Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(127 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6170 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
MD-265
CAS :MD-265 is a PROTAC degrader that targets and degrades MDM2, leading to the activation of p53 in cancer cells with wild-type p53. MD-265 achieves complete tumor regression and enhances long-term survival in leukemic mice.Formule :C50H51Cl2FN6O6Masse moléculaire :921.885-Methoxysterigmatocystin
CAS :5-Methoxysterigmatocystin is a mycotoxin characterized by its cytotoxic and genotoxic properties. It exhibits cytotoxic effects on cancer cell lines A549 and HepG2, with IC50 values of 5.5 μM and 0.7 μM, respectively. Additionally, it induces DNA damage. 5-Methoxysterigmatocystin acts as a photosensitizer, generating singlet oxygen (1O2) under visible light.Formule :C19H14O7Masse moléculaire :354.31CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μMFormule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55Bcl-2-IN-21
Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.Formule :C45H33F6IrN5PMasse moléculaire :980.96Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75HSP70-IN-6
HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).Couleur et forme :Odour SolidWKYMVM TFA
CAS :WKYMVm is a selective FPR2 agonist with high affinity, which was identified through screening of a synthetic peptide library.Formule :C43H62F3N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :970.13Necroptosis-IN-4
Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.Couleur et forme :Odour Solid5-Fluorouracil-13C,15N2
CAS :5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.Formule :C4H3FN2O2Couleur et forme :SolidMasse moléculaire :133.0575,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin
CAS :5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a capable of forming complexes with metal ions and exhibit phototoxicity towards Hep-2 cells.Formule :C48H38N4O4Couleur et forme :SolidMasse moléculaire :734.84Topoisomerase I inhibitor 17
CAS :TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1). It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and γH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.Formule :C28H21FN2O7Couleur et forme :SolidMasse moléculaire :516.47CDC20-IN-2
CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.Couleur et forme :Odour SolidXY077
XY077 (compound 14a) is a RORγ inverse agonist with an IC50 value of 0.004 μM. It induces cell apoptosis (cellapoptosis) and exhibits antiproliferative activity both in vitro and in vivo.Formule :C27H27F3N2O5S2Masse moléculaire :580.13135FOXO4-DRI
CAS :FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Formule :C228H388N86O64Couleur et forme :SolidMasse moléculaire :5358.06Tomatine hydrochloride
CAS :Tomatine hydrochloride halts fungi/bacteria growth, is extracted from wild tomato leaves, and precipitates steroids.Formule :C50H84ClNO21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1070.65PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52Antitumor agent-145
CAS :Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].Formule :C44H34IrN5OSCouleur et forme :SolidMasse moléculaire :873.06HNPMI
CAS :HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Formule :C22H20N2O3Degré de pureté :97.19%Couleur et forme :SoildMasse moléculaire :360.41Halenaquinone
CAS :Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.Formule :C20H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31H3B-8800
CAS :H3B-8800 is an SF3B1 modulator that can be used to study transfusion-dependent anemia.Formule :C31H45N3O6Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :555.71
