Apoptose

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GDF15. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GDF15. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GDF15, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GDF15 in the samples is then determined by comparing the OD of the samples to the standard curve.

Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.

PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.

Avermectin B1 is served as anthelmintic and insecticide.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse sRANKL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse sRANKL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse sRANKL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse sRANKL in the samples is then determined by comparing the OD of the samples to the standard curve.

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.

Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.

9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist and can be used to study advanced tumors.

Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM.

Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.

Maprotiline hydrochloride (Psymion) is a tetracyclic antidepressant akin to tricyclics with similar side effects.

Ibandronate sodium (Boniva) is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.

Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

D-(-)-3-Phosphoglyceric acid disodium: a key glycolysis/gluconeogenesis intermediate, inhibits yeast enolase, crucial in serine, glycine, threonine synthesis.