Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(127 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
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6170 produits trouvés pour "Apoptose"
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c-Myc inhibitor 16 iodide
CAS :c-Myc inhibitor16 iodide (Compound W11) is a selective inhibitor of the c-MycG-quadruplex (c-MycG4). It suppresses the transcription and translation of the c-Myc gene, disrupts the tumor cell cycle by halting growth at the G0/G1 phase, and activates mitochondrial apoptotic pathways, leading to early apoptosis in cancer cells. This compound shows potential for research in breast cancer.Formule :C26H24INOCouleur et forme :SolidMasse moléculaire :493.379CRI9
CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.Formule :C26H18N6O4Couleur et forme :SolidMasse moléculaire :478.46GLUT-1-IN-4
CAS :GLUT-1-IN-4 (Compound 13) is an inhibitor of the GLUT-1 glucose transporter that depends on the p53 protein. It suppresses the proliferation of various cancer cells at submicromolar IC50 levels. Additionally, GLUT-1-IN-4 can halt the cell cycle, induce oxidative stress, and promote apoptosis (cell death).Formule :C15H10N2O3Couleur et forme :SolidMasse moléculaire :266.251BMI-135
CAS :BMI-135, a selective estrogen mimic, demonstrates agonist activity for the estrogen receptor and induces a rapid endoplasmic reticulum stress response (UPR) alongside apoptosis in breast cancer cells.Formule :C23H13FO2SCouleur et forme :SolidMasse moléculaire :372.41(Rac)-Idroxioleic acid sodium
CAS :(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.Formule :C18H33NaO3Couleur et forme :SolidMasse moléculaire :320.44XIAP/cIAP1 antagonist-1
Potent oral XIAP/cIAP1 inhibitor with EC50s: XIAP 5.1 nM, cIAP1 0.32 nM; curbs tumor growth in vivo.Couleur et forme :SolidAQIM-I
CAS :AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].Formule :C17H13IN2O2Couleur et forme :SolidMasse moléculaire :404.20PARP10/15-IN-3
Compound 8a, a dual PARP10 & PARP15 inhibitor, has IC50s: PARP10 at 0.14μM & PARP15 at 0.40μM; it's cell-permeable & anti-apoptotic.Formule :C12H12N2O3Couleur et forme :SolidMasse moléculaire :232.24Top/HDAC-IN-3
CAS :Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47Flonoltinib sulfate
CAS :Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.Formule :C25H36FN7O5SCouleur et forme :SolidMasse moléculaire :565.661HBV/HDV-IN-2
CAS :HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.Formule :C38H44ClN7O5Couleur et forme :SolidMasse moléculaire :714.25Antitumor agent-184
CAS :Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Formule :C22H16N4O2SCouleur et forme :SolidMasse moléculaire :400.45Ketorolac hydrochloride
CAS :Ketorolac (RS37619) hydrochloride is a nonsteroidal anti-inflammatory drug and a non-selective COX inhibitor, exhibiting IC50 values of 20 nM for COX-1 and 120 nM for COX-2. This compound is utilized in a 0.5% ophthalmic solution format for the investigation of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and post-operative ocular inflammation pain. Additionally, Ketorolac hydrochloride serves as a DDX3 inhibitor, making it pertinent for research in cancer therapies.Formule :C15H14ClNO3Couleur et forme :SolidMasse moléculaire :291.73Cetzole
CAS :Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formule :C11H11NOSCouleur et forme :SolidMasse moléculaire :205.28Topoisomerase inhibitor 4
CAS :Topoisomerase inhibitor4 (compound 45) acts as an effective inhibitor of Topoisomerase1/2, arresting the cell cycle at the G2/M phase and inducing Apoptosis. This compound exhibits potent antitumor activity.Formule :C30H28F3IN4O3Couleur et forme :SolidMasse moléculaire :676.47Nenocorilant
CAS :Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55SILA-123
CAS :SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.Formule :C24H25N5O2Couleur et forme :SolidMasse moléculaire :415.49HL001
CAS :HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1). It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.Formule :C21H16N2O4Couleur et forme :SolidMasse moléculaire :360.363Microtubulin-IN-1
CAS :Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.Formule :C25H21FN4O3Couleur et forme :SolidMasse moléculaire :444.458GPX4-IN-3
CAS :GPX4-IN-3 (26a) is a potent GPX4 inhibitor, inducing selective ferroptosis with 71.7% inhibition at 1 μM.Formule :C29H24ClN3O3SCouleur et forme :SolidMasse moléculaire :530.04DPP-21
CAS :DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 μM). It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2). DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.Formule :C17H16N4SCouleur et forme :SolidMasse moléculaire :308.40TBC-1
CAS :TBC-1 is a chlorophyll-a derivative that acts as a photosensitizer for photodynamic therapy (PDT). It efficiently generates type I ROS and targets the endoplasmic reticulum. TBC-1 demonstrates in vitro biocompatibility and PDT effectiveness under both normoxic and hypoxic conditions.Formule :C31H28BrN3O3Couleur et forme :SolidMasse moléculaire :570.476Metamizole hemimagnesium
CAS :Metamizole (Dipyrone) hemimagnesium is an anti-inflammatory and antioxidant compound known for its ability to reduce fever. It decreases levels of C-reactive protein (CRP) and interleukin 6 (IL-6). Additionally, Metamizole hemimagnesium acts as an orally active cyclooxygenase (COX) inhibitor, suppressing cell proliferation and promoting apoptosis. It is utilized in the study of inflammation and fever.Formule :C13H17MgN3O4SCouleur et forme :SolidMasse moléculaire :335.662Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23Tubulin inhibitor 43
CAS :Tubulin inhibitor 43 exhibits significant antitumor activity by impeding the proliferation and growth of cancer cells through the inhibition of β-microtubulin activity, ultimately inducing apoptosis [1].Formule :C20H21NO6Couleur et forme :SolidMasse moléculaire :371.38Antitumor agent-42
Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.Formule :C24H19BrN2O8SCouleur et forme :SolidMasse moléculaire :575.39PDEδ/NAMPT IN-1
CAS :PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.Formule :C26H30N4O4SCouleur et forme :SolidMasse moléculaire :494.61Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride
CAS :Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTAC.Formule :C19H24ClN5O6Masse moléculaire :453.88DL-Buthionine-(S,R)-sulfoximine hydrochloride
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitorFormule :C8H19ClN2O3SCouleur et forme :SolidMasse moléculaire :258.77Antitumor agent-77
Antitumor agent-77 suppresses cancer cell growth, migration, induces apoptosis, and hinders EMT.Formule :C7H11F3N2O5PtCouleur et forme :SolidMasse moléculaire :455.25SL-176
CAS :SL-176, a WIP1 inhibitor, when combined with GSK-J4, can induce cell cycle arrest and apoptosis (apoptosis), thereby inhibiting tumor growth both in vitro and in vivo.Formule :C24H48O4Si2Couleur et forme :SolidMasse moléculaire :456.806DWP-05195
CAS :DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.Formule :C18H10BrF3N4Couleur et forme :SolidMasse moléculaire :419.2p53-MDM2-IN-6
CAS :p53-MDM2-IN-6, an LSM-83177 hydrazone analog, acts as an efficacious p53-MDM2 inhibitor with an IC50 of 11.08 µg/mL. This compound inhibits the p53-MDM2 interaction leading to an increase in p-53 levels while concurrently decreasing GST enzyme expression. It halts the cell cycle at the S phase and induces early and late apoptosis (Apoptosis), exhibiting antiproliferative activity against the HT29 cell line with an IC50 of 10.44 µg/mL. p53-MDM2-IN-6 holds promise for research in colorectal cancer.Formule :C17H17N3O4Couleur et forme :SolidMasse moléculaire :327.33IMB5046
CAS :IMB5046 is a microtubule inhibitor that induces apoptosis (cell death) by obstructing the G2/M phase of the cell cycle. It possesses antitumor properties.Formule :C19H20N2O5SCouleur et forme :SolidMasse moléculaire :388.438RIP3 activator 1
CAS :RIP3 Activator 1 (compound C8) is an effective RIP3 activator that inhibits cell growth and induces necroptotic cell death (necroptosis) and autophagy through the RIP3/p62/Keap1 signaling pathway. Additionally, this compound enhances the expression of p-MLKL and promotes the accumulation of LC3-II and p62 proteins.Formule :C26H50N4O3Couleur et forme :SolidMasse moléculaire :466.7RIPK3-IN-6
CAS :RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with low selectivity within the RIPK family, particularly in relation to RIPK2 activity.Formule :C21H17N3OCouleur et forme :SolidMasse moléculaire :327.38Apoptosis inducer 42
CAS :Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer.Formule :C11H13OPSCouleur et forme :SolidMasse moléculaire :224.26ZSH-512
CAS :ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.
Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.464Aplysin
CAS :Aplysin suppresses breast cancer cells and protects liver cells by blocking PI3K/AKT/FOXO3a and preventing oxidative damage.Formule :C15H19BrOCouleur et forme :SolidMasse moléculaire :295.21VEGFR-IN-3
CAS :VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52TrxR-IN-8
CAS :TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.Formule :C16H16INO2Couleur et forme :SolidMasse moléculaire :381.21Antitumor agent-78
Antitumor agent-78 blocks GPx-4, raises COX2, triggers apoptosis, halts EMT, and stifles cancer cell growth and migration.Couleur et forme :SoildDecarbamoylmitomycin C
CAS :Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formule :C14H17N3O4Couleur et forme :SolidMasse moléculaire :291.302MRK003
CAS :MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.Formule :C25H31F6N3O2SCouleur et forme :SolidMasse moléculaire :551.59HDAC-IN-34
HDAC-IN-34 inhibits HDAC1 (IC50: 0.022 μM) & HDAC6 (IC50: 0.45 μM), binds DNA causing damage, and halts HCT-116 cell growth (IC50: 1.41 μM).Formule :C24H26N6O3Couleur et forme :SolidMasse moléculaire :446.5UR-AK49
CAS :UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.Formule :C16H27N5OCouleur et forme :SolidMasse moléculaire :305.42QTX125 TFA
QTX125 TFA: Potent, selective HDAC6 inhibitor with antitumor effects.Formule :C25H20F3N3O7Couleur et forme :SolidMasse moléculaire :531.44GGTI-2154 hydrochloride
CAS :GGTI-2154 hydrochloride: selective GGTase I inhibitor, IC50 21 nM, used in cancer research.Formule :C24H29ClN4O3Couleur et forme :SolidMasse moléculaire :456.97LSD1-IN-35
CAS :LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.Formule :C25H26N4O2SCouleur et forme :SolidMasse moléculaire :446.57Samuraciclib
CAS :Samuraciclib (CT7001) is an oral CDK7 inhibitor with 41 nM IC50, notable for its high selectivity and potency against breast cancer cells.Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51Ran-IN-1
CAS :Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ). This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.Formule :C27H26F3NO4SCouleur et forme :SolidMasse moléculaire :517.56Minnelide
CAS :Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types.Formule :C21H25Na2O10PDegré de pureté :98.49% - 99.59%Couleur et forme :SolidMasse moléculaire :514.373-AP-Me
CAS :3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.Formule :C9H13N5SCouleur et forme :SolidMasse moléculaire :223.298BMS-751324
CAS :BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.Formule :C32H35N6O10PCouleur et forme :SolidMasse moléculaire :694.63T-1-PMPA
CAS :T-1-PMPA, a potent EGFR inhibitor, demonstrates apoptotic properties and effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively [1].Formule :C16H17N5O3Couleur et forme :SolidMasse moléculaire :327.34WEHI-9625
CAS :WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).Formule :C34H27NO5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.71TrxR/EGFR-IN-1
CAS :TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.Formule :C24H24AuClFN6O2PCouleur et forme :SolidMasse moléculaire :710.878TMC353121
CAS :TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).Formule :C32H42N6O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :558.71Minnelide free acid
CAS :Minnelide treats pancreatic cancer, hinders androgen-related prostate growth, shrinks tumors, and improves survival.Formule :C21H27O10PCouleur et forme :SolidMasse moléculaire :470.41eIF4A3-IN-6
CAS :eIF4A3-IN-6 is a potent eIF4A inhibitor, potentially used for treating eIF4A-related diseases like cancer. (US20170145026A1)Formule :C26H25N3O5Couleur et forme :SolidMasse moléculaire :459.49Topoisomerase I/II inhibitor 8
CAS :TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.Formule :C14H11Br2NO5S2Couleur et forme :SolidMasse moléculaire :497.179Anticancer agent 183
CAS :Anticancer agent 183 (compound 4h) exhibits potent inhibition of matrix metalloproteinase-9 (MMP-9), reducing its viability by more than 75% at a concentration of 100 μg/mL. Additionally, it demonstrates significant anticancer activity, with an IC50 value of <0.14 μM against the A549 cell line and induces apoptotic [1] processes.Formule :C19H18N4O4SCouleur et forme :SolidMasse moléculaire :398.44Ivaltinostat formic
Ivaltinostat (CG-200745) is an oral panHDAC inhibitor, inducing apoptosis and enhancing cancer drug sensitivity.Formule :C25H35N3O6Couleur et forme :SolidMasse moléculaire :473.56NLRP3-IN-81
CAS :NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.Formule :C16H15F3N2O3SCouleur et forme :SolidMasse moléculaire :372.36Mcl-1 inhibitor 21
CAS :Mcl-1 inhibitor21 (Example 1-36) is an Mcl-1 inhibitor with an IC50 of 328 nM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it applicable for cancer research.Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622ZIF-8
CAS :ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513TZEP7
CAS :TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.Formule :C27H19ClFNSCouleur et forme :SolidMasse moléculaire :443.963SphK1-IN-2
SphK1-IN-2: SphK1 inhibitor, IC50: 19.81 nM; less effective on SphK2. Induces apoptosis, hinders cancer cell growth.Formule :C27H30BrNO4SCouleur et forme :SolidMasse moléculaire :544.5p53 Activator 11
CAS :P53 Activator 11 (compound A-1) is a highly effective p53 activator, demonstrating an EC50 value of 0.478 µM for p53 (Y220C). It holds potential for cancer research [1].Formule :C26H29N7O2SCouleur et forme :SolidMasse moléculaire :503.62INNO-220
CAS :INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis). It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.Formule :C23H20N4O3Couleur et forme :SolidMasse moléculaire :400.43N-Nitrosonornicotine
CAS :N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2MNK1/2-IN-6
MNK1/2-IN-6: Strong, selective MNK1/2 inhibitor; IC50s: MNK1 at 2.3 nM, MNK2 at 3.4 nM; triggers dose-dependent apoptosis.Formule :C27H24N6OCouleur et forme :SolidMasse moléculaire :448.52APD-94
CAS :APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.Formule :C18H17N3O4Couleur et forme :SolidMasse moléculaire :339.345NLRP3-IN-78
CAS :NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Formule :C12H5Cl2N3O4S2Couleur et forme :SolidMasse moléculaire :390.222NF-κB-IN-4
NF-κB-IN-4 (compound 17) is a potent inhibitor of NF-κB pathway which can cross blood brain barrier (BBB).Formule :C18H15FN4OCouleur et forme :SolidMasse moléculaire :322.34VEGFR-2-IN-15
VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.Formule :C23H18ClN3O4SCouleur et forme :SolidMasse moléculaire :467.92XIAP degrader-1
XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).Formule :C34H45N5O4Couleur et forme :SolidMasse moléculaire :587.75CDK2/9-IN-1
CAS :CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.Formule :C14H14N6O2S2Couleur et forme :SolidMasse moléculaire :362.43Thalidomide-O-PEG4-amine TFA
CAS :Thalidomide-O-PEG4-amine TFA is a synthetic E3 ligase ligand-linker conjugate, composed of a cereblon ligand derived from Thalidomide and a single linker.Formule :C25H32F3N3O11Masse moléculaire :607.53GGTI298
CAS :GGTI298 is a potent GGTase I inhibitor; IC50 3μM for Rap1A, >20μM for Ha-Ras.Formule :C27H33N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.63PD-L1/Nampt-IN-1
CAS :PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formule :C28H28N4O2Couleur et forme :SolidMasse moléculaire :452.55EMT inhibitor-3
CAS :EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.Formule :C29H21F2N3O4SeCouleur et forme :SolidMasse moléculaire :592.456:2 Cl-PFAES
CAS :6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.Formule :C8ClF16KO4SCouleur et forme :SolidMasse moléculaire :570.67Apoptosis inducer 36
CAS :Apoptosisinducer 36 (Compound 42) exhibits anti-leukemic activity by reducing leukemia stem cells (LSC) and inducing differentiation. It inhibits proliferation of AML cells by causing cell cycle arrest in the G1 phase, and induces PANoptosis, which includes apoptosis, pyroptosis, and necrosis.Formule :C23H40O3SiCouleur et forme :SolidMasse moléculaire :392.647Caspase-3-IN-2
CAS :Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Formule :C10H6ClNO5Couleur et forme :SolidMasse moléculaire :255.611Mcl-1 inhibitor 9
CAS :Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.Formule :C32H39ClN2O5SCouleur et forme :SolidMasse moléculaire :599.18Bim-IN-1
Bim-IN-1 is a potent inhibitor of Bim expression with low toxicity, Bim-IN-1 reduces Bim expression levels with little inhibition of protein kinase A.Formule :C19H20Cl2FNO2SCouleur et forme :SolidMasse moléculaire :416.34Tofacitinib Prodrug-1
Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.Formule :C36H39ClN10O7Couleur et forme :SolidMasse moléculaire :759.21NSC308848
CAS :NSC308848 is an effective apoptosis (cell death) inducer that operates in a Myc-dependent manner. It acts by inhibiting Myc transactivation and disrupting the DNA binding activity of Myc family proteins.Formule :C18H21N3O2Couleur et forme :SolidMasse moléculaire :311.378MTDH-SND1 blocker 2
CAS :MTDH-SND1 blocker 2 (compound C19) is an effective MTDH-SND1 inhibitor with an IC50 value of 487 nM. It binds to the SND1 protein with a Kd of 279 nM and can degrade the SND1 protein. Additionally, MTDH-SND1 blocker 2 exhibits antiproliferative activity and induces apoptosis, showing potential for breast cancer research.Formule :C18H12FN3O2SCouleur et forme :SolidMasse moléculaire :353.37Ferroptosis-IN-18
CAS :Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).Formule :C25H27N3SCouleur et forme :SolidMasse moléculaire :401.567Tuspetinib dihydrochloride
CAS :Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).Formule :C29H35Cl3N6Couleur et forme :SolidMasse moléculaire :573.99M3258
CAS :LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor ofFormule :C17H20BNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.16JND4135
CAS :JND4135, a type II TRK inhibitor, exhibits IC50 values targeting TRKA, TRKB, and TRKC at 2.79, 3.19, and 3.01 nM, respectively. It can overcome resistance due to TRKxDFG and other mutations in the BaF3 stable model, inhibiting the phosphorylation of TRKs WT, xDFG mutations, and their downstream signaling molecules. Additionally, JND4135 induces G0/G1 phase arrest and cell apoptosis (apoptosis) in BaF3–CD74-TRKA-G667C cells. This compound also demonstrates antitumor activity in a BaF3-CD74-TRKA-G667C mouse xenograft model by suppressing tumor growth.Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75Antiproliferative agent-4
Antiproliferative agent-4 suppresses cancer cell growth with low toxicity, inhibits tumors in mice, and induces apoptosis in EC109 cells.Formule :C29H35ClO8Couleur et forme :SolidMasse moléculaire :547.04HSP90-IN-10
HSP90-IN-10 is a potent HSP90 inhibitor, targeting HCC1954 cells (IC50: 6 μM) and inducing apoptosis, sparing normal cells.Formule :C30H26FN3O6Couleur et forme :SolidMasse moléculaire :543.54Anti-inflammatory agent 16
Compound 14 is a peptidomimetic that significantly lowers TNFα, NO, CD40, and CD86, showcasing strong anti-inflammatory effects.Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.44ZLMT-12
ZLMT-12: tacrine derivative, inhibits CDK2/CDK9, weak on AChE/BuChE, anti-proliferative, low toxicity, blocks S/G2/M phase, induces apoptosis.Formule :C26H31ClN6OCouleur et forme :SolidMasse moléculaire :479.02PD-L1/HDAC6-IN-1
CAS :PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.Formule :C27H33N3O3Couleur et forme :SolidMasse moléculaire :447.569Bayer-18
CAS :Bayer-18 is an inhibitor of TYK2. It inhibits the viability of anaplastic large cell lymphoma cells, including K299, SR786, Mac1, and Mac2a, with an IC50 ranging from 2-3 µM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells.Formule :C19H27FN6O2Couleur et forme :SolidMasse moléculaire :390.46
