Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(144 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(62 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6064 produits trouvés pour "Apoptose"
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JR5-26B
CAS :JR5-26B is an orally active apoptosis (apoptosis) inducer. It induces cell death via copper-mediated apoptosis and necroptosis (necroptosis). JR5-26B exhibits antiproliferative activity against MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells, with IC50 values of 0.6, 4.4, 8.0, 1.1, and 3.4 μM, respectively.Formule :C19H17FN6OCouleur et forme :SolidMasse moléculaire :364.38HDAC/PSMD14-IN-1
CAS :HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.Formule :C20H24N4O3S2Couleur et forme :SolidMasse moléculaire :432.56PD-1/PD-L1-IN-55
CAS :PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.Formule :C25H23ClN2O3Couleur et forme :SolidMasse moléculaire :434.92HR-19011
CAS :HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Formule :C25H19F6N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :523.43Ref: TM-T63665
2mg90,00€5mg137,00€10mg219,00€25mg440,00€50mg704,00€100mg1.103,00€200mg1.499,00€1mL*10mM (DMSO)157,00€Pamiparib maleate
CAS :Pamiparib (BGB-290) is a selective PARP inhibitor that blocks DNA repair and promotes apoptosis.Formule :C44H42F2N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :944.859NiCur
CAS :NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM.Formule :C22H16N2ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :324.38DX3-234
CAS :DX3-234 is a OXPHOS inhibitor that acts by inhibiting complex I in the mitochondrial ETC,for cancers dependent on aerobic metabolism, such as pancreatic cancer.Formule :C25H35N5O6S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :565.71Tubulin inhibitor 43
CAS :Tubulin inhibitor 43 exhibits significant antitumor activity by impeding the proliferation and growth of cancer cells through the inhibition of β-microtubulin activity, ultimately inducing apoptosis [1].Formule :C20H21NO6Couleur et forme :SolidMasse moléculaire :371.38HBV/HDV-IN-2
CAS :<p>HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.</p>Formule :C38H44ClN7O5Couleur et forme :SolidMasse moléculaire :714.25Urease-IN-20
CAS :Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.Formule :C14H8FNO2SeCouleur et forme :SolidMasse moléculaire :320.18GQN-B37-E
CAS :GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.Formule :C29H23ClN4O4Couleur et forme :SolidMasse moléculaire :526.97Necrosis inhibitor 3
CAS :Necrosis Inhibitor 3 (compound B3) effectively inhibits necrosis, demonstrating an IC50 of 0.29 nM in HT29 cells [1].Formule :C25H26N4O4SCouleur et forme :SolidMasse moléculaire :478.56pan-KRAS-IN-5
CAS :<p>Pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor targeting 5′-UTR RNA G-quadruplexes (rG4s). It induces cell cycle arrest and promotes apoptosis in KRAS-driven cancer cells [1].</p>Formule :C31H36FIN4O2Couleur et forme :SolidMasse moléculaire :642.55GLI1-IN-1
CAS :GLI1-IN-1 (CBC-1), a GLI-1 inhibitor, exhibits superior water solubility and anticancer properties. It effectively induces apoptosis and inhibits colorectal cancer growth by targeting the Hedgehog (HH) pathway (IC 50 = 1.3 μM) [1].Formule :C42H60N2O9Couleur et forme :SolidMasse moléculaire :736.93NLRP3-IN-72
CAS :NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. It exhibits anti-inflammatory and antioxidant properties, with an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protection against cell pyroptosis, and an EC50 of 0.6 μM for inducing HO-1.Formule :C19H20FN5OCouleur et forme :SolidMasse moléculaire :353.393MD102
CAS :MD102, with an IC50 value of 0.35 μM, is a potent TG2 inhibitor that stabilizes p53 by inhibiting TG2. This results in a decrease in p-AKT and p-mTOR downstream signaling, ultimately inducing tumor cell apoptosis [1].Formule :C13H4BrCl2FN2O2Couleur et forme :SolidMasse moléculaire :389.994-Hydroxyresveratrol
CAS :<p>4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) is a resveratrol analog that variably induces the expression of pro-apoptotic genes such as p53 and Bax. It triggers apoptosis in SV40 virus-transformed WI38 cells (WI38VA), but not in WI38 cells. Additionally, 4-Hydroxyresveratrol significantly increases the expression of p53, GADD45, and Bax genes in WI38VA cells, while suppressing the expression of the bcl-2 gene.</p>Formule :C14H12O4Couleur et forme :SolidMasse moléculaire :244.243Fluvastatin sodium monohydrate
CAS :Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].Formule :C24H27FNNaO5Couleur et forme :SolidMasse moléculaire :451.46Tubulin inhibitor 41
CAS :Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].Formule :C20H15N3OCouleur et forme :SolidMasse moléculaire :313.35YK5
CAS :YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.Formule :C18H24N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.50
