Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(144 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6071 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tubulin inhibitor 41
CAS :Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].Formule :C20H15N3OCouleur et forme :SolidMasse moléculaire :313.35MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38TAI-95
CAS :TAI-95 is an inhibitor of highly expressed cancer protein 1 (Hec1).Formule :C24H23N5O3S2Couleur et forme :SolidMasse moléculaire :493.60WB436B
CAS :WB436B, a highly selective STAT3 inhibitor, effectively targets and inhibits STAT3-Tyr705 phosphorylation along with the expression of STAT3 target genes. It exhibits cytotoxic effects on pancreatic cancer cells by inducing apoptosis. Furthermore, WB436B suppresses tumor growth and metastasis in pancreatic cancer mouse models, thereby prolonging the survival of tumor-bearing mice.Formule :C21H20N6O3SCouleur et forme :SolidMasse moléculaire :436.49CB-184
CAS :CB-184 is a selective ligand for sigma-2 (σ2) receptors, with Ki values of 7436 nM for sigma-1 (σ1) and 13.4 nM for sigma-2 (σ2), and it promotes apoptosis with antitumor activity.Formule :C22H21Cl2NO2Couleur et forme :SolidMasse moléculaire :402.31PAK4-IN-5
PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).Formule :C31H28ClN5OCouleur et forme :SolidMasse moléculaire :522.04CAR-2
CAS :<p>CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.</p>Formule :C27H23BF2I2N4O2Couleur et forme :SolidMasse moléculaire :738.114WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Formule :C30H38N6O2Couleur et forme :SolidMasse moléculaire :514.66(Rac)-Idroxioleic acid sodium
CAS :(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.Formule :C18H33NaO3Couleur et forme :SolidMasse moléculaire :320.44Top/HDAC-IN-3
CAS :Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47PROTAC FKBP Degrader-3
CAS :PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.Formule :C68H90N6O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1295.54Minnelide
CAS :Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types.Formule :C21H25Na2O10PDegré de pureté :98.49% - 99.59%Couleur et forme :SolidMasse moléculaire :514.37Antibacterial agent 254
CAS :Antibacterialagent 254 (Compound 2) is an antimicrobial agent capable of eradicating 7-day-old P. aeruginosa biofilms at a concentration of 50 μM without affecting bacterial growth. Additionally, Antibacterialagent 254 enhances the efficacy of Ciprofloxacin against P. aeruginosa and upregulates the expression of the matrix-degrading enzyme genes pelA, pslG, and eddA.Formule :C13H15NO4Masse moléculaire :249.26YW3-56 (hydrochloride) (technical grade)
CAS :YW3-56: PAD2 & PAD4 inhibitor (IC50 = 0.5-5 μM), halts U2OS cell growth (IC50 ~2.5 μM), reduces S-180 & MDA-MB-231 tumor growth in mice.Formule :C27H33Cl2N5O2Couleur et forme :SolidMasse moléculaire :530.49Bafilomycin C1
CAS :vacuolar H+-ATPases (V-ATPases) inhibitorFormule :C39H60O12Degré de pureté :98%Couleur et forme :Light Tan SolidMasse moléculaire :720.89BNN27
CAS :BNN27 is an agonist of the TrkA receptor (TrkAreceptor) and the p75NTR receptor (p75NTR receptor), exhibiting neurotrophic and anti-apoptotic properties. It enhances levels of glutamate, GABA, and glutamine in the hippocampus and prefrontal cortex of rats, improving glutamate turnover. In a mouse model of amyotrophic lateral sclerosis (ALS), BNN27 demonstrates neuroprotective effects, shows anti-inflammatory properties in an experimental autoimmune encephalomyelitis (EAE) model, and exhibits retinal protection in a rat diabetes model. BNN27 also possesses blood-brain barrier permeability.Formule :C21H32O3Couleur et forme :SolidMasse moléculaire :332.477NTU281
CAS :NTU281 inhibits transglutaminase-2, lowers creatinine in diabetic rats, reduces proteinuria, and fights glomerulosclerosis.Formule :C25H31N2O6SCouleur et forme :SolidMasse moléculaire :487.59p53 Activator 12
CAS :Compound 510B, also known as p53 Activator 12, is a powerful activator of p53. This compound specifically interacts with mutant p53 to restore its DNA-binding function.Formule :C28H35F3N8O2Masse moléculaire :572.63Aeroplysinin 1
CAS :Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.Formule :C9H9Br2NO3Couleur et forme :SolidMasse moléculaire :338.98ZSH-512
CAS :<p>ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.</p>Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.464
