.57 nM).</p>Formule :C29H26FN9OCouleur et forme :SolidMasse moléculaire :535.57HDAC-IN-50
CAS :<p>HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.</p>Formule :C31H41N7O4Couleur et forme :SolidMasse moléculaire :575.7HDAC1/CDK7-IN-1
CAS :<p>HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively.</p>Formule :C33H32ClN7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :626.11SF5
CAS :<p>SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.</p>Formule :C15H13NSDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :239.34BRD4 Inhibitor-18
CAS :<p>BRD4 Inhibitor-18: potent (IC50: 110 nM), impairs MV-4-11 cell growth, disrupts G0/G1 phase, and induces apoptosis.</p>Formule :C26H26ClN3O3SCouleur et forme :SolidMasse moléculaire :496.02Zn(BQTC)
CAS :<p>Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.</p>Formule :C30H36Cl2N5O3ZnDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :650.92IM156
CAS :<p>IM156, a Metformin derivative, activates AMPK, enhances cognition in aging animals, and inhibits OXPHOS in solid tumor research.</p>Formule :C13H16F3N5ODegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :315.29c-Met/MEK1/Flt-3-IN-1
<p>Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cell</p>Formule :C39H37FN6O5Couleur et forme :SolidMasse moléculaire :688.75WF-210
CAS :<p>WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.</p>Formule :C41H38FN7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.85HDAC/JAK/BRD4-IN-1
CAS :<p>HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.</p>Formule :C24H28N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52Anticancer agent 128
CAS :<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Formule :C26H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.6MP7
CAS :<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Formule :C28H22F2N4O4Degré de pureté :99.84% - 99.89%Couleur et forme :SolidMasse moléculaire :516.5Eeyarestatin I
CAS :<p>Eeyarestatin I blocks ER protein degradation, hinders p97/atx3 processes, and induces anticancer proteins.</p>Formule :C27H25Cl2N7O7Degré de pureté :98% - 98.99%Couleur et forme :SolidMasse moléculaire :630.44AT-9283 L-lactate
CAS :<p>AT-9283 L-lactate is an inhibitor of aurora kinase.</p>Formule :C22H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.52TMX-2164
CAS :<p>TMX-2164: strong, irreversible BCL6 inhibitor, IC50=152 nM, long-lasting action, inhibits cell proliferation.</p>Formule :C25H24ClFN6O6SCouleur et forme :SolidMasse moléculaire :591.01HM90822
CAS :<p>HM90822 is an IAP antagonist that inhibits XIAP and cIAP1/2 protein expression, induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.</p>Formule :C30H36ClF2N7O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :632.1DLC-50
CAS :<p>DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.</p>Formule :C28H32FN5O4S2Couleur et forme :SolidMasse moléculaire :585.71RIP1 kinase inhibitor 8
CAS :<p>RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectively</p>Formule :C18H19F2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.37GSK2245035
CAS :<p>GSK2245035: selective nasal TLR7 agonist, boosts Type-1 IFN (pEC50: 9.3 IFNα, 6.5 TFNα), curbs Th2 cytokines in blood cultures.</p>Formule :C20H34N6O2Couleur et forme :SolidMasse moléculaire :390.52Lepadin H
CAS :<p>Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing</p>Formule :C26H45NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.64ZINC00784494
CAS :<p>ZINC00784494 is a selective inhibitor of LCN2 (lipocalin-2), which inhibits cancer cell proliferation and reduces p-AKT , and promotes apoptosis. IBC.</p>Formule :C20H14N2O3SDegré de pureté :98.90%Couleur et forme :SolidMasse moléculaire :362.4eIF4A3-IN-18
CAS :<p>eIF4A3-IN-18, a silvestrol analogue with EC50s: 0.8/35/2 nM, inhibits eIF4F complex and is cytotoxic (LC50: 0.06 nM) for cancer research.</p>Formule :C29H28N2O6Couleur et forme :SolidMasse moléculaire :500.54c-Met/HDAC-IN-3
CAS :<p>c-Met/HDAC-IN-3: dual inhibitor; IC50: c-Met 12.5 nM, HDAC1 26.97 nM; induces apoptosis, G2/M arrest.</p>Formule :C34H35FN4O7Couleur et forme :SolidMasse moléculaire :630.66KSQ-4279
CAS :<p>KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,</p>Formule :C27H25F3N8ODegré de pureté :99.76% - 99.79%Couleur et forme :SoildMasse moléculaire :534.54JHU395
CAS :<p>JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.</p>Formule :C22H29N3O7Degré de pureté :99.15% - 99.26%Couleur et forme :SolidMasse moléculaire :447.48CDC801
CAS :<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formule :C23H24N2O5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :408.45VU0661013
CAS :<p>VU0661013 is an effective and selective inhibitor of MCL-1.</p>Formule :C39H39Cl2N5O4Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :712.66GP 1a
CAS :<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formule :C23H22Cl2N4ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :441.35DuP-697
CAS :<p>DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.</p>Formule :C17H12BrFO2S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :411.31PARP1/2/TNKS1/2-IN-1
CAS :<p>PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.</p>Formule :C35H31FN6O5Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :634.66CDDO-3P-Im
CAS :<p>CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.</p>Formule :C39H46N4O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :618.81LB42708
CAS :<p>LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).</p>Formule :C30H27BrN4O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :555.47PP5-IN-1
CAS :<p>PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.</p>Formule :C18H18N2O3SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :342.41Tefinostat
CAS :<p>Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.</p>Formule :C28H37N3O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :495.61NSC697923
CAS :<p>NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.</p>Formule :C11H9NO5SDegré de pureté :97% - 99.71%Couleur et forme :SolidMasse moléculaire :267.26AZA197
CAS :<p>AZA197 (AZA-197) is a selective Cdc42 inhibitor.</p>Formule :C24H36N6Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :408.58Alrizomadlin
CAS :<p>Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.</p>Formule :C34H38Cl2FN3O4Degré de pureté :98.41% - 99.47%Couleur et forme :SolidMasse moléculaire :642.59GCN2-IN-7
CAS :<p>GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.</p>Formule :C22H23BrN8OSDegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :527.44RH01386
CAS :<p>RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.</p>Formule :C18H15F3N4O3SDegré de pureté :99.16% - 99.67%Couleur et forme :SolidMasse moléculaire :424.4Ac-DEVD-CHO
CAS :<p>Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.</p>Formule :C20H30N4O11Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :502.47CDDO-2P-Im
CAS :<p>CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.</p>Formule :C39H46N4O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :618.81MC4033
CAS :<p>MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].</p>Formule :C16H13N3O3Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :295.29M3541
CAS :<p>M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.</p>Formule :C23H17FN6O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :428.42CPI-360
CAS :<p>CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.</p>Formule :C25H31N3O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :437.53Elobixibat
CAS :<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Formule :C36H45N3O7S2Degré de pureté :97.43% - 98.03%Couleur et forme :SolidMasse moléculaire :695.89ZNL 02-096
CAS :<p>ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar</p>Formule :C42H45N11O6Degré de pureté :99.02% - 99.84%Couleur et forme :SolidMasse moléculaire :799.88Nanatinostat
CAS :<p>Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.</p>Formule :C20H19FN6O2Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :394.4HM43239
CAS :<p>HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.</p>Formule :C29H33ClN6Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :501.07MI-888 TFA
CAS :<p>MI-888 (TFA) is an orally active inhibitor of the MDM2-p53 interaction with a Ki of 0.44 nM. It can induce rapid, complete, and durable tumor regression in xenograft mouse models.</p>Formule :C30H33Cl2F4N3O5Couleur et forme :SolidMasse moléculaire :662.5BRD1991
CAS :<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formule :C33H35Cl2N3O4Couleur et forme :SolidMasse moléculaire :608.55GPX4-IN-13
CAS :<p>GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM).</p>Formule :C23H15NO3Couleur et forme :SolidMasse moléculaire :353.37DHU-Se1
<p>DHU-Se1: potent anti-inflammatory, releases reactive selenium from macrophages, inhibits iNOS/TNF-α, blocks M0 to M1 polarization.</p>Formule :C23H23N3OSSeCouleur et forme :SolidMasse moléculaire :468.47ADH-6
CAS :<p>ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.</p>Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64PD-1-IN-17 TFA
<p>PD-1-IN-17 TFA is a potent PD-1 inhibitor, blocking 92% of splenocyte growth at 100 nM.</p>Formule :C15H23F3N6O9Couleur et forme :SolidMasse moléculaire :488.37p53 Activator 14
CAS :<p>p53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.</p>Formule :C28H29ClN4O3Couleur et forme :SolidMasse moléculaire :505.008PD-1/PD-L1-IN-16
<p>PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.</p>Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63YCW-E11
CAS :<p>YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.</p>Formule :C25H21Cl2N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.49HSP90-IN-10
<p>HSP90-IN-10 is a potent HSP90 inhibitor, targeting HCC1954 cells (IC50: 6 μM) and inducing apoptosis, sparing normal cells.</p>Formule :C30H26FN3O6Couleur et forme :SolidMasse moléculaire :543.54DNMT1-IN-5
CAS :<p>DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 μM. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.</p>Formule :C24H32FN7Couleur et forme :SolidMasse moléculaire :437.556TfR-1-IN-1
CAS :<p>TfR-1-IN-1 is a TfR-1 inhibitor, also a Fe(III) salivary phenol complex, inducing apoptosis and inhibiting tumor and normal cell growth.</p>Formule :C20H12ClF2FeN2O2Degré de pureté :96.96%Couleur et forme :SolidMasse moléculaire :441.62Fosizensertib
CAS :<p>Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.</p>Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397Nenocorilant
CAS :<p>Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.</p>Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55HP590
CAS :<p>HP590: potent oral STAT3 inhibitor, IC50=27.8 nM, blocks ATP, IC50=24.7 nM, hinders gastric cancer growth, triggers cell death.</p>Formule :C29H24F6N4O3Couleur et forme :SolidMasse moléculaire :590.52ZIF-8
CAS :<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513NCAO
CAS :<p>N-ω-chloroacetyl-L-ornithine (NCAO) serves as a powerful reversible competitive inhibitor of ornithine decarboxylase (ODC), displaying cytotoxic and antiproliferative properties against various tumor cell lines, with EC50 values spanning from 1 to 50.6 µM. In vitro studies reveal that NCAO promotes Apoptosis and restricts tumor cell migration. Additionally, it demonstrates significant antitumor efficacy in a mouse model, targeting both solid and ascitic tumors using the myeloma (Ag8) cell line. NCAO holds promise in the development of antitumor agents.</p>Formule :C7H13ClN2O3Couleur et forme :SolidMasse moléculaire :208.64
