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Apoptose

Apoptose

Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.

Sous-catégories appartenant à la catégorie "Apoptose"

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5599 produits trouvés pour "Apoptose"

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  • SLCB050
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    SLCB050

    CAS :
    <p>SLCB050 is a compound with anticancer activity that inhibits the interaction between DX2 and p14/ARF. It decreases the viability of human lung cancer cells, particularly small cell lung cancer cells, in a p14/ARF-dependent manner, and induces cell apoptosis (apoptosis) and senescence.</p>
    Formule :C21H18O6
    Couleur et forme :Solid
    Masse moléculaire :366.36

    Ref: TM-T200005

  • WK88-1
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    WK88-1

    CAS :
    <p>WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis.</p>
    Formule :C28H42N2O6
    Couleur et forme :Solid
    Masse moléculaire :502.64

    Ref: TM-T200115

  • ZNU-IMB-Z15
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    ZNU-IMB-Z15

    CAS :
    <p>Compound Z15 (ZNU-IMB-Z15) acts as an antagonist and degrader of the androgen receptor (AR). It inhibits the proliferation of castration-resistant prostate cancer (CRPC) cell lines that are AR-positive and induces apoptosis. Compound Z15 exhibits anticancer activity both in vivo and in vitro.</p>
    Formule :C20H17N3O3S2
    Couleur et forme :Solid
    Masse moléculaire :411.5

    Ref: TM-T200015

  • p53 Stabilizer 2
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    p53 Stabilizer 2

    CAS :
    <p>p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizing agent. It can induce S-phase arrest and apoptosis in both p53-functional and p53-deficient cancer cells. Additionally, p53 Stabilizer 2 triggers mitochondrial stress and activates two immune checkpoint pathways: NA-PKcs dependent p53 stabilization and the ATR-Chk1 axis activation. It also inhibits tumor growth in p53-deficient xenograft models.</p>
    Formule :C30H37NO7Se
    Couleur et forme :Solid
    Masse moléculaire :602.58

    Ref: TM-T207330

  • PDEδ/NAMPT IN-1
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    PDEδ/NAMPT IN-1

    CAS :
    <p>PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.</p>
    Formule :C26H30N4O4S
    Couleur et forme :Solid
    Masse moléculaire :494.61

    Ref: TM-T207578

  • TrxR-IN-8
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    TrxR-IN-8

    CAS :
    <p>TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.</p>
    Formule :C16H16INO2
    Couleur et forme :Solid
    Masse moléculaire :381.21

    Ref: TM-T207620

  • GNE684
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    GNE684

    CAS :
    <p>GNE684 inhibits RIP1; Ki app: 21 nM (human), 189 nM (mouse), 691 nM (rat).</p>
    Formule :C23H24N6O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :432.48

    Ref: TM-T11442

  • Minnelide
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    Minnelide

    CAS :
    <p>Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types.</p>
    Formule :C21H25Na2O10P
    Degré de pureté :98.49% - 99.59%
    Couleur et forme :Solid
    Masse moléculaire :514.37

    Ref: TM-T12042

  • HL001
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    HL001

    CAS :
    <p>HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1). It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.</p>
    Formule :C21H16N2O4
    Couleur et forme :Solid
    Masse moléculaire :360.363

    Ref: TM-T204158

  • p53 Activator 14
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    p53 Activator 14

    CAS :
    <p>p53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.</p>
    Formule :C28H29ClN4O3
    Couleur et forme :Solid
    Masse moléculaire :505.008

    Ref: TM-T204386

  • HC-7366
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    HC-7366

    CAS :
    <p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>
    Formule :C20H15ClF2N6O4S
    Degré de pureté :99.84%
    Couleur et forme :Solid
    Masse moléculaire :508.89

    Ref: TM-T86497

  • Topoisomerase I/II inhibitor 8
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    Topoisomerase I/II inhibitor 8

    CAS :
    <p>TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.</p>
    Formule :C14H11Br2NO5S2
    Couleur et forme :Solid
    Masse moléculaire :497.179

    Ref: TM-T204994

  • Ferroptosis-IN-15
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    Ferroptosis-IN-15

    CAS :
    <p>Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.</p>
    Formule :C17H14O5
    Couleur et forme :Solid
    Masse moléculaire :298.29

    Ref: TM-T200858

  • BRD-K44839765
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    BRD-K44839765

    CAS :
    <p>BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.</p>
    Formule :C23H19N3O2S2
    Couleur et forme :Solid
    Masse moléculaire :433.55

    Ref: TM-T201093

  • BRD-K20733377
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    BRD-K20733377

    CAS :
    <p>BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.</p>
    Formule :C23H18N4O3S
    Couleur et forme :Solid
    Masse moléculaire :430.48

    Ref: TM-T201286

  • HDAC-IN-81
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    HDAC-IN-81

    CAS :
    <p>HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).</p>
    Formule :C20H27N3O3
    Couleur et forme :Solid
    Masse moléculaire :357.45

    Ref: TM-T201210

  • VNPP433-3β
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    VNPP433-3β

    CAS :
    <p>VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.</p>
    Formule :C29H34N4
    Couleur et forme :Solid
    Masse moléculaire :438.61

    Ref: TM-T88141

  • Elocalcitol
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    Elocalcitol

    CAS :
    <p>Elocalcitol is a calcitriol analog for inhibition of prostate cell growth.</p>
    Formule :C29H43FO2
    Couleur et forme :Solid
    Masse moléculaire :442.65

    Ref: TM-T19869

  • 06:0 PE
    Targetmol
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    06:0 PE

    CAS :
    <p>06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.</p>
    Formule :C17H34NO8P
    Couleur et forme :Solid
    Masse moléculaire :411.43

    Ref: TM-T200930

  • HAC-Y6
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    HAC-Y6

    CAS :
    <p>HAC-Y6 exerts its anticancer effects by inducing cell cycle arrest. It prompts apoptosis in COLO 205 cells with an IC50 of 0.52 µM.</p>
    Formule :C23H22N2O4
    Couleur et forme :Solid
    Masse moléculaire :390.43

    Ref: TM-T200179