Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(8 produits)
- Caspase(145 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(140 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(92 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6109 produits trouvés pour "Apoptose"
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Gallium 8-Hydroxyquinolinate
CAS :Gallium 8-Hydroxyquinolinate is an inducer of apoptosis that initiates both p53-dependent and independent cell death in cancer cells through the induction of Ca2+ signaling transduction. In addition to its apoptotic properties, this compound's nanostructures exhibit excellent optical performance, making it suitable for use in tumor research.Formule :C27H18GaN3O3Couleur et forme :SolidMasse moléculaire :502.17PD-L1-IN-1
PD-L1-IN-1, potent PD-L1 inhibitor with 115 nM IC50, suppresses tumors, boosts immune response, and spares healthy cells.Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44Ferroptosis-IN-6
CAS :Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Formule :C15H17NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :227.3Ref: TM-T86417
1mg57,00€5mg120,00€10mg187,00€25mg376,00€50mg605,00€100mg938,00€1mL*10mM (DMSO)133,00€Enpp-1-IN-25
CAS :Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423Thalidomide-O-PEG4-amine TFA
CAS :Thalidomide-O-PEG4-amine TFA is a synthetic E3 ligase ligand-linker conjugate, composed of a cereblon ligand derived from Thalidomide and a single linker.Formule :C25H32F3N3O11Masse moléculaire :607.53GLUT-1-IN-4
CAS :GLUT-1-IN-4 (Compound 13) is an inhibitor of the GLUT-1 glucose transporter that depends on the p53 protein. It suppresses the proliferation of various cancer cells at submicromolar IC50 levels. Additionally, GLUT-1-IN-4 can halt the cell cycle, induce oxidative stress, and promote apoptosis (cell death).Formule :C15H10N2O3Couleur et forme :SolidMasse moléculaire :266.251MJC13
CAS :<p>MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.</p>Formule :C13H15Cl2NOCouleur et forme :SolidMasse moléculaire :272.17Soquelitinib
CAS :Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Formule :C25H30N4O4S2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :514.66Ref: TM-T87429
1mg170,00€5mg411,00€10mg677,00€25mg1.349,00€50mg2.023,00€100mg2.745,00€200mg3.695,00€1mL*10mM (DMSO)465,00€BRD-K44839765
CAS :BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.Formule :C23H19N3O2S2Couleur et forme :SolidMasse moléculaire :433.55SPI-001
CAS :SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.Formule :C30H60O4Si2Couleur et forme :SolidMasse moléculaire :540.97SM-433 hydrochloride
SM-433 hydrochloride, a Smac mimetic & IAP inhibitor, binds XIAP BIR3; potent IC50 <1 μM. (Patent WO2008128171A2)Formule :C32H44ClN5O4Couleur et forme :SolidMasse moléculaire :598.18Silvestrol
CAS :Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis.Formule :C34H38O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.66Nur77 agonist-1
CAS :Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.Formule :C24H18ClN5O2Couleur et forme :SolidMasse moléculaire :443.885Antitumor agent-42
Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.Formule :C24H19BrN2O8SCouleur et forme :SolidMasse moléculaire :575.39PIM-1/HDAC-IN-1
PIM-1/HDAC-IN-1 (4d): inhibits PIM-1 (IC50: 343.87nM), HDAC1 (63.65nM), HDAC6 (62.39nM); induces apoptosis in MCF-7 cells.Formule :C22H19N3O3Couleur et forme :SolidMasse moléculaire :373.4HDAC-IN-34
HDAC-IN-34 inhibits HDAC1 (IC50: 0.022 μM) & HDAC6 (IC50: 0.45 μM), binds DNA causing damage, and halts HCT-116 cell growth (IC50: 1.41 μM).Formule :C24H26N6O3Couleur et forme :SolidMasse moléculaire :446.5Antitumor agent-77
Antitumor agent-77 suppresses cancer cell growth, migration, induces apoptosis, and hinders EMT.Formule :C7H11F3N2O5PtCouleur et forme :SolidMasse moléculaire :455.25RET-IN-1
CAS :RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).Formule :C29H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.61c-Met/HDAC-IN-2
CAS :Potent dual c-Met/HDAC inhibitor, IC50: HDAC1 5.4 nM, c-Met 18.49 nM; anti-cancer, induces apoptosis, G2/M arrest in HCT-116.Formule :C34H33N5O7Couleur et forme :SolidMasse moléculaire :623.66Samuraciclib
CAS :Samuraciclib (CT7001) is an oral CDK7 inhibitor with 41 nM IC50, notable for its high selectivity and potency against breast cancer cells.Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51
