Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(144 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(62 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6064 produits trouvés pour "Apoptose"
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sEH-IN-21
CAS :sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).Formule :C30H40N4O5SCouleur et forme :SolidMasse moléculaire :568.73ST-899
CAS :ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Formule :C22H29BrClNO6Couleur et forme :SolidMasse moléculaire :518.83c-Myc inhibitor 16 iodide
CAS :c-Myc inhibitor16 iodide (Compound W11) is a selective inhibitor of the c-MycG-quadruplex (c-MycG4). It suppresses the transcription and translation of the c-Myc gene, disrupts the tumor cell cycle by halting growth at the G0/G1 phase, and activates mitochondrial apoptotic pathways, leading to early apoptosis in cancer cells. This compound shows potential for research in breast cancer.Formule :C26H24INOCouleur et forme :SolidMasse moléculaire :493.379YW3-56 (hydrochloride) (technical grade)
CAS :YW3-56: PAD2 & PAD4 inhibitor (IC50 = 0.5-5 μM), halts U2OS cell growth (IC50 ~2.5 μM), reduces S-180 & MDA-MB-231 tumor growth in mice.Formule :C27H33Cl2N5O2Couleur et forme :SolidMasse moléculaire :530.49KIRA9
KIRA9 inhibits IRE1 with a 4.8 μM IC50, blocking ER-stress-induced mRNA decay and apoptosis by fully binding IRE1's ATP site.Formule :C27H27F3N6O3SCouleur et forme :SolidMasse moléculaire :572.6AKN-028 acetate
AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.Formule :C19H18N6O2Couleur et forme :SolidMasse moléculaire :362.39p53 Activator 8
CAS :p53 Activator 8 (compound 5), a potent p53 activator, exhibits significant anti-proliferative effects on MCF7 breast cancer cell lines, demonstrating an IC 50 value of 0.5 μM [1] [2].Formule :C15H17NO2SMasse moléculaire :275.37NCAO
CAS :<p>N-ω-chloroacetyl-L-ornithine (NCAO) serves as a powerful reversible competitive inhibitor of ornithine decarboxylase (ODC), displaying cytotoxic and antiproliferative properties against various tumor cell lines, with EC50 values spanning from 1 to 50.6 µM. In vitro studies reveal that NCAO promotes Apoptosis and restricts tumor cell migration. Additionally, it demonstrates significant antitumor efficacy in a mouse model, targeting both solid and ascitic tumors using the myeloma (Ag8) cell line. NCAO holds promise in the development of antitumor agents.</p>Formule :C7H13ClN2O3Couleur et forme :SolidMasse moléculaire :208.64PBX-7011
CAS :PBX-7011, an active camptothecin derivative, binds to the DDX5 protein in cells and induces cell death through DDX5 protein degradation [1].Formule :C24H21N3O6Masse moléculaire :447.44Utibaprilat
CAS :Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.Formule :C20H27N3O5SCouleur et forme :SolidMasse moléculaire :421.51Bcl-2-IN-7
Bcl-2-IN-7 inhibits Bcl-2, encourages apoptosis in cancer cells, and has anti-tumor activity with various IC50 values.Formule :C24H22N4O5S2Couleur et forme :SolidMasse moléculaire :510.59DC-U4106
CAS :DC-U4106: USP8 inhibitor, Kd 4.7μM, IC50 1.2μM, degrades Erα, low-toxicity tumor suppressor for breast cancer research.Formule :C29H27N5O5Couleur et forme :SolidMasse moléculaire :525.56FTO-IN-13
CAS :<p>FTO-IN-13 (compound 8t) is a potent FTO inhibitor with antiproliferative properties. It induces apoptosis (cell apoptosis) and reduces the expression of Bcl-2 and Caspase 3 active proteins. Additionally, FTO-IN-13 lowers the expression of MYC and CEBPA genes and demonstrates anticancer activity.</p>Formule :C18H12Br2N2O4Couleur et forme :SolidMasse moléculaire :480.107DOR agonist 2
CAS :Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formule :C29H26N2O3Couleur et forme :SolidMasse moléculaire :450.53PD-1/PD-L1-IN-16
PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63PARP10/15-IN-3
Compound 8a, a dual PARP10 & PARP15 inhibitor, has IC50s: PARP10 at 0.14μM & PARP15 at 0.40μM; it's cell-permeable & anti-apoptotic.Formule :C12H12N2O3Couleur et forme :SolidMasse moléculaire :232.24Laulimalide
CAS :Microtubule stabilizer; halts cancer cell growth (IC50: 3-30 nM); arrests cells in prometaphase; prevents bipolar spindle formation.Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65RIPK2-IN-6
CAS :RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formule :C26H21NO3Couleur et forme :SolidMasse moléculaire :395.45Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23ZSH-512
CAS :<p>ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.</p>Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.464
