Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(144 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(62 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6068 produits trouvés pour "Apoptose"
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LL-Z 1640-4
CAS :A signal-specific JNK/p38 pathway and TAK 1 inhibitorFormule :C19H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.39ISR modulator-1
CAS :ISR Modulator-1 (Compound 212) acts as a regulator for the integrated stress response pathway (ISR).Formule :C20H21ClF4N4O4Couleur et forme :SolidMasse moléculaire :492.85JNK-IN-19
CAS :JNK-IN-19 (Compound Q8) is an inhibitor of c-Jun N-terminal kinase, utilized for the treatment and/or prevention of injuries prior to, during, or following surgery.Formule :C22H24F3N6Na2O6PCouleur et forme :SolidMasse moléculaire :602.41SBI-0640726
CAS :SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83TRPM7-IN-1
CAS :TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48EGFR/VEGFR2-IN-3
CAS :EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03t9,t11,c15-CLNA
CAS :t9,t11,c15-CLNA is an isomer of conjugated linolenic acid (CLNA) produced by Lactobacillus plantarum ZS2058. It exhibits key activities including anti-inflammatory and antioxidant effects, as well as enhancement of intestinal barrier function. The regulatory mechanisms of t9,t11,c15-CLNA involve the upregulation of tight junction proteins, the inhibition of pro-inflammatory cytokines (such as TNF-α, IL-6), and the activation of antioxidant enzymes (such as SOD, CAT). t9,t11,c15-CLNA can be utilized in research on inflammatory bowel disease (like colitis).Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.43LRRK2-IN-17
CAS :LRRK2-IN-17 is an orally active LRRK2 inhibitor with IC50 values of 3.5 nM for WT and 3.3 nM for G2019S, and it also inhibits RET kinase with an IC50 of 59 nM. LRRK2-IN-17 is utilized in research related to cancer and Parkinson's disease (PD).Formule :C18H18N8Couleur et forme :SolidMasse moléculaire :346.39Erythromycin B
CAS :Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.Formule :C37H67NO12Couleur et forme :SolidMasse moléculaire :717.93RET-IN-30
CAS :RET-IN-30 (Compound 28) is a RET inhibitor that exhibits inhibitory activity against both wild-type RET and some of its mutants. It is capable of inhibiting the proliferation of A549 cells and demonstrates antitumor properties.Formule :C26H26FN5OCouleur et forme :SolidMasse moléculaire :443.52FKBP51-Hsp90-IN-1
CAS :FKBP51-Hsp90-IN-1 (Compound D10) serves as a selective inhibitor targeting the FKBP51-Hsp90 protein-protein interaction, demonstrating an IC 50 value of 0.1 μM against FKBP51. It holds potential for research applications in stress-related diseases, Alzheimer's disease, and metabolic disorders [1].Formule :C19H24N4O4S2Masse moléculaire :436.55MDM2-IN-26
CAS :MDM2-IN-26 (compound A3) is an inhibitor of MDM2 that facilitates the activation of p53's tumor suppressor functions by inhibiting the MDM2-p53 interaction, with MDM2 being the primary negative regulator of p53. This compound is utilized in cancer research [1].Formule :C32H32Cl2F3N3O4Masse moléculaire :650.52HC-7366
CAS :<p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>Formule :C20H15ClF2N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :508.89NPB-1575
CAS :NPB-1575 is a potent, orally active anti-inflammatory agent capable of crossing the blood-brain barrier. It mitigates neuroinflammation and resists ferroptosis by activating IRS2/Nrf2/NF-κB. NPB-1575 protects against cerebral ischemic injury and improves neurological function outcomes, making it suitable for research in focal ischemic stroke.Formule :C19H22O4Couleur et forme :SolidMasse moléculaire :314.38Nampt-IN-16
CAS :Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC50 of 0.15 μM. It reduces intracellular NAD+ and ATP levels. Nampt-IN-16 inhibits the proliferation, migration, and invasion of gastric cancer cells, induces cell cycle arrest and apoptosis, and alters cellular metabolism. This compound is applicable for research in tumors such as gastric cancer.Formule :C25H25FN4O3Couleur et forme :SolidMasse moléculaire :448.49Ferrostatin-1 diyne
CAS :Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.Formule :C18H22N2O2Couleur et forme :SolidMasse moléculaire :298.38Rafutrombopag
CAS :Rafutrombopag is a thrombopoietin (TPO) agonist.Formule :C25H22N4O5Couleur et forme :SolidMasse moléculaire :458.47HI042
CAS :HI042 is an FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing an IC50 value of 0.62 μM for MOLM-13 cells, 0.33 μM for MV4-11 cells, and 0.89 μM for OCI-AML3 cells. It selectively reduces the survival rate of FLT3-internal tandem duplication (FLT3-ITD) positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes colony-forming ability. HI042 is applicable for acute myeloid leukemia (AML) research.Formule :C14H11N3O3SCouleur et forme :SolidMasse moléculaire :301.32Antiangiogenic agent 7
CAS :Antiangiogenic agent 7 (Compound 1) induces apoptosis, elevates Reactive Oxygen Species (Reactive Oxygen Species), and inhibits the intracellular enzyme thioredoxin reductase. It exhibits anticancer activity with IC50 values ranging from 0.08 to 3.5 μM against cervical cancer cells (HeLa), prostate cancer cells (PC-3), and non-small cell lung cancer cells (A549). Additionally, Antiangiogenic agent 7 suppresses tumor growth in a mouse xenograft model.Formule :C24H26AuN3P2SCouleur et forme :SolidMasse moléculaire :647.463′-Hydroxyflavanone
CAS :3′-Hydroxyflavanone is a cyclized flavonoid with anti-tumor properties that induces apoptosis in HeLa cells.Formule :C15H12O3Couleur et forme :SolidMasse moléculaire :240.25
