Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(141 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(138 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(14 produits)
- Survivant(14 produits)
- TNF(92 produits)
- c-RET(55 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
5865 produits trouvés pour "Apoptose"
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GL392
<p>GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.</p>Formule :C55H52ClN13O5SCouleur et forme :SolidMasse moléculaire :1042.6Hypoxia inducer-1
<p>Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.</p>Formule :C14H12FN3O4Couleur et forme :SolidMasse moléculaire :305.261NS3694
CAS :<p>NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.</p>Formule :C15H10ClF3N2O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :358.7PD-L1/VISTA-IN-2
<p>PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.</p>Formule :C22H22N2O3Couleur et forme :SolidMasse moléculaire :362.42Cuprichydroxide
CAS :<p>Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.</p>Formule :CuH2O2Couleur et forme :SolidMasse moléculaire :97.56MNK8
CAS :MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formule :C18H26AsClN4O9SDegré de pureté :99.74%Couleur et forme :SoildMasse moléculaire :584.86Tubulin polymerization-IN-72
<p>Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.</p>Formule :C19H19FN4OCouleur et forme :SolidMasse moléculaire :338.379TNF-α-IN-6
CAS :<p>TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).</p>Formule :C26H25N9O2Couleur et forme :SolidMasse moléculaire :495.547Calcimycin hemicalcium salt
CAS :<p>Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.</p>Formule :C58H72CaN6O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1085.322(Rac)-AMXT-1501 4HCl
CAS :<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Formule :C32H72Cl4N6O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :714.77dMCL1-2
CAS :<p>dMCL1-2 is a PROTAC-based MCL1 degrader, binding at 30 nM, and induces apoptosis in leukemia.</p>Formule :C61H66N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1163.3FC-116
CAS :<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Formule :C21H20FNO4Degré de pureté :98.18%Couleur et forme :SoildMasse moléculaire :369.39ILS-920
CAS :<p>ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.</p>Formule :C57H86N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1023.3CPTH2 (hydrochloride) (357649-93-5 free base)
CAS :CPTH2 is an inhibitor of the HAT activity of Gcn5.Formule :C14H15Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.26FLT3-IN-29
<p>FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.545Antagonist G
CAS :<p>Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.</p>Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19QZ2135
<p>QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.</p>Formule :C53H54N12O4Couleur et forme :SolidMasse moléculaire :923.07Osajin
CAS :<p>Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.</p>Formule :C25H24O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.46Targaprimir-96
CAS :Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.Formule :C77H102N18O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1391.75
