Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(127 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6169 produits trouvés pour "Apoptose"
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Vepafestinib
CAS :Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].Formule :C26H30N6O3Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :474.55Myrothecine A
CAS :Myrothecine A, a trichothecene mycotoxin discovered in M. roridum, exhibits anticancer properties. It effectively inhibits the proliferation of various cancer cell lines, specifically A549, MCF-7, HepG2, and SMMC-7721, with IC50 values of 95, 70, 60, and 25 µM, respectively. At a concentration of 50 µM, Myrothecine A induces G1 cell cycle arrest in HepG2 cells and promotes apoptosis in SMMC-7721 cells by elevating levels of Bax and cleaved caspase-3, -5, and -8.Formule :C29H38O10Couleur et forme :SolidMasse moléculaire :546.61NSC194598
CAS :NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM.Formule :C20H19N3OCouleur et forme :SolidMasse moléculaire :317.38PLK1/BRD4-IN-1
CAS :PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).Formule :C31H43N9O2Couleur et forme :SolidMasse moléculaire :573.73MTI-31
CAS :MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formule :C26H30N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :474.55HDAC-IN-50
CAS :HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.Formule :C31H41N7O4Couleur et forme :SolidMasse moléculaire :575.7CR-1-31-B
CAS :CR-1-31-B, a synthetic rocaglate, inhibits eIF4A, hinders protein synthesis initiation, and induces apoptosis in cancer cells.Formule :C28H29NO8Couleur et forme :SolidMasse moléculaire :507.539Ataquimast
CAS :Ataquimast is used in curing advanced receptor-positive breast cancer.Formule :C11H14ClN3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :239.7Ref: TM-T30190
1mg64,00€1mL*10mM (DMSO)116,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€WEHI-345 analog
CAS :WEHI-345 analog is an Src inhibitor.Formule :C23H25N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49AGN194204
CAS :AGN194204 (IRX4204), an oral RXR agonist, inactive against RAR, has Kd 0.4-3.8 nM & EC50 0.08-0.8 nM, with anti-inflammatory and anticarcinogenic properties.Formule :C24H32O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.51RIP2 kinase inhibitor 2
CAS :RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.Formule :C21H28N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.54Ethylene dimethanesulfonate
CAS :Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs. Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diesterFormule :C4H10O6S2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :218.25erythro-Austrobailignan-6
CAS :Erythro-Austrobailignan-6: orally active, anti-cancer, inhibits DNA topoisomerases, induces apoptosis, boosts p38/JNK phosphorylation.Formule :C20H24O4Couleur et forme :SolidMasse moléculaire :328.4CUR61414
CAS :CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Formule :C31H42N4O5Degré de pureté :97.34% - 98%Couleur et forme :SolidMasse moléculaire :550.69Ref: TM-T15019
1mg50,00€2mg71,00€5mg104,00€1mL*10mM (DMSO)116,00€10mg168,00€25mg326,00€50mg492,00€100mg738,00€200mg973,00€BAX-IN-1
CAS :BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).Formule :C16H14N6OCouleur et forme :SolidMasse moléculaire :306.32Ezatiostat hydrochloride
CAS :Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formule :C27H36ClN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.11Ref: TM-T22776
2mg55,00€5mg78,00€1mL*10mM (DMSO)112,00€10mg114,00€25mg190,00€50mg290,00€100mg490,00€200mg735,00€500mg1.104,00€SWS1
CAS :SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating antiFormule :C47H53ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :849.48E235
CAS :E235, an activator of the transcription factor 4 (ATF4), enhances the integrated stress response (ISR) and DNA damage response, thereby reducing cell viabilityFormule :C28H25FN4OSDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :484.59EAD1 TFA(1644388-26-0 Free base)
CAS :EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis
Formule :C26H28Cl2F3N7O2Degré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :598.45C 87
CAS :C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Formule :C24H15ClN6O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :502.93Eeyarestatin I
CAS :Eeyarestatin I blocks ER protein degradation, hinders p97/atx3 processes, and induces anticancer proteins.Formule :C27H25Cl2N7O7Degré de pureté :98% - 98.99%Couleur et forme :SolidMasse moléculaire :630.44GSK-2245035 maleate
CAS :GSK-2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties.Formule :C24H38N6O6Couleur et forme :SolidMasse moléculaire :506.6DC_AC50
CAS :"DC_AC50 inhibits Atox1/CCS to reduce cancer cell growth and prevent chemotherapy resistance."Formule :C17H12BrF2N3OSDegré de pureté :99.84% - 99.9%Couleur et forme :SolidMasse moléculaire :424.26Ogremorphin
CAS :Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Formule :C21H17N3OSDegré de pureté :99.65% - 99.65%Couleur et forme :SolidMasse moléculaire :359.44Cu(II)-Elesclomol
CAS :Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.Formule :C19H18CuN4O2S2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :462.05S-Adenosyl-L-methionine (1,4-butanedisulfonate)
CAS :S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for itsFormule :C19H32N6O11S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.69D359-0396
CAS :D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerizationFormule :C24H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.47CHM-1
CAS :CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity.Formule :C16H10FNO3Degré de pureté :99.839%Couleur et forme :SolidMasse moléculaire :283.25GNE-900
CAS :GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectivelyFormule :C23H21N5Degré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :367.45BCL6-IN-4
CAS :BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].Formule :C25H35ClN6O3Couleur et forme :SolidMasse moléculaire :503.04Bcl-2-IN-11
CAS :Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xlFormule :C45H49ClFN7O8SCouleur et forme :SolidMasse moléculaire :902.43MI-219
CAS :MI-219 is a human double minute 2 (HDM2) inhibitor.Formule :C27H32Cl2FN3O4Couleur et forme :SolidMasse moléculaire :552.47MP7
CAS :MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Formule :C28H22F2N4O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :516.5NSC 689534
CAS :NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].Formule :C19H18N6SCouleur et forme :SolidMasse moléculaire :362.45Anticancer agent 118
CAS :Anticancer Agent 118, an N‑acylated ciprofloxacin derivative, exhibits antibacterial efficacy against Gram-positive strains and antiproliferative effects onFormule :C19H19ClFN3O4Couleur et forme :SolidMasse moléculaire :407.82INCB3619
CAS :INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.Formule :C22H27N3O5Degré de pureté :98.41% - 99.51%Couleur et forme :SolidMasse moléculaire :413.47M190S
CAS :M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.Formule :C21H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.42Famitinib malate
CAS :Famitinib malate (SHR1020) is a potent oral kinase inhibitor targeting c-kit, VEGFR-2, and PDGFRβ, with IC50s 2.3, 4.7, 6.6 nM, useful for cancer research.Formule :C27H33FN4O7Couleur et forme :SolidMasse moléculaire :544.57Pelcitoclax
CAS :Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].Formule :C57H66ClF4N6O11PS4Couleur et forme :SolidMasse moléculaire :1281.84viFSP1
CAS :viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].Formule :C16H17N3O3SCouleur et forme :SolidMasse moléculaire :331.39BHD
CAS :BHD, a reversible male contraceptive agent, effectively induces spermatogenic cell apoptosis and causes abnormalities in seminiferous tubules in vivo at dosesFormule :C21H16Cl2N4OCouleur et forme :SolidMasse moléculaire :411.28Estrogen receptor modulator 10
CAS :Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM).Formule :C32H37F9N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :728.71PDK4-IN-1 hydrochloride
CAS :PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).Formule :C22H20ClN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :393.87Ref: TM-T12412L
1mg70,00€5mg150,00€1mL*10mM (DMSO)165,00€10mg215,00€25mg358,00€50mg515,00€100mg707,00€200mg1.009,00€RIPK-IN-4
CAS :RIPK-IN-4 is a potent, selective RIPK2 inhibitor with nanomolar activity and oral bioavailability for studying innate immune pathways.Formule :C18H21FN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45PD-1/PD-L1-IN-33
CAS :PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53AGN 192870
CAS :AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.Formule :C27H22O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :378.46Colletofragarone A2
CAS :Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44RIPK1-IN-8
CAS :RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseasesFormule :C26H24F2N6O3Couleur et forme :SolidMasse moléculaire :506.5GSK2245035
CAS :GSK2245035: selective nasal TLR7 agonist, boosts Type-1 IFN (pEC50: 9.3 IFNα, 6.5 TFNα), curbs Th2 cytokines in blood cultures.Formule :C20H34N6O2Couleur et forme :SolidMasse moléculaire :390.52HSP90/mTOR-IN-1
"HSP90/mTOR-IN-1 is a dual Hsp90/mTOR inhibitor (IC50: 69/29 nM), halting SW780 cell growth and inducing apoptosis/autophagy in cancer research."Formule :C36H34ClFN6O5SCouleur et forme :SolidMasse moléculaire :717.21N-Oleoyl serinol
CAS :N-Oleoyl serinol, a ceramide analog, plays a crucial role in stem cell therapy by inhibiting the development of teratomas in stem cells. It triggers apoptosis in remaining pluripotent embryoid body-derived cells (EBCs), thwarts teratoma formation, and promotes the enrichment of EBC cells that proceed to neural differentiation post-transplantation [1].Formule :C21H41NO3Couleur et forme :SolidMasse moléculaire :355.563CR-6086
CAS :CR6086: potent EP4 antagonist with DMARD effects, low Ki (16.6 nM), and specific anti-inflammatory action.Formule :C26H27F3N2O3Couleur et forme :SolidMasse moléculaire :472.5iMAC2 hydrochloride
CAS :iMAC2 hydrochloride, a potent inhibitor of the mitochondrial apoptosis-induced channel (MAC), demonstrates an IC50 of 28 nM and an LD50 of 15000 nM. It exhibits an anti-apoptotic effect by blocking the release of cytochrome c [1].Formule :C19H22Br2Cl2FN3Couleur et forme :SolidMasse moléculaire :542.11FOXO1-IN-3
CAS :FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that diminishes hepatic glucose production and enhances insulin sensitivity and glucoseFormule :C22H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.46AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€GGTI2417
CAS :GGTI2417 blocks Geranylgeranyltransferase I, targeting RalB for apoptosis and RalA to stop growth.Formule :C24H33N5O4Couleur et forme :SolidMasse moléculaire :455.55Zn(BQTC)
CAS :Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.Formule :C30H36Cl2N5O3ZnDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :650.92(Rac)-Lisaftoclax
CAS :(Rac)-Lisaftoclax ((Rac)-APG-2575), a Bcl-2 inhibitor, is utilized in hematologic malignancy research (CN112898295A) [1].Formule :C45H48ClN7O8SCouleur et forme :SolidMasse moléculaire :882.42RIP2 kinase inhibitor 1
CAS :Potent RIP2 kinase inhibitor with 0.03 μM IC50, selective for autoimmune disease treatment.Formule :C17H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.41NF 023
CAS :NF 023 is a potent, selective P2X1 purinoceptor antagonist.Formule :C35H26N4O21S6Couleur et forme :SolidMasse moléculaire :1030.99USP7-IN-3
CAS :USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59Lacutoclax
CAS :Lacutoclax (LP-108) is an orally active and selective Bcl-2 inhibitor with antitumor activity both in vivo and ex vivo，lymphoma and leukemia.Formule :C48H55ClN8O7SCouleur et forme :SolidMasse moléculaire :923.52EP1013
CAS :EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.Formule :C18H23FN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.38SF5
CAS :SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.Formule :C15H13NSDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :239.34Antitumor agent-60
CAS :Antitumor agent-60 inhibits growth by targeting RAS-RAF, binding CRAF (Kd: 721.3 nM), boosting p53/ROS, causing apoptosis, and arresting G2/M phase.Formule :C24H28O10SCouleur et forme :SolidMasse moléculaire :508.54RET-IN-24
CAS :RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].Formule :C27H26F2N8OCouleur et forme :SolidMasse moléculaire :516.55PIM447
CAS :PIM447 (LGH447) is a pan-PIM kinase inhibitor with anti-tumor and bone protective effects. PIM447 reduces the viability, and motility of HuH6 cell.Formule :C24H23F3N4ODegré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :440.46K145 hydrochloride
CAS :K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.Formule :C18H25ClN2O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :384.92YS-363
CAS :YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (Formule :C30H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.581-Stearoyl-2-Adrenoyl-sn-glycero-3-PC
CAS :1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) acts as a cyclin-dependent kinase (CDK) inhibitor, promoting apoptosis and restricting the proliferation of various cancer cell lines [1].Formule :C48H88NO8PCouleur et forme :SolidMasse moléculaire :838.19INI-43
CAS :INI-43 targets Kpnβ1, disrupting nuclear transport in cervical/esophageal cancers, affecting NFAT, NFκB, AP-1, NF localization.Formule :C22H23N7Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :385.46HJC0152 free base
CAS :HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFormule :C15H13Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.19Z-LLY-FMK
CAS :Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems.Formule :C30H40FN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.65WF-210
CAS :WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.Formule :C41H38FN7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.85A-1293102
CAS :A-1293102 is a potent, selective inhibitor of BCL-XL, effective in inducing apoptosis in tumor cells reliant on BCL-XL [1].Formule :C42H40F3N7O7S5Couleur et forme :SolidMasse moléculaire :972.13CIL62
CAS :CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].Formule :C23H26O5Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :382.45Ref: TM-T8468
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg116,00€25mg222,00€50mg371,00€100mg504,00€200mg675,00€TM5441 sodium
CAS :TM5441, an orally bioavailable plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 values ranging from 13.9 to 51.1 μM, effectively induces intrinsic apoptosis across multiple human cancer cell lines. Additionally, it mitigates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] [2].Formule :C21H16ClN2NaO6Couleur et forme :SolidMasse moléculaire :450.8TL02-59
CAS :TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.Formule :C32H34F3N5O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :609.64Ref: TM-T13186
1mg49,00€2mg62,00€5mg93,00€1mL*10mM (DMSO)111,00€10mg133,00€25mg260,00€50mg401,00€100mg557,00€200mg790,00€MY-673
CAS :MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 proteinFormule :C18H14N2O4Couleur et forme :SolidMasse moléculaire :322.31FGFR-IN-8
CAS :FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.Formule :C27H31Cl2N9O2Couleur et forme :SolidMasse moléculaire :584.5Thaspine acetate
CAS :Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.Formule :C22H23NO8Couleur et forme :SolidMasse moléculaire :429.425WEHI-345
CAS :WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.Formule :C22H23N7ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :401.46Lactoferrin (17-41) acetate
CAS :Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide derived from bovine lactoferrin spanning residues 17-41, exhibits broad-spectrum antimicrobial properties against Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. Additionally, this compound demonstrates antitumor activities [1] [2].Formule :C143H226N46O33S3Couleur et forme :SolidMasse moléculaire :3183.82Mezigdomide
CAS :Mezigdomide (CC-92480) is a potent, novel cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue.Cost-effective and quality-assured.Formule :C32H30FN5O4Degré de pureté :97.21% - 99.68%Couleur et forme :SolidMasse moléculaire :567.61AR420626
CAS :AR420626: selective FA3R agonist, guards against SALS, effects blocked by BHB, a FA3R antagonist.Formule :C21H18Cl2N2O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :417.29DLC-50
CAS :DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.Formule :C28H32FN5O4S2Couleur et forme :SolidMasse moléculaire :585.71ICL-CCIC-0019
CAS :ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.Formule :C26H44Br2N4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :572.46Ref: TM-T27579
2mg43,00€5mg70,00€1mL*10mM (DMSO)88,00€10mg92,00€25mg132,00€50mg200,00€100mg344,00€200mg505,00€HAPSBC
CAS :HAPSBC, an S-benzyl iron chelator, modulates the intracellular distribution of ^59Fe [1].Formule :C15H15N3S2Couleur et forme :SolidMasse moléculaire :301.43SM-433
CAS :SM-433: Smac mimetic, blocks IAPs, strong XIAP BIR3 affinity (IC50 <1 μM). See patent WO2008128171A2.Formule :C32H43N5O4Couleur et forme :SolidMasse moléculaire :561.71Delmitide acetate
CAS :Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties.Formule :C61H109N17O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1288.62Nedometinib
CAS :Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Formule :C17H16FIN4O3Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :470.24Ref: TM-T78209
1mg66,00€5mg145,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg708,00€Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767.00ICy-Q
CAS :ICy-Q, a NIR reagent activated by NQO-1, triggers pyroptosis in pancreatic cancer cells, aiding diagnosis.Formule :C48H50I2N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :988.731,2-Di-13(Z)-Docosenoyl-3-Oleoyl-rac-glycerol
CAS :1,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol is a triacylglycerol composed of 13(Z)-docosenoic acid at both the sn-1 and sn-2 positions and oleic acid at the sn-3 position.Formule :C65H120O6Couleur et forme :SolidMasse moléculaire :997.64HDAC-IN-63
CAS :HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.Formule :C25H26Cl2N6O3Couleur et forme :SolidMasse moléculaire :529.42NBI-961
CAS :NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cellFormule :C28H27F3N6O2SCouleur et forme :SolidMasse moléculaire :568.61NSC 48160
CAS :NSC 48160 is an anti-pancreatic cancersmall molecule that inhibits growth and enhance apoptosis of pancreatic cancer cells through the mitochondrial pathway.Formule :C18H29NODegré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :275.43Ref: TM-T79783
1mg83,00€5mg175,00€1mL*10mM (DMSO)193,00€10mg282,00€25mg556,00€50mg914,00€100mg1.468,00€UNC3474
CAS :UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting aFormule :C17H28N2OCouleur et forme :SolidMasse moléculaire :276.42eIF4A3-IN-9
CAS :eIF4A3-IN-9, a silvestrol analogue, disrupts eIF4F complex assembly; EC50s: 29/450/80 nM (myc/tub-LUC, MB-231 cells); for cancer research.Formule :C28H27NO8Couleur et forme :SolidMasse moléculaire :505.52Lepadin E
CAS :Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.Formule :C26H47NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.66
