Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
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6223 produits trouvés pour "Apoptose"
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ATWLPPRAANLLMAAS
CAS :ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Formule :C76H123N21O20SMasse moléculaire :1682.98HLDA-212
CAS :HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formule :C70H90BrFN8O19SCouleur et forme :SolidMasse moléculaire :1478.47ALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.Formule :C30H36ClF3N6O3Degré de pureté :98.66%Couleur et forme :SoildMasse moléculaire :621.09Human membrane-bound PD-L1 polypeptide
CAS :Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formule :C85H140N26O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2134.24(Iso)-Z-VAD(OMe)-FMK
CAS :(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.495,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin
CAS :5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a capable of forming complexes with metal ions and exhibit phototoxicity towards Hep-2 cells.Formule :C48H38N4O4Couleur et forme :SolidMasse moléculaire :734.84Asudemotide
CAS :Asudemotide is a bioactive chemical.Formule :C58H80N10O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1189.31Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS :Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Formule :C20H14ClFeN2O2Couleur et forme :SolidMasse moléculaire :405.64AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57(E)-Ajoene
CAS :(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.Formule :C9H14OS3Couleur et forme :SolidMasse moléculaire :234.39Stem bromelain
CAS :Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.Couleur et forme :SolidAnticancer agent 267
Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.Formule :C13H11N5O4SCouleur et forme :SolidMasse moléculaire :333.32EGFR-IN-169
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.Couleur et forme :Odour SolidNSD-IN-4
NSD-IN-4 (Compound A8) is a potent and orally active inhibitor of NSD3, inducing apoptosis in a dose-dependent manner. It demonstrates significant antitumor activity against lung squamous cell carcinoma.Formule :C17H12ClFN2O2Couleur et forme :SolidMasse moléculaire :330.741RK-10
CAS :RK-10 is a peptide that binds to PD-L1. After being conjugated with Cy5 or Biotin, RK-10 can be used to identify PD-L1-expressing tumors through flow cytometry or immunohistochemistry. It is applicable for research in detecting cancers such as non-small cell lung cancer (NSCLC), breast cancer, squamous cell carcinoma, and melanoma.Formule :C105H176N28O36SCouleur et forme :SolidMasse moléculaire :2438.75WR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52Nogo-B-IN-1
Nogo-B-IN-1 ((S,R)-4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28 µM) and induces apoptosis. This compound is applicable for targeted OS research.Couleur et forme :Odour SolidSuc-Ala-Leu-Pro-Phe-pNA
CAS :Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], showcases the intricate interactions necessary for specificFormule :C33H42N6O9Couleur et forme :SolidMasse moléculaire :666.72RIPK1 ligand-Linker Conjugate-1
RIPK1ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that consists of a RIPK1 ligand and a PROTAC linker, designed to recruit E3 ligase. It is utilized in the synthesis of PROTACRIPK1Degrader-1.Couleur et forme :Odour SolidD-Trimannuronic acid
CAS :D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.Formule :C18H26O19Couleur et forme :SolidMasse moléculaire :546.387
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