Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(126 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(91 produits)
- c-RET(61 produits)
- p53(63 produits)
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6170 produits trouvés pour "Apoptose"
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MAPK-IN-5
CAS :MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 μM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.Formule :C30H29F3N6O4Couleur et forme :SolidMasse moléculaire :594.58Z-VAD
CAS :Z-VAD is an irreversible pan-caspase inhibitor, suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy in tumour cells.
Formule :C20H27N3O8Degré de pureté :98.961%Couleur et forme :SolidMasse moléculaire :437.44eIF4A-IN-1
CAS :eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formule :C31H33N3O5Couleur et forme :SolidMasse moléculaire :527.61Flizasertib
CAS :Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Formule :C15H14FN3ODegré de pureté :99.39% - 99.57%Couleur et forme :SolidMasse moléculaire :271.29Bim-IN-1
Bim-IN-1 is a potent inhibitor of Bim expression with low toxicity, Bim-IN-1 reduces Bim expression levels with little inhibition of protein kinase A.Formule :C19H20Cl2FNO2SCouleur et forme :SolidMasse moléculaire :416.34Neral
CAS :Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23MB710
CAS :MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Formule :C16H16IN3O3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.29DWP-05195
CAS :DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.Formule :C18H10BrF3N4Couleur et forme :SolidMasse moléculaire :419.2Hdm2 E3 ligase inhibitor 1
CAS :Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.Formule :C10H8F6N2O3SMasse moléculaire :350.24Topoisomerase II inhibitor 20 TFA
TopoisomeraseII Inhibitor 20 TFA is a potent inhibitor of topoisomerase II with an IC50 of 0.98 µM. It can induce cell apoptosis and exhibits broad-spectrum anticancer activity.Formule :C24H24F5N5O4SCouleur et forme :SolidMasse moléculaire :573.54Tandutinib sulfate
CAS :Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.Formule :C31H44N6O8SCouleur et forme :SolidMasse moléculaire :660.78Ferrostatin-1 diyne
CAS :Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.Formule :C18H22N2O2Couleur et forme :SolidMasse moléculaire :298.38EGFR/VEGFR2-IN-3
CAS :EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03GlcNAc-MurNAc
CAS :GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.Formule :C19H32N2O13Couleur et forme :SolidMasse moléculaire :496.46Z-VAD-AMC
CAS :Z-VAD-AMC acts as a substrate specifically for caspase-9.Formule :C30H34N4O9Masse moléculaire :594.61TRPM7-IN-1
CAS :TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48TNF-α-IN-12
CAS :TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.4QTX125 TFA
QTX125 TFA: Potent, selective HDAC6 inhibitor with antitumor effects.Formule :C25H20F3N3O7Couleur et forme :SolidMasse moléculaire :531.44SphK1-IN-2
SphK1-IN-2: SphK1 inhibitor, IC50: 19.81 nM; less effective on SphK2. Induces apoptosis, hinders cancer cell growth.Formule :C27H30BrNO4SCouleur et forme :SolidMasse moléculaire :544.5Ph-Ph+
Ph-Ph+ is a dimerized phenanthroline derivative with antitumor, antibacterial, and antifungal effects.Formule :C24H17N4Couleur et forme :SolidMasse moléculaire :361.42DC-U4106
CAS :DC-U4106: USP8 inhibitor, Kd 4.7μM, IC50 1.2μM, degrades Erα, low-toxicity tumor suppressor for breast cancer research.Formule :C29H27N5O5Couleur et forme :SolidMasse moléculaire :525.56NCI-006
CAS :NCI-006, an LDH inhibitor, slows tumor growth and enhances pyruvate's role in mitochondrial metabolism.Formule :C31H24F2N4O4S3Couleur et forme :SolidMasse moléculaire :650.74Thalidomide-NH-amido-C4-NH2
CAS :Thalidomide-NH-amido-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate composed of a Thalidomide-based cereblon ligand and a linker, which is utilized in the synthesis of PROTAC.Formule :C19H23N5O5Masse moléculaire :401.426:2 Cl-PFAES
CAS :6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.Formule :C8ClF16KO4SCouleur et forme :SolidMasse moléculaire :570.67N-Nitrosonornicotine
CAS :N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2p53 Activator 11
CAS :P53 Activator 11 (compound A-1) is a highly effective p53 activator, demonstrating an EC50 value of 0.478 µM for p53 (Y220C). It holds potential for cancer research [1].Formule :C26H29N7O2SCouleur et forme :SolidMasse moléculaire :503.62AKN-028 acetate
AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.Formule :C19H18N6O2Couleur et forme :SolidMasse moléculaire :362.39XIAP degrader-1
XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).Formule :C34H45N5O4Couleur et forme :SolidMasse moléculaire :587.75Topoisomerase I/II inhibitor 8
CAS :TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.Formule :C14H11Br2NO5S2Couleur et forme :SolidMasse moléculaire :497.179JNK-IN-19
CAS :JNK-IN-19 (Compound Q8) is an inhibitor of c-Jun N-terminal kinase, utilized for the treatment and/or prevention of injuries prior to, during, or following surgery.Formule :C22H24F3N6Na2O6PCouleur et forme :SolidMasse moléculaire :602.41YK5
CAS :YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.Formule :C18H24N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.50ASK1-IN-7
CAS :ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formule :C13H8N2O2S2Couleur et forme :SolidMasse moléculaire :288.345T-1-PMPA
CAS :T-1-PMPA, a potent EGFR inhibitor, demonstrates apoptotic properties and effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively [1].Formule :C16H17N5O3Couleur et forme :SolidMasse moléculaire :327.34UR-AK49
CAS :UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.Formule :C16H27N5OCouleur et forme :SolidMasse moléculaire :305.42Aplysin
CAS :Aplysin suppresses breast cancer cells and protects liver cells by blocking PI3K/AKT/FOXO3a and preventing oxidative damage.Formule :C15H19BrOCouleur et forme :SolidMasse moléculaire :295.21PIM-1/HDAC-IN-1
PIM-1/HDAC-IN-1 (4d): inhibits PIM-1 (IC50: 343.87nM), HDAC1 (63.65nM), HDAC6 (62.39nM); induces apoptosis in MCF-7 cells.Formule :C22H19N3O3Couleur et forme :SolidMasse moléculaire :373.4Spliceostatin A
CAS :Spliceostatin A is an anticancer agent and splicing inhibitor that induces apoptosis by inducing cell cycle arrest in the G1 and G2/M phases.Formule :C28H43NO8Degré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :521.643Sinulatumolin E
CAS :Sinulatumolin E, a terpenoid, inhibits TNF-α (IC 50: 3.6 μM); has anti-inflammatory properties.Formule :C15H22O2Couleur et forme :SolidMasse moléculaire :234.33Etalocib sodium
CAS :Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.Formule :C33H32FNaO6Couleur et forme :SolidMasse moléculaire :566.59AQIM-I
CAS :AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].Formule :C17H13IN2O2Couleur et forme :SolidMasse moléculaire :404.20Antitumor agent-184
CAS :Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Formule :C22H16N4O2SCouleur et forme :SolidMasse moléculaire :400.45TLBC
CAS :TLBC, a borane-chalcone derivative, exhibits dose-dependent inhibitory effects across various glioma cell lines with IC50 values ranging from 5.5 to 25.5 μM. TLBC induces apoptosis independently of alterations in the tumor suppressor factor p53.Formule :C15H12BIO3Couleur et forme :SolidMasse moléculaire :377.97Tubulin polymerization-IN-3
Tubulin polymerization-IN-3 is a potent inhibitor of microtubulin polymerization (IC50: 3.84 μM) and induces apoptosis in colon cancer cells.Formule :C20H20ClN5O3Couleur et forme :SolidMasse moléculaire :413.86Antiproliferative agent-63
CAS :Antiproliferative agent-63 (compound 4d) is a cyclic analog of cannabidiol that acts as an anticancer agent. It demonstrates favorable activity against breast and colorectal cancer. Moreover, this compound can arrest the cell cycle in the G1 phase and induce apoptosis through the mitochondrial pathway in breast cancer cell lines.Formule :C27H41NO2Couleur et forme :SolidMasse moléculaire :411.62NDs-IN-1
CAS :NDs-IN-1 (Compound 3g) is a novel non-covalent multi-target inhibitor that inhibits the activities of key enzymes such as hBACE-1, hAChE, and hMAO-B, and is primarily used in the study of neurodegenerative diseases [1].Formule :C20H18N2O2Couleur et forme :SolidMasse moléculaire :318.37EGFR-IN-62
EGFR-IN-62: IC50 of 10-242 nM for various EGFR mutations, blocks A549/H1975 cell cycle, induces apoptosis, and inhibits cell motility and proliferation.Formule :C30H33N9O2Couleur et forme :SolidMasse moléculaire :551.64Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23sEH-IN-21
CAS :sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).Formule :C30H40N4O5SCouleur et forme :SolidMasse moléculaire :568.73RMS5
CAS :RMS5: hambanine analogue, inhibits P-gp, anti-cancer with cytotoxic, anti-proliferative effects, reduces Bcl-2 proteins, cleaves PARP.Formule :C35H38N2O5SCouleur et forme :SolidMasse moléculaire :598.75ADH-6
CAS :ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64CDK-IN-9
CDK-IN-9: A potent CDK inhibitor, gels to enhance CDK12/DDB1 binding, targets CDK2/E (IC50: 4 nM), induces apoptosis via dephosphorylation.Formule :C21H24N8SCouleur et forme :SolidMasse moléculaire :420.53Anticancer agent 64
CAS :Anticancer agent 64 (5m) induces apoptosis, has IC50 2.4μM in CCRF-CEM, activates caspases, cleaves PARP, affects mitochondria.Formule :C31H46N2O2SCouleur et forme :SolidMasse moléculaire :510.77D18
CAS :D18: Dual agonist for TLR7/8, boosts PD-L1, aids tumor sensitivity to PD-1/PD-L1 inhibitors, and is a cytotoxin for ADC HE-S2.Formule :C21H28N6Couleur et forme :SolidMasse moléculaire :364.49MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38HDAC-IN-37
HDAC-IN-37 inhibits HDACs 1, 3, 8, & 6, induces histone acetylation, halts G1 to S phase, and triggers early apoptosis.Formule :C23H24ClN7OCouleur et forme :SolidMasse moléculaire :449.94FLT3-ITD-IN-3
CAS :FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).Formule :C27H21ClF2N6O5Couleur et forme :SolidMasse moléculaire :582.943PD-1/PD-L1-IN-15
PD-1/PD-L1-IN-15 is a potent inhibitor of PD-1/PD-L1 (IC50: 60.1 nM) and has shown investigational potential for tumor immunotherapy.Formule :C32H30N4O3Couleur et forme :SolidMasse moléculaire :518.61ZLMT-12
ZLMT-12: tacrine derivative, inhibits CDK2/CDK9, weak on AChE/BuChE, anti-proliferative, low toxicity, blocks S/G2/M phase, induces apoptosis.Formule :C26H31ClN6OCouleur et forme :SolidMasse moléculaire :479.02ZLHQ-5f
ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.Formule :C28H25N5O2Couleur et forme :SolidMasse moléculaire :463.53Lometrexol hydrate
CAS :Lometrexol hydrate, an antipurine antifolate, inhibits GARFT and purine synthesis, leading to cancer cell apoptosis without causing DNA breaks.Formule :C21H27N5O7Couleur et forme :SolidMasse moléculaire :461.475BTK-IN-7
BTK-IN-7 is a potent inhibitor for BTK with 4.0 nM IC50, highly selective over ITK and EGFR, showing strong antitumor activity.Formule :C30H32N6O4Couleur et forme :SolidMasse moléculaire :540.61TP-030-2
CAS :TP-030-2 is a RIPK1 inhibitor (human K i =0.43 nM ; mouse IC 50 =100 nM) .Formule :C23H21BrN4O3Couleur et forme :SolidMasse moléculaire :481.34D-Cl-amidine hydrochloride
D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1].Formule :C14H20Cl2N4O2Couleur et forme :SolidMasse moléculaire :347.24Top/HDAC-IN-3
CAS :Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47(Rac)-Idroxioleic acid sodium
CAS :(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.Formule :C18H33NaO3Couleur et forme :SolidMasse moléculaire :320.44RIPK1-IN-23
CAS :RIPK1-IN-23 (compound 19) is an RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 = 1.7 nM). Additionally, RIPK1-IN-23 exhibits anti-inflammatory properties.Formule :C27H22N6O3Masse moléculaire :478.50TH-6
TH-6, a potent HDAC inhibitor (IC50: HDAC1-0.115, 2-0.135, 3-0.242, 6-0.138, 8-2.120 μM), blocks cell migration, invasion, and has anti-tumor properties.Formule :C22H24FN3O5Couleur et forme :SolidMasse moléculaire :429.44Pamiparib maleate
CAS :Pamiparib (BGB-290) is a selective PARP inhibitor that blocks DNA repair and promotes apoptosis.Formule :C44H42F2N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :944.859CB-184
CAS :CB-184 is a selective ligand for sigma-2 (σ2) receptors, with Ki values of 7436 nM for sigma-1 (σ1) and 13.4 nM for sigma-2 (σ2), and it promotes apoptosis with antitumor activity.Formule :C22H21Cl2NO2Couleur et forme :SolidMasse moléculaire :402.31FHND5071 (1H)
CAS :FHND5071 (1H) is a selective inhibitor of RET (rearranged during transfection) tyrosine kinase. It shows potential for research applications in RET-driven cancers, such as thyroid and lung cancer.Formule :C30H33N9OCouleur et forme :SolidMasse moléculaire :535.64Cofpropamine
CAS :Cofpropamine, a caffeine derivative that inhibits polyadenylation, enhances the suppressive effects of Cyclophosphamide in animal models of rat adjuvant arthritis and mouse collagen-induced arthritis.Formule :C13H21N5O3Couleur et forme :SolidMasse moléculaire :295.34MGD-22
CAS :MGD-22 is a molecular glue and orally active degrader of IKZF1/2/3, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. It exhibits strong anti-proliferative activity against various hematological cancer cells and induces cell apoptosis (apoptosis). MGD-22 demonstrates significant anti-tumor efficacy in mice with NCI-H929 or WSU-DLCL-2 xenografts. This compound is useful for researching blood cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).Formule :C33H35N7O3Couleur et forme :SolidMasse moléculaire :577.68LSD1/ER-IN-1
LSD1/ER-IN-1 inhibits ER & LSD1 (IC50: 1.55 μM), and fights MCF-7 breast cancer (IC50: 8.79 μM).Formule :C23H18FNO6SCouleur et forme :SolidMasse moléculaire :455.46Dicycloplatin
CAS :Dicycloplatin is an inducer of DNA damage. It activates doubly phosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1), and triply phosphorylated p53 to induce DNA damage. Dicycloplatin can cause cell cycle arrest, inhibit proliferation, and trigger apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. It is applicable for research in the field of cancer.Formule :C12H20N2O8PtMasse moléculaire :515.38p53 Activator 14
CAS :p53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.Formule :C28H29ClN4O3Couleur et forme :SolidMasse moléculaire :505.008ADAR1-IN-1
CAS :ADAR1-IN-1 is a potent ADAR1 inhibitor. It significantly suppresses the proliferation of DU-145 cells (IC50 = 1.11 μM), inhibits colony formation, migration, and invasion, and induces cell cycle arrest and apoptosis. ADAR1-IN-1 effectively and safely impedes tumor growth and can be utilized in prostate cancer (PCa) research.Formule :C17H15F4N5O6SCouleur et forme :SolidMasse moléculaire :493.39PD-1/PD-L1-IN-23
CAS :PD-1/PD-L1-IN-23: potent, oral PD-1/PD-L1 inhibitor; L7's ester prodrug; exhibits strong antitumor effects.Formule :C32H30BrCl2N3O6Couleur et forme :SolidMasse moléculaire :703.41ZSH-512
CAS :ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.
Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.464tDHU, acid
CAS :tDHU, acid is a dihydropyrimidine cereblon ligand consisting of an E3 ligase ligand and a benzoic acid linker. It serves as an E3 ubiquitin ligase ligand-linker conjugate in the development of PROTACs.Formule :C12H12N2O4Masse moléculaire :248.23Anticancer agent 53
CAS :Anticancer agent 53 exhibits potent in vitro cytotoxicity, triggers apoptosis, halts S/G2/M cycle, and has antitumor effects without toxicity.Formule :C31H25FN4O6SCouleur et forme :SolidMasse moléculaire :600.62Lometrexol disodium
CAS :Lometrexol disodium: Inhibits hSHMT1/2 and GARFT, anticancer by blocking purine synthesis, induces apoptosis and cell cycle arrest.Formule :C21H23N5Na2O6Couleur et forme :SolidMasse moléculaire :487.424EGFR-IN-3
EGFR-IN-3 is an EGFR inhibitor with antitumor activity.EGFR-IN-3 inhibits EGFRwt-TK, induces apoptosis (cell death), and can block cells in the G2/M phase.Formule :C24H18F4N6O2SDegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :530.5NPB-1575
CAS :NPB-1575 is a potent, orally active anti-inflammatory agent capable of crossing the blood-brain barrier. It mitigates neuroinflammation and resists ferroptosis by activating IRS2/Nrf2/NF-κB. NPB-1575 protects against cerebral ischemic injury and improves neurological function outcomes, making it suitable for research in focal ischemic stroke.Formule :C19H22O4Couleur et forme :SolidMasse moléculaire :314.38ASK1 ligand 1
CAS :ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Formule :C17H16F2N6OCouleur et forme :SolidMasse moléculaire :358.35eIF4A-IN-3
CAS :eIF4A-IN-3 (Compound 71E) is an inhibitor of the eukaryotic translation initiation factor 4A (eIF4A). This compound can be utilized as a cytotoxic payload for antibody-drug conjugates (ADCs).Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67SF-9-2
CAS :SF-9-2 is a PD-L1/PD-1 binding inhibitor with an IC50 of 24.9 nM. It suppresses epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, while also inducing apoptosis and causing cell cycle arrest. SF-9-2 blocks PD-L1-induced growth of SK-N-SH cells via the MAPK signaling pathway. It restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. In the SK-N-SH NOG mouse model, SF-9-2 inhibits tumor growth without notable toxicity. Additionally, SF-9-2 acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function and is applicable to neuroblastoma research.Formule :C30H27F2N3O3Couleur et forme :SolidMasse moléculaire :515.55PBX-7011
CAS :PBX-7011, an active camptothecin derivative, binds to the DDX5 protein in cells and induces cell death through DDX5 protein degradation [1].Formule :C24H21N3O6Couleur et forme :SolidMasse moléculaire :447.44RET-IN-7
CAS :RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice throughFormule :C22H24ClFN6O2Couleur et forme :SolidMasse moléculaire :458.92ST-899
CAS :ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Formule :C22H29BrClNO6Couleur et forme :SolidMasse moléculaire :518.83LLW-018
CAS :LLW-018 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 2.61 nM. It can disrupt the PD-1/PD-L1 interaction, with a cell-based PD-1/PD-L1 blocking bioassay IC50 value of 0.88 μM. LLW-018 holds potential for research in immune-related diseases.Formule :C35H38Cl2N4O5SMasse moléculaire :697.67(±)-Perillaldehyde
CAS :(±)-Perillaldehyde exhibits antidepressant effects in mice with stress-induced depressive-like behavior by modulating the olfactory nervous system. Additionally, it demonstrates anti-inflammatory activity by activating JNK in RAW264.7 cells and suppressing the expression of TNF-α, with an IC50 value of 171.7 μM.Formule :C10H14OCouleur et forme :SolidMasse moléculaire :150.22Neuroprotective agent 11
CAS :Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Formule :C32H30O12Couleur et forme :SolidMasse moléculaire :606.57YW3-56 (hydrochloride) (technical grade)
CAS :YW3-56: PAD2 & PAD4 inhibitor (IC50 = 0.5-5 μM), halts U2OS cell growth (IC50 ~2.5 μM), reduces S-180 & MDA-MB-231 tumor growth in mice.Formule :C27H33Cl2N5O2Couleur et forme :SolidMasse moléculaire :530.49Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride
CAS :Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprised of a cereblon ligand based on Thalidomide and a linker, utilized in the synthesis of PROTACs.
Formule :C21H28ClN5O7Masse moléculaire :497.93MDK-3345
CAS :MDK-3345 is a reversible covalent inhibitor for Mcl-1.Formule :C36H34BN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :631.48BMS-751324
CAS :BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.Formule :C32H35N6O10PCouleur et forme :SolidMasse moléculaire :694.63Mcl-1 inhibitor 9
CAS :Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.Formule :C32H39ClN2O5SCouleur et forme :SolidMasse moléculaire :599.18KIRA9
KIRA9 inhibits IRE1 with a 4.8 μM IC50, blocking ER-stress-induced mRNA decay and apoptosis by fully binding IRE1's ATP site.Formule :C27H27F3N6O3SCouleur et forme :SolidMasse moléculaire :572.6Lepidozin G
Lepidozin G blocks cancer growth (IC50=4.2-5.7μM) and triggers apoptosis in PC-3 cells via mitochondria.Formule :C30H48O4Couleur et forme :SolidMasse moléculaire :472.7p38 MAPK-IN-3
Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.Formule :C22H17BrO2Couleur et forme :SolidMasse moléculaire :393.27
